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Literature for peptidase M01.011: cystinyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Stam,F., Bjurling,S., Nylander,E., Hakansson,E.O., Gising,J., Larhed,M., Odell,L.R., Gronbladh,A. and Hallberg,M.<br>Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures<br>Neurosci Lett (2025) 869, 138415-138415. PubMed  Europe PubMed DOI
  2. Xu,W., Neal,E.S., Barlow,N., Thompson,P. and Borges,K.<br>Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy and Contributions to Glucose Transport in Neurons and Astrocytes<br>J Neurochem (2025) 169, e70320-e70320. PubMed  Europe PubMed DOI
    3. 2024
  3. Mpakali,A., Barla,I., Lu,L., Ramesh,K.M., Thomaidis,N., Stern,L.J., Giastas,P. and Stratikos,E.<br>Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase<br>J Mol Biol (2024) 436, 168449-168449. PubMed  Europe PubMed DOI  I
  4. Mpakali,A., Georgaki,G., Buson,A., Findlay,A.D., Foot,J.S., Mauvais,F.X., van Endert,P., Giastas,P., Hamprecht,D.W. and Stratikos,E.<br>Stabilization of the open conformation omicronf insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor<br>Protein Sci (2024) 33, e5151-e5151. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Vear,A., Chakraborty,A., Fahimi,F., Ferens,D., Widdop,R., Samuel,C.S., Gaspari,T., van Endert,P.M. and Chai,S.Y.<br>Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharide-induced inflammation<br>Front Immunol (2024) 15, 1466692-1466692. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Diel de Amorim,M., Dong,L., Byron,M., Foster,R.A., Klein,C., Saleh,M., Saleh,T. and Card,C.<br>Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare<br>Sci Rep (2023) 13, 4616-4616. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Evnouchidou,I., Koumantou,D., Nugue,M. and Saveanu,L.<br>M1-aminopeptidase family - beyond antigen-trimming activities<br>Curr Opin Immunol (2023) 83, 102337-102337. PubMed  Europe PubMed DOI  V
  8. Vear,A., Thalmann,C., Youngs,K., Hannan,N., Gaspari,T. and Chai,S.Y.<br>Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker<br>Sci Rep (2023) 13, 17565-17565. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Zuchowski,Y., Carty,J., Terker,A.S., Bock,F., Trapani,J.B., Bhave,G., Watts,J.A., Keller,S., Zhang,M., Zent,R., Harris,R.C. and Arroyo,J.P.<br>Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress<br>Am J Physiol Renal Physiol (2023) 324, F521-F521. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2022
  10. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.<br>The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation<br>Front Immunol (2022) 13, 1002375- PubMed  Europe PubMed
  11. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.<br>The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation<br>Front Immunol (2022) 13, 1002375-1002375. PubMed  Europe PubMed DOI  PMC  EPMC  M
  12. Mattorre,B., Caristi,S., Donato,S., Volpe,E., Faiella,M., Paiardini,A., Sorrentino,R. and Paladini,F.<br>A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  M
    13. 2021
  13. Temponeras,I., Chiniadis,L., Papakyriakou,A. and Stratikos,E.<br>Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase<br>Pharmaceuticals (Basel) (2021) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2020
  14. Barlow,N. and Thompson,P.E.<br>IRAP Inhibitors: M1-Aminopeptidase Family Inspiration<br>Front Pharmacol (2020) 11, 585930-585930. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Descamps,D., Evnouchidou,I., Caillens,V., Drajac,C., Riffault,S., van Endert,P. and Saveanu,L.<br>The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells<br>Front Mol Biosci (2020) 7, 583556-583556. PubMed  Europe PubMed DOI  PMC  EPMC  V
