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Literature for peptidase M02.004: angiotensin-converting enzyme peptidase unit 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, K Knockout, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Cozier,G.E., Coulson,L.B., Eyermann,C.J., Basarab,G.S., Schwager,S.L., Chibale,K., Sturrock,E.D. and Acharya,K.R.<br>Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors<br>J Med Chem (2025) 68, 7720-7736. PubMed  Europe PubMed DOI
  2. Gregory,K.S., Ramasamy,V., Sturrock,E.D. and Acharya,K.R.<br>Ciprofloxacin Inhibits Angiotensin Iƒ_'Converting Enzyme (ACE) Activity by Binding at the Exosite, Distal to the Catalytic Pocket<br>ACS Bio Med Chem Au (2025) 5, 852-859. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Shibata,T., Bhat,S.A., Cao,D., Saito,S., Bernstein,E.A., Nishi,E., Medenilla,J.D., Wang,E.T., Chan,J.L., Pisarska,M.D., Tourtellotte,W.G., Giani,J.F., Bernstein,K.E. and Khan,Z.<br>Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARgamma<br>J Biol Chem (2024) 300, 105486-105486. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2021
  4. Alves-Lopes,R., Montezano,A.C., Neves,K.B., Harvey,A., Rios,F.J., Skiba,D.S., Arendse,L.B., Guzik,T.J., Graham,D., Poglitsch,M., Sturrock,E. and Touyz,R.M.<br>Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension<br>Hypertension (2021) 78, 604-616. PubMed  Europe PubMed DOI
    5. 2019
  5. Khan,Z., Cao,D.Y., Giani,J.F., Bernstein,E.A., Veiras,L.C., Fuchs,S., Wang,Y., Peng,Z., Kalkum,M., Liu,G.Y. and Bernstein,K.E.<br>Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization<br>J Biol Chem (2019) 294, 4368-4380. PubMed  Europe PubMed DOI
    6. 2018
  6. Cozier,G.E., Arendse,L.B., Schwager,S.L., Sturrock,E.D. and Acharya,K.R.<br>Molecular basis for multiple omapatrilat binding sites within the ACE C-domain: implications for drug design<br>J Med Chem (2018) 61, 10141-10154. PubMed  Europe PubMed DOI  I
    7. 2017
  7. Yan,H.Y., Mita,K., Zhao,X., Tanaka,Y., Moriyama,M., Wang,H., Iwanaga,M. and Kawasaki,H.<br>The angiotensin-converting enzyme (ACE) gene family of Bombyx mori<br>Gene (2017) 608, 58-65. PubMed  Europe PubMed DOI
    8. 2016
  8. Larmuth,K.M., Masuyer,G., Douglas,R.G., Schwager,S.L., Acharya,K.R. and Sturrock,E.D.<br>Kinetic and structural characterization of amyloid-beta peptide hydrolysis by human angiotensin-1-converting enzyme<br>FEBS J (2016) 283, 1060-1076. PubMed  Europe PubMed DOI  S
    9. 2015
  9. Lunow,D., Kaiser,S., Ruckriemen,J., Pohl,C. and Henle,T.<br>Tryptophan-containing dipeptides are C-domain selective inhibitors of angiotensin converting enzyme<br>Food Chem (2015) 166, 596-602. PubMed  Europe PubMed DOI  I
    10. 2014
  10. Kramer,G.J., Mohd,A., Schwager,S.L.U., Masuyer,G., Acharya,K.R., Sturrock,E.D. and Bachmann,B.O.<br>Interkingdom pharmacology of angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes<br>ACS Med Chem Lett (2014) 5, 346-351. PubMed  Europe PubMed DOI  S  I
  11. Masuyer,G., Akif,M., Czarny,B., Beau,F., Schwager,S.L., Sturrock,E.D., Isaac,R.E., Dive,V. and Acharya,K.R.<br>Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme<br>FEBS J (2014) 281, 943-956. PubMed  Europe PubMed DOI  S  I
