Substrates for peptidase M12.016: vertebrate tolloid-like 1 protein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
chordin	Q9Z0E2	27-948	peptide-Ala670+Thr-peptide	P		Gly	Glu	Ala	Ala	Thr	Ser	Pro	Met	Scott et al., 2000	16707
chordin precursor	Q9H2X0	27-955	peptide-Ser153+Asp-peptide	P		Arg	Ser	Tyr	Ser	Asp	Arg	Gly	Glu	Scott et al., 1999
chordin precursor	Q9H2X0	27-955	peptide-Ala866+Asp-peptide	P		Pro	Met	Gln	Ala	Asp	Gly	Pro	Arg	Scott et al., 1999
collagen alpha 2(I) chain precursor	P08123	25-1366	peptide-Ala1119+Asp-peptide	P		Phe	Tyr	Arg	Ala	Asp	Gln	Pro	Arg	Scott et al., 1999
collagen alpha-1(I) chain	P02452	23-1464	peptide-Ala1218+Asp-peptide	P		Tyr	Tyr	Arg	Ala	Asp	Asp	Ala	Asn	Scott et al., 1999
collagen alpha-1(II) chain precursor	P02458	26-1487	peptide-Ala1241+Asp-peptide	P	NT	Tyr	Met	Arg	Ala	Asp	Gln	Ala	Ala	Ge et al., 2004
collagen alpha-1(III) chain	P02461	24-1466	peptide-Gly1221+Asp-peptide	P	NT	Pro	Tyr	Tyr	Gly	Asp	Glu	Pro	Met	Ge et al., 2004
collagen alpha-1(VII) chain	Q02388	17-2944	peptide-Ala2821+Asp-peptide	P	NT	Ser	Tyr	Ala	Ala	Asp	Thr	Ala	Gly	Ge et al., 2004
collagen alpha-2(V) chain precursor	P05997	27-1499	peptide-Glu1253+Asp-peptide	P	NT	Glu	Phe	Thr	Glu	Asp	Gln	Ala	Ala	Ge et al., 2004
dentin matrix acidic phosphoprotein 1	Q13316	17-513	peptide-Ser217+Asp-peptide	P	NT	Gly	Met	Gln	Ser	Asp	Asp	Pro	Glu	Ge et al., 2004
growth/differentiation factor 8	O14793	24-375	peptide-Arg98+Asp-peptide	P	NT	Asp	Val	Gln	Arg	Asp	Asp	Ser	Ser	Ge et al., 2004
growth/differentiation factor 8 precursor	O08689	25-376	peptide-Arg99+Asp-peptide	P		Asp	Val	Gln	Arg	Asp	Asp	Ser	Ser	Wolfman et al., 2003
laminin subunit gamma-2	Q13753	22-1193	peptide-Gly434+Asp-peptide	P	NT	Cys	Tyr	Ser	Gly	Asp	Glu	Asn	Pro	Ge et al., 2004
mimecan	Q62000	20-298	peptide-Lys75+Asp-peptide	P	NT	Gln	Leu	Gln	Lys	Asp	Glu	Val	Ile	Ge et al., 2004
mimecan	P19879	20-299	peptide-Lys76+Asp-peptide	P	NT	Gln	Leu	Gln	Lys	Asp	Glu	Asn	Ile	Ge et al., 2004
probiglycan	P21810	20-368	peptide-Asn18+Asp-peptide	P		Phe	Met	Met	Asn	Asp	Glu	Glu	Ala	Scott et al., 2000	16708
prolysyl oxidase	P28300	22-417	peptide-Gly169+Asp-peptide	P		Gly	Met	Val	Gly	Asp	Asp	Pro	Tyr	Uzel et al., 2001	16709