  16. Goto,Y., Nakamura,T.J., Ogawa,K., Hattori,A. and Tsujimoto,M.<br>Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain<br>Front Mol Biosci (2020) 7, 168-168. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Hallberg,M. and Larhed,M.<br>From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase<br>Front Pharmacol (2020) 11, 590855-590855. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Krskova,K., Balazova,L., Dobrocsyova,V., Olszanecki,R., Suski,M., Chai,S.Y. and Zorad,S.<br>Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats<br>Front Mol Biosci (2020) 7, 586225-586225. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Li,D.T., Habtemichael,E.N. and Bogan,J.S.<br>Vasopressin inactivation: role of insulin-regulated aminopeptidase<br>Vitam Horm (2020) 113, 101-128. PubMed  Europe PubMed DOI
  20. Mpakali,A., Saridakis,E., Giastas,P., Maben,Z., Stern,L.J., Larhed,M., Hallberg,M. and Stratikos,E.<br>Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor<br>ACS Med Chem Lett (2020) 11, 1429-1434. PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Paladini,F., Fiorillo,M.T., Tedeschi,V., Mattorre,B. and Sorrentino,R.<br>The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease<br>Front Immunol (2020) 11, 1576-1576. PubMed  Europe PubMed
  22. Ramirez-Exposito,M.J., Duenas-Rodriguez,B., Carrera-Gonzalez,M.P., Navarro-Cecilia,J. and Martinez-Martos,J.M.<br>Insulin-Regulated Aminopeptidase in Women with Breast Cancer: A Role beyond the Regulation of Oxytocin and Vasopressin<br>Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  23. Ramirez-Exposito,M.J., Martinez-Martos,J.M., Canton-Habas,V. and Del Pilar Carrera Gonzalez,M.<br>Putative Involvement of Endocrine Disruptors in the Alzheimer's disease Via the Insulin-Regulated Aminopeptidase / GLUT4 Pathway<br>Curr Neuropharmacol (2020) PubMed  Europe PubMed DOI
  24. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.<br>Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas<br>Brain Res Bull (2020) 168, 1-7. PubMed  Europe PubMed DOI
  25. Sanchez-Aguilar,M., Ibarra-Lara,L., Del Valle-Mondragon,L., Soria-Castro,E., Torres-Narvaez,J.C., Carreon-Torres,E., Sanchez-Mendoza,A. and Rubio-Ruiz,M.E.<br>Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model<br>PPAR Res (2020) 2020, 8894525-8894525. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Walton,S.L., Mirabito Colafella,K.M., Ansari,A., Chai,S.Y. and Denton,K.M.<br>Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy<br>Clin Sci (Lond) (2020) 134, 3213-3228. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Weimershaus,M., Mauvais,F.X., Evnouchidou,I., Lawand,M., Saveanu,L. and van Endert,P.<br>IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells<br>Front Cell Dev Biol (2020) 8, 585713-585713. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2019
  28. Burns,P., Bowditch,J., McFadyen,J., Loiacono,R., Albiston,A.L., Pham,V. and Chai,S.Y.<br>Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse<br>Behav Brain Res (2019) 376, 112150-112150. PubMed  Europe PubMed DOI  K
  29. Luo,L., Wang,S., Zhu,L., Fan,B., Liu,T., Wang,L., Zhao,P., Dang,Y., Sun,P., Chen,J., Zhang,Y., Chang,X., Yu,Z., Wang,H., Guo,R., Li,B. and Zhang,K.<br>Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus<br>Sci Rep (2019) 9, 13186-13186. PubMed  Europe PubMed DOI  PMC  EPMC  K
    30. 2018
  30. Vanga,S.R., Savmarker,J., Ng,L., Larhed,M., Hallberg,M., Aqvist,J., Hallberg,A., Chai,S.Y. and Gutierrez-de-Teran,H.<br>Structural basis of inhibition of human insulin-regulated aminopeptidase (IRAP) by aryl sulfonamides<br>ACS Omega (2018) 3, 4509-4521. PubMed  Europe PubMed DOI  PMC  EPMC  I
