Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02452

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
22	unknown peptidase	1-1464	P		NT	<%Agarwal et al., 2012[]%>
161	procollagen I N-peptidase	162-1218	N
263	cathepsin K	23-1464	P	normal turnover		Sassi et al., 2000
551	peptidyl-Lys metallopeptidase	1-1464	N		MS
611	peptidyl-Lys metallopeptidase	1-1464	N		MS
708	peptidyl-Lys metallopeptidase	1-1464	N		MS
758	peptidyl-Lys metallopeptidase	1-1464	N		MS
953	matrix metallopeptidase-1	162-1218	P	normal turnover		Cawston, 2004
953	matrix metallopeptidase-8	162-1218	P	normal turnover		Krane, 1995
953	matrix metallopeptidase-2	162-1218	P			Aimes & Quigley, 1995
953	matrix metallopeptidase-13	162-1218	P	normal turnover		Billinghurst et al., 1997
953	membrane-type matrix metallopeptidase-1	162-1218	P			Ohuchi et al., 1997
953	matrix metallopeptidase-18	162-1218	P			Stolow et al., 1997
1196	chymotrypsin A (cattle-type)	23-1464	N			Sassi et al., 2000
1198	chymotrypsin A (cattle-type)	23-1464	N			Sassi et al., 2000
1200	cathepsin K	162-1218	P	normal turnover		Sassi et al., 2000
1206	cathepsin K	162-1218	P	normal turnover		Sassi et al., 2000
1218	procollagen C-peptidase	23-1464	P			Kofford et al., 1997
1218	vertebrate tolloid-like 1 protein	23-1464	P			Scott et al., 1999
1238	chymase (Homo sapiens-type)	23-1464	P			Kofford et al., 1997