Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Structure for peptidase homologue T01.976: proteasome subunit alpha 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

 

TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Bos taurus
20S proteasome complex 2.75 Å 1IRU 1IRU 1IRU 1IRU 1IRU 1IRU Unno et al., 2002
Homo sapiens
20S proteasome 2.60 Å 4R3O 4R3O 4R3O 4R3O 4R3O 4R3O Harshbarger et al., 2015
20S proteasome; complex with carfilzomib 2.89 Å 4R67 4R67 4R67 4R67 4R67 4R67 Harshbarger et al., 2015
cryo-em reveals the conformation of a substrate analogue in the human 20s proteasome core 3.50 Å 5A0Q 5A0Q 5A0Q 5A0Q 5A0Q 5A0Q
26S proteasome; complex with USP14-UbAl 4.35 Å 5GJQ 5GJQ 5GJQ 5GJQ 5GJQ 5GJQ
26S proteasome 3.50 Å 5GJR 5GJR 5GJR 5GJR 5GJR 5GJR
native human 20s proteasome at 1.8 angstrom ***caveat 5le5 6v1 u 47 has wrong chirality at atom c1 1.80 Å 5LE5 5LE5 5LE5 5LE5 5LE5 5LE5
native human 20s proteasome in mg-acetate at 2.2 angstrom ***caveat 5lex 6v1 u 47 has wrong chirality at atom c1 2.20 Å 5LEX 5LEX 5LEX 5LEX 5LEX 5LEX
20s proteasome; complex with oprozomib 1.90 Å 5LEY 5LEY 5LEY 5LEY 5LEY 5LEY
20s proteasome; complex with oprozomib in mg-acetate 2.19 Å 5LEZ 5LEZ 5LEZ 5LEZ 5LEZ 5LEZ
human 20s proteasome complex with epoxomicin at 2.4 angstrom ***caveat 5lf0 6v1 u 47 has wrong chirality at atom c1 iml c 2 has wrong ***caveat 2 5lf0 chirality at atom cb iml d 2 has wrong chirality at atom ca ***caveat 3 5lf0 iml d 2 has wrong chirality 2.41 Å 5LF0 5LF0 5LF0 5LF0 5LF0 5LF0
human 20s proteasome complex with dihydroeponemycin at 2.0 angstrom ***caveat 5lf1 6v1 u 47 has wrong chirality at atom c1 2.00 Å 5LF1 5LF1 5LF1 5LF1 5LF1 5LF1
human 20s proteasome complex with bortezomib at 2.1 angstrom ***caveat 5lf3 6v1 u 47 has wrong chirality at atom c1 2.10 Å 5LF3 5LF3 5LF3 5LF3 5LF3 5LF3
human 20s proteasome complex with delanzomib at 2.0 angstrom ***caveat 5lf4 6v1 u 47 has wrong chirality at atom c1 6v7 n 307 has wrong ***caveat 2 5lf4 chirality at atom c9 6v7 y 306 has wrong chirality at atom ***caveat 3 5lf4 c9 1.99 Å 5LF4 5LF4 5LF4 5LF4 5LF4 5LF4
human 20s proteasome complex with z-lly-ketoaldehyde at 2.1 angstrom ***caveat 5lf6 6v1 u 47 has wrong chirality at atom c1 2.07 Å 5LF6 5LF6 5LF6 5LF6 5LF6 5LF6
human 20s proteasome complex with ixazomib at 2.0 angstrom ***caveat 5lf7 6v1 u 47 has wrong chirality at atom c1 2.00 Å 5LF7 5LF7 5LF7 5LF7 5LF7 5LF7
the human 26s proteasome at 6.8 ang. ***caveat 5ln3 pro h 311 has wrong chirality at atom ca thr n 752 has wrong ***caveat 2 5ln3 chirality at atom ca 6.80 Å 5LN3 5LN3 5LN3 5LN3 5LN3 5LN3
26s proteasome in complex with oprozomib 3.80 Å 5M32 5M32 5M32 5M32 5M32 5M32
structural basis for dynamic regulation of the human 26s proteasome ***caveat 5t0g entry contains improper peptide linkages. 4.40 Å 5T0G 5T0G 5T0G 5T0G 5T0G 5T0G
structural basis for dynamic regulation of the human 26s proteasome ***caveat 5t0h entry contains improper peptide linkages. 6.80 Å 5T0H 5T0H 5T0H 5T0H 5T0H 5T0H
