Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02461

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-1466	P		NT	<%Agarwal et al., 2012[]%>
108	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
108	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
130	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
130	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
153	unknown peptidase	1-1466	P		NT	<%Agarwal et al., 2012[]%>
198	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
198	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
219	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
219	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
374	ADAMTS5 peptidase	154-1221	P			Zhen et al., 2008
389	ADAMTS5 peptidase	154-1221	P			Zhen et al., 2008
609	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
609	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
613	cathepsin B	611-626	N		MS	Biniossek et al., 2011
617	LAST_MAM peptidase (Limulus-type)	614-629	N		MS	Becker-Pauly et al., 2011
639	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
639	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
693	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
693	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
717	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
717	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
741	matrix metallopeptidase-8	154-1221	P			Zhen et al., 2008
741	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
741	matrix metallopeptidase-12	154-1221	P			Zhen et al., 2008
741	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
741	ADAMTS4 peptidase	154-1221	P			Zhen et al., 2008
774	matrix metallopeptidase-8	154-1221	P			Zhen et al., 2008
774	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
774	matrix metallopeptidase-12	154-1221	P			Zhen et al., 2008
774	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
774	ADAMTS4 peptidase	154-1221	P			Zhen et al., 2008
840	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
840	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
858	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
858	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
948	matrix metallopeptidase-1	24-1466	P	normal turnover		Billinghurst et al., 1997
948	matrix metallopeptidase-8	154-1221	P			Zhen et al., 2008
948	matrix metallopeptidase-12	154-1221	P			Zhen et al., 2008
948	matrix metallopeptidase-13	1-1466	P			Billinghurst et al., 1997
948	membrane-type matrix metallopeptidase-3	154-1221	P			Shimada et al., 1999
951	membrane-type matrix metallopeptidase-3	154-1221	P			Shimada et al., 1999
952	elastase-2	154-1221	P	normal turnover		Mainardi et al., 1980
955	elastase-2	154-1221	P	normal turnover		Mainardi et al., 1980
956	trypsin 1	154-1221	N			Mainardi et al., 1980
957	thermolysin	154-1221	N			Mainardi et al., 1980
975	matrix metallopeptidase-8	154-1221	P			Zhen et al., 2008
975	matrix metallopeptidase-12	154-1221	P			Zhen et al., 2008
1125	matrix metallopeptidase-8	154-1221	P	normal turnover		Zhen et al., 2008
1125	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
1125	matrix metallopeptidase-12	154-1221	P			Zhen et al., 2008
1125	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
1128	matrix metallopeptidase-8	154-1221	P			Zhen et al., 2008
1128	matrix metallopeptidase-3	154-1221	P			Zhen et al., 2008
1128	matrix metallopeptidase-12	154-1221	P			Zhen et al., 2008
1128	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
1129	matrix metallopeptidase-2	154-1221	P			Zhen et al., 2008
1129	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
1149	matrix metallopeptidase-8	154-1221	P			Zhen et al., 2008
1149	matrix metallopeptidase-2	154-1221	P			Zhen et al., 2008
1149	matrix metallopeptidase-9	154-1221	P			Zhen et al., 2008
1149	matrix metallopeptidase-3	154-1221	P			Zhen et al., 2008
1149	matrix metallopeptidase-12	154-1221	P			Zhen et al., 2008
1149	matrix metallopeptidase-13	154-1221	P			Zhen et al., 2008
1221	procollagen C-peptidase	24-1466	P			Scott et al., 2000
1221	vertebrate tolloid-like 1 protein	24-1466	P		NT	Ge et al., 2004