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Literature for peptidase M01.011: cystinyl aminopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Stam,F., Bjurling,S., Nylander,E., Hakansson,E.O., Gising,J., Larhed,M., Odell,L.R., Gronbladh,A. and Hallberg,M.
    Insulin-regulated aminopeptidase inhibitor C9 restores cellular activity in methadone-damaged primary cell cultures
    Neurosci Lett (2025) 869, 138415-138415. PubMed  Europe PubMed DOI
  2. Xu,W., Neal,E.S., Barlow,N., Thompson,P. and Borges,K.
    Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy and Contributions to Glucose Transport in Neurons and Astrocytes
    J Neurochem (2025) 169, e70320-e70320. PubMed  Europe PubMed DOI
    3. 2024
  3. Mpakali,A., Barla,I., Lu,L., Ramesh,K.M., Thomaidis,N., Stern,L.J., Giastas,P. and Stratikos,E.
    Mechanisms of Allosteric Inhibition of Insulin-Regulated Aminopeptidase
    J Mol Biol (2024) 436, 168449-168449. PubMed  Europe PubMed DOI  I
  4. Mpakali,A., Georgaki,G., Buson,A., Findlay,A.D., Foot,J.S., Mauvais,F.X., van Endert,P., Giastas,P., Hamprecht,D.W. and Stratikos,E.
    Stabilization of the open conformation omicronf insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor
    Protein Sci (2024) 33, e5151-e5151. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Vear,A., Chakraborty,A., Fahimi,F., Ferens,D., Widdop,R., Samuel,C.S., Gaspari,T., van Endert,P.M. and Chai,S.Y.
    Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharide-induced inflammation
    Front Immunol (2024) 15, 1466692-1466692. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Diel de Amorim,M., Dong,L., Byron,M., Foster,R.A., Klein,C., Saleh,M., Saleh,T. and Card,C.
    Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare
    Sci Rep (2023) 13, 4616-4616. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Evnouchidou,I., Koumantou,D., Nugue,M. and Saveanu,L.
    M1-aminopeptidase family - beyond antigen-trimming activities
    Curr Opin Immunol (2023) 83, 102337-102337. PubMed  Europe PubMed DOI  V
  8. Vear,A., Thalmann,C., Youngs,K., Hannan,N., Gaspari,T. and Chai,S.Y.
    Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker
    Sci Rep (2023) 13, 17565-17565. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Zuchowski,Y., Carty,J., Terker,A.S., Bock,F., Trapani,J.B., Bhave,G., Watts,J.A., Keller,S., Zhang,M., Zent,R., Harris,R.C. and Arroyo,J.P.
    Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress
    Am J Physiol Renal Physiol (2023) 324, F521-F521. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2022
  10. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol (2022) 13, 1002375- PubMed  Europe PubMed
  11. Mattorre,B., Tedeschi,V., Paldino,G., Fiorillo,M.T., Paladini,F. and Sorrentino,R.
    The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation
    Front Immunol (2022) 13, 1002375-1002375. PubMed  Europe PubMed DOI  PMC  EPMC  M
  12. Mattorre,B., Caristi,S., Donato,S., Volpe,E., Faiella,M., Paiardini,A., Sorrentino,R. and Paladini,F.
    A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  M
    13. 2021
  13. Temponeras,I., Chiniadis,L., Papakyriakou,A. and Stratikos,E.
    Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase
    Pharmaceuticals (Basel) (2021) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2020
  14. Barlow,N. and Thompson,P.E.
    IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
    Front Pharmacol (2020) 11, 585930-585930. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Descamps,D., Evnouchidou,I., Caillens,V., Drajac,C., Riffault,S., van Endert,P. and Saveanu,L.
    The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells
    Front Mol Biosci (2020) 7, 583556-583556. PubMed  Europe PubMed DOI  PMC  EPMC  V
  16. Goto,Y., Nakamura,T.J., Ogawa,K., Hattori,A. and Tsujimoto,M.
    Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain
    Front Mol Biosci (2020) 7, 168-168. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Hallberg,M. and Larhed,M.
    From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
    Front Pharmacol (2020) 11, 590855-590855. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Krskova,K., Balazova,L., Dobrocsyova,V., Olszanecki,R., Suski,M., Chai,S.Y. and Zorad,S.
    Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats
    Front Mol Biosci (2020) 7, 586225-586225. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Li,D.T., Habtemichael,E.N. and Bogan,J.S.
    Vasopressin inactivation: role of insulin-regulated aminopeptidase
    Vitam Horm (2020) 113, 101-128. PubMed  Europe PubMed DOI
  20. Mpakali,A., Saridakis,E., Giastas,P., Maben,Z., Stern,L.J., Larhed,M., Hallberg,M. and Stratikos,E.
    Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor
    ACS Med Chem Lett (2020) 11, 1429-1434. PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Paladini,F., Fiorillo,M.T., Tedeschi,V., Mattorre,B. and Sorrentino,R.
    The Multifaceted Nature of Aminopeptidases ERAP1, ERAP2, and LNPEP: From Evolution to Disease
    Front Immunol (2020) 11, 1576-1576. PubMed  Europe PubMed
  22. Ramirez-Exposito,M.J., Duenas-Rodriguez,B., Carrera-Gonzalez,M.P., Navarro-Cecilia,J. and Martinez-Martos,J.M.
    Insulin-Regulated Aminopeptidase in Women with Breast Cancer: A Role beyond the Regulation of Oxytocin and Vasopressin
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  23. Ramirez-Exposito,M.J., Martinez-Martos,J.M., Canton-Habas,V. and Del Pilar Carrera Gonzalez,M.
    Putative Involvement of Endocrine Disruptors in the Alzheimer's disease Via the Insulin-Regulated Aminopeptidase / GLUT4 Pathway
    Curr Neuropharmacol (2020) PubMed  Europe PubMed DOI
  24. Ramirez-Exposito,M.J., Carrera-Gonzalez,M.P. and Martinez-Martos,J.M.
    Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas
    Brain Res Bull (2020) 168, 1-7. PubMed  Europe PubMed DOI
  25. Sanchez-Aguilar,M., Ibarra-Lara,L., Del Valle-Mondragon,L., Soria-Castro,E., Torres-Narvaez,J.C., Carreon-Torres,E., Sanchez-Mendoza,A. and Rubio-Ruiz,M.E.
    Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model
    PPAR Res (2020) 2020, 8894525-8894525. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Walton,S.L., Mirabito Colafella,K.M., Ansari,A., Chai,S.Y. and Denton,K.M.
    Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy
    Clin Sci (Lond) (2020) 134, 3213-3228. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Weimershaus,M., Mauvais,F.X., Evnouchidou,I., Lawand,M., Saveanu,L. and van Endert,P.
    IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells
    Front Cell Dev Biol (2020) 8, 585713-585713. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2019
  28. Burns,P., Bowditch,J., McFadyen,J., Loiacono,R., Albiston,A.L., Pham,V. and Chai,S.Y.
    Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse
    Behav Brain Res (2019) 376, 112150-112150. PubMed  Europe PubMed DOI  K
  29. Luo,L., Wang,S., Zhu,L., Fan,B., Liu,T., Wang,L., Zhao,P., Dang,Y., Sun,P., Chen,J., Zhang,Y., Chang,X., Yu,Z., Wang,H., Guo,R., Li,B. and Zhang,K.
    Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus
    Sci Rep (2019) 9, 13186-13186. PubMed  Europe PubMed DOI  PMC  EPMC  K
    30. 2018
  30. Vanga,S.R., Savmarker,J., Ng,L., Larhed,M., Hallberg,M., Aqvist,J., Hallberg,A., Chai,S.Y. and Gutierrez-de-Teran,H.
    Structural basis of inhibition of human insulin-regulated aminopeptidase (IRAP) by aryl sulfonamides
    ACS Omega (2018) 3, 4509-4521. PubMed  Europe PubMed DOI  PMC  EPMC  I
    31. 2017
  31. Albiston,A.L., Cacador,M., Sinnayah,P., Burns,P. and Chai,S.Y.
    Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats
    J Mol Endocrinol (2017) 58, 193-198. PubMed  Europe PubMed DOI  I
  32. El-Hawli,A., Qaradakhi,T., Hayes,A., Rybalka,E., Smith,R., Caprnda,M., Opatrilova,R., Gazdikova,K., Benckova,M., Kruzliak,P. and Zulli,A.
