Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P08123

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-1366	P		NT	<%Agarwal et al., 2012[]%>
79	unknown peptidase	1-1366	P		NT	<%Agarwal et al., 2012[]%>
175	cathepsin K	80-1102	P	normal turnover		Sassi et al., 2000
865	matrix metallopeptidase-1	80-1102	P	normal turnover		Billinghurst et al., 1997
865	matrix metallopeptidase-2	80-1102	P			Aimes & Quigley, 1995
865	matrix metallopeptidase-13	80-1102	P			Billinghurst et al., 1997
865	membrane-type matrix metallopeptidase-1	80-1102	P			Ohuchi et al., 1997
871	membrane-type matrix metallopeptidase-1	80-1102	P			Li et al., 2004
1102	unknown peptidase	1-1366	P		NT	<%Agarwal et al., 2012[]%>
1119	procollagen C-peptidase	25-1366	P			Scott et al., 2000
1119	vertebrate tolloid-like 1 protein	25-1366	P			Scott et al., 1999