Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M01.011: cystinyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Mpakali,A., Barla,I., Lu,L., Ramesh,K.M., Thomaidis,N., Stern,L.J., Giastas,P. and Stratikos,E.
    Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
    J Mol Biol436, 168449-168449. PubMed  Europe PubMed DOI  I
  2. Mpakali,A., Georgaki,G., Buson,A., Findlay,A.D., Foot,J.S., Mauvais,F.X., van Endert,P., Giastas,P., Hamprecht,D.W. and Stratikos,E.
    Stabilization of the open conformation omicronf insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor
    Protein Sci33, e5151-e5151. PubMed  Europe PubMed DOI
  3. Vear,A., Chakraborty,A., Fahimi,F., Ferens,D., Widdop,R., Samuel,C.S., Gaspari,T., van Endert,P.M. and Chai,S.Y.
    Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharide-induced inflammation
    Front Immunol15, 1466692-1466692. PubMed  Europe PubMed DOI
    4. 2023
  4. Diel de Amorim,M., Dong,L., Byron,M., Foster,R.A., Klein,C., Saleh,M., Saleh,T. and Card,C.
    Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare
    Sci Rep13, 4616-4616. PubMed  Europe PubMed DOI
  5. Evnouchidou,I., Koumantou,D., Nugue,M. and Saveanu,L.
    M1-aminopeptidase family - beyond antigen-trimming activities
    Curr Opin Immunol83, 102337-102337. PubMed  Europe PubMed DOI  V
  6. Vear,A., Thalmann,C., Youngs,K., Hannan,N., Gaspari,T. and Chai,S.Y.
    Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker
    Sci Rep13, 17565-17565. PubMed  Europe PubMed DOI
  7. Zuchowski,Y., Carty,J., Terker,A.S., Bock,F., Trapani,J.B., Bhave,G., Watts,J.A., Keller,S., Zhang,M., Zent,R., Harris,R.C. and Arroyo,J.P.
    Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress
    Am J Physiol Renal Physiol324, F521-F521. PubMed  Europe PubMed DOI
    8. 2022
  8. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol13, 1002375-1002375. PubMed  Europe PubMed DOI  M
  9. Mattorre,B., Caristi,S., Donato,S., Volpe,E., Faiella,M., Paiardini,A., Sorrentino,R. and Paladini,F.
    A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation
    Int J Mol Sci23, PubMed  Europe PubMed DOI  M
  10. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol13, 1002375- PubMed  Europe PubMed
    11. 2021
  11. Temponeras,I., Chiniadis,L., Papakyriakou,A. and Stratikos,E.
    Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase
    Pharmaceuticals (Basel)14, PubMed  Europe PubMed DOI
    12. 2020
  12. Barlow,N. and Thompson,P.E.
    IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
    Front Pharmacol11, 585930-585930. PubMed  Europe PubMed DOI
  13. Descamps,D., Evnouchidou,I., Caillens,V., Drajac,C., Riffault,S., van Endert,P. and Saveanu,L.
    The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells
    Front Mol Biosci7, 583556-583556. PubMed  Europe PubMed DOI  V
  14. Goto,Y., Nakamura,T.J., Ogawa,K., Hattori,A. and Tsujimoto,M.
    Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain
    Front Mol Biosci7, 168-168. PubMed  Europe PubMed DOI
  15. Hallberg,M. and Larhed,M.
    From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
    Front Pharmacol11, 590855-590855. PubMed  Europe PubMed DOI  V
  16. Krskova,K., Balazova,L., Dobrocsyova,V., Olszanecki,R., Suski,M., Chai,S.Y. and Zorad,S.
    Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats
    Front Mol Biosci7, 586225-586225. PubMed  Europe PubMed DOI
  17. Li,D.T., Habtemichael,E.N. and Bogan,J.S.
    Vasopressin inactivation: role of insulin-regulated aminopeptidase
    Vitam Horm113, 101-128. PubMed  Europe PubMed DOI
  18. Mpakali,A., Saridakis,E., Giastas,P., Maben,Z., Stern,L.J., Larhed,M., Hallberg,M. and Stratikos,E.
    Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor
    ACS Med Chem Lett11, 1429-1434. PubMed  Europe PubMed DOI  I
  19. Paladini,F., Fiorillo,M.T., Tedeschi,V., Mattorre,B. and Sorrentino,R.
    The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
    Front Immunol11, 1576-1576. PubMed  Europe PubMed
  20. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.
    Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas
    Brain Res Bull168, 1-7. PubMed  Europe PubMed DOI
  21. Ramirez-Exposito,M.J., Martinez-Martos,J.M., Canton-Habas,V. and Del Pilar Carrera Gonzalez,M.
    Putative Involvement of Endocrine Disruptors in the Alzheimer's disease Via the Insulin-Regulated Aminopeptidase / GLUT4 Pathway
    Curr Neuropharmacol PubMed  Europe PubMed DOI
  22. Ramirez-Exposito,M.J., Duenas-Rodriguez,B., Carrera-Gonzalez,M.P., Navarro-Cecilia,J. and Martinez-Martos,J.M.
    Insulin-Regulated Aminopeptidase in Women with Breast Cancer: A Role beyond the Regulation of Oxytocin and Vasopressin
    Cancers (Basel)12, PubMed  Europe PubMed DOI
  23. Sanchez-Aguilar,M., Ibarra-Lara,L., Del Valle-Mondragon,L., Soria-Castro,E., Torres-Narvaez,J.C., Carreon-Torres,E., Sanchez-Mendoza,A. and Rubio-Ruiz,M.E.
    Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model
    PPAR Res2020, 8894525-8894525. PubMed  Europe PubMed DOI
  24. Walton,S.L., Mirabito Colafella,K.M., Ansari,A., Chai,S.Y. and Denton,K.M.
    Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy
    Clin Sci (Lond)134, 3213-3228. PubMed  Europe PubMed DOI
  25. Weimershaus,M., Mauvais,F.X., Evnouchidou,I., Lawand,M., Saveanu,L. and van Endert,P.
    IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells
    Front Cell Dev Biol8, 585713-585713. PubMed  Europe PubMed DOI
    26. 2019
  26. Burns,P., Bowditch,J., McFadyen,J., Loiacono,R., Albiston,A.L., Pham,V. and Chai,S.Y.
    Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse
    Behav Brain Res376, 112150-112150. PubMed  Europe PubMed DOI  K
  27. Luo,L., Wang,S., Zhu,L., Fan,B., Liu,T., Wang,L., Zhao,P., Dang,Y., Sun,P., Chen,J., Zhang,Y., Chang,X., Yu,Z., Wang,H., Guo,R., Li,B. and Zhang,K.
    Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus
    Sci Rep9, 13186-13186. PubMed  Europe PubMed DOI  K
    28. 2018
  28. Vanga,S.R., Savmarker,J., Ng,L., Larhed,M., Hallberg,M., Aqvist,J., Hallberg,A., Chai,S.Y. and Gutierrez-de-Teran,H.
    Structural basis of inhibition of human insulin-regulated aminopeptidase (IRAP) by aryl sulfonamides
    ACS Omega3, 4509-4521. PubMed  Europe PubMed DOI  I
    29. 2017
  29. Albiston,A.L., Cacador,M., Sinnayah,P., Burns,P. and Chai,S.Y.
    Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats
    J Mol Endocrinol58, 193-198. PubMed  Europe PubMed DOI  I
  30. El-Hawli,A., Qaradakhi,T., Hayes,A., Rybalka,E., Smith,R., Caprnda,M., Opatrilova,R., Gazdikova,K., Benckova,M., Kruzliak,P. and Zulli,A.
    IRAP inhibition using HFI419 prevents moderate to severe acetylcholine mediated vasoconstriction in a rabbit model
    Biomed Pharmacother86, 23-26. PubMed  Europe PubMed DOI  I
  31. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Kokkala,P., Georgiadis,D., Giastas,P., Papakyriakou,A. and Stratikos,E.
    Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity
    J Med Chem60, 2963-2972. PubMed  Europe PubMed DOI  S  I
    32. 2016
  32. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Savmarker,J., Ng,L., Pham,V., Lundback,T., Jenmalm-Jensen,A., Svensson,R., Artursson,P., Zelleroth,S., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.
    Aryl sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures
    ACS Chem Neurosci7, 1383-1392. PubMed  Europe PubMed DOI  I
  33. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Ng,L., Pham,V., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Andersson,H., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.
    Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density
    Mol Pharmacol89, 413-424. PubMed  Europe PubMed DOI  I
  34. Engen,K., Rosenstrom,U., Axelsson,H., Konda,V., Dahllund,L., Otrocka,M., Sigmundsson,K., Nikolaou,A., Vauquelin,G., Hallberg,M., Jenmalm Jensen,A., Lundback,T. and Larhed,M.
    Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small-molecule screening
    Assay Drug Dev Technol14, 180-193. PubMed  Europe PubMed DOI  I
  35. Ramirez-Exposito,M.J., Martinez-Martos,J.M., Palomeque,T. and Lorite,P.
    A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism
    Indian J Med Res144, 120-123. PubMed  Europe PubMed DOI  M
  36. Yeatman,H.R., Albiston,A.L., Burns,P. and Chai,S.Y.
    Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory
    Neurobiol Learn Mem136, 174-182. PubMed  Europe PubMed DOI  K
    37. 2015
  37. Alponti,R.F., Viana,L.G., Yamanouye,N. and Silveira,P.F.
    Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity
    J Mol Endocrinol55, 1-8. PubMed  Europe PubMed DOI  P
  38. Hermans,S.J., Ascher,D.B., Hancock,N.C., Holien,J.K., Michell,B.J., Yeen Chai,S., Morton,C.J. and Parker,M.W.
    Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides
    Protein Sci24, 190-199. PubMed  Europe PubMed DOI  S
  39. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Papakyriakou,A., Kokkala,P., Georgiadis,D. and Stratikos,E.
    Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing
    J Immunol195, 2842-2851. PubMed  Europe PubMed DOI  S  I
  40. Svensson,F., Engen,K., Lundback,T., Larhed,M. and Skold,C.
    Virtual screening for transition state analogue inhibitors of IRAP based on quantum mechanically derived reaction coordinates
    J Chem Inf Model55, 1984-1993. PubMed  Europe PubMed DOI  I
  41. Werno,M.W. and Chamberlain,L.H.
    S-acylation of the insulin-responsive aminopeptidase (IRAP): quantitative analysis and identification of modified cysteines
    Sci Rep5, 12413-12413. PubMed  Europe PubMed DOI
    42. 2014
  42. Borhade,S.R., Rosenstrom,U., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Sigmundsson,K., Axelsson,H., Svensson,F., Konda,V., Skold,C., Larhed,M. and Hallberg,M.
    Inhibition of insulin-regulated aminopeptidase (IRAP) by arylsulfonamides
    ChemistryOpen3, 256-263. PubMed  Europe PubMed DOI  I
  43. Mountford,S.J., Albiston,A.L., Charman,W.N., Ng,L., Holien,J.K., Parker,M.W., Nicolazzo,J.A., Thompson,P.E. and Chai,S.Y.
    Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase
    J Med Chem57, 1368-1377. PubMed  Europe PubMed DOI  I
    44. 2013
  44. Loyens,E., De Bundel,D., Demaegdt,H., Chai,S.Y., Vanderheyden,P., Michotte,Y., Gard,P. and Smolders,I.
    Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase
    Int J Neuropsychopharmacol16, 1153-1163. PubMed  Europe PubMed DOI  K  I
  45. Muller,S., Lendeckel,U., Dobrowolny,H., Steiner,J., Bogerts,B. and Bernstein,H.G.
    Some notes on insulin-regulated aminopeptidase in depression
    Int J Neuropsychopharmacol16, 1877-1878. PubMed  Europe PubMed DOI
  46. Nikolaou,A., Eynde,I.V., Tourwe,D., Vauquelin,G., Toth,G., Mallareddy,J.R., Poglitsch,M., Van Ginderachter,J.A. and Vanderheyden,P.M.
    [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase
    Eur J Pharmacol702, 93-102. PubMed  Europe PubMed DOI  I
  47. Saveanu,L., Babdor,J., Lawand,M. and van Endert,P.
    Insulin-regulated aminopeptidase and its compartment in dendritic cells
    Mol Immunol55, 153-155. PubMed  Europe PubMed DOI
    48. 2012
  48. Andersson,H. and Hallberg,M.
    Discovery of inhibitors of insulin-regulated aminopeptidase as cognitive enhancers
    Int J Hypertens2012, 789671-789671. PubMed  Europe PubMed DOI  I
  49. Demaegdt,H., De Backer,J.P., Lukaszuk,A., Toth,G., Szemenyei,E., Tourwe,D. and Vauquelin,G.
    Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP)
    Fundam Clin Pharmacol26, 194-197. PubMed  Europe PubMed DOI  I
  50. Nomura,S., Tsujimoto,M. and Mizutani,S.
    Cystinyl aminopeptidase/oxytocinase
    [ISSN:978-0-12-407744-7]3, 419-425. DOI
  51. Pham,V., Albiston,A.L., Downes,C.E., Wong,C.H., Diwakarla,S., Ng,L., Lee,S., Crack,P.J. and Chai,S.Y.
    Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice
    J Neurotrauma29, 1243-1248. PubMed  Europe PubMed DOI  K
  52. Saveanu,L. and van Endert,P.
    The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
    Front Immunol3, 57-57. PubMed  Europe PubMed DOI
    53. 2011
  53. Albiston,A.L., Diwakarla,S., Fernando,R.N., Mountford,S.J., Yeatman,H.R., Morgan,B., Pham,V., Holien,J.K., Parker,M.W., Thompson,P.E. and Chai,S.Y.
    Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers
    Br J Pharmacol164, 37-47. PubMed  Europe PubMed DOI  I
  54. Andersson,H., Demaegdt,H., Johnsson,A., Vauquelin,G., Lindeberg,G., Hallberg,M., Erdelyi,M., Karlen,A. and Hallberg,A.
    Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis
    J Med Chem54, 3779-3792. PubMed  Europe PubMed DOI  I
  55. Ascher,D.B., Cromer,B.A., Morton,C.J., Volitakis,I., Cherny,R.A., Albiston,A.L., Chai,S.Y. and Parker,M.W.
    Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain
    Biochemistry50, 2611-2622. PubMed  Europe PubMed DOI
  56. Demaegdt,H., Gard,P., De Backer,J.P., Lukaszuk,A., Szemenyei,E., Toth,G., Tourwe,D. and Vauquelin,G.
    Binding of "AT4 receptor" ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells
    Mol Cell Endocrinol339, 34-44. PubMed  Europe PubMed DOI  I
  57. Loyens,E., Schallier,A., Chai,S.Y., De Bundel,D., Vanderheyden,P., Michotte,Y. and Smolders,I.
    Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures
    Seizure20, 602-605. PubMed  Europe PubMed DOI  K
  58. Nakada,T.A., Russell,J.A., Wellman,H., Boyd,J.H., Nakada,E., Thain,K.R., Thair,S.A., Hirasawa,H., Oda,S. and Walley,K.R.
    Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Chest139, 1042-1049. PubMed  Europe PubMed DOI  M
    59. 2010
  59. Albiston,A.L., Pham,V., Ye,S., Ng,L., Lew,R.A., Thompson,P.E., Holien,J.K., Morton,C.J., Parker,M.W. and Chai,S.Y.
    Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase
    Mol Pharmacol78, 600-607. PubMed  Europe PubMed DOI
  60. Albiston,A.L., Fernando,R.N., Yeatman,H.R., Burns,P., Ng,L., Daswani,D., Diwakarla,S., Pham,V. and Chai,S.Y.
    Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory
    Neurobiol Learn Mem93, 19-30. PubMed  Europe PubMed DOI  K  I
  61. Andersson,H., Demaegdt,H., Vauquelin,G., Lindeberg,G., Karlen,A., Hallberg,M., Erdelyi,M. and Hallberg,A.
    Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)
    J Med Chem53, 8059-8071. PubMed  Europe PubMed DOI  I
  62. Beyer,C.E., Dwyer,J.M., Platt,B.J., Neal,S., Luo,B., Ling,H.P., Lin,Q., Mark,R.J., Rosenzweig-Lipson,S. and Schechter,L.E.
    Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation
    Psychopharmacology (Berl)209, 303-311. PubMed  Europe PubMed DOI  I
  63. Georgiadou,D., Hearn,A., Evnouchidou,I., Chroni,A., Leondiadis,L., York,I.A., Rock,K.L. and Stratikos,E.
    Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1
    J Immunol185, 1584-1592. PubMed  Europe PubMed DOI  P
    64. 2009
  64. Demaegdt,H., Lukaszuk,A., De Buyser,E., De Backer,J.P., Szemenyei,E., Toth,G., Chakravarthy,S., Panicker,M., Michotte,Y., Tourwe,D. and Vauquelin,G.
    Selective labeling of IRAP by the tritiated AT(4) receptor ligand [3H]angiotensin IV and its stable analog [3H]AL-11
    Mol Cell Endocrinol311, 77-86. PubMed  Europe PubMed DOI  I
  65. Kawai,M., Araragi,K., Shimizu,Y. and Hara,Y.
    Identification of placental leucine aminopeptidase and Triton-slowed aminopeptidase N in serum of pregnant women
    Clin Chim Acta400, 37-41. PubMed  Europe PubMed DOI
  66. Pham,V., Burns,P., Albiston,A.L., Yeatman,H.R., Ng,L., Diwakarla,S. and Chai,S.Y.
    Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice
    Peptides30, 1861-1865. PubMed  Europe PubMed DOI  K
  67. Saveanu,L., Carroll,O., Weimershaus,M., Guermonprez,P., Firat,E., Lindo,V., Greer,F., Davoust,J., Kratzer,R., Keller,S.R., Niedermann,G. and van Endert,P.
    IRAP identifies an endosomal compartment required for MHC class I cross-presentation
    Science325, 213-217. PubMed  Europe PubMed DOI
    68. 2008
  68. Albiston,A.L., Morton,C.J., Ng,H.L., Pham,V., Yeatman,H.R., Ye,S., Fernando,R.N., De Bundel,D., Ascher,D.B., Mendelsohn,F.A., Parker,M.W. and Chai,S.Y.
    Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
    FASEB J22, 4209-4217. PubMed  Europe PubMed DOI  T  I
  69. Chai,S.Y., Yeatman,H.R., Parker,M.W., Ascher,D.B., Thompson,P.E., Mulvey,H.T. and Albiston,A.L.
    Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase
    BMC Neurosci9 Suppl 2, S14-S14. PubMed  Europe PubMed DOI  T  I
  70. Cohen,M., Wuillemin,C., Chai,S.Y. and Bischof,P.
    Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion
    J Pept Sci14, 883-887. PubMed  Europe PubMed DOI  I
  71. Demaegdt,H., Smitz,L., De Backer,J.P., Le,M.T., Bauwens,M., Szemenyei,E., Toth,G., Michotte,Y., Vanderheyden,P. and Vauquelin,G.
    Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding
    Br J Pharmacol154, 872-881. PubMed  Europe PubMed DOI  I
  72. Fernando,R.N., Albiston,A.L. and Chai,S.Y.
    The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - potential role in modulation of glucose uptake in neurones?
