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Literature for peptidase M14.005: carboxypeptidase E

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, M Mutation, I Inhibitor, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Fan,F.C., Liu,L.M., Guo,M., Du,Y., Chen,Y.W., Loh,Y.P. and Cheng,Y.
    Neurotrophic factor-alpha1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice
    Theranostics (2025) 15, 2279-2292. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Xiao,L., Sharma,P., Yang,X., Abebe,D. and Loh,Y.P.
    Neurotrophic factor-alpha1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's disease mice
    Transl Neurodegener (2025) 14, 59-59. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Armoza-Eilat,S., Malis,Y., Caspi,M., Tarabe,R., Shomron,O., Hirschberg,K. and Rosin-Arbesfeld,R.
    The C-terminal Amphipathic Helix of Carboxypeptidase E Mediates Export from the ER and Secretion via Lysosomes
    J Mol Biol (2023) 435, 168171-168171. PubMed  Europe PubMed DOI
  4. Chen,Y.C., Taylor,A.J., Fulcher,J.M., Swensen,A.C., Dai,X.Q., Komba,M., Wrightson,K.L.C., Fok,K., Patterson,A.E., Klein Geltink,R.I., MacDonald,P.E., Qian,W.J. and Verchere,C.B.
    Deletion of Carboxypeptidase E in beta-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice
    Diabetes (2023) 72, 1277-1288. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Fan,F.C., Du,Y., Zheng,W.H., Loh,Y.P. and Cheng,Y.
    Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration
    Transl Psychiatry (2023) 13, 135-135. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Fulcher,J.M., Swensen,A.C., Chen,Y.C., Verchere,C.B., Petyuk,V.A. and Qian,W.J.
    Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing
    Endocrinology (2023) 164 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Fricker,L.D., Lemos Duarte,M., Jeltyi,A., Lueptow,L., Fakira,A.K., Tashima,A.K., Hochgeschwender,U., Wetsel,W.C. and Devi,L.A.
    Mice heterozygous for a null mutation of CPE show reduced expression of carboxypeptidase e mRNA and enzyme activity but normal physiology, behavior, and levels of neuropeptides
    Brain Res (2022) 1789, 147951-147951. PubMed  Europe PubMed DOI
  8. Hareendran,S., Yang,X., Sharma,V.K. and Loh,Y.P.
    Carboxypeptidase E and its splice variants: Key regulators of growth and metastasis in multiple cancer types
    Cancer Lett (2022) 548, 215882-215882. PubMed  Europe PubMed DOI  PMC  EPMC  K  V
  9. Liang,C., Carrel,D., Singh,N.K., Hiester,L.L., Fanget,I., Kim,H. and Firestein,B.L.
    Carboxypeptidase E Independently Changes Microtubule Glutamylation, Dendritic Branching, and Neuronal Migration
    ASN Neuro (2022) 14, 17590914211062765-17590914211062765. PubMed  Europe PubMed DOI  PMC  EPMC  K
    10. 2020
  10. Bai,Z., Du,Y., Cong,L. and Cheng,Y.
    Carboxypeptidase E down-regulation regulates transcriptional and epigenetic profiles in pancreatic cancer cell line: A network analysis
    Cancer Biomark (2020) PubMed  Europe PubMed DOI
  11. Moon,Y., Moon,R., Roh,H., Chang,S., Lee,S. and Park,H.
    HIF-1alpha-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells
    Mol Cells (2020) 43, 945-952. PubMed  Europe PubMed DOI
  12. Sun,J., Meng,D., Yu,T., Li,F., Zhang,G., Tian,X., Zhao,N., Li,G., Li,L., Wang,H., Liu,Y., Meng,Y., Ma,Y., Wan,Z., Bao,J. and Piao,H.
