Literature for peptidase M14.005: carboxypeptidase E

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, M Mutation, I Inhibitor, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Fan,F.C., Liu,L.M., Guo,M., Du,Y., Chen,Y.W., Loh,Y.P. and Cheng,Y. Neurotrophic factor-alpha1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice Theranostics (2025) 15, 2279-2292. PubMed Europe PubMed DOI PMC EPMC
Xiao,L., Sharma,P., Yang,X., Abebe,D. and Loh,Y.P. Neurotrophic factor-alpha1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's disease mice Transl Neurodegener (2025) 14, 59-59. PubMed Europe PubMed DOI PMC EPMC

2023

Armoza-Eilat,S., Malis,Y., Caspi,M., Tarabe,R., Shomron,O., Hirschberg,K. and Rosin-Arbesfeld,R. The C-terminal Amphipathic Helix of Carboxypeptidase E Mediates Export from the ER and Secretion via Lysosomes J Mol Biol (2023) 435, 168171-168171. PubMed Europe PubMed DOI
Chen,Y.C., Taylor,A.J., Fulcher,J.M., Swensen,A.C., Dai,X.Q., Komba,M., Wrightson,K.L.C., Fok,K., Patterson,A.E., Klein Geltink,R.I., MacDonald,P.E., Qian,W.J. and Verchere,C.B. Deletion of Carboxypeptidase E in beta-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice Diabetes (2023) 72, 1277-1288. PubMed Europe PubMed DOI PMC EPMC
Fan,F.C., Du,Y., Zheng,W.H., Loh,Y.P. and Cheng,Y. Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration Transl Psychiatry (2023) 13, 135-135. PubMed Europe PubMed DOI PMC EPMC
Fulcher,J.M., Swensen,A.C., Chen,Y.C., Verchere,C.B., Petyuk,V.A. and Qian,W.J. Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing Endocrinology (2023) 164 PubMed Europe PubMed DOI PMC EPMC

2022

Fricker,L.D., Lemos Duarte,M., Jeltyi,A., Lueptow,L., Fakira,A.K., Tashima,A.K., Hochgeschwender,U., Wetsel,W.C. and Devi,L.A. Mice heterozygous for a null mutation of CPE show reduced expression of carboxypeptidase e mRNA and enzyme activity but normal physiology, behavior, and levels of neuropeptides Brain Res (2022) 1789, 147951-147951. PubMed Europe PubMed DOI
Hareendran,S., Yang,X., Sharma,V.K. and Loh,Y.P. Carboxypeptidase E and its splice variants: Key regulators of growth and metastasis in multiple cancer types Cancer Lett (2022) 548, 215882-215882. PubMed Europe PubMed DOI PMC EPMC K V
Liang,C., Carrel,D., Singh,N.K., Hiester,L.L., Fanget,I., Kim,H. and Firestein,B.L. Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration ASN Neuro (2022) 14, 17590914211062765-17590914211062765. PubMed Europe PubMed DOI PMC EPMC K

2020

Bai,Z., Du,Y., Cong,L. and Cheng,Y. Carboxypeptidase E down-regulation regulates transcriptional and epigenetic profiles in pancreatic cancer cell line: A network analysis Cancer Biomark (2020) PubMed Europe PubMed DOI
Moon,Y., Moon,R., Roh,H., Chang,S., Lee,S. and Park,H. HIF-1alpha-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells Mol Cells (2020) 43, 945-952. PubMed Europe PubMed DOI
Sun,J., Meng,D., Yu,T., Li,F., Zhang,G., Tian,X., Zhao,N., Li,G., Li,L., Wang,H., Liu,Y., Meng,Y., Ma,Y., Wan,Z., Bao,J. and Piao,H. N-terminal truncated carboxypeptidase E represses E-cadherin expression in lung cancer by stabilizing the Snail-HDAC complex Am J Cancer Res (2020) 10, 925-938. PubMed Europe PubMed PMC EPMC