    Eur J Neurosci28, 588-598. PubMed  Europe PubMed DOI  I
  73. Gard,P.R.
    Cognitive-enhancing effects of angiotensin IV
    BMC Neurosci9 Suppl 2, S15-S15. PubMed  Europe PubMed DOI  T
  74. Stragier,B., De Bundel,D., Sarre,S., Smolders,I., Vauquelin,G., Dupont,A., Michotte,Y. and Vanderheyden,P.
    Involvement of insulin-regulated aminopeptidase in the effects of the renin-angiotensin fragment angiotensin IV: a review
    Heart Fail Rev13, 321-337. PubMed  Europe PubMed DOI  V  I
  75. Ye,S., Chai,S.Y., Lew,R.A., Ascher,D.B., Morton,C.J., Parker,M.W. and Albiston,A.L.
    Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase
    Biochem Cell Biol86, 251-261. PubMed  Europe PubMed DOI  P  I
    76. 2007
  76. Albiston,A.L., Peck,G.R., Yeatman,H.R., Fernando,R., Ye,S. and Chai,S.Y.
    Therapeutic targeting of insulin-regulated aminopeptidase: heads and tails?
    Pharmacol Ther116, 417-427. PubMed  Europe PubMed DOI  V  T
  77. Fernando,R.N., Luff,S.E., Albiston,A.L. and Chai,S.Y.
    Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons
    J Neurochem102, 967-976. PubMed  Europe PubMed DOI  I
  78. Mizutani,S., Shibata,K., Kikkawa,F., Hattori,A., Tsujimoto,M., Ishii,M. and Kobayashi,H.
    Essential role of placental leucine aminopeptidase in gynecologic malignancy
    Expert Opin Ther Targets11, 453-461. PubMed  Europe PubMed DOI  V
  79. Stragier,B., Demaegdt,H., De Bundel,D., Smolders,I., Sarre,S., Vauquelin,G., Ebinger,G., Michotte,Y. and Vanderheyden,P.
    Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat
    Brain Res1131, 97-105. PubMed  Europe PubMed DOI  I
  80. Wallis,M.G., Lankford,M.F. and Keller,S.R.
    Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP
    Am J Physiol Endocrinol Metab293, E1092-E1102. PubMed  Europe PubMed DOI
  81. Ye,S., Chai,S.Y., Lew,R.A. and Albiston,A.L.
    Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain
    Biol Chem388, 399-403. PubMed  Europe PubMed DOI  I
    82. 2005
  82. Tsujimoto,M. and Hattori,A.
    The oxytocinase subfamily of M1 aminopeptidases
    Biochim Biophys Acta1751, 9-18. PubMed  Europe PubMed DOI
    83. 2004
  83. Abel,E.D., Graveleau,C., Betuing,S., Pham,M., Reay,P.A., Kandror,V., Kupriyanova,T., Xu,Z. and Kandror,K.V.
    Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes
    Mol Endocrinol18, 2491-2501. PubMed  Europe PubMed DOI
  84. [YEAR:1-10-2004]Demaegdt,H., Laeremans,H., De Backer,J.P., Mosselmans,S., Le,M.T., Kersemans,V., Michotte,Y., Vauquelin,G. and Vanderheyden,P.M.
    Synergistic modulation of cystinyl aminopeptidase by divalent cation chelators
    Biochem Pharmacol68, 893-900. PubMed  Europe PubMed DOI  I
  85. [YEAR:1-10-2004]Demaegdt,H., Vanderheyden,P., De Backer,J.P., Mosselmans,S., Laeremans,H., Le,M.T., Kersemans,V., Michotte,Y. and Vauquelin,G.
    Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [125I]Ang IV binding and catalytic activity
    Biochem Pharmacol68, 885-892. PubMed  Europe PubMed DOI  I
  86. [YEAR:20-2-2004]Ito,N., Nomura,S., Iwase,A., Ito,T., Kikkawa,F., Tsujimoto,M., Ishiura,S. and Mizutani,S.
    ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase
    Biochem Biophys Res Commun314, 1008-1013. PubMed  Europe PubMed DOI  I
  87. [YEAR:15-10-2004]Mustafa,T., Chai,S.Y., May,C.N., Mendelsohn,F.A. and Albiston,A.L.
    Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus
    Regul Pept122, 85-89. PubMed  Europe PubMed DOI
  88. Nomura,S., Tsujimoto,M. and Mizutani,S.
    Cystinyl aminopeptidase, oxytocinase and insulin-regulated aminopeptidase
    [ISSN:0-12-079610-4]2, 307-311.  V
    89. 2003
  89. Albiston,A.L., Mustafa,T., McDowall,S.G., Mendelsohn,F.A., Lee,J. and Chai,S.Y.
    AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement
    Trends Endocrinol Metab14, 72-77. PubMed  Europe PubMed DOI
  90. [YEAR:15-5-2003]Caron,A.Z., Arguin,G. and Guillemette,G.