    N-terminal truncated carboxypeptidase E represses E-cadherin expression in lung cancer by stabilizing the Snail-HDAC complex
    Am J Cancer Res (2020) 10, 925-938. PubMed  Europe PubMed  PMC  EPMC
    13. 2019
  13. Fan,S., Gao,X., Chen,P. and Li,X.
    Carboxypeptidase E-DeltaN promotes migration invasiveness, and epithelial-mesenchymal transition of human osteosarcoma cells via the Wnt-beta-catenin pathway
    Biochem Cell Biol (2019) 97, 446-453. PubMed  Europe PubMed DOI  M
  14. Hareendran,S., Yang,X., Lou,H., Xiao,L. and Loh,Y.P.
    Carboxypeptidase E-N promotes proliferation and invasion of pancreatic cancer cells via upregulation of CXCR2 gene expression
    Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI
  15. Liang,C., Carrel,D., Omelchenko,A., Kim,H., Patel,A., Fanget,I. and Firestein,B.L.
    Cortical neuron migration and dendrite morphology are regulated by carboxypeptidase E
    Cereb Cortex (2019) 29, 2890-2903. PubMed  Europe PubMed DOI  K
  16. Xiao,L., Yang,X., Sharma,V.K. and Loh,Y.P.
    Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-alphal variants in embryonic mouse brain
    FASEB J (2019) 33, 808-820. PubMed  Europe PubMed DOI  M
  17. Xiao,L., Yang,X. and Loh,Y.P.
    Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-alpha1 and its variants
    Front Neurosci (2019) 13, 243-243. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Yang,X., Lou,H., Chen,Y.T., Huang,S.F. and Loh,Y.P.
    A novel 40kDa N-terminal truncated carboxypeptidase E splice variant: cloning, cDNA sequence analysis and role in regulation of metastatic genes in human cancers
    Genes Cancer (2019) 10, 160-170. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2018
  19. Fricker,L.D.
    Carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets
    Adv Pharmacol (2018) 82, 85-102. PubMed  Europe PubMed DOI
    20. 2017
  20. Cong,L., Cheng,Y., Cawley,N.X., Murthy,S.R. and Loh,Y.P.
    A novel single nucleotide T980C polymorphism in the human carboxypeptidase E gene results in loss of neuroprotective function
    PLoS ONE (2017) 12, e0170169-e0170169. PubMed  Europe PubMed DOI  M
  21. Ji,L., Wu,H.T., Qin,X.Y. and Lan,R.
    Dissecting carboxypeptidase E: properties, functions and pathophysiological roles in disease
    Endocr Connect (2017) 6, R18-R38. PubMed  Europe PubMed DOI
  22. Xiao,L., Chang,S.Y., Xiong,Z.G., Selveraj,P. and Peng Loh,Y.
    Absence of carboxypeptidase E/neurotrophic factor-alpha1 in knock-out mice leads to dysfunction of BDNF-TRKB signaling in hippocampus
    J Mol Neurosci (2017) 62, 79-87. PubMed  Europe PubMed DOI  K
    23. 2016
  23. Cheng,Y., Cawley,N.X., Yanik,T., Murthy,S.R., Liu,C., Kasikci,F., Abebe,D. and Loh,Y.P.
    A human carboxypeptidase E/NF-alpha1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice
    Transl Psychiatry (2016) 6, e973-e973. PubMed  Europe PubMed DOI  M
  24. Fan,S., Li,X., Li,L., Wang,L., Du,Z., Yang,Y., Zhao,J. and Li,Y.
    Silencing of carboxypeptidase E inhibits cell proliferation, tumorigenicity, and metastasis of osteosarcoma cells
    Onco Targets Ther (2016) 9, 2795-2803. PubMed  Europe PubMed DOI  PMC  EPMC  K  T
  25. Skalka,N., Caspi,M., Lahav-Ariel,L., Loh,Y.P., Hirschberg,K. and Rosin-Arbesfeld,R.
    Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a
    Oncogene (2016) 35, 6416-6428. PubMed  Europe PubMed DOI
    26. 2015
  26. Alsters,S.I., Goldstone,A.P., Buxton,J.L., Zekavati,A., Sosinsky,A., Yiorkas,A.M., Holder,S., Klaber,R.E., Bridges,N., van Haelst,M.M., le Roux,C.W., Walley,A.J., Walters,R.G., Mueller,M. and Blakemore,A.I.
