Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M14.005: carboxypeptidase E

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, M Mutation, I Inhibitor, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Fan,F.C., Liu,L.M., Guo,M., Du,Y., Chen,Y.W., Loh,Y.P. and Cheng,Y.
    Neurotrophic factor-alpha1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice
    Theranostics15, 2279-2292. PubMed  Europe PubMed DOI
    2. 2023
  2. Armoza-Eilat,S., Malis,Y., Caspi,M., Tarabe,R., Shomron,O., Hirschberg,K. and Rosin-Arbesfeld,R.
    The C-terminal Amphipathic Helix of Carboxypeptidase E Mediates Export from the ER and Secretion via Lysosomes
    J Mol Biol435, 168171-168171. PubMed  Europe PubMed DOI
  3. Chen,Y.C., Taylor,A.J., Fulcher,J.M., Swensen,A.C., Dai,X.Q., Komba,M., Wrightson,K.L.C., Fok,K., Patterson,A.E., Klein Geltink,R.I., MacDonald,P.E., Qian,W.J. and Verchere,C.B.
    Deletion of Carboxypeptidase E in beta-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice
    Diabetes72, 1277-1288. PubMed  Europe PubMed DOI
  4. Fan,F.C., Du,Y., Zheng,W.H., Loh,Y.P. and Cheng,Y.
    Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration
    Transl Psychiatry13, 135-135. PubMed  Europe PubMed DOI
  5. Fulcher,J.M., Swensen,A.C., Chen,Y.C., Verchere,C.B., Petyuk,V.A. and Qian,W.J.
    Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing
    Endocrinology164, PubMed  Europe PubMed DOI
    6. 2022
  6. Fricker,L.D., Lemos Duarte,M., Jeltyi,A., Lueptow,L., Fakira,A.K., Tashima,A.K., Hochgeschwender,U., Wetsel,W.C. and Devi,L.A.
    Mice heterozygous for a null mutation of CPE show reduced expression of carboxypeptidase e mRNA and enzyme activity but normal physiology, behavior, and levels of neuropeptides
    Brain Res1789, 147951-147951. PubMed  Europe PubMed DOI
  7. Hareendran,S., Yang,X., Sharma,V.K. and Loh,Y.P.
    Carboxypeptidase E and its splice variants: Key regulators of growth and metastasis in multiple cancer types
    Cancer Lett548, 215882-215882. PubMed  Europe PubMed DOI  K  V
  8. Liang,C., Carrel,D., Singh,N.K., Hiester,L.L., Fanget,I., Kim,H. and Firestein,B.L.
    Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration
    ASN Neuro14, 17590914211062765-17590914211062765. PubMed  Europe PubMed DOI  K
    9. 2020
  9. Bai,Z., Du,Y., Cong,L. and Cheng,Y.
    Carboxypeptidase E down-regulation regulates transcriptional and epigenetic profiles in pancreatic cancer cell line: A network analysis
    Cancer Biomark PubMed  Europe PubMed DOI
  10. Moon,Y., Moon,R., Roh,H., Chang,S., Lee,S. and Park,H.
    HIF-1alpha-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells
    Mol Cells43, 945-952. PubMed  Europe PubMed DOI
  11. Sun,J., Meng,D., Yu,T., Li,F., Zhang,G., Tian,X., Zhao,N., Li,G., Li,L., Wang,H., Liu,Y., Meng,Y., Ma,Y., Wan,Z., Bao,J. and Piao,H.
    N-terminal truncated carboxypeptidase E represses E-cadherin expression in lung cancer by stabilizing the Snail-HDAC complex
    Am J Cancer Res10, 925-938. PubMed  Europe PubMed
    12. 2019
  12. Fan,S., Gao,X., Chen,P. and Li,X.
    Carboxypeptidase E-DeltaN promotes migration invasiveness, and epithelial-mesenchymal transition of human osteosarcoma cells via the Wnt-beta-catenin pathway