    31. 2017
  31. Albiston,A.L., Cacador,M., Sinnayah,P., Burns,P. and Chai,S.Y.<br>Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats<br>J Mol Endocrinol (2017) 58, 193-198. PubMed  Europe PubMed DOI  I
  32. El-Hawli,A., Qaradakhi,T., Hayes,A., Rybalka,E., Smith,R., Caprnda,M., Opatrilova,R., Gazdikova,K., Benckova,M., Kruzliak,P. and Zulli,A.<br>IRAP inhibition using HFI419 prevents moderate to severe acetylcholine mediated vasoconstriction in a rabbit model<br>Biomed Pharmacother (2017) 86, 23-26. PubMed  Europe PubMed DOI  I
  33. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Kokkala,P., Georgiadis,D., Giastas,P., Papakyriakou,A. and Stratikos,E.<br>Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity<br>J Med Chem (2017) 60, 2963-2972. PubMed  Europe PubMed DOI  S  I
    34. 2016
  34. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Ng,L., Pham,V., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Andersson,H., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.<br>Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density<br>Mol Pharmacol (2016) 89, 413-424. PubMed  Europe PubMed DOI  I
  35. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Savmarker,J., Ng,L., Pham,V., Lundback,T., Jenmalm-Jensen,A., Svensson,R., Artursson,P., Zelleroth,S., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.<br>Aryl sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures<br>ACS Chem Neurosci (2016) 7, 1383-1392. PubMed  Europe PubMed DOI  I
  36. Engen,K., Rosenstrom,U., Axelsson,H., Konda,V., Dahllund,L., Otrocka,M., Sigmundsson,K., Nikolaou,A., Vauquelin,G., Hallberg,M., Jenmalm Jensen,A., Lundback,T. and Larhed,M.<br>Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small-molecule screening<br>Assay Drug Dev Technol (2016) 14, 180-193. PubMed  Europe PubMed DOI  I
  37. Ramirez-Exposito,M.J., Martinez-Martos,J.M., Palomeque,T. and Lorite,P.<br>A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism<br>Indian J Med Res (2016) 144, 120-123. PubMed  Europe PubMed DOI  M
  38. Yeatman,H.R., Albiston,A.L., Burns,P. and Chai,S.Y.<br>Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory<br>Neurobiol Learn Mem (2016) 136, 174-182. PubMed  Europe PubMed DOI  K
    39. 2015
  39. Alponti,R.F., Viana,L.G., Yamanouye,N. and Silveira,P.F.<br>Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity<br>J Mol Endocrinol (2015) 55, 1-8. PubMed  Europe PubMed DOI  P
  40. Hermans,S.J., Ascher,D.B., Hancock,N.C., Holien,J.K., Michell,B.J., Yeen Chai,S., Morton,C.J. and Parker,M.W.<br>Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides<br>Protein Sci (2015) 24, 190-199. PubMed  Europe PubMed DOI  S
  41. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Papakyriakou,A., Kokkala,P., Georgiadis,D. and Stratikos,E.<br>Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing<br>J Immunol (2015) 195, 2842-2851. PubMed  Europe PubMed DOI  S  I
  42. Svensson,F., Engen,K., Lundback,T., Larhed,M. and Skold,C.<br>Virtual screening for transition state analogue inhibitors of IRAP based on quantum mechanically derived reaction coordinates<br>J Chem Inf Model (2015) 55, 1984-1993. PubMed  Europe PubMed DOI  I
  43. Werno,M.W. and Chamberlain,L.H.<br>S-acylation of the insulin-responsive aminopeptidase (IRAP): quantitative analysis and identification of modified cysteines<br>Sci Rep (2015) 5, 12413-12413. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2014