    Truncating homozygous mutation of carboxypeptidase E (CPE) in a morbidly obese female with Type 2 diabetes mellitus, intellectual disability and hypogonadotrophic hypogonadism
    PLoS ONE (2015) 10, e0131417-e0131417. PubMed  Europe PubMed DOI  PMC  EPMC  M
    27. 2014
  27. Bar,F., Foh,B., Pagel,R., Schroder,T., Schlichting,H., Hirose,M., Lemcke,S., Klinger,A., Konig,P., Karsten,C.M., Buning,J., Lehnert,H., Fellermann,K., Ibrahim,S.M. and Sina,C.
    Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice
    PLoS ONE (2014) 9, e102347-e102347. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Qin,X.Y., Cheng,Y., Murthy,S.R., Selvaraj,P. and Loh,Y.P.
    Carboxypeptidase E-deltaN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity
    PLoS ONE (2014) 9, e112996-e112996. PubMed  Europe PubMed DOI  R
    29. 2013
  29. Murthy,S.R., Dupart,E., Al-Sweel,N., Chen,A., Cawley,N.X. and Loh,Y.P.
    Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion
    Cancer Lett (2013) 341, 204-213. PubMed  Europe PubMed DOI
    30. 2012
  30. Cawley,N.X., Wetsel,W.C., Murthy,S.R., Park,J.J., Pacak,K. and Loh,Y.P.
    New roles of carboxypeptidase E in endocrine and neural function and cancer
    Endocr Rev (2012) 33, 216-253. PubMed  Europe PubMed DOI  V
  31. Fricker,L.D.
    Carboxypeptidase E
    [ISSN:978-0-12-407744-7] (2012) 3, 1342-1345. DOI
  32. Horing,E., Harter,P.N., Seznec,J., Schittenhelm,J., Buhring,H.J., Bhattacharyya,S., von Hattingen,E., Zachskorn,C., Mittelbronn,M. and Naumann,U.
    The "go or grow" potential of gliomas is linked to the neuropeptide processing enzyme carboxypeptidase E and mediated by metabolic stress
    Acta Neuropathol (2012) 124, 83-97. PubMed  Europe PubMed DOI
    33. 2011
  33. Chu,K.Y., Briggs,M.J., Albrecht,T., Drain,P.F. and Johnson,J.D.
    Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse beta-cells
    Islets (2011) 3, 155-165. PubMed  Europe PubMed DOI
    34. 2010
  34. Cawley,N.X., Yanik,T., Woronowicz,A., Chang,W., Marini,J.C. and Loh,Y.P.
    Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density
    Am J Physiol Endocrinol Metab (2010) 299, E189-E197. PubMed  Europe PubMed DOI  K
  35. Johnston,R.A., Zhu,M., Hernandez,C.B., Williams,E.S. and Shore,S.A.
    Onset of obesity in carboxypeptidase E-deficient mice and effect on airway responsiveness and pulmonary responses to ozone