    Biochem Cell Biol97, 446-453. PubMed  Europe PubMed DOI  M
  13. Hareendran,S., Yang,X., Lou,H., Xiao,L. and Loh,Y.P.
    Carboxypeptidase E-N promotes proliferation and invasion of pancreatic cancer cells via upregulation of CXCR2 gene expression
    Int J Mol Sci20, PubMed  Europe PubMed DOI
  14. Liang,C., Carrel,D., Omelchenko,A., Kim,H., Patel,A., Fanget,I. and Firestein,B.L.
    Cortical neuron migration and dendrite morphology are regulated by carboxypeptidase E
    Cereb Cortex29, 2890-2903. PubMed  Europe PubMed DOI  K
  15. Xiao,L., Yang,X. and Loh,Y.P.
    Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-alpha1 and its variants
    Front Neurosci13, 243-243. PubMed  Europe PubMed DOI
  16. Xiao,L., Yang,X., Sharma,V.K. and Loh,Y.P.
    Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-alphal variants in embryonic mouse brain
    FASEB J33, 808-820. PubMed  Europe PubMed DOI  M
  17. Yang,X., Lou,H., Chen,Y.T., Huang,S.F. and Loh,Y.P.
    A novel 40kDa N-terminal truncated carboxypeptidase E splice variant: cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers
    Genes Cancer10, 160-170. PubMed  Europe PubMed DOI
    18. 2018
  18. Fricker,L.D.
    Carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets
    Adv Pharmacol82, 85-102. PubMed  Europe PubMed DOI
    19. 2017
  19. Cong,L., Cheng,Y., Cawley,N.X., Murthy,S.R. and Loh,Y.P.
    A novel single nucleotide T980C polymorphism in the human carboxypeptidase E gene results in loss of neuroprotective function
    PLoS ONE12, e0170169-e0170169. PubMed  Europe PubMed DOI  M
  20. Ji,L., Wu,H.T., Qin,X.Y. and Lan,R.
    Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease
    Endocr Connect6, R18-R38. PubMed  Europe PubMed DOI
  21. Xiao,L., Chang,S.Y., Xiong,Z.G., Selveraj,P. and Peng Loh,Y.
    Absence of carboxypeptidase E/neurotrophic factor-alpha1 in knock-out mice leads to dysfunction of BDNF-TRKB signaling in hippocampus
    J Mol Neurosci62, 79-87. PubMed  Europe PubMed DOI  K
    22. 2016
  22. Cheng,Y., Cawley,N.X., Yanik,T., Murthy,S.R., Liu,C., Kasikci,F., Abebe,D. and Loh,Y.P.
    A human carboxypeptidase E/NF-alpha1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice
    Transl Psychiatry6, e973-e973. PubMed  Europe PubMed DOI  M
  23. Fan,S., Li,X., Li,L., Wang,L., Du,Z., Yang,Y., Zhao,J. and Li,Y.
    Silencing of carboxypeptidase E inhibits cell proliferation, tumorigenicity, and metastasis of osteosarcoma cells
    Onco Targets Ther9, 2795-2803. PubMed  Europe PubMed DOI  K  T
  24. Skalka,N., Caspi,M., Lahav-Ariel,L., Loh,Y.P., Hirschberg,K. and Rosin-Arbesfeld,R.
    Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a
    Oncogene35, 6416-6428. PubMed  Europe PubMed DOI
    25. 2015
  25. Alsters,S.I., Goldstone,A.P., Buxton,J.L., Zekavati,A., Sosinsky,A., Yiorkas,A.M., Holder,S., Klaber,R.E., Bridges,N., van Haelst,M.M., le Roux,C.W., Walley,A.J., Walters,R.G., Mueller,M. and Blakemore,A.I.
    Truncating homozygous mutation of carboxypeptidase E (CPE) in a morbidly obese female with Type 2 diabetes mellitus, intellectual disability and hypogonadotrophic hypogonadism
    PLoS ONE10, e0131417-e0131417. PubMed  Europe PubMed DOI  M
    26. 2014
  26. Bar,F., Foh,B., Pagel,R., Schroder,T., Schlichting,H., Hirose,M., Lemcke,S., Klinger,A., Konig,P., Karsten,C.M., Buning,J., Lehnert,H., Fellermann,K., Ibrahim,S.M. and Sina,C.
    Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice
    PLoS ONE9, e102347-e102347. PubMed  Europe PubMed DOI
  27. Qin,X.Y., Cheng,Y., Murthy,S.R., Selvaraj,P. and Loh,Y.P.
    Carboxypeptidase E-deltaN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity
    PLoS ONE9, e112996-e112996. PubMed  Europe PubMed DOI  R
    28. 2013
  28. Murthy,S.R., Dupart,E., Al-Sweel,N., Chen,A., Cawley,N.X. and Loh,Y.P.
    Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion
    Cancer Lett341, 204-213. PubMed  Europe PubMed DOI
    29. 2012
  29. Cawley,N.X., Wetsel,W.C., Murthy,S.R., Park,J.J., Pacak,K. and Loh,Y.P.
    New roles of carboxypeptidase E in endocrine and neural function and cancer
    Endocr Rev33, 216-253. PubMed  Europe PubMed DOI  V
  30. Fricker,L.D.
    Carboxypeptidase E
    [ISSN:978-0-12-407744-7]3, 1342-1345. DOI
  31. Horing,E., Harter,P.N., Seznec,J., Schittenhelm,J., Buhring,H.J., Bhattacharyya,S., von Hattingen,E., Zachskorn,C., Mittelbronn,M. and Naumann,U.
    The "go or grow" potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress
    Acta Neuropathol124, 83-97. PubMed  Europe PubMed DOI
    32. 2011
  32. Chu,K.Y., Briggs,M.J., Albrecht,T., Drain,P.F. and Johnson,J.D.
    Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse beta-cells
    Islets3, 155-165. PubMed  Europe PubMed DOI
    33. 2010
  33. Cawley,N.X., Yanik,T., Woronowicz,A., Chang,W., Marini,J.C. and Loh,Y.P.
    Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density
    Am J Physiol Endocrinol Metab299, E189-E197. PubMed  Europe PubMed DOI  K
  34. Johnston,R.A., Zhu,M., Hernandez,C.B., Williams,E.S. and Shore,S.A.
    Onset of obesity in carboxypeptidase E-deficient mice and effect on airway responsiveness and pulmonary responses to ozone
    J Appl Physiol108, 1812-1819. PubMed  Europe PubMed DOI  K
  35. Woronowicz,A., Cawley,N.X., Chang,S.Y., Koshimizu,H., Phillips,A.W., Xiong,Z.G. and Loh,Y.P.
    Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons
    J Neurosci Res88, 64-72. PubMed  Europe PubMed DOI  K
    36. 2009
  36. Carrel,D., Du,Y., Komlos,D., Hadzimichalis,N.M., Kwon,M., Wang,B., Brzustowicz,L.M. and Firestein,B.L.
    NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway
    J Neurosci29, 8248-8258. PubMed  Europe PubMed DOI
  37. Jia,E.Z., Wang,J., Yang,Z.J., Zhu,T.B., Wang,L.S., Wang,H., Li,C.J., Chen,B., Cao,K.J., Huang,J. and Ma,W.Z.
    Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis
    Mol Biol Rep36, 245-254. PubMed  Europe PubMed DOI  M
  38. Johnson,J.D.
    Proteomic identification of carboxypeptidase E connects lipid-induced beta-cell apoptosis and dysfunction in type 2 diabetes
    Cell Cycle8, 38-42. PubMed  Europe PubMed
  39. Zhang,X., Zhu,J., Loh,Y.P. and Berghman,L.R.
    Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus
    Cell Tissue Res337, 371-379. PubMed  Europe PubMed DOI
    40. 2008
  40. Jeffrey,K.D., Alejandro,E.U., Luciani,D.S., Kalynyak,T.B., Hu,X., Li,H., Lin,Y., Townsend,R.R., Polonsky,K.S. and Johnson,J.D.
    Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis
    Proc Natl Acad Sci U S A105, 8452-8457. PubMed  Europe PubMed DOI
  41. Jia,E.Z., Wang,J., Yang,Z.J., Zhu,T.B., Wang,L.S., Chen,B., Cao,K.J., Huang,J. and Ma,W.Z.
    Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis
    Mol Cell Biochem307, 31-39. PubMed  Europe PubMed DOI  M
  42. Park,J.J., Cawley,N.X. and Loh,Y.P.
    A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons
    Mol Cell Neurosci39, 63-73. PubMed  Europe PubMed DOI
  43. Park,J.J., Cawley,N.X. and Loh,Y.P.
    Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones
    Mol Endocrinol22, 989-1005. PubMed  Europe PubMed DOI
  44. Woronowicz,A., Koshimizu,H., Chang,S.Y., Cawley,N.X., Hill,J.M., Rodriguiz,R.M., Abebe,D., Dorfman,C., Senatorov,V., Zhou,A., Xiong,Z.G., Wetsel,W.C. and Loh,Y.P.
    Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits
    Hippocampus18, 1051-1063. PubMed  Europe PubMed DOI  K
    45. 2007
  45. Hreidarsdottir,G.E., Cirera,S. and Fredholm,M.
    Characterization of the porcine carboxypeptidase E cDNA: comparative analysis and investigation of a non-synonymous SNP
    Anim Biotechnol18, 61-64. PubMed  Europe PubMed DOI
    46. 2006
  46. Singh,U., Yu,Y., Kalinina,E., Konno,T., Sun,T., Ohta,H., Wakayama,T., Soares,M.J., Hemberger,M. and Fundele,R.H.
    Carboxypeptidase E in the mouse placenta
    Differentiation74, 648-660. PubMed  Europe PubMed DOI
    47. 2005
  47. [YEAR:20-1-2005]Lou,H., Kim,S.K., Zaitsev,E., Snell,C.R., Lu,B. and Loh,Y.P.
    Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase E
    Neuron45, 245-255. PubMed  Europe PubMed DOI
  48. Marzban,L., Soukhatcheva,G. and Verchere,C.B.
    Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells
    Endocrinology146, 1808-1817. PubMed  Europe PubMed DOI
    49. 2004
  49. Cawley,N.X., Zhou,J., Hill,J.M., Abebe,D., Romboz,S., Yanik,T., Rodriguiz,R.M., Wetsel,W.C. and Loh,Y.P.
    The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits
    Endocrinology145, 5807-5819. PubMed  Europe PubMed DOI  K
  50. Fricker,L.D.
    Carboxypeptidase E
    [ISSN:0-12-079610-4]2, 840-844.  V
  51. He,P., Varticovski,L., Bowman,E.D., Fukuoka,J., Welsh,J.A., Miura,K., Jen,J., Gabrielson,E., Brambilla,E., Travis,W.D. and Harris,C.C.
    Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray
    Hum Pathol35, 1196-1209. PubMed  Europe PubMed DOI
  52. Srinivasan,S., Bunch,D.O., Feng,Y., Rodriguiz,R.M., Li,M., Ravenell,R.L., Luo,G.X., Arimura,A., Fricker,L.D., Eddy,E.M. and Wetsel,W.C.
    Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice
    Endocrinology145, 2023-2034. PubMed  Europe PubMed DOI  M
  53. [YEAR:15-9-2004]Wu,C.M., Chang,H.T. and Chang,M.D.
    Membrane-bound carboxypeptidase E facilitates the entry of eosinophil cationic protein into neuroendocrine cells
    Biochem J382, 841-848. PubMed  Europe PubMed DOI
    54. 2003
  54. Cawley,N.X., Rodriguez,Y.M., Maldonado,A. and Loh,Y.P.
    Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice
    Endocrinology144, 292-298. PubMed  Europe PubMed DOI
  55. [YEAR:1-2-2003]Zhang,C.F., Dhanvantari,S., Lou,H. and Loh,Y.P.
    Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts
    Biochem J369, 453-460. PubMed  Europe PubMed DOI
    56. 2002
  56. Boudarine,M., Yegorov,O., Sterling-Dubrovsky,A., Devi,L.A. and Berman,Y.
    Developmental changes in opioid peptides and their receptors in Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E
    J Pharmacol Exp Ther303, 1317-1324. PubMed  Europe PubMed DOI
  57. [YEAR:8-1-2002]Dhanvantari,S., Arnaoutova,I., Snell,C.R., Steinbach,P.J., Hammond,K., Caputo,G.A., London,E. and Loh,Y.P.
    Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion
    Biochemistry41, 52-60. PubMed  Europe PubMed DOI
    58. 2001
  58. [YEAR:12-1-2001]Berman,Y., Mzhavia,N., Polonskaia,A. and Devi,L.A.
    Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice
    J Biol Chem276, 1466-1473. PubMed  Europe PubMed DOI
  59. [YEAR:14-8-2001]Che,F.Y., Yan,L., Li,H., Mzhavia,N., Devi,L.A. and Fricker,L.D.
    Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice
    Proc Natl Acad Sci U S A98, 9971-9976. PubMed  Europe PubMed DOI
  60. Chen,H., Jawahar,S., Qian,Y.M., Duong,Q.Y., Chan,G.Y., Parker,A., Meyer,J.M., Moore,K.J., Chayen,S., Gross,D.J., Glaser,B., Permutt,M.A. and Fricker,L.D.
    Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity
    Hum Mutat18, 120-131. PubMed  Europe PubMed DOI
  61. Feng,Y., Reznik,S.E. and Fricker,L.D.
    Distribution of proSAAS-derived peptides in rat neuroendocrine tissues
    Neuroscience105, 469-478. PubMed  Europe PubMed DOI
  62. Friis-Hansen,L., Lacourse,K.A., Samuelson,L.C. and Holst,J.J.
    Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice
    J Endocrinol169, 595-602. PubMed  Europe PubMed DOI
    63. 2000
  63. [YEAR:19-1-2000]Friis-Hansen,L. and Rehfeld,J.F.
    Impaired feedback of gastric functions in carboxypeptidase E-deficient mice
    Biochem Biophys Res Commun267, 638-642. PubMed  Europe PubMed DOI
    64. 1999
  64. Fricker,L.D. and Leiter,E.H.
    Peptides, enzymes and obesity: new insights from a 'dead' enzyme
    Trends Biochem Sci24, 390-393. PubMed  Europe PubMed DOI  M
  65. Gomez,P., Hallberg,L. and Greeley,G.H., Jr.
    Carboxypeptidase E (CPE) deficiency in mice with the fat mutation have reduced stomach function
    Proc Soc Exp Biol Med220, 52-53. PubMed  Europe PubMed
  66. [YEAR:23-4-1999]Qian,Y., Varlamov,O. and Fricker,L.D.
    Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway
    J Biol Chem274, 11582-11586. PubMed  Europe PubMed DOI  I
  67. Zhang,C.F., Snell,C.R. and Loh,Y.P.
    Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor
    Mol Endocrinol13, 527-536. PubMed  Europe PubMed DOI
    68. 1998
  68. [YEAR:30-4-1998]Cool,D.R. and Loh,Y.P.
    Carboxypeptidase E is a sorting receptor for prohormones: Binding and kinetic studies
    Mol Cell Endocrinol139, 7-13. PubMed  Europe PubMed DOI
  69. [YEAR:9-1-1998]Day,R., Lazure,C., Basak,A., Boudreault,A., Limperis,P., Dong,W. and Lindberg,I.
    Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity
    J Biol Chem273, 829-836. PubMed  Europe PubMed DOI  I
  70. Normant,E. and Loh,Y.P.
    Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A
    Endocrinology139, 2137-2145. PubMed  Europe PubMed DOI
  71. Utsunomiya,N., Ohagi,S., Sanke,T., Tatsuta,H., Hanabusa,T. and Nanjo,K.
    Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity
    Diabetologia41, 701-705. PubMed  Europe PubMed DOI  M
  72. Wang,W., Cain,B.M. and Beinfeld,M.C.
    Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain
    Endocrine9, 329-332. PubMed  Europe PubMed DOI
    73. 1997
  73. Cool,D.R., Normant,E., Shen,F., Chen,H.C., Pannell,L., Zhang,Y. and Loh,Y.P.
    Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice
    Cell88, 73-83. PubMed  Europe PubMed  K
  74. Juvvadi,S., Fan,X., Nagle,G.T. and Fricker,L.D.
    Characterization of Aplysia carboxypeptidase E
    FEBS Lett408, 195-200. PubMed  Europe PubMed DOI
  75. Lacourse,K.A., Friis-Hansen,L., Rehfeld,J.F. and Samuelson,L.C.
    Disturbed progastrin processing in carboxypeptidase E-deficient fat mice
    FEBS Lett416, 45-50. PubMed  Europe PubMed DOI  K
  76. Loh,Y.P., Snell,C.R. and Cool,D.R.
    Receptor-mediated targeting of hormones to secretory granules: role of carboxypeptidase E
    Trends Endocrinol Metab8, 130-137. PubMed  Europe PubMed  K
  77. Song,L. and Fricker,L.D.
    The pro region is not required for the expression or intracellular routeing of carboxypeptidase E
    Biochem J323, 265-271. PubMed  Europe PubMed
  78. Udupi,V., Gomez,P., Song,L., Varlamov,O., Reed,J.T., Leiter,E.H., Fricker,L.D. and Greeley,G.H., Jr.
    Effect of carboxypeptidase E deficiency on progastrin processing and gastrin messenger ribonucleic acid expression in mice with the fat mutation
    Endocrinology138, 1959-1963. PubMed  Europe PubMed DOI  K
    79. 1996
  79. Fan,X. and Nagle,G.T.
    Molecular cloning of Aplysia neuronal cDNAs that encode carboxypeptidases related to mammalian prohormone processing enzymes
    DNA Cell Biol15, 937-945. PubMed  Europe PubMed
  80. Fricker,L.D., Berman,Y.L., Leiter,E.H. and Devi,L.A.
    Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing
    J Biol Chem271, 30619-30624. PubMed  Europe PubMed DOI  K
  81. Varlamov,O. and Fricker,L.D.
    The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing
    J Biol Chem271, 6077-6083. PubMed  Europe PubMed DOI
    82. 1995
  82. Naggert,J.K., Fricker,L.D., Varlamov,O., Nishina,P.M., Rouille,Y., Steiner,D.F., Carroll,R.J., Paigen,B.J. and Leiter,E.H.
    Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
    Nat Genet10, 135-142. PubMed  Europe PubMed DOI  K
  83. Yajima,R., Chikuma,T. and Kato,T.
    Highly sensitive high-performance liquid chromatography-fluorimetric assay method for carboxypeptidase H activity
    J Chromatogr B Biomed Appl667, 333-338. PubMed  Europe PubMed DOI  A
    84. 1994
  84. Bernasconi,P.
    Molecular cloning of a Drosophila melanogaster gene coding for an homologue of human carboxypeptidase E
    Arch Insect Biochem Physiol27, 169-178. PubMed  Europe PubMed DOI
  85. Zheng,M., Streck,R.D., Scott,R.E., Seidah,N.G. and Pintar,J.E.
    The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity
    J Neurosci14, 4656-4673. PubMed  Europe PubMed
    86. 1993
  86. Hall,C., Manser,E., Spurr,N.K. and Lim,L.
    Assignment of the human carboxypeptidase E (CPE) gene to chromosome 4
    Genomics15, 461-463. PubMed  Europe PubMed DOI
    87. 1992
  87. Greene,D., Das,B. and Fricker,L.D.
    Regulation of carboxypeptidase E. Effect of pH, temperature and Co2+ on kinetic parameters of substrate hydrolysis
    Biochem J285, 613-618. PubMed  Europe PubMed
    88. 1991
  88. Jung,Y.K., Kunczt,C.J., Pearson,R.K., Dixon,J.E. and Fricker,L.D.
    Structural characterization of the rat carboxypeptidase-E gene
    Mol Endocrinol5, 1257-1268. PubMed  Europe PubMed DOI
  89. Roth,W.W., Mackin,R.B., Spiess,J., Goodman,R.H. and Noe,B.D.
    Primary structure and tissue distribution of anglerfish carboxypeptidase H
    Mol Cell Endocrinol78, 171-178. PubMed  Europe PubMed DOI
    90. 1990
  90. Fricker,L.D. and Devi,L.
    Comparison of a spectrophotometric, a fluorometric, and a novel radiometric assay for carboxypeptidase E (EC 3.4.17.10) and other carboxypeptidase B-like enzymes
    Anal Biochem184, 21-27. PubMed  Europe PubMed DOI
  91. Manser,E., Fernandez,D., Loo,L., Goh,P.Y., Monfries,C., Hall,C. and Lim,L.
    Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro
    Biochem J267, 517-525. PubMed  Europe PubMed
  92. [YEAR:5-10-1990]Parkinson,D.