    Angiotensin IV interacts with a juxtamembrane site on AT(4)/IRAP suggesting an allosteric mechanism of enzyme modulation
    Regul Pept113, 9-15. PubMed  Europe PubMed DOI
  91. Ito,N., Nomura,S., Iwase,A., Ito,T., Ino,K., Nagasaka,T., Tsujimoto,M., Kobayashi,M. and Mizutani,S.
    Ultrastructural localization of aminopeptidase A/angiotensinase and placental leucine aminopeptidase/oxytocinase in chorionic villi of human placenta
    Early Hum Dev71, 29-37. PubMed  Europe PubMed DOI
  92. Lew,R.A., Mustafa,T., Ye,S., McDowall,S.G., Chai,S.Y. and Albiston,A.L.
    Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)
    J Neurochem86, 344-350. PubMed  Europe PubMed DOI  I
    93. 2002
  93. [YEAR:25-1-2002]Ito,T., Nomura,S., Okada,M., Katsumata,Y., Kikkawa,F., Rogi,T., Tsujimoto,M. and Mizutani,S.
    AP-2 and Ikaros regulate transcription of human placental leucine aminopeptidase/oxytocinase gene
    Biochem Biophys Res Commun290, 1048-1053. PubMed  Europe PubMed DOI
  94. Katagiri,H., Asano,T., Yamada,T., Aoyama,T., Fukushima,Y., Kikuchi,M., Kodama,T. and Oka,Y.
    Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif
    Mol Endocrinol16, 1049-1059. PubMed  Europe PubMed DOI
  95. [YEAR:17-5-2002]Keller,S.R., Davis,A.C. and Clairmont,K.B.
    Mice deficient in the insulin-regulated membrane aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasis
    J Biol Chem277, 17677-17686. PubMed  Europe PubMed DOI  K
    96. 2001
  96. [YEAR:28-12-2001]Albiston,A.L., McDowall,S.G., Matsacos,D., Sim,P., Clune,E., Mustafa,T., Lee,J., Mendelsohn,F.A., Simpson,R.J., Connolly,L.M. and Chai,S.Y.
    Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase
    J Biol Chem276, 48623-48626. PubMed  Europe PubMed DOI  I
  97. Ito,T., Nomura,S., Okada,M., Katsumata,Y., Iwase,A., Kikkawa,F., Tsujimoto,M. and Mizutani,S.
    Transcriptional regulation of human placental leucine aminopeptidase/oxytocinase gene
    Mol Hum Reprod7, 887-894. PubMed  Europe PubMed
  98. [YEAR:8-6-2001]Jiang,H., Li,J., Katz,E.B. and Charron,M.J.
    GLUT4 ablation in mice results in redistribution of IRAP to the plasma membrane
    Biochem Biophys Res Commun284, 519-525. PubMed  Europe PubMed DOI
  99. Kozaki,H., Itakura,A., Okamura,M., Ohno,Y., Wakai,K. and Mizutani,S.
    Maternal serum placental leucine aminopeptidase (P-LAP) /oxytocinase and preterm delivery
    Int J Gynaecol Obstet73, 207-213. PubMed  Europe PubMed DOI
  100. Laustsen,P.G., Vang,S. and Kristensen,T.
    Mutational analysis of the active site of human insulin-regulated aminopeptidase
    Eur J Biochem268, 98-104. PubMed  Europe PubMed DOI
  101. Matsumoto,H., Nagasaka,T., Hattori,A., Rogi,T., Tsuruoka,N., Mizutani,S. and Tsujimoto,M.
    Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides
    Eur J Biochem268, 3259-3266. PubMed  Europe PubMed DOI
  102. Thoidis,G. and Kandror,K.V.
    A Glut4-vesicle marker protein, insulin-responsive aminopeptidase, is localized in a novel vesicular compartment in PC12 cells
    Traffic2, 577-587. PubMed  Europe PubMed DOI
    103. 2000
  103. Matsumoto,H., Rogi,T., Yamashiro,K., Kodama,S., Tsuruoka,N., Hattori,A., Takio,K., Mizutani,S. and Tsujimoto,M.
    Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells
    Eur J Biochem267, 46-52. PubMed  Europe PubMed DOI  E
  104. Nakanishi,Y., Nomura,S., Okada,M., Ito,T., Katsumata,Y., Kikkawa,F., Hattori,A., Tsujimoto,M. and Mizutani,S.
    Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta
    Placenta21, 628-634. PubMed  Europe PubMed DOI
  105. Rasmussen,T.E., Pedraza-Diaz,S., Hardre,R., Laustsen,P.G., Carrion,A.G. and Kristensen,T.
    Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21
    Eur J Biochem267, 2297-2306. PubMed  Europe PubMed DOI
  106. [YEAR:3-3-2000]Yamahara,N., Nomura,S., Suzuki,T., Itakura,A., Ito,M., Okamoto,T., Tsujimoto,M., Nakazato,H. and Mizutani,S.
    Placental leucine aminopeptidase/oxytocinase in maternal serum and placenta during normal pregnancy
    Life Sci66, 1401-1410. PubMed  Europe PubMed DOI
    107. 1999
  107. [YEAR:19-8-1999]Horio,J., Nomura,S., Okada,M., Katsumata,Y., Nakanishi,Y., Kumano,Y., Takami,S., Kinoshita,M., Tsujimoto,M., Nakazato,H. and Mizutani,S.