2019

Fan,S., Gao,X., Chen,P. and Li,X. Carboxypeptidase E-DeltaN promotes migration invasiveness, and epithelial-mesenchymal transition of human osteosarcoma cells via the Wnt-beta-catenin pathway Biochem Cell Biol (2019) 97, 446-453. PubMed Europe PubMed DOI M
Hareendran,S., Yang,X., Lou,H., Xiao,L. and Loh,Y.P. Carboxypeptidase E-N promotes proliferation and invasion of pancreatic cancer cells via upregulation of CXCR2 gene expression Int J Mol Sci (2019) 20 PubMed Europe PubMed DOI
Liang,C., Carrel,D., Omelchenko,A., Kim,H., Patel,A., Fanget,I. and Firestein,B.L. Cortical neuron migration and dendrite morphology are regulated by carboxypeptidase E Cereb Cortex (2019) 29, 2890-2903. PubMed Europe PubMed DOI K
Xiao,L., Yang,X., Sharma,V.K. and Loh,Y.P. Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-alphal variants in embryonic mouse brain FASEB J (2019) 33, 808-820. PubMed Europe PubMed DOI M
Xiao,L., Yang,X. and Loh,Y.P. Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-alpha1 and its variants Front Neurosci (2019) 13, 243-243. PubMed Europe PubMed DOI PMC EPMC
Yang,X., Lou,H., Chen,Y.T., Huang,S.F. and Loh,Y.P. A novel 40kDa N-terminal truncated carboxypeptidase E splice variant: cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers Genes Cancer (2019) 10, 160-170. PubMed Europe PubMed DOI PMC EPMC

2018

Fricker,L.D. Carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets Adv Pharmacol (2018) 82, 85-102. PubMed Europe PubMed DOI

2017

Cong,L., Cheng,Y., Cawley,N.X., Murthy,S.R. and Loh,Y.P. A novel single nucleotide T980C polymorphism in the human carboxypeptidase E gene results in loss of neuroprotective function PLoS ONE (2017) 12, e0170169-e0170169. PubMed Europe PubMed DOI M
Ji,L., Wu,H.T., Qin,X.Y. and Lan,R. Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease Endocr Connect (2017) 6, R18-R38. PubMed Europe PubMed DOI
Xiao,L., Chang,S.Y., Xiong,Z.G., Selveraj,P. and Peng Loh,Y. Absence of carboxypeptidase E/neurotrophic factor-alpha1 in knock-out mice leads to dysfunction of BDNF-TRKB signaling in hippocampus J Mol Neurosci (2017) 62, 79-87. PubMed Europe PubMed DOI K

2016

Cheng,Y., Cawley,N.X., Yanik,T., Murthy,S.R., Liu,C., Kasikci,F., Abebe,D. and Loh,Y.P. A human carboxypeptidase E/NF-alpha1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice Transl Psychiatry (2016) 6, e973-e973. PubMed Europe PubMed DOI M
Fan,S., Li,X., Li,L., Wang,L., Du,Z., Yang,Y., Zhao,J. and Li,Y. Silencing of carboxypeptidase E inhibits cell proliferation, tumorigenicity, and metastasis of osteosarcoma cells Onco Targets Ther (2016) 9, 2795-2803. PubMed Europe PubMed DOI PMC EPMC K T
Skalka,N., Caspi,M., Lahav-Ariel,L., Loh,Y.P., Hirschberg,K. and Rosin-Arbesfeld,R. Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a Oncogene (2016) 35, 6416-6428. PubMed Europe PubMed DOI

2015

Alsters,S.I., Goldstone,A.P., Buxton,J.L., Zekavati,A., Sosinsky,A., Yiorkas,A.M., Holder,S., Klaber,R.E., Bridges,N., van Haelst,M.M., le Roux,C.W., Walley,A.J., Walters,R.G., Mueller,M. and Blakemore,A.I. Truncating homozygous mutation of carboxypeptidase E (CPE) in a morbidly obese female with Type 2 diabetes mellitus, intellectual disability and hypogonadotrophic hypogonadism PLoS ONE (2015) 10, e0131417-e0131417. PubMed Europe PubMed DOI PMC EPMC M

