Cryo-EM structure of 80S ribosome

Cryo-EM structure of 80S ribosome

Structure of Ebinur lake virus polymerase complexed with suramin

C. acnes 70S ribosome bound to Minocycline

C. acnes 70S ribosome bound to Sarecycline

C. acnes 70S ribosome bound to Doxycycline

328-363 tau mutant S341L_S352I

Cryo-EM strucutre of MbpAgo-gDNA complex

Composite map of Type II-A CRISPR integrase prespacer catching complex, State I

Cryo-EM strucutre of MbpAgo-gDNA-tgRNA complex

Focused map of Type II-A CRISPR integrase prespacer catching complex, State I

Cryo-EM strucutre of the apo Mucilaginibacter paludis Argonaute

Focused map of Type II-A CRISPR integrase prespacer catching complex, State II

E. coli 70S ribosome bound to Minocycline

E. coli 70S ribosome bound to Sarecycline

E. coli 70S ribosome bound to Doxycycline

Focused map of HBV Capsid with compound HAP12

S. marcescens Cas10-Csm bound to target RNA

Focused map of HBV with BAY41-4109

Cryo-EM reconstruction of human PI3KC3-C1, focused map 2/2

Cryo-EM reconstruction of human PI3KC3-C1, composite map

Human Argonaute2 R315V/H316A - guide RNA in complex with a fully complementary target (conformation 2)

Human Argonaute2 WT - guide(3 prime-amino) RNA in complex with a fully complementary target

Human Argonaute2 R315V/H316A - guide10U RNA in complex with a complementary target to position 19

Cryo-EM reconstruction of human PI3KC3-C1, focused map 1/2

The partially ruptured LBD state of GluK2/K5 with 5-iodowillardiine and kynurenic acid sodium salt

Structure of the Porcine deltacoronavirus (PDCoV) receptor-binding domain bound to the RBD minibinder 11, the PD3 Fab, and the Kappa light chain nanobody (local refinement)

Cryo-EM structure of ncBAF bound to the nucleosome

CryoEM structure of transcribing RNA polymerase II elongation complex_Local density map of Jaw/RPB9

Structure of BmrA T123C-S428C reduced form (apo state)

CryoEM structure of transcribing RNA polymerase II elongation complex_Composite map

CryoEM structure of transcribing RNA polymerase II elongation complex_Local density map of RPB9

CryoEM structure of transcribing RNA polymerase II elongation complex_Local density map of RPB12/Wall

CryoEM structure of transcribing RNA polymerase II elongation complex_3D classification map containing the complete nucleic acid scaffold

Structure of BmrA T123C-S428C cross-linked form (apo state)

CryoEM structure of transcribing RNA polymerase II elongation complex_Local density map of RPB4/7

Assembly intermediate of human mitochondrial ribosome small subunit in complex with NOA1 and TFB1M (state N3)

Phospho-MCM double hexamer bound to Sld3-Sld7-Cdc45 on ARS1 DNA

pre-Initiation Complex on ARS1 DNA (monomer)

Structure of the human chimera HCN112 hyperpolarization-activated cyclic nucleotide-gated ion channel.

Human TRPC5 in complex with (-) englerin A, full occupancy, intermediary desensitized state

Structure of the human HCN1dC hyperpolarization-activated cyclic nucleotide-gated ion channel.

Human TRPC5 in complex with (-) englerin A, full occupancy, state 1, on 290 nm gold foil holes (HexAuFoil)

TRPC5 apo cryoEM map in the presence of pluronic acid (PA), state 2

Human TRPC5 in complex with (-) englerin A, mixed occupancy, state 2

Human TRPC5 in complex with (-) englerin A, partial occupancy (2EA:2LIP stoichiometry) state 1

Human TRPC5 in complex with (-) englerin A, mixed occupancy, state 1

Cryo-EM structure of the human pre-Bact-OTS complex (whole map)

Human TRPC5 in complex with (-) englerin A, full occupancy, state 2, on 290 nm gold foil holes (HexAuFoil)

Human TRPC5 in complex with (-) englerin A, mixed occupancy_2, state 2

Pre-Initiation Complex on ARS1 DNA (dimer)

Human TRPC5 in complex with (-) englerin A, partial occupancy (2EA:2LIP stoichiometry) state 2

