$VAR1 = undef;
Summary for peptidase M01.011: cystinyl aminopeptidase
| Names | |
|---|---|
| MEROPS Name | cystinyl aminopeptidase |
| Other names | angiotensin IV receptor, cystine aminopeptidase, cystyl-aminopeptidase, gp160 [ambig.], insulin-regulated membrane aminopeptidase, insulin-responsive aminopeptidase, LNPEP g.p. (Homo sapiens), IRAP, otase, oxytocinase, placental leucine aminopeptidase, P-LAP, vasopressinase, vp165 |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan MA >> Subclan MA(E) >> Family M1 >> Subfamily (none) >> M01.011 |
| Holotype | cystinyl aminopeptidase (Homo sapiens), Uniprot accession Q9UIQ6 (peptidase unit: 375-593), MERNUM MER0002060 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Metallo | ||
| Peplist | Included in the Peplist with identifier PL00129 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.3 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (4 cleavages) | ||
| Activity status | human: active (Nomura et al., 2004) mouse: active (by similarity to rat) (Mitchell et al., 1997) | ||
| Physiology | An ectoenzyme degrading oxytocin and vasopressin. Reported to be identical to the angiotensin IV receptor and thus implicated in the facilitation of learning and memory (Albiston et al., 2003). | ||
| Knockout | It is reported that mice deficient in cystinyl aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasis (Keller et al., 2002). | ||
| Pharmaceutical relevance | 'Conclusion: Maternal serum P-LAP activity decreases in cases with spontaneous preterm delivery and may be a … marker for some cases of preterm labor.' (Kozaki et al., 2001). 'These results suggest that P-LAP plays an important role in the regulation of neuronal cell function in the brain.' (Matsumoto et al., 2001) | ||
| Pathways | KEGG | Renin-angiotensin system | |
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/Cystinyl_aminopeptidase | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | -/-/-/- -/-/-/- (based on 11 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| LNPEP | 5q15 | ENSG00000113441 | 4012 | LNPEP | 151300 | |