structural basis for dynamic regulation of the human 26s proteasome ***caveat 5t0i entry contains improper peptide linkages. residue arg k 20 ***caveat 2 5t0i is incorrectly modeled. 8.00 Å 5T0I 5T0I 5T0I 5T0I 5T0I 5T0I
structural basis for dynamic regulation of the human 26s proteasome ***caveat 5t0j entry contains improper peptide linkages. 8.00 Å 5T0J 5T0J 5T0J 5T0J 5T0J 5T0J
nucleotide-driven triple-state remodeling of the aaa-atpase channel inthe activated human 26s proteasome 3.50 Å 5VFO 5VFO 5VFO 5VFO 5VFO 5VFO
nucleotide-driven triple-state remodeling of the aaa-atpase channel inthe activated human 26s proteasome 4.90 Å 5VFR 5VFR 5VFR 5VFR 5VFR 5VFR
nucleotide-driven triple-state remodeling of the aaa-atpase channel inthe activated human 26s proteasome 7.00 Å 5VFT 5VFT 5VFT 5VFT 5VFT 5VFT
cryo-em structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes 3.80 Å 6AVO 6AVO 6AVO 6AVO 6AVO 6AVO
endogeneous native human 20s proteasome 3.50 Å 6R70 6R70 6R70 6R70 6R70 6R70
Mus musculus
20S proteasome; complex with PR-957 2.90 Å 3UNB 3UNB 3UNB 3UNB 3UNB 3UNB Huber et al., 2012
20S proteasome 3.20 Å 3UNE 3UNE 3UNE 3UNE 3UNE 3UNE Huber et al., 2012
20S immunoproteasome; complex with PR-957 2.90 Å 3UNF 3UNF 3UNF 3UNF 3UNF 3UNF Huber et al., 2012
20S immunoproteasome 3.20 Å 3UNH 3UNH 3UNH 3UNH 3UNH 3UNH Huber et al., 2012
Saccharomyces cerevisiae
20S proteasome in complex with activator PA26 (Trypanosoma brucei) 3.20 Å 1FNT 1FNT 1FNT 1FNT 1FNT 1FNT Whitby et al., 2000
complete proteasome 2.40 Å 1G0U 1G0U 1G0U 1G0U 1G0U 1G0U Groll et al., 2000
complex with epoxomicin 2.25 Å 1G65 1G65 1G65 1G65 1G65 1G65 Groll et al., 2000
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
20S proteasome 2.40 Å 1RYP 1RYP 1RYP 1RYP 1RYP 1RYP Groll et al., 1997
20S proteasome; complex with the proteasome activator PA26 from Trypanosoma brucei 3.22 Å 1Z7Q 1Z7Q 1Z7Q 1Z7Q 1Z7Q 1Z7Q Forster et al., 2005
20S proteasome; complex with bortezomib 2.80 Å 2F16 2F16 2F16 2F16 2F16 2F16 Groll et al., 2006
20S proteasome; complex with salinosporamide A 2.80 Å 2FAK 2FAK 2FAK 2FAK 2FAK 2FAK Groll et al., 2006
20S proteasome; complex with homobelactosin C 3.00 Å 2FNY 2FNY 2FNY 2FNY 2FNY 2FNY Groll et al., 2006
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
20S proteasome; complex with syringolin A 2.90 Å 2ZCY 2ZCY 2ZCY 2ZCY 2ZCY 2ZCY Groll et al., 2008
20S proteasome; complex with glidobactin A 2.70 Å 3BDM 3BDM 3BDM 3BDM 3BDM 3BDM Groll et al., 2008
20S proteasome; complex with fellutamide B 2.60 Å 3D29 3D29 3D29 3D29 3D29 3D29 Hines et al., 2008
20s proteasome; complex with the epimer form of spirolactacystin 2.81 Å 3DY3 3DY3 3DY3 3DY3 3DY3 3DY3 Groll et al., 2008
20s proteasome; complex with spirolactacystin 2.80 Å 3DY4 3DY4 3DY4 3DY4 3DY4 3DY4 Groll et al., 2008
20s proteasome; complex with homobelactosin C 3.00 Å 3E47 3E47 3E47 3E47 3E47 3E47 Groll et al., 2006
20s proteasome; complex with syringolin B 2.70 Å 3GPJ 3GPJ 3GPJ 3GPJ 3GPJ 3GPJ Clerc et al., 2009
20S proteasome; complex with salinosporamide derivative 2.41 Å 3GPT 3GPT 3GPT 3GPT 3GPT 3GPT Groll et al., 2009
