Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02458

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
25	unknown peptidase	1-1487	P		NT	<%Agarwal et al., 2012[]%>
92	matrix metallopeptidase-7	26-1487	P	normal turnover		Fukui et al., 2002
111	matrix metallopeptidase-7	26-1487	P	normal turnover		Fukui et al., 2002
111	matrix metallopeptidase-13	26-1487	P	normal turnover		Fukui et al., 2002
114	matrix metallopeptidase-7	26-1487	P	normal turnover		Fukui et al., 2002
114	matrix metallopeptidase-13	26-1487	P	normal turnover		Fukui et al., 2002
181	matrix metallopeptidase-9	26-1487	P	release of an activation peptide		Fukui et al., 2002
181	matrix metallopeptidase-3	26-1487	P	release of an activation peptide		Fukui et al., 2002
181	membrane-type matrix metallopeptidase-1	26-1487	P			Fukui et al., 2002
181	procollagen I N-peptidase	26-1487	P			Fukui et al., 2002
182	matrix metallopeptidase-9	26-1487	P	release of an activation peptide		Fukui et al., 2002
182	matrix metallopeptidase-3	26-1487	P	release of an amino acid		Fukui et al., 2002
182	matrix metallopeptidase-7	26-1487	P			Fukui et al., 2002
182	matrix metallopeptidase-13	26-1487	P			Fukui et al., 2002
194	matrix metallopeptidase-3	182-1241	P	normal turnover		Fukui et al., 2002
195	matrix metallopeptidase-7	182-1241	P	normal turnover		Fukui et al., 2002
197	membrane-type matrix metallopeptidase-1	182-1241	P			Fukui et al., 2002
198	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
198	matrix metallopeptidase-9	182-1241	P	normal turnover		Fukui et al., 2002
198	matrix metallopeptidase-3	182-1241	P	normal turnover		Fukui et al., 2002
198	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
198	matrix metallopeptidase-13	182-1241	P	normal turnover		Fukui et al., 2002
199	matrix metallopeptidase-9	182-1241	P	normal turnover		Fukui et al., 2002
222	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
222	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
222	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
222	matrix metallopeptidase-12	182-1241	P	normal turnover		Zhen et al., 2008
273	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
327	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
339	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
342	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
342	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
381	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
387	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
405	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
420	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
432	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
432	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
432	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
452	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
452	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
452	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
453	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
486	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
507	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
507	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
507	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
507	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
507	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
507	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
513	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
513	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
513	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
537	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
537	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
537	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
537	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
537	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
537	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
543	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
557	ADAMTS4 peptidase	182-1241	P			Zhen et al., 2008
561	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
561	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
561	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
561	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
573	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
594	matrix metallopeptidase-8	182-1241	P	normal turnover		Zhen et al., 2008
594	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
594	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
594	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
594	ADAMTS4 peptidase	182-1241	P			Zhen et al., 2008
627	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
627	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
627	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
627	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
627	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
627	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
630	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
630	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
651	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
651	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
651	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
663	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
663	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
663	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
663	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
663	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
699	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
714	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
714	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
714	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
720	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
720	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
720	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
720	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
747	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
747	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
747	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
747	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
798	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
818	trypsin-2 type A	182-1241	P		MS	Stenman et al., 2005
831	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
834	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
859	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
879	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
879	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
894	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
894	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
894	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
894	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
902	ADAMTS5 peptidase	182-1241	P			Zhen et al., 2008
904	trypsin-2 type A	182-1241	P		MS	Stenman et al., 2005
906	matrix metallopeptidase-1	182-1241	P			Mitchell et al., 1996
906	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
906	matrix metallopeptidase-13	182-1241	P	normal turnover		Leeman et al., 2002
909	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
909	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
909	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
909	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
909	matrix metallopeptidase-13	1-1487	P			Mitchell et al., 1996
922	ADAMTS5 peptidase	182-1241	P			Zhen et al., 2008
923	ADAMTS5 peptidase	182-1241	P			Zhen et al., 2008
930	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
930	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
930	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
930	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
930	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
930	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
939	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
954	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
966	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
975	matrix metallopeptidase-1	182-1241	P	normal turnover		Billinghurst et al., 1997
975	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
975	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
975	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
975	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
975	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
975	matrix metallopeptidase-13	182-1241	P	normal turnover		Zhen et al., 2008
981	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
981	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
981	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
981	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
981	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
981	matrix metallopeptidase-13	182-1241	P	normal turnover		Zhen et al., 2008
1006	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
1006	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
1006	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
1006	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
1006	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
1026	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
1026	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
1026	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
1026	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
1026	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
1026	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
1053	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
1053	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
1053	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
1053	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
1053	matrix metallopeptidase-12	182-1241	P			Zhen et al., 2008
1053	matrix metallopeptidase-13	182-1241	P			Zhen et al., 2008
1053	ADAMTS5 peptidase	182-1241	P			Zhen et al., 2008
1078	ADAMTS5 peptidase	182-1241	P			Zhen et al., 2008
1083	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
1083	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
1107	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
1129	peptidyl-Lys metallopeptidase	1-1487	N		MS
1134	matrix metallopeptidase-9	182-1241	P	normal turnover		Van den Steen et al., 2004
1137	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
1149	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
1149	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
1173	matrix metallopeptidase-2	182-1241	P			Zhen et al., 2008
1173	matrix metallopeptidase-9	182-1241	P			Zhen et al., 2008
1190	trypsin-2 type A	182-1241	P		MS	Stenman et al., 2005
1191	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
1191	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
1191	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
1222	matrix metallopeptidase-8	182-1241	P			Zhen et al., 2008
1222	matrix metallopeptidase-2	182-1241	P	normal turnover		Zhen et al., 2008
1222	matrix metallopeptidase-3	182-1241	P			Zhen et al., 2008
1241	procollagen C-peptidase	182-1241	P			Kessler, 2004
1241	vertebrate tolloid-like 1 protein	26-1487	P		NT	Ge et al., 2004