$VAR1 = undef;

Summary for peptidase M14.005: carboxypeptidase E

Names
MEROPS Name	carboxypeptidase E
Other names	carboxypeptidase H, cobalt-stimulated chromaffin granule carboxypeptidase, crino carboxypeptidase B, enkephalin convertase, insulin granule-associated carboxypeptidase, neurotrophic factor-alpha1

Domain architecture

MEROPS Classification
Classification	Clan MC >> Subclan (none) >> Family M14 >> Subfamily B >> M14.005
Holotype	carboxypeptidase E (Bos taurus), Uniprot accession P04836 (peptidase unit: 42-475), MERNUM MER0001202
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00210
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.10
Enzymology	BRENDA database
Proteolytic events	CutDB database (3 cleavages)
Activity status	human: active (Fricker, 2004) mouse: active (Gomez et al., 1999)
Physiology	Involved in biosynthesis of many peptide hormones and neurotransmitters.
Knockout	A spontaneous point mutation in the coding region of the carboxypeptidase E gene results in a loss of enzymatic activity that correlates with the development of late onset obesity (Naggert et al., 1995). The protein acts as a sorting receptor as well as an enzyme, and its obliteration leads to multiple endocrine disorders including hyperproinsulinemia and infertility (Berman et al., 2001).
Pathways	KEGG	Type I diabetes mellitus
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Carboxypeptidase_E
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/fg/garR/-/-/- (based on 24 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	4	3	6	6	1
Pro	2	2	0	1	0
Ala	0	0	0	5	0
Val	0	0	0	0	0
Leu	0	1	2	1	0
Ile	0	0	0	0	0
Met	3	0	0	0	0
Phe	0	3	6	0	0
Tyr	0	1	2	1	0
Trp	0	0	0	0	0
Ser	2	1	0	0	0
Thr	2	1	2	1	0
Cys	0	0	0	0	0
Asn	1	1	0	0	0
Gln	0	0	1	1	0
Asp	2	3	0	0	0
Glu	0	0	0	0	0
Lys	1	1	1	3	4
Arg	1	1	1	5	19
His	0	0	0	0	0