2014

Bar,F., Foh,B., Pagel,R., Schroder,T., Schlichting,H., Hirose,M., Lemcke,S., Klinger,A., Konig,P., Karsten,C.M., Buning,J., Lehnert,H., Fellermann,K., Ibrahim,S.M. and Sina,C. Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice PLoS ONE (2014) 9, e102347-e102347. PubMed Europe PubMed DOI PMC EPMC
Qin,X.Y., Cheng,Y., Murthy,S.R., Selvaraj,P. and Loh,Y.P. Carboxypeptidase E-deltaN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity PLoS ONE (2014) 9, e112996-e112996. PubMed Europe PubMed DOI R

2013

Murthy,S.R., Dupart,E., Al-Sweel,N., Chen,A., Cawley,N.X. and Loh,Y.P. Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion Cancer Lett (2013) 341, 204-213. PubMed Europe PubMed DOI

2012

Cawley,N.X., Wetsel,W.C., Murthy,S.R., Park,J.J., Pacak,K. and Loh,Y.P. New roles of carboxypeptidase E in endocrine and neural function and cancer Endocr Rev (2012) 33, 216-253. PubMed Europe PubMed DOI V
Fricker,L.D. Carboxypeptidase E [ISSN:978-0-12-407744-7] (2012) 3, 1342-1345. DOI
Horing,E., Harter,P.N., Seznec,J., Schittenhelm,J., Buhring,H.J., Bhattacharyya,S., von Hattingen,E., Zachskorn,C., Mittelbronn,M. and Naumann,U. The "go or grow" potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress Acta Neuropathol (2012) 124, 83-97. PubMed Europe PubMed DOI

2011

Chu,K.Y., Briggs,M.J., Albrecht,T., Drain,P.F. and Johnson,J.D. Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse beta-cells Islets (2011) 3, 155-165. PubMed Europe PubMed DOI

2010

Cawley,N.X., Yanik,T., Woronowicz,A., Chang,W., Marini,J.C. and Loh,Y.P. Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density Am J Physiol Endocrinol Metab (2010) 299, E189-E197. PubMed Europe PubMed DOI K
Johnston,R.A., Zhu,M., Hernandez,C.B., Williams,E.S. and Shore,S.A. Onset of obesity in carboxypeptidase E-deficient mice and effect on airway responsiveness and pulmonary responses to ozone J Appl Physiol (2010) 108, 1812-1819. PubMed Europe PubMed DOI K
Woronowicz,A., Cawley,N.X., Chang,S.Y., Koshimizu,H., Phillips,A.W., Xiong,Z.G. and Loh,Y.P. Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons J Neurosci Res (2010) 88, 64-72. PubMed Europe PubMed DOI K

2009

Carrel,D., Du,Y., Komlos,D., Hadzimichalis,N.M., Kwon,M., Wang,B., Brzustowicz,L.M. and Firestein,B.L. NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway J Neurosci (2009) 29, 8248-8258. PubMed Europe PubMed DOI
Jia,E.Z., Wang,J., Yang,Z.J., Zhu,T.B., Wang,L.S., Wang,H., Li,C.J., Chen,B., Cao,K.J., Huang,J. and Ma,W.Z. Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis Mol Biol Rep (2009) 36, 245-254. PubMed Europe PubMed DOI M
Johnson,J.D. Proteomic identification of carboxypeptidase E connects lipid-induced beta-cell apoptosis and dysfunction in type 2 diabetes Cell Cycle (2009) 8, 38-42. PubMed Europe PubMed
Zhang,X., Zhu,J., Loh,Y.P. and Berghman,L.R. Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus Cell Tissue Res (2009) 337, 371-379. PubMed Europe PubMed DOI