20S proteasome; complex with salinosporamide derivative 2.50 Å 3GPW 3GPW 3GPW 3GPW 3GPW 3GPW Groll et al., 2009
20S proteasome; complex with hyroxylated salinosporamide 2.50 Å 3HYE 3HYE 3HYE 3HYE 3HYE 3HYE Groll et al., 2009
20S proteasome; complex with bortezomib 2.68 Å 3MG0 3MG0 3MG0 3MG0 3MG0 3MG0 Blackburn et al., 2010
20S proteasome; complex with compound 1 3.11 Å 3MG4 3MG4 3MG4 3MG4 3MG4 3MG4 Blackburn et al., 2010
20S proteasome; complex with compound 6 2.60 Å 3MG6 3MG6 3MG6 3MG6 3MG6 3MG6 Blackburn et al., 2010
20S open-gate proteasome; complex with compound 6 2.78 Å 3MG7 3MG7 3MG7 3MG7 3MG7 3MG7 Blackburn et al., 2010
20S open-gate proteasome; complex with compound 16 2.59 Å 3MG8 3MG8 3MG8 3MG8 3MG8 3MG8 Blackburn et al., 2010
20S proteasome; complex with ligand 2a 2.40 Å 3NZJ 3NZJ 3NZJ 3NZJ 3NZJ 3NZJ Groll et al., 2010
20S proteasome; complex with ligand 2b 2.50 Å 3NZW 3NZW 3NZW 3NZW 3NZW 3NZW Groll et al., 2010
20S proteasome; complex with ligand 2c 2.70 Å 3NZX 3NZX 3NZX 3NZX 3NZX 3NZX Groll et al., 2010
20S open-gate proteasome; complex with compound 24 2.60 Å 3OEU 3OEU 3OEU 3OEU 3OEU 3OEU Blackburn et al., 2010
20S open-gate proteasome; complex with compound 25 2.85 Å 3OEV 3OEV 3OEV 3OEV 3OEV 3OEV Blackburn et al., 2010
20S proteasome; complex with alpha-keto-aldehyde 2.70 Å 3OKJ 3OKJ 3OKJ 3OKJ 3OKJ 3OKJ Grawert et al., 2011
20S open-gate proteasome; complex with compound 20 2.65 Å 3SDI 3SDI 3SDI 3SDI 3SDI 3SDI Blackburn et al., 2010
20S open-gate proteasome; complex with compound 34 2.70 Å 3SDK 3SDK 3SDK 3SDK 3SDK 3SDK Blackburn et al., 2010
20S proteasome; complex with hydroxyurea derivative HU10 2.80 Å 3SHJ 3SHJ 3SHJ 3SHJ 3SHJ 3SHJ Gallastegui et al., 2012
20S proteasome; complex with homobelactosin C 2.70 Å 3TDD 3TDD 3TDD 3TDD 3TDD 3TDD Korotkov et al., 2011
20S open-gate proteasome; complex with PR-957 (morpholine) 3.40 Å 3UN4 3UN4 3UN4 3UN4 3UN4 3UN4 Huber et al., 2012
20S proteasome; complex with PR-957 (epoxide) 2.70 Å 3UN8 3UN8 3UN8 3UN8 3UN8 3UN8 Huber et al., 2012
26S proteasome 3.15 Å 3WXR 3WXR 3WXR 3WXR 3WXR 3WXR Yashiroda et al., 2015
26S proteasome 7.70 Å 4CR2 4CR2 4CR2 4CR2 4CR2 4CR2 Unverdorben et al., 2014
26S proteasome 9.30 Å 4CR3 4CR3 4CR3 4CR3 4CR3 4CR3 Unverdorben et al., 2014
26S proteasome 8.80 Å 4CR4 4CR4 4CR4 4CR4 4CR4 4CR4 Unverdorben et al., 2014
20S proteasome; complex with K-7174 2.51 Å 4EU2 4EU2 4EU2 4EU2 4EU2 4EU2 Kikuchi et al., 2013
20S proteasome; complex with cepafungin I 2.80 Å 4FZC 4FZC 4FZC 4FZC 4FZC 4FZC Stein et al., 2012
20S proteasome; complex with glidobactin 3.00 Å 4FZG 4FZG 4FZG 4FZG 4FZG 4FZG Stein et al., 2012
20S proteasome; complex with Syringolin-Glidobactin chimera 2.49 Å 4G4S 4G4S 4G4S 4G4S 4G4S 4G4S Stadtmueller et al., 2012
20S proteasome; complex with Syringolin-Glidobactin chimera 2.80 Å 4GK7 4GK7 4GK7 4GK7 4GK7 4GK7 Archer et al., 2012
20S proteasome; complex with vinylketone carmaphycin analogue VNK1 2.80 Å 4HNP 4HNP 4HNP 4HNP 4HNP 4HNP Trivella et al., 2014
20S proteasome; complex with epoxyketone carmaphycin analogue 3 2.80 Å 4HRC 4HRC 4HRC 4HRC 4HRC 4HRC Trivella et al., 2014