    J Appl Physiol (2010) 108, 1812-1819. PubMed  Europe PubMed DOI  K
  36. Woronowicz,A., Cawley,N.X., Chang,S.Y., Koshimizu,H., Phillips,A.W., Xiong,Z.G. and Loh,Y.P.
    Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons
    J Neurosci Res (2010) 88, 64-72. PubMed  Europe PubMed DOI  K
    37. 2009
  37. Carrel,D., Du,Y., Komlos,D., Hadzimichalis,N.M., Kwon,M., Wang,B., Brzustowicz,L.M. and Firestein,B.L.
    NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway
    J Neurosci (2009) 29, 8248-8258. PubMed  Europe PubMed DOI
  38. Jia,E.Z., Wang,J., Yang,Z.J., Zhu,T.B., Wang,L.S., Wang,H., Li,C.J., Chen,B., Cao,K.J., Huang,J. and Ma,W.Z.
    Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis
    Mol Biol Rep (2009) 36, 245-254. PubMed  Europe PubMed DOI  M
  39. Johnson,J.D.
    Proteomic identification of carboxypeptidase E connects lipid-induced beta-cell apoptosis and dysfunction in type 2 diabetes
    Cell Cycle (2009) 8, 38-42. PubMed  Europe PubMed
  40. Zhang,X., Zhu,J., Loh,Y.P. and Berghman,L.R.
    Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus
    Cell Tissue Res (2009) 337, 371-379. PubMed  Europe PubMed DOI
    41. 2008
  41. Jeffrey,K.D., Alejandro,E.U., Luciani,D.S., Kalynyak,T.B., Hu,X., Li,H., Lin,Y., Townsend,R.R., Polonsky,K.S. and Johnson,J.D.
    Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis
    Proc Natl Acad Sci U S A (2008) 105, 8452-8457. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Jia,E.Z., Wang,J., Yang,Z.J., Zhu,T.B., Wang,L.S., Chen,B., Cao,K.J., Huang,J. and Ma,W.Z.
    Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis
    Mol Cell Biochem (2008) 307, 31-39. PubMed  Europe PubMed DOI  M
  43. Park,J.J., Cawley,N.X. and Loh,Y.P.
    Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones
    Mol Endocrinol (2008) 22, 989-1005. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Park,J.J., Cawley,N.X. and Loh,Y.P.
    A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons
    Mol Cell Neurosci (2008) 39, 63-73. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Woronowicz,A., Koshimizu,H., Chang,S.Y., Cawley,N.X., Hill,J.M., Rodriguiz,R.M., Abebe,D., Dorfman,C., Senatorov,V., Zhou,A., Xiong,Z.G., Wetsel,W.C. and Loh,Y.P.
    Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits
    Hippocampus (2008) 18, 1051-1063. PubMed  Europe PubMed DOI  PMC  EPMC  K
    46. 2007
  46. Hreidarsdottir,G.E., Cirera,S. and Fredholm,M.
    Characterization of the porcine carboxypeptidase E cDNA: comparative analysis and investigation of a non-synonymous SNP
    Anim Biotechnol (2007) 18, 61-64. PubMed  Europe PubMed DOI
    47. 2006
  47. Singh,U., Yu,Y., Kalinina,E., Konno,T., Sun,T., Ohta,H., Wakayama,T., Soares,M.J., Hemberger,M. and Fundele,R.H.
    Carboxypeptidase E in the mouse placenta
    Differentiation (2006) 74, 648-660. PubMed  Europe PubMed DOI
    48. 2005
  48. [YEAR:20-1-2005]Lou,H., Kim,S.K., Zaitsev,E., Snell,C.R., Lu,B. and Loh,Y.P.
    Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase E
    Neuron (20-1-2005) 45, 245-255. PubMed  Europe PubMed DOI
  49. Marzban,L., Soukhatcheva,G. and Verchere,C.B.
    Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells
    Endocrinology (2005) 146, 1808-1817. PubMed  Europe PubMed DOI
    50. 2004
  50. Cawley,N.X., Zhou,J., Hill,J.M., Abebe,D., Romboz,S., Yanik,T., Rodriguiz,R.M., Wetsel,W.C. and Loh,Y.P.
    The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits
    Endocrinology (2004) 145, 5807-5819. PubMed  Europe PubMed DOI  K
  51. Fricker,L.D.
    Carboxypeptidase E
    [ISSN:0-12-079610-4] (2004) 2, 840-844.  V
  52. He,P., Varticovski,L., Bowman,E.D., Fukuoka,J., Welsh,J.A., Miura,K., Jen,J., Gabrielson,E., Brambilla,E., Travis,W.D. and Harris,C.C.
    Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray
    Hum Pathol (2004) 35, 1196-1209. PubMed  Europe PubMed DOI
  53. Srinivasan,S., Bunch,D.O., Feng,Y., Rodriguiz,R.M., Li,M., Ravenell,R.L., Luo,G.X., Arimura,A., Fricker,L.D., Eddy,E.M. and Wetsel,W.C.
    Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice
    Endocrinology (2004) 145, 2023-2034. PubMed  Europe PubMed DOI  M
  54. [YEAR:15-9-2004]Wu,C.M., Chang,H.T. and Chang,M.D.
    Membrane-bound carboxypeptidase E facilitates the entry of eosinophil cationic protein into neuroendocrine cells
    Biochem J (15-9-2004) 382, 841-848. PubMed  Europe PubMed DOI  PMC  EPMC
    55. 2003
  55. Cawley,N.X., Rodriguez,Y.M., Maldonado,A. and Loh,Y.P.
    Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice
    Endocrinology (2003) 144, 292-298. PubMed  Europe PubMed DOI
  56. [YEAR:1-2-2003]Zhang,C.F., Dhanvantari,S., Lou,H. and Loh,Y.P.
    Sorting of carboxypeptidase E to the regulated secretory pathway requires interaction of its transmembrane domain with lipid rafts
    Biochem J (1-2-2003) 369, 453-460. PubMed  Europe PubMed DOI  PMC  EPMC
    57. 2002
  57. Boudarine,M., Yegorov,O., Sterling-Dubrovsky,A., Devi,L.A. and Berman,Y.
    Developmental changes in opioid peptides and their receptors in Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E
    J Pharmacol Exp Ther (2002) 303, 1317-1324. PubMed  Europe PubMed DOI
  58. [YEAR:8-1-2002]Dhanvantari,S., Arnaoutova,I., Snell,C.R., Steinbach,P.J., Hammond,K., Caputo,G.A., London,E. and Loh,Y.P.
    Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion
    Biochemistry (8-1-2002) 41, 52-60. PubMed  Europe PubMed DOI
    59. 2001
  59. [YEAR:12-1-2001]Berman,Y., Mzhavia,N., Polonskaia,A. and Devi,L.A.
    Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice
    J Biol Chem (12-1-2001) 276, 1466-1473. PubMed  Europe PubMed DOI
  60. [YEAR:14-8-2001]Che,F.Y., Yan,L., Li,H., Mzhavia,N., Devi,L.A. and Fricker,L.D.
    Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice
    Proc Natl Acad Sci U S A (14-8-2001) 98, 9971-9976. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Chen,H., Jawahar,S., Qian,Y.M., Duong,Q.Y., Chan,G.Y., Parker,A., Meyer,J.M., Moore,K.J., Chayen,S., Gross,D.J., Glaser,B., Permutt,M.A. and Fricker,L.D.
    Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity
    Hum Mutat (2001) 18, 120-131. PubMed  Europe PubMed DOI
  62. Feng,Y., Reznik,S.E. and Fricker,L.D.
    Distribution of proSAAS-derived peptides in rat neuroendocrine tissues
    Neuroscience (2001) 105, 469-478. PubMed  Europe PubMed DOI
  63. Friis-Hansen,L., Lacourse,K.A., Samuelson,L.C. and Holst,J.J.
    Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice
    J Endocrinol (2001) 169, 595-602. PubMed  Europe PubMed DOI
    64. 2000
  64. [YEAR:19-1-2000]Friis-Hansen,L. and Rehfeld,J.F.
    Impaired feedback of gastric functions in carboxypeptidase E-deficient mice
    Biochem Biophys Res Commun (19-1-2000) 267, 638-642. PubMed  Europe PubMed DOI
    65. 1999
  65. Fricker,L.D. and Leiter,E.H.
    Peptides, enzymes and obesity: new insights from a 'dead' enzyme
    Trends Biochem Sci (1999) 24, 390-393. PubMed  Europe PubMed DOI  M
  66. Gomez,P., Hallberg,L. and Greeley,G.H., Jr.
    Carboxypeptidase E (CPE) deficiency in mice with the fat mutation have reduced stomach function
    Proc Soc Exp Biol Med (1999) 220, 52-53. PubMed  Europe PubMed
  67. [YEAR:23-4-1999]Qian,Y., Varlamov,O. and Fricker,L.D.
    Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway
    J Biol Chem (23-4-1999) 274, 11582-11586. PubMed  Europe PubMed DOI  I
  68. Zhang,C.F., Snell,C.R. and Loh,Y.P.
    Identification of a novel prohormone sorting signal-binding site on carboxypeptidase E, a regulated secretory pathway-sorting receptor
    Mol Endocrinol (1999) 13, 527-536. PubMed  Europe PubMed DOI
    69. 1998
  69. [YEAR:30-4-1998]Cool,D.R. and Loh,Y.P.
    Carboxypeptidase E is a sorting receptor for prohormones: Binding and kinetic studies
    Mol Cell Endocrinol (30-4-1998) 139, 7-13. PubMed  Europe PubMed DOI
  70. [YEAR:9-1-1998]Day,R., Lazure,C., Basak,A., Boudreault,A., Limperis,P., Dong,W. and Lindberg,I.
    Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity
    J Biol Chem (9-1-1998) 273, 829-836. PubMed  Europe PubMed DOI  I
  71. Normant,E. and Loh,Y.P.
    Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A
    Endocrinology (1998) 139, 2137-2145. PubMed  Europe PubMed DOI
  72. Utsunomiya,N., Ohagi,S., Sanke,T., Tatsuta,H., Hanabusa,T. and Nanjo,K.
    Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity
    Diabetologia (1998) 41, 701-705. PubMed  Europe PubMed DOI  M
  73. Wang,W., Cain,B.M. and Beinfeld,M.C.
    Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain
    Endocrine (1998) 9, 329-332. PubMed  Europe PubMed DOI
    74. 1997
  74. Cool,D.R., Normant,E., Shen,F., Chen,H.C., Pannell,L., Zhang,Y. and Loh,Y.P.
    Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice
    Cell (1997) 88, 73-83. PubMed  Europe PubMed  K
  75. Juvvadi,S., Fan,X., Nagle,G.T. and Fricker,L.D.
    Characterization of Aplysia carboxypeptidase E
    FEBS Lett (1997) 408, 195-200. PubMed  Europe PubMed DOI
  76. Lacourse,K.A., Friis-Hansen,L., Rehfeld,J.F. and Samuelson,L.C.
    Disturbed progastrin processing in carboxypeptidase E-deficient fat mice
    FEBS Lett (1997) 416, 45-50. PubMed  Europe PubMed DOI  K
  77. Loh,Y.P., Snell,C.R. and Cool,D.R.
    Receptor-mediated targeting of hormones to secretory granules: role of carboxypeptidase E
    Trends Endocrinol Metab (1997) 8, 130-137. PubMed  Europe PubMed  K
  78. Song,L. and Fricker,L.D.
    The pro region is not required for the expression or intracellular routeing of carboxypeptidase E
    Biochem J (1997) 323, 265-271. PubMed  Europe PubMed  PMC  EPMC
  79. Udupi,V., Gomez,P., Song,L., Varlamov,O., Reed,J.T., Leiter,E.H., Fricker,L.D. and Greeley,G.H., Jr.
    Effect of carboxypeptidase E deficiency on progastrin processing and gastrin messenger ribonucleic acid expression in mice with the fat mutation
    Endocrinology (1997) 138, 1959-1963. PubMed  Europe PubMed DOI  K
    80. 1996
  80. Fan,X. and Nagle,G.T.
    Molecular cloning of Aplysia neuronal cDNAs that encode carboxypeptidases related to mammalian prohormone processing enzymes
    DNA Cell Biol (1996) 15, 937-945. PubMed  Europe PubMed
  81. Fricker,L.D., Berman,Y.L., Leiter,E.H. and Devi,L.A.
    Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing
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  82. Varlamov,O. and Fricker,L.D.
    The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing
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  83. Naggert,J.K., Fricker,L.D., Varlamov,O., Nishina,P.M., Rouille,Y., Steiner,D.F., Carroll,R.J., Paigen,B.J. and Leiter,E.H.
    Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
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  84. Yajima,R., Chikuma,T. and Kato,T.
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  85. Bernasconi,P.
    Molecular cloning of a Drosophila melanogaster gene coding for an homologue of human carboxypeptidase E
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  86. Zheng,M., Streck,R.D., Scott,R.E., Seidah,N.G. and Pintar,J.E.