2008

Jeffrey,K.D., Alejandro,E.U., Luciani,D.S., Kalynyak,T.B., Hu,X., Li,H., Lin,Y., Townsend,R.R., Polonsky,K.S. and Johnson,J.D. Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis Proc Natl Acad Sci U S A (2008) 105, 8452-8457. PubMed Europe PubMed DOI PMC EPMC
Jia,E.Z., Wang,J., Yang,Z.J., Zhu,T.B., Wang,L.S., Chen,B., Cao,K.J., Huang,J. and Ma,W.Z. Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis Mol Cell Biochem (2008) 307, 31-39. PubMed Europe PubMed DOI M
Park,J.J., Cawley,N.X. and Loh,Y.P. Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones Mol Endocrinol (2008) 22, 989-1005. PubMed Europe PubMed DOI PMC EPMC
Park,J.J., Cawley,N.X. and Loh,Y.P. A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons Mol Cell Neurosci (2008) 39, 63-73. PubMed Europe PubMed DOI PMC EPMC
Woronowicz,A., Koshimizu,H., Chang,S.Y., Cawley,N.X., Hill,J.M., Rodriguiz,R.M., Abebe,D., Dorfman,C., Senatorov,V., Zhou,A., Xiong,Z.G., Wetsel,W.C. and Loh,Y.P. Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits Hippocampus (2008) 18, 1051-1063. PubMed Europe PubMed DOI PMC EPMC K

2007

Hreidarsdottir,G.E., Cirera,S. and Fredholm,M. Characterization of the porcine carboxypeptidase E cDNA: comparative analysis and investigation of a non-synonymous SNP Anim Biotechnol (2007) 18, 61-64. PubMed Europe PubMed DOI

2006

Singh,U., Yu,Y., Kalinina,E., Konno,T., Sun,T., Ohta,H., Wakayama,T., Soares,M.J., Hemberger,M. and Fundele,R.H. Carboxypeptidase E in the mouse placenta Differentiation (2006) 74, 648-660. PubMed Europe PubMed DOI

2005

[YEAR:20-1-2005]Lou,H., Kim,S.K., Zaitsev,E., Snell,C.R., Lu,B. and Loh,Y.P. Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase E Neuron (20-1-2005) 45, 245-255. PubMed Europe PubMed DOI
Marzban,L., Soukhatcheva,G. and Verchere,C.B. Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells Endocrinology (2005) 146, 1808-1817. PubMed Europe PubMed DOI

2004

Cawley,N.X., Zhou,J., Hill,J.M., Abebe,D., Romboz,S., Yanik,T., Rodriguiz,R.M., Wetsel,W.C. and Loh,Y.P. The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits Endocrinology (2004) 145, 5807-5819. PubMed Europe PubMed DOI K
Fricker,L.D. Carboxypeptidase E [ISSN:0-12-079610-4] (2004) 2, 840-844. V
He,P., Varticovski,L., Bowman,E.D., Fukuoka,J., Welsh,J.A., Miura,K., Jen,J., Gabrielson,E., Brambilla,E., Travis,W.D. and Harris,C.C. Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray Hum Pathol (2004) 35, 1196-1209. PubMed Europe PubMed DOI
Srinivasan,S., Bunch,D.O., Feng,Y., Rodriguiz,R.M., Li,M., Ravenell,R.L., Luo,G.X., Arimura,A., Fricker,L.D., Eddy,E.M. and Wetsel,W.C. Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice Endocrinology (2004) 145, 2023-2034. PubMed Europe PubMed DOI M
[YEAR:15-9-2004]Wu,C.M., Chang,H.T. and Chang,M.D. Membrane-bound carboxypeptidase E facilitates the entry of eosinophil cationic protein into neuroendocrine cells Biochem J (15-9-2004) 382, 841-848. PubMed Europe PubMed DOI PMC EPMC

2003

Cawley,N.X., Rodriguez,Y.M., Maldonado,A. and Loh,Y.P. Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice Endocrinology (2003) 144, 292-298. PubMed Europe PubMed DOI
[YEAR:1-2-2003]Zhang,C.F., Dhanvantari,S., Lou,H. and Loh,Y.P. Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts Biochem J (1-2-2003) 369, 453-460. PubMed Europe PubMed DOI PMC EPMC

2002

Boudarine,M., Yegorov,O., Sterling-Dubrovsky,A., Devi,L.A. and Berman,Y. Developmental changes in opioid peptides and their receptors in Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E J Pharmacol Exp Ther (2002) 303, 1317-1324. PubMed Europe PubMed DOI
[YEAR:8-1-2002]Dhanvantari,S., Arnaoutova,I., Snell,C.R., Steinbach,P.J., Hammond,K., Caputo,G.A., London,E. and Loh,Y.P. Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion Biochemistry (8-1-2002) 41, 52-60. PubMed Europe PubMed DOI