20S proteasome; complex with carmaphycin A 2.80 Å 4HRD 4HRD 4HRD 4HRD 4HRD 4HRD Trivella et al., 2014
20S proteasome; complex with vinyl sulfone LU102 2.70 Å 4INR 4INR 4INR 4INR 4INR 4INR Geurink et al., 2013
20S proteasome; complex with vinyl sulfone LU122 2.90 Å 4INT 4INT 4INT 4INT 4INT 4INT Geurink et al., 2013
20S proteasome; complex with vinyl sulfone LU112 3.10 Å 4INU 4INU 4INU 4INU 4INU 4INU Geurink et al., 2013
20S proteasome; complex with belactosin derivative 3E 2.80 Å 4J70 4J70 4J70 4J70 4J70 4J70 Kawamura et al., 2013
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
20S proteasome; complex with vibralactone 2.70 Å 4LQI 4LQI 4LQI 4LQI 4LQI 4LQI List et al., 2014
20S proteasome; complex with enone carmaphycin analogue 6 2.50 Å 4LTC 4LTC 4LTC 4LTC 4LTC 4LTC Trivella et al., 2014
20S proteasome; complex with MG132 2.50 Å 4NNN 4NNN 4NNN 4NNN 4NNN 4NNN Stein et al., 2014
20S proteasome; complex with Z-Leu-Leu-Leu-ketoaldehyde 2.60 Å 4NNW 4NNW 4NNW 4NNW 4NNW 4NNW Stein et al., 2014
20S proteasome; complex with Z-Leu-Leu-Leu-B(OH)2 2.50 Å 4NO1 4NO1 4NO1 4NO1 4NO1 4NO1 Stein et al., 2014
20S proteasome; complex with Z-Leu-Leu-Leu-vinylsulfone 3.00 Å 4NO6 4NO6 4NO6 4NO6 4NO6 4NO6 Stein et al., 2014
20S proteasome; complex with Z-Leu-Leu-Leu-ketoamide 2.70 Å 4NO8 4NO8 4NO8 4NO8 4NO8 4NO8 Stein et al., 2014
20S proteasome; complex with Z-Leu-Leu-Leu-epoxyketone 2.90 Å 4NO9 4NO9 4NO9 4NO9 4NO9 4NO9 Stein et al., 2014
20S proteasome; complex with kendomycin 2.60 Å 4Q1S 4Q1S 4Q1S 4Q1S 4Q1S 4Q1S Beck et al., 2014
20S proteasome; complex with Boc-Ala-Ala-Ala-CHO 3.00 Å 4QBY 4QBY 4QBY 4QBY 4QBY 4QBY Arciniega et al., 2014
20S proteasome; complex with epoxyketone inhibitor 8 2.40 Å 4QLQ 4QLQ 4QLQ 4QLQ 4QLQ 4QLQ de Bruin et al., 2014
20S proteasome; complex with epoxyketone inhibitor 11 2.80 Å 4QLS 4QLS 4QLS 4QLS 4QLS 4QLS de Bruin et al., 2014
20S proteasome; complex with tripeptidic epoxyketone inhibitor 2 2.80 Å 4QLT 4QLT 4QLT 4QLT 4QLT 4QLT de Bruin et al., 2014
20S proteasome; complex with tripeptidic epoxyketone inhibitor 9 2.80 Å 4QLU 4QLU 4QLU 4QLU 4QLU 4QLU de Bruin et al., 2014
20S proteasome; complex with tripeptidic epoxyketone inhibitor 17 2.90 Å 4QLV 4QLV 4QLV 4QLV 4QLV 4QLV de Bruin et al., 2014
20S proteasome 3.00 Å 4QUX 4QUX 4QUX 4QUX 4QUX 4QUX Huber et al., 2015
20S proteasome 2.80 Å 4QUY 4QUY 4QUY 4QUY 4QUY 4QUY Huber et al., 2015
20S proteasome 3.10 Å 4QV0 4QV0 4QV0 4QV0 4QV0 4QV0 Huber et al., 2015
20S proteasome 2.50 Å 4QV1 4QV1 4QV1 4QV1 4QV1 4QV1 Huber et al., 2015
20S proteasome 3.00 Å 4QV3 4QV3 4QV3 4QV3 4QV3 4QV3 Huber et al., 2015
20S proteasome beta5 Met45Thr mutant 2.70 Å 4QV4 4QV4 4QV4 4QV4 4QV4 4QV4 Huber et al., 2015
20S proteasome beta5 Met45Ile mutant 2.70 Å 4QV5 4QV5 4QV5 4QV5 4QV5 4QV5 Huber et al., 2015
20S proteasome 2.80 Å 4QV6 4QV6 4QV6 4QV6 4QV6 4QV6 Huber et al., 2015
20S proteasome 2.60 Å 4QV7 4QV7 4QV7 4QV7 4QV7 4QV7 Huber et al., 2015
20S proteasome 2.90 Å 4QV8 4QV8 4QV8 4QV8 4QV8 4QV8 Huber et al., 2015