  44. Borhade,S.R., Rosenstrom,U., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Sigmundsson,K., Axelsson,H., Svensson,F., Konda,V., Skold,C., Larhed,M. and Hallberg,M.<br>Inhibition of insulin-regulated aminopeptidase (IRAP) by arylsulfonamides<br>ChemistryOpen (2014) 3, 256-263. PubMed  Europe PubMed DOI  PMC  EPMC  I
  45. Mountford,S.J., Albiston,A.L., Charman,W.N., Ng,L., Holien,J.K., Parker,M.W., Nicolazzo,J.A., Thompson,P.E. and Chai,S.Y.<br>Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase<br>J Med Chem (2014) 57, 1368-1377. PubMed  Europe PubMed DOI  I
    46. 2013
  46. Loyens,E., De Bundel,D., Demaegdt,H., Chai,S.Y., Vanderheyden,P., Michotte,Y., Gard,P. and Smolders,I.<br>Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase<br>Int J Neuropsychopharmacol (2013) 16, 1153-1163. PubMed  Europe PubMed DOI  K  I
  47. Muller,S., Lendeckel,U., Dobrowolny,H., Steiner,J., Bogerts,B. and Bernstein,H.G.<br>Some notes on insulin-regulated aminopeptidase in depression<br>Int J Neuropsychopharmacol (2013) 16, 1877-1878. PubMed  Europe PubMed DOI
  48. Nikolaou,A., Eynde,I.V., Tourwe,D., Vauquelin,G., Toth,G., Mallareddy,J.R., Poglitsch,M., Van Ginderachter,J.A. and Vanderheyden,P.M.<br>[3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase<br>Eur J Pharmacol (2013) 702, 93-102. PubMed  Europe PubMed DOI  I
  49. Saveanu,L., Babdor,J., Lawand,M. and van Endert,P.<br>Insulin-regulated aminopeptidase and its compartment in dendritic cells<br>Mol Immunol (2013) 55, 153-155. PubMed  Europe PubMed DOI
    50. 2012
  50. Andersson,H. and Hallberg,M.<br>Discovery of inhibitors of insulin-regulated aminopeptidase as cognitive enhancers<br>Int J Hypertens (2012) 2012, 789671-789671. PubMed  Europe PubMed DOI  PMC  EPMC  I
  51. Demaegdt,H., De Backer,J.P., Lukaszuk,A., Toth,G., Szemenyei,E., Tourwe,D. and Vauquelin,G.<br>Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP)<br>Fundam Clin Pharmacol (2012) 26, 194-197. PubMed  Europe PubMed DOI  I
  52. Nomura,S., Tsujimoto,M. and Mizutani,S.<br>Cystinyl aminopeptidase/oxytocinase<br>[ISSN:978-0-12-407744-7] (2012) 3, 419-425. DOI
  53. Pham,V., Albiston,A.L., Downes,C.E., Wong,C.H., Diwakarla,S., Ng,L., Lee,S., Crack,P.J. and Chai,S.Y.<br>Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice<br>J Neurotrauma (2012) 29, 1243-1248. PubMed  Europe PubMed DOI  K
  54. Saveanu,L. and van Endert,P.<br>The role of insulin-regulated aminopeptidase in MHC class I antigen presentation<br>Front Immunol (2012) 3, 57-57. PubMed  Europe PubMed DOI  PMC  EPMC
    55. 2011
  55. Albiston,A.L., Diwakarla,S., Fernando,R.N., Mountford,S.J., Yeatman,H.R., Morgan,B., Pham,V., Holien,J.K., Parker,M.W., Thompson,P.E. and Chai,S.Y.<br>Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers<br>Br J Pharmacol (2011) 164, 37-47. PubMed  Europe PubMed DOI  I
  56. Andersson,H., Demaegdt,H., Johnsson,A., Vauquelin,G., Lindeberg,G., Hallberg,M., Erdelyi,M., Karlen,A. and Hallberg,A.<br>Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis<br>J Med Chem (2011) 54, 3779-3792. PubMed  Europe PubMed DOI  I
  57. Ascher,D.B., Cromer,B.A., Morton,C.J., Volitakis,I., Cherny,R.A., Albiston,A.L., Chai,S.Y. and Parker,M.W.<br>Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain<br>Biochemistry (2011) 50, 2611-2622. PubMed  Europe PubMed DOI
  58. Demaegdt,H., Gard,P., De Backer,J.P., Lukaszuk,A., Szemenyei,E., Toth,G., Tourwe,D. and Vauquelin,G.<br>Binding of "AT4 receptor" ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells<br>Mol Cell Endocrinol (2011) 339, 34-44. PubMed  Europe PubMed DOI  I
  59. Loyens,E., Schallier,A., Chai,S.Y., De Bundel,D., Vanderheyden,P., Michotte,Y. and Smolders,I.<br>Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures<br>Seizure (2011) 20, 602-605. PubMed  Europe PubMed DOI  K