2001

[YEAR:12-1-2001]Berman,Y., Mzhavia,N., Polonskaia,A. and Devi,L.A. Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice J Biol Chem (12-1-2001) 276, 1466-1473. PubMed Europe PubMed DOI
[YEAR:14-8-2001]Che,F.Y., Yan,L., Li,H., Mzhavia,N., Devi,L.A. and Fricker,L.D. Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice Proc Natl Acad Sci U S A (14-8-2001) 98, 9971-9976. PubMed Europe PubMed DOI PMC EPMC
Chen,H., Jawahar,S., Qian,Y.M., Duong,Q.Y., Chan,G.Y., Parker,A., Meyer,J.M., Moore,K.J., Chayen,S., Gross,D.J., Glaser,B., Permutt,M.A. and Fricker,L.D. Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity Hum Mutat (2001) 18, 120-131. PubMed Europe PubMed DOI
Feng,Y., Reznik,S.E. and Fricker,L.D. Distribution of proSAAS-derived peptides in rat neuroendocrine tissues Neuroscience (2001) 105, 469-478. PubMed Europe PubMed DOI
Friis-Hansen,L., Lacourse,K.A., Samuelson,L.C. and Holst,J.J. Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice J Endocrinol (2001) 169, 595-602. PubMed Europe PubMed DOI

2000

[YEAR:19-1-2000]Friis-Hansen,L. and Rehfeld,J.F. Impaired feedback of gastric functions in carboxypeptidase E-deficient mice Biochem Biophys Res Commun (19-1-2000) 267, 638-642. PubMed Europe PubMed DOI

1999

Fricker,L.D. and Leiter,E.H. Peptides, enzymes and obesity: new insights from a 'dead' enzyme Trends Biochem Sci (1999) 24, 390-393. PubMed Europe PubMed DOI M
Gomez,P., Hallberg,L. and Greeley,G.H., Jr. Carboxypeptidase E (CPE) deficiency in mice with the fat mutation have reduced stomach function Proc Soc Exp Biol Med (1999) 220, 52-53. PubMed Europe PubMed
[YEAR:23-4-1999]Qian,Y., Varlamov,O. and Fricker,L.D. Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway J Biol Chem (23-4-1999) 274, 11582-11586. PubMed Europe PubMed DOI I
Zhang,C.F., Snell,C.R. and Loh,Y.P. Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor Mol Endocrinol (1999) 13, 527-536. PubMed Europe PubMed DOI

1998

[YEAR:30-4-1998]Cool,D.R. and Loh,Y.P. Carboxypeptidase E is a sorting receptor for prohormones: Binding and kinetic studies Mol Cell Endocrinol (30-4-1998) 139, 7-13. PubMed Europe PubMed DOI
[YEAR:9-1-1998]Day,R., Lazure,C., Basak,A., Boudreault,A., Limperis,P., Dong,W. and Lindberg,I. Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity J Biol Chem (9-1-1998) 273, 829-836. PubMed Europe PubMed DOI I
Normant,E. and Loh,Y.P. Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A Endocrinology (1998) 139, 2137-2145. PubMed Europe PubMed DOI
Utsunomiya,N., Ohagi,S., Sanke,T., Tatsuta,H., Hanabusa,T. and Nanjo,K. Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity Diabetologia (1998) 41, 701-705. PubMed Europe PubMed DOI M
Wang,W., Cain,B.M. and Beinfeld,M.C. Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain Endocrine (1998) 9, 329-332. PubMed Europe PubMed DOI