    Structural organization of the 5'-end and chromosomal assignment of human placental leucine aminopeptidase/insulin-regulated membrane aminopeptidase gene
    Biochem Biophys Res Commun262, 269-274. PubMed  Europe PubMed DOI
    108. 1997
  108. Itoh,C., Watanabe,M., Nagamatsu,A., Soeda,S., Kawarabayashi,T. and Shimeno,H.
    Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization
    Biol Pharm Bull20, 20-24. PubMed  Europe PubMed
  109. Laustsen,P.G., Rasmussen,T.E., Petersen,K., Pedraza-Diaz,S., Moestrup,S.K., Gliemann,J., Sottrup-Jensen,L. and Kristensen,T.
    The complete amino acid sequence of human placental oxytocinase
    Biochim Biophys Acta1352, 1-7. PubMed  Europe PubMed DOI
  110. Mitchell,B.F., Fang,X. and Wong,S.
    Metabolism of oxytocin in rat uterus and placenta in late gestation
    Biol Reprod57, 807-812. PubMed  Europe PubMed DOI
  111. Sumitani,S., Ramlal,T., Somwar,R., Keller,S.R. and Klip,A.
    Insulin regulation and selective segregation with glucose transporter-4 of the membrane aminopeptidase vp165 in rat skeletal muscle cells
    Endocrinology138, 1029-1034. PubMed  Europe PubMed DOI
    112. 1996
  112. Naruki,M., Mizutani,S., Goto,K., Tsujimoto,M., Nakazato,H., Itakura,A., Mizuno,K., Kurauchi,O., Kikkawa,F. and Tomoda,Y.
    Oxytocin is hydrolyzed by an enzyme in human placenta that is identical to the oxytocinase of pregnancy serum
    Peptides17, 257-261. PubMed  Europe PubMed DOI
  113. Rogi,T., Tsujimoto,M., Nakazato,H., Mizutani,S. and Tomoda,Y.
    Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family
    J Biol Chem271, 56-61. PubMed  Europe PubMed
    114. 1995
  114. Itoh,C. and Nagamatsu,A.
    An aminopeptidase activity from porcine kidney that hydrolyzes oxytocin and vasopressin: Purification and partial characterization
    Biochim Biophys Acta1243, 203-208. PubMed  Europe PubMed DOI
  115. Keller,S.R., Scott,H.M., Mastick,C.C., Aebersold,R. and Lienhard,G.E.
    Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from GluT4 vesicles
    J Biol Chem270, 23612-23618. PubMed  Europe PubMed DOI
    116. 1994
  116. Ikenaga,H., Ono,K. and Tomoda,I.
    Elution profiles and molecular weights of placental cystine aminopeptidase in animals
    J Vet Med Sci56, 1139-1142. PubMed  Europe PubMed
  117. Kandror,K.V., Yu,L. and Pilch,P.F.
    The major protein of GLUT4-containing vesicles, gp160, has aminopeptidase activity
    J Biol Chem269, 30777-30780. PubMed  Europe PubMed
    118. 1992
  118. Mizutani,S. and Tomoda,Y.
    Oxytocinase: placental cystine aminopeptidase or placental leucine aminopeptidase (P-LAP)
    Semin Reprod Endocrinol10, 146-153.  V
    119. 1982
  119. Lampelo,S., Lalu,K. and Vanha-Perttula,T.
    Purification and partial characterization of human placental particle-bound aminopeptidase
    Placenta3, 379-394. PubMed  Europe PubMed
  120. Majkic-Singh,N., Vukovic,A., Spasic,S., Ruzic,A., Stojanov,M. and Berkes,I.
    Oxytocinase (CAP) activity in serum during normal pregnancy
    Clin Biochem15, 152-153. PubMed  Europe PubMed
    121. 1981
  121. Sakura,H., Lin,T.Y., Doi,M., Mizutani,S. and Kawashima,Y.
    Purification and properties of oxytocinase, a metalloenzyme
    Biochem Int2, 173-179.
  122. [YEAR:10-9-1981]Suzuki,M., Ueno,T., Takahashi,T., Kanaoka,Y., Okuyama,T., Furuya,H. and Sekine,T.
    A new fluorometric ultramicro determination of serum cystine aminopeptidase using an aminocoumarine derivative
    Clin Chim Acta115, 223-228. PubMed  Europe PubMed DOI  A
    123. 1978
  123. [YEAR:1-9-1978]Tiderstrom,G. and Heinegard,D.
    Determination of cystyl-aminopeptidase. Isoenzymes in seminal plasma and serum of different origin
    Clin Chim Acta88, 293-304. PubMed  Europe PubMed
    124. 1977
  124. Uete,T., Morikawa,M., Shimizu,S., Shimano,N. and Konishi,A.
    Simple, refined fluorometric method for measuring cystyl-amino peptidase activity
    Clin Biochem10, 193-196. PubMed  Europe PubMed  A
    125. 1974
  125. [YEAR:26-3-1974]Chapman,L., Burrows-Peakin,R., Rege,V.P. and Silk,E.