    IRAP inhibition using HFI419 prevents moderate to severe acetylcholine mediated vasoconstriction in a rabbit model
    Biomed Pharmacother (2017) 86, 23-26. PubMed  Europe PubMed DOI  I
  33. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Kokkala,P., Georgiadis,D., Giastas,P., Papakyriakou,A. and Stratikos,E.
    Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity
    J Med Chem (2017) 60, 2963-2972. PubMed  Europe PubMed DOI  S  I
    34. 2016
  34. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Ng,L., Pham,V., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Andersson,H., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.
    Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density
    Mol Pharmacol (2016) 89, 413-424. PubMed  Europe PubMed DOI  I
  35. Diwakarla,S., Nylander,E., Gronbladh,A., Vanga,S.R., Khan,Y.S., Gutierrez-de-Teran,H., Savmarker,J., Ng,L., Pham,V., Lundback,T., Jenmalm-Jensen,A., Svensson,R., Artursson,P., Zelleroth,S., Engen,K., Rosenstrom,U., Larhed,M., Aqvist,J., Chai,S.Y. and Hallberg,M.
    Aryl sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures
    ACS Chem Neurosci (2016) 7, 1383-1392. PubMed  Europe PubMed DOI  I
  36. Engen,K., Rosenstrom,U., Axelsson,H., Konda,V., Dahllund,L., Otrocka,M., Sigmundsson,K., Nikolaou,A., Vauquelin,G., Hallberg,M., Jenmalm Jensen,A., Lundback,T. and Larhed,M.
    Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small-molecule screening
    Assay Drug Dev Technol (2016) 14, 180-193. PubMed  Europe PubMed DOI  I
  37. Ramirez-Exposito,M.J., Martinez-Martos,J.M., Palomeque,T. and Lorite,P.
    A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism
    Indian J Med Res (2016) 144, 120-123. PubMed  Europe PubMed DOI  M
  38. Yeatman,H.R., Albiston,A.L., Burns,P. and Chai,S.Y.
    Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory
    Neurobiol Learn Mem (2016) 136, 174-182. PubMed  Europe PubMed DOI  K
    39. 2015
  39. Alponti,R.F., Viana,L.G., Yamanouye,N. and Silveira,P.F.
    Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity
    J Mol Endocrinol (2015) 55, 1-8. PubMed  Europe PubMed DOI  P
  40. Hermans,S.J., Ascher,D.B., Hancock,N.C., Holien,J.K., Michell,B.J., Yeen Chai,S., Morton,C.J. and Parker,M.W.
    Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides
    Protein Sci (2015) 24, 190-199. PubMed  Europe PubMed DOI  S
  41. Mpakali,A., Saridakis,E., Harlos,K., Zhao,Y., Papakyriakou,A., Kokkala,P., Georgiadis,D. and Stratikos,E.
    Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing
    J Immunol (2015) 195, 2842-2851. PubMed  Europe PubMed DOI  S  I
  42. Svensson,F., Engen,K., Lundback,T., Larhed,M. and Skold,C.
    Virtual screening for transition state analogue inhibitors of IRAP based on quantum mechanically derived reaction coordinates
    J Chem Inf Model (2015) 55, 1984-1993. PubMed  Europe PubMed DOI  I
  43. Werno,M.W. and Chamberlain,L.H.
    S-acylation of the insulin-responsive aminopeptidase (IRAP): quantitative analysis and identification of modified cysteines
    Sci Rep (2015) 5, 12413-12413. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2014
  44. Borhade,S.R., Rosenstrom,U., Savmarker,J., Lundback,T., Jenmalm-Jensen,A., Sigmundsson,K., Axelsson,H., Svensson,F., Konda,V., Skold,C., Larhed,M. and Hallberg,M.
    Inhibition of insulin-regulated aminopeptidase (IRAP) by arylsulfonamides
    ChemistryOpen (2014) 3, 256-263. PubMed  Europe PubMed DOI  PMC  EPMC  I
  45. Mountford,S.J., Albiston,A.L., Charman,W.N., Ng,L., Holien,J.K., Parker,M.W., Nicolazzo,J.A., Thompson,P.E. and Chai,S.Y.
    Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase
    J Med Chem (2014) 57, 1368-1377. PubMed  Europe PubMed DOI  I
    46. 2013
  46. Loyens,E., De Bundel,D., Demaegdt,H., Chai,S.Y., Vanderheyden,P., Michotte,Y., Gard,P. and Smolders,I.
    Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase
    Int J Neuropsychopharmacol (2013) 16, 1153-1163. PubMed  Europe PubMed DOI  K  I
  47. Muller,S., Lendeckel,U., Dobrowolny,H., Steiner,J., Bogerts,B. and Bernstein,H.G.
    Some notes on insulin-regulated aminopeptidase in depression
    Int J Neuropsychopharmacol (2013) 16, 1877-1878. PubMed  Europe PubMed DOI
  48. Nikolaou,A., Eynde,I.V., Tourwe,D., Vauquelin,G., Toth,G., Mallareddy,J.R., Poglitsch,M., Van Ginderachter,J.A. and Vanderheyden,P.M.
    [3H]IVDE77, a novel radioligand with high affinity and selectivity for the insulin-regulated aminopeptidase
    Eur J Pharmacol (2013) 702, 93-102. PubMed  Europe PubMed DOI  I
  49. Saveanu,L., Babdor,J., Lawand,M. and van Endert,P.
    Insulin-regulated aminopeptidase and its compartment in dendritic cells
    Mol Immunol (2013) 55, 153-155. PubMed  Europe PubMed DOI
    50. 2012
  50. Andersson,H. and Hallberg,M.
    Discovery of inhibitors of insulin-regulated aminopeptidase as cognitive enhancers
    Int J Hypertens (2012) 2012, 789671-789671. PubMed  Europe PubMed DOI  PMC  EPMC  I
  51. Demaegdt,H., De Backer,J.P., Lukaszuk,A., Toth,G., Szemenyei,E., Tourwe,D. and Vauquelin,G.
    Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP)
    Fundam Clin Pharmacol (2012) 26, 194-197. PubMed  Europe PubMed DOI  I
  52. Nomura,S., Tsujimoto,M. and Mizutani,S.
    Cystinyl aminopeptidase/oxytocinase
    [ISSN:978-0-12-407744-7] (2012) 3, 419-425. DOI
  53. Pham,V., Albiston,A.L., Downes,C.E., Wong,C.H., Diwakarla,S., Ng,L., Lee,S., Crack,P.J. and Chai,S.Y.
    Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice
    J Neurotrauma (2012) 29, 1243-1248. PubMed  Europe PubMed DOI  K
  54. Saveanu,L. and van Endert,P.
    The role of insulin-regulated aminopeptidase in MHC class I antigen presentation
    Front Immunol (2012) 3, 57-57. PubMed  Europe PubMed DOI  PMC  EPMC
    55. 2011
  55. Albiston,A.L., Diwakarla,S., Fernando,R.N., Mountford,S.J., Yeatman,H.R., Morgan,B., Pham,V., Holien,J.K., Parker,M.W., Thompson,P.E. and Chai,S.Y.
    Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers
    Br J Pharmacol (2011) 164, 37-47. PubMed  Europe PubMed DOI  I
  56. Andersson,H., Demaegdt,H., Johnsson,A., Vauquelin,G., Lindeberg,G., Hallberg,M., Erdelyi,M., Karlen,A. and Hallberg,A.
    Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis
    J Med Chem (2011) 54, 3779-3792. PubMed  Europe PubMed DOI  I
  57. Ascher,D.B., Cromer,B.A., Morton,C.J., Volitakis,I., Cherny,R.A., Albiston,A.L., Chai,S.Y. and Parker,M.W.
    Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain
    Biochemistry (2011) 50, 2611-2622. PubMed  Europe PubMed DOI
  58. Demaegdt,H., Gard,P., De Backer,J.P., Lukaszuk,A., Szemenyei,E., Toth,G., Tourwe,D. and Vauquelin,G.
    Binding of "AT4 receptor" ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells
    Mol Cell Endocrinol (2011) 339, 34-44. PubMed  Europe PubMed DOI  I
  59. Loyens,E., Schallier,A., Chai,S.Y., De Bundel,D., Vanderheyden,P., Michotte,Y. and Smolders,I.
    Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures
    Seizure (2011) 20, 602-605. PubMed  Europe PubMed DOI  K
  60. Nakada,T.A., Russell,J.A., Wellman,H., Boyd,J.H., Nakada,E., Thain,K.R., Thair,S.A., Hirasawa,H., Oda,S. and Walley,K.R.
    Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Chest (2011) 139, 1042-1049. PubMed  Europe PubMed DOI  M
    61. 2010
  61. Albiston,A.L., Fernando,R.N., Yeatman,H.R., Burns,P., Ng,L., Daswani,D., Diwakarla,S., Pham,V. and Chai,S.Y.
    Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory
    Neurobiol Learn Mem (2010) 93, 19-30. PubMed  Europe PubMed DOI  K  I
  62. Albiston,A.L., Pham,V., Ye,S., Ng,L., Lew,R.A., Thompson,P.E., Holien,J.K., Morton,C.J., Parker,M.W. and Chai,S.Y.
    Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase
    Mol Pharmacol (2010) 78, 600-607. PubMed  Europe PubMed DOI
  63. Andersson,H., Demaegdt,H., Vauquelin,G., Lindeberg,G., Karlen,A., Hallberg,M., Erdelyi,M. and Hallberg,A.
    Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)
    J Med Chem (2010) 53, 8059-8071. PubMed  Europe PubMed DOI  I
  64. Beyer,C.E., Dwyer,J.M., Platt,B.J., Neal,S., Luo,B., Ling,H.P., Lin,Q., Mark,R.J., Rosenzweig-Lipson,S. and Schechter,L.E.
    Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation
    Psychopharmacology (Berl) (2010) 209, 303-311. PubMed  Europe PubMed DOI  I
  65. Georgiadou,D., Hearn,A., Evnouchidou,I., Chroni,A., Leondiadis,L., York,I.A., Rock,K.L. and Stratikos,E.
    Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1
    J Immunol (2010) 185, 1584-1592. PubMed  Europe PubMed DOI  P
    66. 2009
  66. Demaegdt,H., Lukaszuk,A., De Buyser,E., De Backer,J.P., Szemenyei,E., Toth,G., Chakravarthy,S., Panicker,M., Michotte,Y., Tourwe,D. and Vauquelin,G.
    Selective labeling of IRAP by the tritiated AT(4) receptor ligand [3H]angiotensin IV and its stable analog [3H]AL-11
    Mol Cell Endocrinol (2009) 311, 77-86. PubMed  Europe PubMed DOI  I
  67. Kawai,M., Araragi,K., Shimizu,Y. and Hara,Y.
    Identification of placental leucine aminopeptidase and Triton-slowed aminopeptidase N in serum of pregnant women
    Clin Chim Acta (2009) 400, 37-41. PubMed  Europe PubMed DOI
  68. Pham,V., Burns,P., Albiston,A.L., Yeatman,H.R., Ng,L., Diwakarla,S. and Chai,S.Y.
    Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice
    Peptides (2009) 30, 1861-1865. PubMed  Europe PubMed DOI  K
  69. Saveanu,L., Carroll,O., Weimershaus,M., Guermonprez,P., Firat,E., Lindo,V., Greer,F., Davoust,J., Kratzer,R., Keller,S.R., Niedermann,G. and van Endert,P.
    IRAP identifies an endosomal compartment required for MHC class I cross-presentation
    Science (2009) 325, 213-217. PubMed  Europe PubMed DOI
    70. 2008
  70. Albiston,A.L., Morton,C.J., Ng,H.L., Pham,V., Yeatman,H.R., Ye,S., Fernando,R.N., De Bundel,D., Ascher,D.B., Mendelsohn,F.A., Parker,M.W. and Chai,S.Y.
    Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
    FASEB J (2008) 22, 4209-4217. PubMed  Europe PubMed DOI  T  I
  71. Chai,S.Y., Yeatman,H.R., Parker,M.W., Ascher,D.B., Thompson,P.E., Mulvey,H.T. and Albiston,A.L.
    Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase
    BMC Neurosci (2008) 9 Suppl 2, S14-S14. PubMed  Europe PubMed DOI  PMC  EPMC  T  I
  72. Cohen,M., Wuillemin,C., Chai,S.Y. and Bischof,P.
    Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion
    J Pept Sci (2008) 14, 883-887. PubMed  Europe PubMed DOI  I
  73. Demaegdt,H., Smitz,L., De Backer,J.P., Le,M.T., Bauwens,M., Szemenyei,E., Toth,G., Michotte,Y., Vanderheyden,P. and Vauquelin,G.
    Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding
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