1997

Cool,D.R., Normant,E., Shen,F., Chen,H.C., Pannell,L., Zhang,Y. and Loh,Y.P. Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice Cell (1997) 88, 73-83. PubMed Europe PubMed K
Juvvadi,S., Fan,X., Nagle,G.T. and Fricker,L.D. Characterization of Aplysia carboxypeptidase E FEBS Lett (1997) 408, 195-200. PubMed Europe PubMed DOI
Lacourse,K.A., Friis-Hansen,L., Rehfeld,J.F. and Samuelson,L.C. Disturbed progastrin processing in carboxypeptidase E-deficient fat mice FEBS Lett (1997) 416, 45-50. PubMed Europe PubMed DOI K
Loh,Y.P., Snell,C.R. and Cool,D.R. Receptor-mediated targeting of hormones to secretory granules: role of carboxypeptidase E Trends Endocrinol Metab (1997) 8, 130-137. PubMed Europe PubMed K
Song,L. and Fricker,L.D. The pro region is not required for the expression or intracellular routeing of carboxypeptidase E Biochem J (1997) 323, 265-271. PubMed Europe PubMed PMC EPMC
Udupi,V., Gomez,P., Song,L., Varlamov,O., Reed,J.T., Leiter,E.H., Fricker,L.D. and Greeley,G.H., Jr. Effect of carboxypeptidase E deficiency on progastrin processing and gastrin messenger ribonucleic acid expression in mice with the fat mutation Endocrinology (1997) 138, 1959-1963. PubMed Europe PubMed DOI K

1996

Fan,X. and Nagle,G.T. Molecular cloning of Aplysia neuronal cDNAs that encode carboxypeptidases related to mammalian prohormone processing enzymes DNA Cell Biol (1996) 15, 937-945. PubMed Europe PubMed
Fricker,L.D., Berman,Y.L., Leiter,E.H. and Devi,L.A. Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing J Biol Chem (1996) 271, 30619-30624. PubMed Europe PubMed DOI K
Varlamov,O. and Fricker,L.D. The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing J Biol Chem (1996) 271, 6077-6083. PubMed Europe PubMed DOI

1995

Naggert,J.K., Fricker,L.D., Varlamov,O., Nishina,P.M., Rouille,Y., Steiner,D.F., Carroll,R.J., Paigen,B.J. and Leiter,E.H. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity Nat Genet (1995) 10, 135-142. PubMed Europe PubMed DOI K
Yajima,R., Chikuma,T. and Kato,T. Highly sensitive high-performance liquid chromatography-fluorimetric assay method for carboxypeptidase H activity J Chromatogr B Biomed Appl (1995) 667, 333-338. PubMed Europe PubMed DOI A

1994

Bernasconi,P. Molecular cloning of a Drosophila melanogaster gene coding for an homologue of human carboxypeptidase E Arch Insect Biochem Physiol (1994) 27, 169-178. PubMed Europe PubMed DOI
Zheng,M., Streck,R.D., Scott,R.E., Seidah,N.G. and Pintar,J.E. The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity J Neurosci (1994) 14, 4656-4673. PubMed Europe PubMed

1993

Hall,C., Manser,E., Spurr,N.K. and Lim,L. Assignment of the human carboxypeptidase E (CPE) gene to chromosome 4 Genomics (1993) 15, 461-463. PubMed Europe PubMed DOI

1992

Greene,D., Das,B. and Fricker,L.D. Regulation of carboxypeptidase E. Effect of pH, temperature and Co2+ on kinetic parameters of substrate hydrolysis Biochem J (1992) 285, 613-618. PubMed Europe PubMed PMC EPMC

1991

Jung,Y.K., Kunczt,C.J., Pearson,R.K., Dixon,J.E. and Fricker,L.D. Structural characterization of the rat carboxypeptidase-E gene Mol Endocrinol (1991) 5, 1257-1268. PubMed Europe PubMed DOI
Roth,W.W., Mackin,R.B., Spiess,J., Goodman,R.H. and Noe,B.D. Primary structure and tissue distribution of anglerfish carboxypeptidase H Mol Cell Endocrinol (1991) 78, 171-178. PubMed Europe PubMed DOI