  60. Nakada,T.A., Russell,J.A., Wellman,H., Boyd,J.H., Nakada,E., Thain,K.R., Thair,S.A., Hirasawa,H., Oda,S. and Walley,K.R.<br>Leucyl/cystinyl aminopeptidase gene variants in septic shock<br>Chest (2011) 139, 1042-1049. PubMed  Europe PubMed DOI  M
    61. 2010
  61. Albiston,A.L., Fernando,R.N., Yeatman,H.R., Burns,P., Ng,L., Daswani,D., Diwakarla,S., Pham,V. and Chai,S.Y.<br>Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory<br>Neurobiol Learn Mem (2010) 93, 19-30. PubMed  Europe PubMed DOI  K  I
  62. Albiston,A.L., Pham,V., Ye,S., Ng,L., Lew,R.A., Thompson,P.E., Holien,J.K., Morton,C.J., Parker,M.W. and Chai,S.Y.<br>Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase<br>Mol Pharmacol (2010) 78, 600-607. PubMed  Europe PubMed DOI
  63. Andersson,H., Demaegdt,H., Vauquelin,G., Lindeberg,G., Karlen,A., Hallberg,M., Erdelyi,M. and Hallberg,A.<br>Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)<br>J Med Chem (2010) 53, 8059-8071. PubMed  Europe PubMed DOI  I
  64. Beyer,C.E., Dwyer,J.M., Platt,B.J., Neal,S., Luo,B., Ling,H.P., Lin,Q., Mark,R.J., Rosenzweig-Lipson,S. and Schechter,L.E.<br>Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation<br>Psychopharmacology (Berl) (2010) 209, 303-311. PubMed  Europe PubMed DOI  I
  65. Georgiadou,D., Hearn,A., Evnouchidou,I., Chroni,A., Leondiadis,L., York,I.A., Rock,K.L. and Stratikos,E.<br>Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1<br>J Immunol (2010) 185, 1584-1592. PubMed  Europe PubMed DOI  P
    66. 2009
  66. Demaegdt,H., Lukaszuk,A., De Buyser,E., De Backer,J.P., Szemenyei,E., Toth,G., Chakravarthy,S., Panicker,M., Michotte,Y., Tourwe,D. and Vauquelin,G.<br>Selective labeling of IRAP by the tritiated AT(4) receptor ligand [3H]angiotensin IV and its stable analog [3H]AL-11<br>Mol Cell Endocrinol (2009) 311, 77-86. PubMed  Europe PubMed DOI  I
  67. Kawai,M., Araragi,K., Shimizu,Y. and Hara,Y.<br>Identification of placental leucine aminopeptidase and Triton-slowed aminopeptidase N in serum of pregnant women<br>Clin Chim Acta (2009) 400, 37-41. PubMed  Europe PubMed DOI
  68. Pham,V., Burns,P., Albiston,A.L., Yeatman,H.R., Ng,L., Diwakarla,S. and Chai,S.Y.<br>Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice<br>Peptides (2009) 30, 1861-1865. PubMed  Europe PubMed DOI  K
  69. Saveanu,L., Carroll,O., Weimershaus,M., Guermonprez,P., Firat,E., Lindo,V., Greer,F., Davoust,J., Kratzer,R., Keller,S.R., Niedermann,G. and van Endert,P.<br>IRAP identifies an endosomal compartment required for MHC class I cross-presentation<br>Science (2009) 325, 213-217. PubMed  Europe PubMed DOI
    70. 2008
  70. Albiston,A.L., Morton,C.J., Ng,H.L., Pham,V., Yeatman,H.R., Ye,S., Fernando,R.N., De Bundel,D., Ascher,D.B., Mendelsohn,F.A., Parker,M.W. and Chai,S.Y.<br>Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase<br>FASEB J (2008) 22, 4209-4217. PubMed  Europe PubMed DOI  T  I
  71. Chai,S.Y., Yeatman,H.R., Parker,M.W., Ascher,D.B., Thompson,P.E., Mulvey,H.T. and Albiston,A.L.<br>Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase<br>BMC Neurosci (2008) 9 Suppl 2, S14-S14. PubMed  Europe PubMed DOI  PMC  EPMC  T  I
  72. Cohen,M., Wuillemin,C., Chai,S.Y. and Bischof,P.<br>Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion<br>J Pept Sci (2008) 14, 883-887. PubMed  Europe PubMed DOI  I
  73. Demaegdt,H., Smitz,L., De Backer,J.P., Le,M.T., Bauwens,M., Szemenyei,E., Toth,G., Michotte,Y., Vanderheyden,P. and Vauquelin,G.<br>Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding<br>Br J Pharmacol (2008) 154, 872-881. PubMed  Europe PubMed DOI  PMC  EPMC  I
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