  12. Yates,C.J., Masuyer,G., Schwager,S.L., Akif,M., Sturrock,E.D. and Acharya,K.R.<br>Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE)<br>J Biol Chem (2014) 289, 1798-1814. PubMed  Europe PubMed DOI  S
    13. 2013
  13. Ehlers,M.R., Abrie,J.A. and Sturrock,E.D.<br>C domain-selective inhibition of angiotensin-converting enzyme<br>J Renin Angiotensin Aldosterone Syst (2013) 14, 189-192. PubMed  Europe PubMed DOI  I
  14. Hocharoen,L., Joyner,J.C. and Cowan,J.A.<br>N- versus C-domain selectivity of catalytic inactivation of human angiotensin converting enzyme by lisinopril-coupled transition metal chelates<br>J Med Chem (2013) 56, 9826-9836. PubMed  Europe PubMed DOI  I
  15. Zhang,C., Wu,S. and Xu,D.<br>Catalytic Mechanism of Angiotensin-Converting Enzyme and Effects of the Chloride Ion<br>J Phys Chem B (2013) 117, 6635-6645. PubMed  Europe PubMed DOI
    16. 2012
  16. Sturrock,E.D., Anthony,C.S. and Danilov,S.M.<br>Peptidyl-dipeptidase A/angiotensin I-converting enzyme<br>[ISSN:978-0-12-407744-7] (2012) 3, 480-494. DOI
  17. Zhou,M., Du,K., Ji,P. and Feng,W.<br>Molecular mechanism of the interactions between inhibitory tripeptides and angiotensin-converting enzyme<br>Biophys Chem (2012) 168-169, 60-66. PubMed  Europe PubMed DOI  I
    18. 2011
  18. Akif,M., Masuyer,G., Schwager,S.L., Bhuyan,B.J., Mugesh,G., Isaac,R.E., Sturrock,E.D. and Acharya,K.R.<br>Structural characterization of angiotensin I-converting enzyme in complex with a selenium analogue of captopril<br>FEBS J (2011) 278, 3644-3650. PubMed  Europe PubMed DOI  S  I
  19. Akif,M., Schwager,S.L., Anthony,C.S., Czarny,B., Beau,F., Dive,V., Sturrock,E.D. and Acharya,K.R.<br>Novel mechanism of inhibition of human angiotensin-I-converting enzyme (ACE) by a highly specific phosphinic tripeptide<br>Biochem J (2011) 436, 53-59. PubMed  Europe PubMed DOI  S  I
  20. Bernstein,K.E., Shen,X.Z., Gonzalez-Villalobos,R.A., Billet,S., Okwan-Duodu,D., Ong,F.S. and Fuchs,S.<br>Different in vivo functions of the two catalytic domains of angiotensin-converting enzyme (ACE)<br>Curr Opin Pharmacol (2011) 11, 105-111. PubMed  Europe PubMed DOI
  21. Wang,X., Wu,S., Xu,D., Xie,D. and Guo,H.<br>Inhibitor and substrate binding by angiotensin-converting enzyme: quantum mechanical/molecular mechanical molecular dynamics studies<br>J Chem Inf Model (2011) 51, 1074-1082. PubMed  Europe PubMed DOI  I
    22. 2010
  22. Jullien,N., Makritis,A., Georgiadis,D., Beau,F., Yiotakis,A. and Dive,V.<br>Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors<br>J Med Chem (2010) 53, 208-220. PubMed  Europe PubMed DOI  I
  23. Spyranti,Z., Galanis,A.S., Pairas,G., Spyroulias,G.A., Manessi-Zoupa,E. and Cordopatis,P.<br>Synthetic peptides as structural maquettes of angiotensin-I converting enzyme catalytic sites<br>Bioinorg Chem Appl (2010) , 820476-820476. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Sun,X., Rentzsch,B., Gong,M., Eichhorst,J., Pankow,K., Papsdorf,G., Maul,B., Bader,M. and Siems,W.E.<br>Signal transduction in CHO cells stably transfected with domain-selective forms of murine ACE<br>Biol Chem (2010) 391, 235-244. PubMed  Europe PubMed DOI
  25. Watermeyer,J., Kroger,W.L., Sturrock,E.D. and Ehlers,M.R.<br>Angiotensin-converting enzyme - new insights into structure, biological significance and prospects for domain-selective inhibitors<br>Curr Enzyme Inhib (2010) 5, 134-147.
  26. Watermeyer,J.M., Kroger,W.L., O'Neill,H.G., Sewell,B.T. and Sturrock,E.D.<br>Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril<br>Biochem J (2010) 428, 67-74. PubMed  Europe PubMed DOI  S  I
  27. Zhao,Y., Xu,J. and Xu,C.<br>[Expression of human angiotensin converting enzyme-C domain in Pichia pastoris]<br>Sheng Wu Gong Cheng Xue Bao (2010) 26, 664-670. PubMed  Europe PubMed  E
    28. 2009
  28. Kroger,W.L., Douglas,R.G., O'Neill,H.G., Dive,V. and Sturrock,E.D.<br>Investigating the domain specificity of phosphinic inhibitors RXPA380 and RXP407 in angiotensin-converting enzyme<br>Biochemistry (2009) 48, 8405-8412. PubMed  Europe PubMed DOI  I
  29. Simunic,J., Soyez,D. and Kamech,N.<br>Characterization of a membrane-bound angiotensin-converting enzyme isoform in crayfish testis and evidence for its release into the seminal fluid<br>FEBS J (2009) 276, 4727-4738. PubMed  Europe PubMed DOI
  30. Vamvakas,S.S., Leondiadis,L., Pairas,G., Manessi-Zoupa,E., Spyroulias,G.A. and Cordopatis,P.<br>Folding in solution of the C-catalytic protein fragment of angiotensin-converting enzyme<br>J Pept Sci (2009) 15, 504-510. PubMed  Europe PubMed DOI
  31. Zou,K., Maeda,T., Watanabe,A., Liu,J., Liu,S., Oba,R., Satoh,Y., Komano,H. and Michikawa,M.<br>Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme<br>J Biol Chem (2009) 284, 31914-31920. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2008
  32. Danilov,S.M., Balyasnikova,I.V., Albrecht,R.F. and Kost,O.A.<br>Simultaneous determination of ACE activity with 2 substrates provides information on the status of somatic ACE and allows detection of inhibitors in human blood<br>J Cardiovasc Pharmacol (2008) 52, 90-103. PubMed  Europe PubMed DOI  A
  33. Fuchs,S., Xiao,H.D., Hubert,C., Michaud,A., Campbell,D.J., Adams,J.W., Capecchi,M.R., Corvol,P. and Bernstein,K.E.<br>Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo<br>Hypertension (2008) 51, 267-274. PubMed  Europe PubMed DOI
  34. O'Neill,H.G., Redelinghuys,P., Schwager,S.L. and Sturrock,E.D.<br>The role of glycosylation and domain interactions in the thermal stability of human angiotensin-converting enzyme<br>Biol Chem (2008) 389, 1153-1161. PubMed  Europe PubMed DOI
  35. Rushworth,C.A., Guy,J.L. and Turner,A.J.<br>Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis<br>FEBS J (2008) 275, 6033-6042. PubMed  Europe PubMed DOI  I
  36. Watermeyer,J.M., Kroger,W.L., O'Neill,H.G., Sewell,B.T. and Sturrock,E.D.<br>Probing the basis of domain-dependent inhibition using novel ketone inhibitors of angiotensin-converting enzyme<br>Biochemistry (2008) 47, 5942-5950. PubMed  Europe PubMed DOI  I
    37. 2007
  37. Corradi,H.R., Chitapi,I., Sewell,B.T., Georgiadis,D., Dive,V., Sturrock,E.D. and Acharya,K.R.<br>The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380<br>Biochemistry (2007) 46, 5473-5478. PubMed  Europe PubMed DOI  S  I
    38. 2006
  38. [YEAR:19-12-2006]Bernstein,K.E.<br>Views of the renin-angiotensin system: brilling, mimsy, and slithy tove<br>Hypertension (19-12-2006) 47, 509-514. PubMed  Europe PubMed DOI  V
  39. Carmona,A.K., Schwager,S.L., Juliano,M.A., Juliano,L. and Sturrock,E.D.<br>A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay<br>Nat Protoc (2006) 1, 1971-1976. PubMed  Europe PubMed DOI  A
  40. Kohlstedt,K., Gershome,C., Friedrich,M., Muller-Esterl,W., Alhenc-Gelas,F., Busse,R. and Fleming,I.<br>Angiotensin-converting enzyme (ACE) dimerization is the initial step in the ACE inhibitor-induced ACE signaling cascade in endothelial cells<br>Mol Pharmacol (2006) 69, 1725-1732. PubMed  Europe PubMed DOI
  41. [YEAR:13-3-2006]Kugaevskaya,E.V., Kolesanova,E.F., Kozin,S.A., Veselovsky,A.V., Dedinsky,I.R. and Elisseeva,Y.E.<br>Epitope mapping of the domains of human angiotensin converting enzyme<br>Biochim Biophys Acta (13-3-2006) 1760, 959-965. PubMed  Europe PubMed DOI
  42. Nchinda,A.T., Chibale,K., Redelinghuys,P. and Sturrock,E.D.<br>Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme<br>Bioorg Med Chem Lett (2006) 16, 4616-4619. PubMed  Europe PubMed DOI  I
  43. Nchinda,A.T., Chibale,K., Redelinghuys,P. and Sturrock,E.D.<br>Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors<br>Bioorg Med Chem Lett (2006) 16, 4612-4615. PubMed  Europe PubMed DOI  I
  44. Schwager,S.L., Carmona,A.K. and Sturrock,E.D.<br>A high-throughput fluorimetric assay for angiotensin I-converting enzyme<br>Nat Protoc (2006) 1, 1961-1964. PubMed  Europe PubMed DOI  A
  45. [YEAR:18-4-2006]Skirgello,O.E., Balyasnikova,I.V., Binevski,P.V., Sun,Z.L., Baskin,I.I., Palyulin,V.A., Nesterovitch,A.B., Albrecht,R.F., Kost,O.A. and Danilov,S.M.<br>Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action<br>Biochemistry (18-4-2006) 45, 4831-4847. PubMed  Europe PubMed DOI
  46. Watermeyer,J.M., Sewell,B.T., Schwager,S.L., Natesh,R., Corradi,H.R., Acharya,K.R. and Sturrock,E.D.<br>Structure of testis ACE glycosylation mutants and evidence for conserved domain movement<br>Biochemistry (2006) 45, 12654-12663. PubMed  Europe PubMed DOI  PMC  EPMC  S
    47. 2005
  47. Alves,M.F., Araujo,M.C., Juliano,M.A., Oliveira,E.M., Krieger,J.E., Casarini,D.E., Juliano,L. and Carmona,A.K.<br>A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity<br>Braz J Med Biol Res (2005) 38, 861-868. PubMed  Europe PubMed DOI  A
  48. Balyasnikova,I.V., Woodman,Z.L., Albrecht,R.F., Natesh,R., Acharya,K.R., Sturrock,E.D. and Danilov,S.M.<br>Localization of an N-domain region of angiotensin-converting enzyme involved in the regulation of ectodomain shedding using monoclonal antibodies<br>J Proteome Res (2005) 4, 258-267. PubMed  Europe PubMed DOI
  49. [YEAR:21-12-2005]Naqvi,N., Liu,K., Graham,R.M. and Husain,A.<br>Molecular basis of exopeptidase activity in the C-terminal domain of human angiotensin I-converting enzyme: insights into the origins of its exopeptidase activity<br>J Biol Chem (21-12-2005) 280, 6669-6675. PubMed  Europe PubMed DOI
  50. Redelinghuys,P., Nchinda,A.T. and Sturrock,E.D.<br>Development of domain-selective angiotensin I-converting enzyme inhibitors<br>Ann N Y Acad Sci (2005) 1056, 160-175. PubMed  Europe PubMed DOI  V
    51. 2004
  51. Bersanetti,P.A., Andrade,M.C., Casarini,D.E., Juliano,M.A., Nchinda,A.T., Sturrock,E.D., Juliano,L. and Carmona,A.K.<br>Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides for defining substrate specificity of the angiotensin I-converting enzyme and development of selective C-domain substrates<br>Biochemistry (2004) 43, 15729-15736. PubMed  Europe PubMed DOI  P
  52. Corvol,P., Eyries,M. and Soubrier,F.<br>Peptidyl-dipeptidase A/angiotensin I-converting enzyme<br>[ISSN:0-12-079610-4] (2004) 2, 332-346.  V
  53. Georgiadis,D., Cuniasse,P., Cotton,J., Yiotakis,A. and Dive,V.<br>Structural determinants of RXPA380, a potent and highly selective inhibitor of the angiotensin-converting enzyme C-domain<br>Biochemistry (2004) 43, 8048-8054. PubMed  Europe PubMed DOI  I
  54. Inguimbert,N., Poras,H., Dhotel,H., Beslot,F., Scalbert,E., Bennejean,C., Renard,P., Fournie-Zaluski,M.C. and Roques,B.P.<br>In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position<br>J Pept Res (2004) 63, 99-107. PubMed  Europe PubMed DOI  I
  55. [YEAR:13-7-2004]Natesh,R., Schwager,S.L., Evans,H.R., Sturrock,E.D. and Acharya,K.R.<br>Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme<br>Biochemistry (13-7-2004) 43, 8718-8724. PubMed  Europe PubMed DOI  S  I
  56. Spyroulias,G.A., Galanis,A.S., Pairas,G., Manessi-Zoupa,E. and Cordopatis,P.<br>Structural features of angiotensin-I converting enzyme catalytic sites: conformational studies in solution, homology models and comparison with other zinc metallopeptidases<br>Curr Top Med Chem (2004) 4, 403-429. PubMed  Europe PubMed DOI
  57. Sturrock,E.D., Natesh,R., van Rooyen,J.M. and Acharya,K.R.<br>Structure of angiotensin I-converting enzyme<br>Cell Mol Life Sci (2004) 61, 2677-2686. PubMed  Europe PubMed DOI  V  S  I
    58. 2003
  58. [YEAR:28-8-2003]Binevski,P.V., Sizova,E.A., Pozdnev,V.F. and Kost,O.A.<br>Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme<br>FEBS Lett (28-8-2003) 550, 84-88. PubMed  Europe PubMed DOI  I
  59. Brew,K.<br>Structure of human ACE gives new insights into inhibitor binding and design<br>Trends Pharmacol Sci (2003) 24, 391-394. PubMed  Europe PubMed DOI  S
  60. [YEAR:22-8-2003]Fernandez,J.H., Hayashi,M.A., Camargo,A.C. and Neshich,G.<br>Structural basis of the lisinopril-binding specificity in N- and C-domains of human somatic ACE<br>Biochem Biophys Res Commun (22-8-2003) 308, 219-226. PubMed  Europe PubMed DOI
  61. [YEAR:15-4-2003]Gordon,K., Redelinghuys,P., Schwager,S.L., Ehlers,M.R., Papageorgiou,A.C., Natesh,R., Acharya,K.R. and Sturrock,E.D.<br>Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme<br>Biochem J (15-4-2003) 371, 437-442. PubMed  Europe PubMed DOI  PMC  EPMC
  62. [YEAR:30-1-2003]Natesh,R., Schwager,S.L., Sturrock,E.D. and Acharya,K.R.<br>Crystal structure of the human angiotensin-converting enzyme-lisinopril complex<br>Nature (30-1-2003) 421, 551-554. PubMed  Europe PubMed DOI  S  I
  63. Tzakos,A.G., Galanis,A.S., Spyroulias,G.A., Cordopatis,P., Manessi-Zoupa,E. and Gerothanassis,I.P.<br>Structure-function discrimination of the N- and C- catalytic domains of human angiotensin-converting enzyme: implications for Cl- activation and peptide hydrolysis mechanisms<br>Protein Eng (2003) 16, 993-1003. PubMed  Europe PubMed DOI
    64. 2002
  64. Chubb,A.J., Schwager,S.L., Woodman,Z.L., Ehlers,M.R. and Sturrock,E.D.<br>Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain<br>Biochem Biophys Res Commun (2002) 297, 1225-1230. PubMed  Europe PubMed DOI
  65. [YEAR:14-5-2002]Cotton,J., Hayashi,M.A., Cuniasse,P., Vazeux,G., Ianzer,D., de Camargo,A.C. and Dive,V.<br>Selective inhibition of the C-domain of angiotensin I converting enzyme by bradykinin potentiating peptides<br>Biochemistry (14-5-2002) 41, 6065-6071. PubMed  Europe PubMed DOI
  66. Hens,K., Vandingenen,A., Macours,N., Baggerman,G., Karaoglanovic,A.C., Schoofs,L., De Loof,A. and Huybrechts,R.<br>Characterization of four substrates emphasizes kinetic similarity between insect and human C-domain angiotensin-converting enzyme<br>Eur J Biochem (2002) 269, 3522-3530. PubMed  Europe PubMed DOI
  67. [YEAR:8-2-2002]Kessler,S.P., Gomos,J.B., Scheidemantel,T.S., Rowe,T.M., Smith,H.L. and Sen,G.C.<br>The germinal isozyme of angiotensin-converting enzyme can substitute for the somatic isozyme in maintaining normal renal structure and functions<br>J Biol Chem (8-2-2002) 277, 4271-4276. PubMed  Europe PubMed DOI
  68. Metayer,S., Dacheux,F., Dacheux,J.L. and Gatti,J.L.<br>Germinal angiotensin I-converting enzyme is totally shed from the rodent sperm membrane during epididymal maturation<br>Biol Reprod (2002) 67, 1763-1767. PubMed  Europe PubMed DOI
  69. Voronov,S., Zueva,N., Orlov,V., Arutyunyan,A. and Kost,O.<br>Temperature-induced selective death of the C-domain within angiotensin-converting enzyme molecule<br>FEBS Lett (2002) 522, 77-82. PubMed  Europe PubMed DOI
    70. 2001
  70. [YEAR:16-2-2001]Fernandez,M., Liu,X., Wouters,M.A., Heyberger,S. and Husain,A.<br>Angiotensin I-converting enzyme transition state stabilization by His1089: evidence for a catalytic mechanism distinct from other gluzincin metalloproteinases<br>J Biol Chem (16-2-2001) 276, 4998-5004. PubMed  Europe PubMed DOI
  71. Kamata,M., Hu,J.G., Shibahara,H. and Nakagawa,H.<br>Assay of testicular angiotensin-converting enzyme activity in human spermatozoa<br>Int J Androl (2001) 24, 225-231. PubMed  Europe PubMed DOI  A
  72. [YEAR:7-9-2001]Liu,X., Fernandez,M., Wouters,M.A., Heyberger,S. and Husain,A.<br>Arg(1098) is critical for the chloride dependence of human angiotensin I-converting enzyme C-domain catalytic activity<br>J Biol Chem (7-9-2001) 276, 33518-33525. PubMed  Europe PubMed DOI
  73. Menard,J. and Patchett,A.A.<br>Angiotensin-converting enzyme inhibitors<br>Adv Protein Chem (2001) 56, 13-75. PubMed  Europe PubMed DOI  V  I
  74. Sabeur,K., Vo,A.T. and Ball,B.A.<br>Characterization of angiotensin-converting enzyme in canine testis<br>Reproduction (2001) 122, 139-146. PubMed  Europe PubMed
    75. 2000
  75. [YEAR:25-7-2000]Araujo,M.C., Melo,R.L., Cesari,M.H., Juliano,M.A., Juliano,L. and Carmona,A.K.<br>Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme<br>Biochemistry (25-7-2000) 39, 8519-8525. PubMed  Europe PubMed DOI
  76. Azizi,M., Massien,C., Michaud,A. and Corvol,P.<br>In vitro and in vivo inhibition of the 2 active sites of ACE by omapatrilat, a vasopeptidase inhibitor<br>Hypertension (2000) 35, 1226-1231. PubMed  Europe PubMed  I
  77. [YEAR:1-8-2000]Coates,D., Isaac,R.E., Cotton,J., Siviter,R., Williams,T.A., Shirras,A., Corvol,P. and Dive,V.<br>Functional conservation of the active sites of human and Drosophila angiotensin I-converting enzyme<br>Biochemistry (1-8-2000) 39, 8963-8969. PubMed  Europe PubMed DOI  I
  78. [YEAR:25-8-2000]Kessler,S.P., Rowe,T.M., Gomos,J.B., Kessler,P.M. and Sen,G.C.<br>Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme<br>J Biol Chem (25-8-2000) 275, 26259-26264. PubMed  Europe PubMed DOI
    79. 1999
  79. [YEAR:30-6-1999]Amour,A., Hutton,M., Knauper,V., Slocombe,P.M., Webster,A., Butler,M., Knight,C.G., Smith,B.J., Docherty,A.J. and Murphy,G.<br>Inhibition of the metalloproteinase domain of mouse TACE<br>Ann N Y Acad Sci (30-6-1999) 878, 728-731. PubMed  Europe PubMed DOI
  80. [YEAR:13-4-1999]Dive,V., Cotton,J., Yiotakis,A., Michaud,A., Vassiliou,S., Jiracek,J., Vazeux,G., Chauvet,M.T., Cuniasse,P. and Corvol,P.<br>RXP 407, a phosphinic peptide, is a potent inhibitor of angiotensin I converting enzyme able to differentiate between its two active sites<br>Proc Natl Acad Sci U S A (13-4-1999) 96, 4330-4335. PubMed  Europe PubMed DOI  PMC  EPMC  I
  81. [YEAR:15-3-1999]Michaud,A., Chauvet,M.T. and Corvol,P.<br>N-domain selectivity of angiotensin I-converting enzyme as assessed by structure-function studies of its highly selective substrate, N-acetyl-seryl-aspartyl-lysyl-proline<br>Biochem Pharmacol (15-3-1999) 57, 611-618. PubMed  Europe PubMed DOI
    82. 1998
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