20S proteasome 2.60 Å 4QV9 4QV9 4QV9 4QV9 4QV9 4QV9 Huber et al., 2015
20S proteasome; complex with bortezomib 2.80 Å 4QVL 4QVL 4QVL 4QVL 4QVL 4QVL Huber et al., 2015
20S proteasome beta5 Met45Ala mutant; complex with bortezomib 2.80 Å 4QVM 4QVM 4QVM 4QVM 4QVM 4QVM Huber et al., 2015
20S proteasome beta5 Met45Val mutant; complex with bortezomib 2.90 Å 4QVN 4QVN 4QVN 4QVN 4QVN 4QVN Huber et al., 2015
20S proteasome beta5 Met45Thr mutant; complex with bortezomib 2.30 Å 4QVP 4QVP 4QVP 4QVP 4QVP 4QVP Huber et al., 2015
20S proteasome beta5 Met45Ile mutant; complex with bortezomib 2.60 Å 4QVQ 4QVQ 4QVQ 4QVQ 4QVQ 4QVQ Huber et al., 2015
20S proteasome beta5 Ala49Val mutant; complex with bortezomib 2.80 Å 4QVV 4QVV 4QVV 4QVV 4QVV 4QVV Huber et al., 2015
20S proteasome beta5 Ala49Ser mutant; complex with bortezomib 3.00 Å 4QVW 4QVW 4QVW 4QVW 4QVW 4QVW Huber et al., 2015
20S proteasome beta5 Ala49Thr mutant; complex with bortezomib 2.51 Å 4QVY 4QVY 4QVY 4QVY 4QVY 4QVY Huber et al., 2015
20S proteasome beta5 Ala49Thr,Ala50Val mutant; complex with bortezomib 2.90 Å 4QW0 4QW0 4QW0 4QW0 4QW0 4QW0 Huber et al., 2015
20S proteasome beta5 Ala50Val mutant; complex with bortezomib 2.90 Å 4QW1 4QW1 4QW1 4QW1 4QW1 4QW1 Huber et al., 2015
20S proteasome beta5 Cys63Phe mutant; complex with bortezomib 2.90 Å 4QW3 4QW3 4QW3 4QW3 4QW3 4QW3 Huber et al., 2015
20S proteasome; complex with carfilzomib 2.80 Å 4QW4 4QW4 4QW4 4QW4 4QW4 4QW4 Huber et al., 2015
20S proteasome beta5 Met45Ala mutant; complex with carfilzomib 3.00 Å 4QW5 4QW5 4QW5 4QW5 4QW5 4QW5 Huber et al., 2015
20S proteasome beta5 Met45Val mutant; complex with carfilzomib 2.90 Å 4QW6 4QW6 4QW6 4QW6 4QW6 4QW6 Huber et al., 2015
20S proteasome beta5 Met45Thr mutant; complex with carfilzomib 2.70 Å 4QW7 4QW7 4QW7 4QW7 4QW7 4QW7 Huber et al., 2015
20S proteasome beta5 Met45Ile mutant; complex with carfilzomib 3.00 Å 4QWF 4QWF 4QWF 4QWF 4QWF 4QWF Huber et al., 2015
20S proteasome beta5 Ala49Val mutant; complex with carfilzomib 2.60 Å 4QWG 4QWG 4QWG 4QWG 4QWG 4QWG Huber et al., 2015
20S proteasome beta5 Ala49Ser mutant; complex with carfilzomib 2.60 Å 4QWI 4QWI 4QWI 4QWI 4QWI 4QWI Huber et al., 2015
20S proteasome beta5 Ala49Thr mutant; complex with carfilzomib 2.90 Å 4QWJ 4QWJ 4QWJ 4QWJ 4QWJ 4QWJ Huber et al., 2015
20S proteasome beta5 Ala49Thr, Ala50Val mutant; complex with carfilzomib 2.80 Å 4QWK 4QWK 4QWK 4QWK 4QWK 4QWK Huber et al., 2015
20S proteasome beta5 Ala50Val mutant; complex with carfilzomib 2.60 Å 4QWL 4QWL 4QWL 4QWL 4QWL 4QWL Huber et al., 2015
20S proteasome beta5 Cys52Phe mutant; complex with carfilzomib 2.90 Å 4QWR 4QWR 4QWR 4QWR 4QWR 4QWR Huber et al., 2015
20S proteasome beta5 Cys63Phe mutant; complex with carfilzomib 3.00 Å 4QWS 4QWS 4QWS 4QWS 4QWS 4QWS Huber et al., 2015
20S proteasome beta5 Cys52Phe mutant; complex with bortezomib 3.00 Å 4QWU 4QWU 4QWU 4QWU 4QWU 4QWU Huber et al., 2015
20S proteasome; complex with epoxyketone inhibitor ONX 0914 2.90 Å 4QWX 4QWX 4QWX 4QWX 4QWX 4QWX Huber et al., 2015