Cryo-EM structure of P. abyssi 70S ribosome in complex with hibernation factor HibA (HibA-uL5 conformation)

in situ subtomogram average of the V-ATPase from dopaminergic varicosities

sCMGE assembled on ARS1 DNA with Sld2 and RPA

sCMGE assembled on ARS1 DNA with RPA and no Sld2

Cryo-EM structure of human urate transporter GLUT9 bound to a selective inhibitor SG4

in situ subtomogram average of TRiC particles from dopaminergic varicosities

Ubiquinol Binding Site of Cytochrome bo3 from A.b

Ubiquinol Binding Site of Cytochrome bo3 from Acinetobacter baumannii

Cryo-EM structure of KP.3 spike in complex with Nb9B

Ubiquinol Binding Site of Cytochrome bo3 from Acinetobacter baumannii

Ubiquinol Binding Site of Cytochrome bo3 from Acinetobacter baumannii

Structure of KP.3 spike in complex with Nanosota-9B (local refinement)

CHIP E3 ligase dimer in Asymmetric state bound to 1 Fab H1

CHIP E3 ligase dimer bound to 1 Fab 2D2

H5N1 HA in complex with HC-5 Fab

Cryo-EM structure of cGAS tetramer in complex with BuDNA (bubble DNA)

CHIP E3 ligase CC domain dimer-Fab 2D2 epitope focused refinement

CHIP E3 ligase dimer in intermediate state bound to 2 Fab H1

HBV wildtype capsid with packaged E. coli RNA

CHIP E3 ligase dimer in Symmetric state bound to 2 Fab H1

CHIP E3 ligase U-box-Fab H1 epitope focused refinement

CryoEM structure of human MATa2 in complex with MAT2B isoform v1 at 2.6 A resolution

Phospho-DH bound by Sld3-MBD on ARS1 DNA

Single particle cryo-EM structure of human MTCH2 (hyperactive mutant K25E Y235A V238D)

Single particle cryo-EM structure of human MTCH2-BRIL fusion

Single particle cryo-EM structure of human MTCH2

Single particle cryo-EM structure of human MTCH2 (hyperactive mutant F285N F286N)

CryoEM map of the ATPase domain of SMARCA4 and the finger helix of BCL7A bound to a nucleosome

Cryo-EM map of the ATPase domain of SMARCA4 bound to a nucleosome

Cryo-electron microscopic structure of a novel amidohydrolase ADH3 triple mutation

Consensus map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 1

Composite map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 5

Composite map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 1

Focused map of area 2 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 1

Consensus map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 2

Focused map of area 2 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 2

Focused map of area 1 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 5

Human carboxyhemoglobin bound to full-length Staphylococcus aureus IsdH - IsdH:Hbdim complex

Consensus map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 5

Composite map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 2

Focused map of area 1 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 1

Focused map of area 1 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 2

CryoEM structure of human MATa2 in complex with MAT2B isoform v1 at 2.6 A resolution

Cryo-EM structure of the spermine-bound sea lamprey TAAR348

Focused map of area 3 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 5

Focused map of area 2 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 5

Cryo-EM structure of the spermine-bound sea lamprey TAAR348-Gs complex

Cryo-EM structure of the spermine-bound sea lamprey TAAR348-Gs complex

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 48

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 1

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 6

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 2

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 7

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 51

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 3

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 55

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 5

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 49

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 4

DalDroS bound to the Escherichia coli 50S ribosomal subunit

Dal2 bound to the Escherichia coli 70S ribosome

DalDro bound to the initiating Escherichia coli 70S ribosome

WT-HEK 80S ribosome bound to H2B mRNA (WT-H2B)

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 18

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 23

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 10

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 20

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 11

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 14

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 16

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 9

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 21

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 8

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 17

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 15

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 22

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 13

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 12

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 19

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 25

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 35

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 24

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 31

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 29

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 33

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 28

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 36

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 26

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 27

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 40

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 43

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 38

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 32

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 42

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 39

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 37

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 34

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 41

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 30

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 47

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 45

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 10

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 46

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 50

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 9

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 8

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 4

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 12

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 53

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 7

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 6

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 3

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 2

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 44

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 54

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 5

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 11

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 1

Cryo-EM structure of RNase P RNA from Geobacillus stearothermophilus, conformer 52

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 20

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 16

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 21

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 14

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 17

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 15

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 19

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 18

Cryo-EM structure of Geobacillus stearothermophilus RNase P holoenzyme in 1 mM Mg2+, conformer 13

SARS-CoV-2 spike trimer in the early fusion intermediate conformation bound to the VN01H1 Fab (Fab local refinement)

SARS-CoV-2 spike trimer in the early fusion intermediate conformation bound to the VN01H1 Fab (S2 local refinement)