1990

Fricker,L.D. and Devi,L. Comparison of a spectrophotometric, a fluorometric, and a novel radiometric assay for carboxypeptidase E (EC 3.4.17.10) and other carboxypeptidase B-like enzymes Anal Biochem (1990) 184, 21-27. PubMed Europe PubMed DOI
Manser,E., Fernandez,D., Loo,L., Goh,P.Y., Monfries,C., Hall,C. and Lim,L. Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro Biochem J (1990) 267, 517-525. PubMed Europe PubMed PMC EPMC
[YEAR:5-10-1990]Parkinson,D. Two soluble forms of bovine carboxypeptidase H have different NH2-terminal sequences J Biol Chem (5-10-1990) 265, 17101-17105. PubMed Europe PubMed

1989

[YEAR:15-9-1989]Grimwood,B.G., Plummer,T.H., Jr. and Tarentino,A.L. Carboxypeptidase H. A regulatory peptide-processing enzyme produced by human hepatoma Hep G2 cells J Biol Chem (15-9-1989) 264, 15662-15667. PubMed Europe PubMed
Rodriguez,C., Brayton,K.A., Brownstein,M. and Dixon,J.E. Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin- releasing factor J Biol Chem (1989) 264, 5988-5995. PubMed Europe PubMed
Smyth,D.G., Maruthainar,K., Darby,N.J. and Fricker,L.D. Catalysis of slow C-terminal processing reactions by carboxypeptidase H J Neurochem (1989) 53, 489-493. PubMed Europe PubMed

1988

Fricker,L.D. Carboxypeptidase E Annu Rev Physiol (1988) 50, 309-321. PubMed Europe PubMed DOI
Fricker,L.D. Activation and membrane binding of carboxypeptidase E J Cell Biochem (1988) 38, 279-289. PubMed Europe PubMed DOI I

1987

[YEAR:15-7-1987]Davidson,H.W. and Hutton,J.C. The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing Biochem J (15-7-1987) 245, 575-582. PubMed Europe PubMed PMC EPMC
Fricker,L.D. and Herbert,E. Molecular biology of carboxypeptidase E (enkephalin convertase), a neuropeptide-synthesizing enzyme Ann N Y Acad Sci (1987) 493, 391-393. DOI

1986

Fricker,L.D., Evans,C.J., Esch,F.S. and Herbert,E. Cloning and sequence analysis of cDNA for bovine carboxypeptidase E Nature (1986) 323, 461-464. PubMed Europe PubMed DOI

1984

Hook,V.Y. and Loh,Y.P. Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary Proc Natl Acad Sci U S A (1984) 81, 2776-2780. PubMed Europe PubMed PMC EPMC I
[YEAR:10-10-1984]Strittmatter,S.M., Lynch,D.R. and Snyder,S.H. [3H]Guanidinoethylmercaptosuccinic acid binding to tissue homogenates. Selective labeling of enkephalin convertase J Biol Chem (10-10-1984) 259, 11812-11817. PubMed Europe PubMed I
Supattapone,S., Fricker,L.D. and Snyder,S.H. Purification and characterization of a membrane-bound enkephalin-forming carboxypeptidase, "enkephalin convertase" J Neurochem (1984) 42, 1017-1023. PubMed Europe PubMed

1983

[YEAR:3-10-1983]Docherty,K. and Hutton,J.C. Carboxypeptidase activity in the insulin secretory granule FEBS Lett (3-10-1983) 162, 137-141. PubMed Europe PubMed DOI
[YEAR:29-3-1983]Fricker,L.D., Plummer,T.H., Jr. and Snyder,S.H. Enkephalin convertase: potent, selective, and irreversible inhibitors Biochem Biophys Res Commun (29-3-1983) 111, 994-1000. PubMed Europe PubMed I
[YEAR:25-9-1983]Fricker,L.D. and Snyder,S.H. Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase J Biol Chem (25-9-1983) 258, 10950-10955. PubMed Europe PubMed

1982

[YEAR:18-10-1982]Fricker,L.D., Supattapone,S. and Snyder,S.H. Enkephalin convertase: a specific enkephalin synthesizing carboxypeptidase in adrenal chromaffin granules, brain, and pituitary gland Life Sci (18-10-1982) 31, 1841-1844. PubMed Europe PubMed
Fricker,L.D. and Snyder,S.H. Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules Proc Natl Acad Sci U S A (1982) 79, 3886-3890. PubMed Europe PubMed PMC EPMC