$VAR1 = undef;

Summary for peptidase M12.016: vertebrate tolloid-like 1 protein

Names
MEROPS Name	vertebrate tolloid-like 1 protein
Other names	TLL-1, colloid (Gallus domesticus)

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily A >> M12.016
Holotype	vertebrate tolloid-like 1 protein (Homo sapiens), Uniprot accession O43897 (peptidase unit: 154-344), MERNUM MER0005124
History	Identifier created: MEROPS 3.21 (12 May 1999)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (3 cleavages)
Activity status	human: active (Scott et al., 2000) mouse: active (Scott et al., 2000)
Physiology	The gene is necessary for normal development of the heart in mouse (Clark et al., 1999).
Knockout	Mice with targeted disruption of the gene for tolloid-like 1 protein died in mid-gestation from cardiac failure. Evidently this gene product plays multiple roles in formation of the mammalian heart and is essential for formation of the interventricular septum (Clark et al., 1999). Mice homozygous null for procollagen C-proteinase and mammalian tolloid-like 1 protein have also been described (Pappano et al., 2003).
Other databases	TREEFAM	http://www.treefam.org/family/TF314351
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/my/qr/agD/deq/pa/- (based on 17 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	0	0	3	0	1	1	1
Pro	2	0	0	0	0	0	6	1
Ala	0	0	2	6	0	0	4	3
Val	0	2	1	0	0	0	1	0
Leu	0	2	0	0	0	0	0	0
Ile	0	0	0	0	0	0	0	2
Met	0	5	1	0	0	0	0	2
Phe	2	1	0	0	0	0	0	0
Tyr	2	5	2	0	0	0	0	1
Trp	0	0	0	0	0	0	0	0
Ser	1	1	1	2	0	1	2	2
Thr	0	0	1	0	1	1	0	0
Cys	1	0	0	0	0	0	0	0
Asn	0	0	0	1	0	0	2	1
Gln	2	0	6	0	0	3	0	0
Asp	2	0	0	0	16	5	0	0
Glu	1	1	0	1	0	5	1	2
Lys	0	0	0	2	0	0	0	0
Arg	1	0	3	2	0	1	0	2
His	0	0	0	0	0	0	0	0