20S proteasome beta 5 Met45Ala mutant; complex with epoxyketone inhibitor ONX 0914 2.80 Å 4QXJ 4QXJ 4QXJ 4QXJ 4QXJ 4QXJ Huber et al., 2015
complete proteasome; complex with epoxyketone inhibitor ONX 0914 3.00 Å 4QZ0 4QZ0 4QZ0 4QZ0 4QZ0 4QZ0 Huber et al., 2015
20S proteasome beta 5 Met45Thr mutant; complex with epoxyketone inhibitor ONX 0914 3.00 Å 4QZ1 4QZ1 4QZ1 4QZ1 4QZ1 4QZ1 Huber et al., 2015
20S proteasome beta 5 Met45Ile mutant; complex with epoxyketone inhibitor ONX 0914 2.70 Å 4QZ2 4QZ2 4QZ2 4QZ2 4QZ2 4QZ2 Huber et al., 2015
20S proteasome beta 5 Ala49Val mutant; complex with epoxyketone inhibitor ONX 0914 2.80 Å 4QZ3 4QZ3 4QZ3 4QZ3 4QZ3 4QZ3 Huber et al., 2015
20S proteasome beta 5 Ala49Ser mutant; complex with epoxyketone inhibitor ONX 0914 3.00 Å 4QZ4 4QZ4 4QZ4 4QZ4 4QZ4 4QZ4 Huber et al., 2015
20S proteasome beta 5 Ala49Thr mutant; complex with epoxyketone inhibitor ONX 0914 2.80 Å 4QZ5 4QZ5 4QZ5 4QZ5 4QZ5 4QZ5 Huber et al., 2015
20S proteasome beta 5 Ala49Thr, Ala50Val mutant; complex with epoxyketone inhibitor ONX 0914 2.90 Å 4QZ6 4QZ6 4QZ6 4QZ6 4QZ6 4QZ6 Huber et al., 2015
20S proteasome beta 5 Ala50Val mutant; complex with epoxyketone inhibitor ONX 0914 2.80 Å 4QZ7 4QZ7 4QZ7 4QZ7 4QZ7 4QZ7 Huber et al., 2015
20S proteasome beta 5 Cys52Phe mutant; complex with epoxyketone inhibitor ONX 0914 3.00 Å 4QZW 4QZW 4QZW 4QZW 4QZW 4QZW Huber et al., 2015
complete proteasome; complex with epoxyketone inhibitor ONX 0914 2.60 Å 4QZX 4QZX 4QZX 4QZX 4QZX 4QZX Huber et al., 2015
20S proteasome; complex with omuralide 2.90 Å 4QZZ 4QZZ 4QZZ 4QZZ 4QZZ 4QZZ Huber et al., 2015
20S proteasome beta 5 Cys52Phe mutant; complex with omuralide 2.80 Å 4R00 4R00 4R00 4R00 4R00 4R00 Huber et al., 2015
20S proteasome; complex with BSC4999 2.50 Å 4R02 4R02 4R02 4R02 4R02 4R02 Voss et al., 2014
20S proteasome; ligand induced aziridine-formation in beta5 2.10 Å 4R17 4R17 4R17 4R17 4R17 4R17 Dubiella et al., 2014
20S proteasome; ligand induced Lys33-Thr1 cross-linking in beta5 2.40 Å 4R18 4R18 4R18 4R18 4R18 4R18 Dubiella et al., 2014
20S proteasome; complex with alkaloid indolo-phakellin 2.50 Å 4RUR 4RUR 4RUR 4RUR 4RUR 4RUR Beck et al., 2015
mature  peptidase 3.00 Å 4V7O 4V7O 4V7O 4V7O 4V7O 4V7O
20S proteasome; complex with PR-VI modulator 2.70 Å 4X6Z 4X6Z 4X6Z 4X6Z 4X6Z 4X6Z
20S proteasome; complex with Ac-Pro-Ala-Asp-EP 2.90 Å 4Y69 4Y69 4Y69 4Y69 4Y69 4Y69 Huber et al., 2015
20S proteasome beta2 His114Asp mutant; complex with Ac-Pro-Ala-Asp-EP 2.60 Å 4Y6A 4Y6A 4Y6A 4Y6A 4Y6A 4Y6A Huber et al., 2015
20S proteasome; complex with Ac-Pro-Ala-Glu-EP 2.80 Å 4Y6V 4Y6V 4Y6V 4Y6V 4Y6V 4Y6V Huber et al., 2015
20S proteasome; complex with Ac-Pro-Ala-Leu-EP 2.70 Å 4Y6Z 4Y6Z 4Y6Z 4Y6Z 4Y6Z 4Y6Z Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Val-EP 2.40 Å 4Y70 4Y70 4Y70 4Y70 4Y70 4Y70 Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Leu-EP 2.70 Å 4Y74 4Y74 4Y74 4Y74 4Y74 4Y74 Huber et al., 2015
