EMD-74963

Single-particle
3.6 Å
EMD-74963
3D View Gallery
Deposition: 06/01/2026
Map released: 07/10/2026
Last modified: 07/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-74963

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9zyr summary report (pdf.gz) Map-9zyr FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Menthol-and PIP2-bound mouse TRPM8 in a closed (C1M) state

EMD-74963

Single-particle
3.6 Å
EMD-74963
3D View Gallery
Deposition: 06/01/2026
Map released: 07/10/2026
Last modified: 07/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus
Sample: Tetrameric complex of mouse TRPM8 in domain-swapped architecture
Fitted models: 9zyr

Deposition Authors: Lee HJ , Lee SY
Molecular basis for cold and menthol sensing by mammalian TRPM8.
Lee HJ , Park CG , Fedor JG , Peele WA, Borgnia MJ , Lee SY
(2026) Nat Commun , 17
PUBMED: 42744822
DOI: doi:10.1038/s41467-026-76926-1
ISSN: 2041-1723