Human insulin receptor domains FnIII-1 and L2 bound to HIR-6 DNA aptamer

Cryo-EM structure of the PI3K alpha/KRas/HER3 phosphopeptide complex dimer on POPC/POPS/PIP2 nanodiscs

SARS-CoV-2 spike trimer in the early fusion intermediate conformation bound to the VN01H1 Fab (global refinement)

Cryo-EM structure of the PI3K alpha/KRas/HER3 phosphopeptide complex on POPC/POPS/PIP2 nanodiscs low-pass filtered to 5 angstroms

Cryo-EM structure of the Class 1 PI3K alpha/KRas complex on POPC/POPS nanodiscs low-pass filtered to 10 angstroms

Cryo-EM structure of the Class 1 PI3K alpha/KRas complex on POPC/POPS nanodiscs

Cryo-EM structure of the PI3K alpha/KRas/HER3 phosphopeptide complex on POPC/POPS/PIP2 nanodiscs

Cryo-EM structure of the PI3K alpha/KRas/HER3 phosphopeptide complex dimer on POPC/POPS/PIP2 nanodiscs low-pass filtered to 5 angstroms

TMPRSS2 (S441A) bound to the HCoV-NL63 S2'region genetically fused to the HCoV-HKU1 RBD

TMPRSS2 S441A in complex with the H1H7 Fab and anti-kappa light chain nanobody

SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to the VN01H1 Fab

SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to C77G12 (Fab local refinement)

SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to the VN01H1 Fab (Fab local refinement)

Structure of the Porcine deltacoronavirus (PDCoV) receptor-binding domain bound to the RBD minibinder 11, the PD3 Fab, and the Kappa light chain nanobody

HCoV-NL63 S2' peptide bound to TMPRSS2 S441A (complexed with the H1H7 Fab and an anti-kappa-nanobody)

SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to the VN01H1 Fab (S2 local refinement)

SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to C77G12 (global refinement)

SARS-CoV-2 S2 trimer stabilized in the early fusion intermediate conformation by circular permutation and clamping by gp41 (E-FICs-v1)

One CAP-1 Bound to the Pointed End of Cofilin F-actin, Consensus map

Cryo-EM Map of Transmembrane Domain of AAA+ protease FtsH

Cryo-EM Structure of the Periplasmic Domain of AAA Protease FtsH

Cryo-EM Map of the Periplasmic Domain of AAA Protease FtsH in a Novel Orientation

Cryo-EM Map of the Transmembrane Domain of AAA Protease FtsH in a Novel Orientation

Focused map of area 1 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 3

Cryo-EM structure of bacteriophage Avs-1 connector

Structure of the ACE2-B0AT1 bound with Phenylalanine

Structure of the ACE2-B0AT1 bound with tryptophan

Local refinement of the ACE2-B0AT1 bound with phenylalanine

Cryo-EM structure of bacteriophage Avs-1 capsid

Composite map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 3

Cryo-EM structure of bacteriophage Avs-1 tube

Cryo-EM structure of bacteriophage Avs-1 spike-tip interface

Consensus map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 3

Focused map of area 1 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 4

Cryo-EM structure of bacteriophage Avs-1 spike

Consensus map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 4

Composite map of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 4

Cryo-EM structure of bacteriophage Avs-1 tip

Focused map of area 2 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 4

Focused map of area 2 of the type III CRISPR-associated deaminase in complex cA6 and ATP, State 3

Structure of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)

Cryo-EM structure of Arabidopsis TIR-NLR WRR4A tetramer in complex with weakly bound effector CCG28 (C2-symmetry)

EGF-bound EGFR(1-672) dimer

EGFR(1-672) fused to CD82

CM1-activated gTuRC in complex with nascent alpha-E254D mutant microtubules

WT-HEK 80S ribosome bound to Kozak mRNA (WT-Kozak)

CM1-activated gTuRC in complex with nascent wildtype microtubules

Human Nap1 in complex with HIV-1 Rev

ATTR Collagen VI Cofibrils

ATTR cardiac amyloid fibrils apex2

Human Collagen VI microfibril

ATTR cardiac amyloid fibrils apex1

ATTR V122I cardiac amyloid fibrils

Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS and Chk1

Apo structure of Ebinur lake virus polymerase

Structure of plant diacylglycerol O-acyltransferase 1

Cryo-EM structure of 80S ribosome

Cryo-EM structure of 80S ribosome

Structure of Ebinur lake virus polymerase at the elongation state