20S proteasome; complex with Ac-Pro-Ala-Phe-EP 2.80 Å 4Y75 4Y75 4Y75 4Y75 4Y75 4Y75 Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Phe-EP 2.50 Å 4Y77 4Y77 4Y77 4Y77 4Y77 4Y77 Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Asp-EP 2.80 Å 4Y78 4Y78 4Y78 4Y78 4Y78 4Y78 Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Glu-EP 2.50 Å 4Y7W 4Y7W 4Y7W 4Y7W 4Y7W 4Y7W Huber et al., 2015
complete proteasome; complex with Ac-PAA-ep 2.60 Å 4Y7X 4Y7X 4Y7X 4Y7X 4Y7X 4Y7X Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Ala-EP 2.40 Å 4Y7Y 4Y7Y 4Y7Y 4Y7Y 4Y7Y 4Y7Y Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Ile-EP 2.50 Å 4Y80 4Y80 4Y80 4Y80 4Y80 4Y80 Huber et al., 2015
20S proteasome; complex with Ac-Pro-Ala-Tyr-EP 2.80 Å 4Y81 4Y81 4Y81 4Y81 4Y81 4Y81 Huber et al., 2015
20S proteasome; complex with Ac-Leu-Ala-Tyr-EP 2.80 Å 4Y82 4Y82 4Y82 4Y82 4Y82 4Y82 Huber et al., 2015
20S proteasome; complex with N3-Ala(4,4-F2P)-Asn-Leu-Leu-EP 2.70 Å 4Y84 4Y84 4Y84 4Y84 4Y84 4Y84 Huber et al., 2015
20S proteasome; complex with N3-Ala-Pro-Asn-Leu-Leu-EP 2.60 Å 4Y8G 4Y8G 4Y8G 4Y8G 4Y8G 4Y8G Huber et al., 2015
20S proteasome; complex with N3-Ala-Pro-Ala-Leu-EP 2.50 Å 4Y8H 4Y8H 4Y8H 4Y8H 4Y8H 4Y8H Huber et al., 2015
20S proteasome; complex with Ac-Pro-Leu-Leu-EP 2.60 Å 4Y8I 4Y8I 4Y8I 4Y8I 4Y8I 4Y8I Huber et al., 2015
20S proteasome; complex with Ac-Leu-Leu-Leu-EP 2.70 Å 4Y8J 4Y8J 4Y8J 4Y8J 4Y8J 4Y8J Huber et al., 2015
20S proteasome; complex with H-Ala-Pro-Leu-Leu-EP 2.60 Å 4Y8K 4Y8K 4Y8K 4Y8K 4Y8K 4Y8K Huber et al., 2015
20S proteasome; complex with Ac-Ala-Pro-Leu-Leu-EP 2.40 Å 4Y8L 4Y8L 4Y8L 4Y8L 4Y8L 4Y8L Huber et al., 2015
20S proteasome beta7-delta7 C-terminal mutant 2.80 Å 4Y8M 4Y8M 4Y8M 4Y8M 4Y8M 4Y8M Huber et al., 2015
20S proteasome beta7-delta7 C-terminal mutant; complex with Ac-Pro-Ala-Glu-EP 2.60 Å 4Y8N 4Y8N 4Y8N 4Y8N 4Y8N 4Y8N Huber et al., 2015
20S proteasome beta 7-delta 7 C-terminal mutant; complex with Ac-Pro-Ala-Phe-EP 2.70 Å 4Y8O 4Y8O 4Y8O 4Y8O 4Y8O 4Y8O Huber et al., 2015
20S proteasome beta 7-delta 7 C-terminal mutant; complex with Ac-Pro-Ala-Leu-EP 2.80 Å 4Y8P 4Y8P 4Y8P 4Y8P 4Y8P 4Y8P Huber et al., 2015
20S proteasome beta 7-delta 7 C-terminal mutant; complex with Ac-Pro-Ala-Tyr-EP 2.60 Å 4Y8Q 4Y8Q 4Y8Q 4Y8Q 4Y8Q 4Y8Q Huber et al., 2015
20S proteasome beta 2 His116Asp mutant 2.70 Å 4Y8R 4Y8R 4Y8R 4Y8R 4Y8R 4Y8R Huber et al., 2015
20S proteasome beta 2 His116Asp mutant; complex with Ac-Leu-Ala-Glu-EP 2.70 Å 4Y8S 4Y8S 4Y8S 4Y8S 4Y8S 4Y8S Huber et al., 2015
20S proteasome beta 2 His116Asp mutant; complex with Ac-Pro-Ala-Glu-EP 2.70 Å 4Y8T 4Y8T 4Y8T 4Y8T 4Y8T 4Y8T Huber et al., 2015
20S proteasome beta 2 His116Asp mutant; complex with Ac-Pro-Ala-Asp-EP 2.90 Å 4Y8U 4Y8U 4Y8U 4Y8U 4Y8U 4Y8U Huber et al., 2015
20S proteasome beta 2 His116Glu mutant 2.80 Å 4Y9Y 4Y9Y 4Y9Y 4Y9Y 4Y9Y 4Y9Y Huber et al., 2015
20S proteasome beta 2 His116Glu mutant; complex with Ac-Leu-Ala-Glu-EP 2.80 Å 4Y9Z 4Y9Z 4Y9Z 4Y9Z 4Y9Z 4Y9Z Huber et al., 2015
20S proteasome beta 2 His116Glu mutant; complex with Ac-Pro-Ala-Glu-EP 2.80 Å 4YA0 4YA0 4YA0 4YA0 4YA0 4YA0 Huber et al., 2015
20S proteasome beta 2 His116Asn mutant 2.90 Å 4YA1 4YA1 4YA1 4YA1 4YA1 4YA1 Huber et al., 2015