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  87. Hall,C., Manser,E., Spurr,N.K. and Lim,L.
    Assignment of the human carboxypeptidase E (CPE) gene to chromosome 4
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    88. 1992
  88. Greene,D., Das,B. and Fricker,L.D.
    Regulation of carboxypeptidase E. Effect of pH, temperature and Co2+ on kinetic parameters of substrate hydrolysis
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  89. Jung,Y.K., Kunczt,C.J., Pearson,R.K., Dixon,J.E. and Fricker,L.D.
    Structural characterization of the rat carboxypeptidase-E gene
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  90. Roth,W.W., Mackin,R.B., Spiess,J., Goodman,R.H. and Noe,B.D.
    Primary structure and tissue distribution of anglerfish carboxypeptidase H
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    91. 1990
  91. Fricker,L.D. and Devi,L.
    Comparison of a spectrophotometric, a fluorometric, and a novel radiometric assay for carboxypeptidase E (EC 3.4.17.10) and other carboxypeptidase B-like enzymes
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  92. Manser,E., Fernandez,D., Loo,L., Goh,P.Y., Monfries,C., Hall,C. and Lim,L.
    Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro
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    Two soluble forms of bovine carboxypeptidase H have different NH2-terminal sequences
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  94. [YEAR:15-9-1989]Grimwood,B.G., Plummer,T.H., Jr. and Tarentino,A.L.
    Carboxypeptidase H. A regulatory peptide-processing enzyme produced by human hepatoma Hep G2 cells
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  95. Rodriguez,C., Brayton,K.A., Brownstein,M. and Dixon,J.E.
    Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin- releasing factor
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  96. Smyth,D.G., Maruthainar,K., Darby,N.J. and Fricker,L.D.
    Catalysis of slow C-terminal processing reactions by carboxypeptidase H
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    97. 1988
  97. Fricker,L.D.
    Carboxypeptidase E
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    Activation and membrane binding of carboxypeptidase E
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    99. 1987
  99. [YEAR:15-7-1987]Davidson,H.W. and Hutton,J.C.
    The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
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  100. Fricker,L.D. and Herbert,E.
    Molecular biology of carboxypeptidase E (enkephalin convertase), a neuropeptide-synthesizing enzyme
    Ann N Y Acad Sci (1987) 493, 391-393. DOI
    101. 1986
  101. Fricker,L.D., Evans,C.J., Esch,F.S. and Herbert,E.
    Cloning and sequence analysis of cDNA for bovine carboxypeptidase E
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    102. 1984
  102. Hook,V.Y. and Loh,Y.P.
    Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary
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    [3H]Guanidinoethylmercaptosuccinic acid binding to tissue homogenates. Selective labeling of enkephalin convertase
    J Biol Chem (10-10-1984) 259, 11812-11817. PubMed  Europe PubMed  I
  104. Supattapone,S., Fricker,L.D. and Snyder,S.H.
    Purification and characterization of a membrane-bound enkephalin-forming carboxypeptidase, "enkephalin convertase"
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    105. 1983
  105. [YEAR:3-10-1983]Docherty,K. and Hutton,J.C.
    Carboxypeptidase activity in the insulin secretory granule
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  106. [YEAR:29-3-1983]Fricker,L.D., Plummer,T.H., Jr. and Snyder,S.H.
    Enkephalin convertase: potent, selective, and irreversible inhibitors
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    Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase
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    108. 1982
  108. [YEAR:18-10-1982]Fricker,L.D., Supattapone,S. and Snyder,S.H.
    Enkephalin convertase: a specific enkephalin synthesizing carboxypeptidase in adrenal chromaffin granules, brain, and pituitary gland
    Life Sci (18-10-1982) 31, 1841-1844. PubMed  Europe PubMed
  109. Fricker,L.D. and Snyder,S.H.
    Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules
    Proc Natl Acad Sci U S A (1982) 79, 3886-3890. PubMed  Europe PubMed  PMC  EPMC

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