    Two soluble forms of bovine carboxypeptidase H have different NH2-terminal sequences
    J Biol Chem265, 17101-17105. PubMed  Europe PubMed
    93. 1989
  93. [YEAR:15-9-1989]Grimwood,B.G., Plummer,T.H., Jr. and Tarentino,A.L.
    Carboxypeptidase H. A regulatory peptide-processing enzyme produced by human hepatoma Hep G2 cells
    J Biol Chem264, 15662-15667. PubMed  Europe PubMed
  94. Rodriguez,C., Brayton,K.A., Brownstein,M. and Dixon,J.E.
    Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin- releasing factor
    J Biol Chem264, 5988-5995. PubMed  Europe PubMed
  95. Smyth,D.G., Maruthainar,K., Darby,N.J. and Fricker,L.D.
    Catalysis of slow C-terminal processing reactions by carboxypeptidase H
    J Neurochem53, 489-493. PubMed  Europe PubMed
    96. 1988
  96. Fricker,L.D.
    Carboxypeptidase E
    Annu Rev Physiol50, 309-321. PubMed  Europe PubMed DOI
  97. Fricker,L.D.
    Activation and membrane binding of carboxypeptidase E
    J Cell Biochem38, 279-289. PubMed  Europe PubMed DOI  I
    98. 1987
  98. [YEAR:15-7-1987]Davidson,H.W. and Hutton,J.C.
    The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
    Biochem J245, 575-582. PubMed  Europe PubMed
  99. Fricker,L.D. and Herbert,E.
    Molecular biology of carboxypeptidase E (enkephalin convertase), a neuropeptide-synthesizing enzyme
    Ann N Y Acad Sci493, 391-393. DOI
    100. 1986
  100. Fricker,L.D., Evans,C.J., Esch,F.S. and Herbert,E.
    Cloning and sequence analysis of cDNA for bovine carboxypeptidase E
    Nature323, 461-464. PubMed  Europe PubMed DOI
    101. 1984
  101. Hook,V.Y. and Loh,Y.P.
    Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary
    Proc Natl Acad Sci U S A81, 2776-2780. PubMed  Europe PubMed  I
  102. [YEAR:10-10-1984]Strittmatter,S.M., Lynch,D.R. and Snyder,S.H.
    [3H]Guanidinoethylmercaptosuccinic acid binding to tissue homogenates. Selective labeling of enkephalin convertase
    J Biol Chem259, 11812-11817. PubMed  Europe PubMed  I
  103. Supattapone,S., Fricker,L.D. and Snyder,S.H.
    Purification and characterization of a membrane-bound enkephalin-forming carboxypeptidase, "enkephalin convertase"
    J Neurochem42, 1017-1023. PubMed  Europe PubMed
    104. 1983
  104. [YEAR:3-10-1983]Docherty,K. and Hutton,J.C.
    Carboxypeptidase activity in the insulin secretory granule
    FEBS Lett162, 137-141. PubMed  Europe PubMed DOI
  105. [YEAR:25-9-1983]Fricker,L.D. and Snyder,S.H.
    Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase
    J Biol Chem258, 10950-10955. PubMed  Europe PubMed
  106. [YEAR:29-3-1983]Fricker,L.D., Plummer,T.H., Jr. and Snyder,S.H.
    Enkephalin convertase: potent, selective, and irreversible inhibitors
    Biochem Biophys Res Commun111, 994-1000. PubMed  Europe PubMed  I
    107. 1982
  107. Fricker,L.D. and Snyder,S.H.
    Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules
    Proc Natl Acad Sci U S A79, 3886-3890. PubMed  Europe PubMed
  108. [YEAR:18-10-1982]Fricker,L.D., Supattapone,S. and Snyder,S.H.
    Enkephalin convertase: a specific enkephalin synthesizing carboxypeptidase in adrenal chromaffin granules, brain, and pituitary gland
    Life Sci31, 1841-1844. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use