    Comparison of L-cystine-di-beta-naphthylamide and S-benzyl-L-cysteine-4-p-nitroanilide as substrates for the assay of serum cystine aminopeptidase in pregnancy
    Clin Chim Acta51, 335-339. PubMed  Europe PubMed  A
  126. [YEAR:15-9-1974]Oya,M., Yoshino,M. and Asano,M.
    Human placental aminopeptidase isozymes
    Experientia30, 985-986. PubMed  Europe PubMed
  127. Small,C.W. and Watkins,W.B.
    S-benzyl-L-cysteine-p-nitroanilide. A new substrate for determination of oxytocinase with improved specificity
    Biochem Med9, 103-112. PubMed  Europe PubMed  A
  128. [YEAR:20-8-1974]Van Buul,T. and Van Oudheusden,A.P.
    A comparative study of recent assays for the determination of cystine aminopeptidase (oxytocinase)
    Clin Chim Acta54, 263-268. PubMed  Europe PubMed  A
    129. 1973
  129. [YEAR:14-9-1973]Usategui-Gomez,M., Tarbutton,P. and Yeager,F.
    A colorimetric assay for oxytocinase in pregnancy serum
    Clin Chim Acta47, 409-415. PubMed  Europe PubMed  A
  130. Watson,D. and Gibbard,S.
    Automated determination of serum cystine aminopeptidase
    Clin Biochem6, 60-61. PubMed  Europe PubMed  A
    131. 1972
  131. Watkins,W.B. and Small,C.W.
    An automated method for the measurement of serum aminopeptidase activity with particular reference to cystine aminopeptidase (oxytocinase)
    Biochem Med6, 82-89. PubMed  Europe PubMed  A
    132. 1971
  132. Skramovsky,V., Vecerek,B., Bendova,M. and Trnka,V.
    Fluorometric determination of cystine aminopeptidase-oxytocinase in blood serum
    Clin Chim Acta35, 353-357. PubMed  Europe PubMed  A
  133. [YEAR:31-8-1971]Small,C.W. and Watkins,W.B.
    An improved method for the determination of human pregnancy serum oxytocinase activity
    Enzymologia41, 121-128. PubMed  Europe PubMed  A
    134. 1970
  134. Yman,L.
    Composition of oxytocinase (cystine aminopeptidase). Amino acid and sugar analysis and some studies on the carbohydrate-polypeptide linkage and orientation of sialic acid
    Acta Pharm Suec7, 29-36. PubMed  Europe PubMed
    135. 1969
  135. Sjoholm,I.
    Oxytocinase and its possible significance in the degradation of oxytocin during pregnancy
    FEBS Lett4, 135-139. PubMed  Europe PubMed
  136. Yman,L. and Kulling,B.
    A convenient method for purification of an aminopeptidase fraction, including oxytocinase (cystine aminopeptidase), from retroplacental serum
    Acta Pharm Suec6, 313-319. PubMed  Europe PubMed
    137. 1967
  137. Sjoholm,I. and Yman,L.
    Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin II amide by oxytocinase (cystine aminopeptidase)
    Acta Pharm Suec4, 65-76. PubMed  Europe PubMed
    138. 1966
  138. Sjoholm,I. and Yman,L.
    Preparation of highly purified oxytocinase (cystine aminopeptidase) from retroplacental serum
    Acta Pharm Suec3, 377-388. PubMed  Europe PubMed
  139. Sjoholm,I. and Yman,L.
    Electrophoretic studies on oxytocinase (cystine aminopeptidase). Relation between electrophoretically found "isozymes"
    Acta Pharm Suec3, 389-396. PubMed  Europe PubMed
    140. 1962
  140. [YEAR:15-11-1962]Tuppy,H., Wiesbauer,U. and Wintersberger,E.
    [Amino acid-p-nitroanilide as a substrate for aminopeptidases and other proteolytic enzymes]
    Hoppe Seylers Z Physiol Chem329, 278-288. PubMed  Europe PubMed  A
    141. 1961
  141. Page,E.W., Titus,M.A., Mohun,G. and Glendening,M.B.
    The origin and distribution of oxytocinase
    Am J Obstet Gynecol82, 1090-1095. PubMed  Europe PubMed
    142. 1960
  142. Titus,M.A., Reynolds,D.R., Glendening,M.B. and Page,E.W.
    Plasma aminopeptidase activity (oxytocinase) in pregnancy and labor
    Am J Obstet Gynecol80, 1124-1128. PubMed  Europe PubMed
    143. 1959
  143. [YEAR:11-6-1959]Hooper,K.C. and Jessup,D.C.
    The distribution of enzymes destroying oxytocin and vasopressin in human placentae
    J Physiol146, 539-549. PubMed  Europe PubMed
    144. 1932
  144. Bergmann,M.
    [Proteolytic enzymes, behaviour of proline peptides]
    Hoppe Seylers Z Physiol Chem212, 72-84.

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use