EMD-75150

Single-particle
2.7 Å
EMD-75150
3D View Gallery
Deposition: 19/01/2026
Map released: 28/10/2026
Last modified: 28/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-75150

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-10gg summary report (pdf.gz) Map-10gg FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

The eukaryotic translation initiation factor 2B from Homo sapiens with a L179V mutation in the delta subunit bound to methylated ISRIB

EMD-75150

Single-particle
2.7 Å
EMD-75150
3D View Gallery
Deposition: 19/01/2026
Map released: 28/10/2026
Last modified: 28/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Eukaryotic translation initiation factor 2-B with an L179V point mutation in the delta subunit bound to mISRIB
Fitted models: 10gg

Deposition Authors: Dalwadi U, Boone M, Croll TI, Laughlin TG, Frost A, Walter P
Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer
Boone M, Dalwadi U, Deal A, Zhu PJ, Croll TI, Yamazaki M, Prescott K, Minopoli R, Biscocho I, Wang J, Lee DJ, Arthur CP, Laughlin TG, Zhou H, Klope MT, Egea PF, Schoof M, Lawrence R, Renslo AR, Costa-Mattioli M, Frost A, Walter P
(2026) bioRxiv
DOI: doi:10.64898/2026.02.04.700910
ISSN: 2692-8205
Grant Support: