Structure for peptidase M02.004: angiotensin-converting enzyme peptidase unit 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1O8A Homo sapiens 2.00 Å mature
The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His988 and His992 in purple and Glu1016 in blue. The catalytic Glu989 is shown in blue. The molecule is rotated with respect to the thermolysin image.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
complex with lisinopril. 2.00 Å 1O86 1O86 1O86 1O86 1O86 1O86 Natesh et al., 2003
mature  peptidase 2.00 Å 1O8A 1O8A 1O8A 1O8A 1O8A 1O8A Natesh et al., 2003
mature  peptidase 3.00 Å 2C6N 2C6N 2C6N 2C6N 2C6N 2C6N Corradi et al., 2006
mature  peptidase 2.01 Å 2IUL 2IUL 2IUL 2IUL 2IUL 2IUL Watermeyer et al., 2006
mature  peptidase 2.80 Å 2IUX 2IUX 2IUX 2IUX 2IUX 2IUX Watermeyer et al., 2006
complex with RXPA380 2.25 Å 2OC2 2OC2 2OC2 2OC2 2OC2 2OC2 Corradi et al., 2007
complex with phosphinic tripeptide 1.97 Å 2XY9 2XY9 2XY9 2XY9 2XY9 2XY9 Akif et al., 2011
complex with phosphinic tripeptide 2.15 Å 2XYD 2XYD 2XYD 2XYD 2XYD 2XYD Akif et al., 2011
complex with a selenium analogue of captopril 2.44 Å 2YDM 2YDM 2YDM 2YDM 2YDM 2YDM Akif et al., 2011
engineered form (N9Q, N25Q, N82Q, N117Q, N131Q, N289Q, Q545R, P576L, R629L) 1.99 Å 3NXQ 3NXQ 3NXQ 3NXQ 3NXQ 3NXQ Anthony et al., 2010