20S proteasome beta 2 His116Asn mutant; complex with Ac-Leu-Ala-Glu-EP 2.70 Å 4YA2 4YA2 4YA2 4YA2 4YA2 4YA2 Huber et al., 2015
20S proteasome beta 2 His116Asn mutant; complex with Ac-Pro-Ala-Glu-EP 2.70 Å 4YA3 4YA3 4YA3 4YA3 4YA3 4YA3 Huber et al., 2015
20S proteasome beta 2 His114Asp mutant 2.90 Å 4YA4 4YA4 4YA4 4YA4 4YA4 4YA4 Huber et al., 2015
20S proteasome beta 2 His114Asp mutant; complex with Ac-Pro-Ala-Glu-EP 2.50 Å 4YA5 4YA5 4YA5 4YA5 4YA5 4YA5 Huber et al., 2015
20S proteasome beta 2 His114Asp mutant; complex with Ac-Leu-Ala-Glu-EP 2.70 Å 4YA7 4YA7 4YA7 4YA7 4YA7 4YA7 Huber et al., 2015
20S proteasome beta 2 His114Asp mutant; complex with AC-Leu-Ala-Asp-EP 2.70 Å 4YA9 4YA9 4YA9 4YA9 4YA9 4YA9 Huber et al., 2015
20S proteasome; complex with belactosin C derivative 3 3.00 Å 4Z1L 4Z1L 4Z1L 4Z1L 4Z1L 4Z1L Groll et al., 2015
26S protease-UBP6 complex 9.50 Å 5A5B 5A5B 5A5B 5A5B 5A5B 5A5B Aufderheide et al., 2015
20S proteasome; complex with macyranone A 2.80 Å 5AHJ 5AHJ 5AHJ 5AHJ 5AHJ 5AHJ Keller et al., 2015
20S proteasome; complex with beta1/beta2 nonspecifici sulfonamide ligand 2.60 Å 5BOU 5BOU 5BOU 5BOU 5BOU 5BOU Beck et al., 2015
yeast 20s proteasome beta2-g170a mutant 2.80 Å 5BXL 5BXL 5BXL 5BXL 5BXL 5BXL
yeast 20s proteasome beta2-g170a mutant in complex with bortezomib 2.80 Å 5BXN 5BXN 5BXN 5BXN 5BXN 5BXN
20S proteasome beta5 Gly48Cys mutant 2.80 Å 5CGF 5CGF 5CGF 5CGF 5CGF 5CGF Dubiella et al., 2015
20S proteasome beta5 Gly48Cys mutant; complex with alpha-chloroacetamide 1 2.90 Å 5CGG 5CGG 5CGG 5CGG 5CGG 5CGG Dubiella et al., 2015
20S proteasome beta5 Gly48Cys mutant; complex with alpha-chloroacetamide 5 2.50 Å 5CGH 5CGH 5CGH 5CGH 5CGH 5CGH Dubiella et al., 2015
20S proteasome beta5 Gly48Cys mutant; complex with ONX 0914 2.80 Å 5CGI 5CGI 5CGI 5CGI 5CGI 5CGI Dubiella et al., 2015
yeast 20s proteasome at 2.3 a resolution 2.30 Å 5CZ4 5CZ4 5CZ4 5CZ4 5CZ4 5CZ4
yeast 20s proteasome beta1-t1a mutant in complex with carfilzomib 2.80 Å 5CZ5 5CZ5 5CZ5 5CZ5 5CZ5 5CZ5
yeast 20s proteasome beta5-t1a mutant in complex with syringolin a, propeptide expressed in trans 2.70 Å 5CZ6 5CZ6 5CZ6 5CZ6 5CZ6 5CZ6
yeast 20s proteasome beta5-t1a beta5-k81r double mutant in complex with bortezomib, propeptide expressed in cis 2.50 Å 5CZ7 5CZ7 5CZ7 5CZ7 5CZ7 5CZ7
yeast 20s proteasome beta5-l(-49)s-k33a mutant in complex with carfilzomib 2.80 Å 5CZ8 5CZ8 5CZ8 5CZ8 5CZ8 5CZ8
yeast 20s proteasome beta5-d17n mutant in complex with carfilzomib; propeptide expressed in trans 2.90 Å 5CZ9 5CZ9 5CZ9 5CZ9 5CZ9 5CZ9
yeast 20s proteasome beta5-d166n mutant 2.50 Å 5CZA 5CZA 5CZA 5CZA 5CZA 5CZA
yeast 20s proteasome beta5-d166n mutant in complex with carfilzomib 2.50 Å 5D0S 5D0S 5D0S 5D0S 5D0S 5D0S
yeast 20s proteasome beta5-d166n mutant in complex with mg132 2.60 Å 5D0T 5D0T 5D0T 5D0T 5D0T 5D0T
yeast 20s proteasome beta5-t1c mutant in complex with carfilzomib 2.90 Å 5D0V 5D0V 5D0V 5D0V 5D0V 5D0V
yeast 20s proteasome beta5-t1s mutant 2.80 Å 5D0W 5D0W 5D0W 5D0W 5D0W 5D0W
yeast 20s proteasome beta5-t1s mutant in complex with bortezomib 2.60 Å 5D0X 5D0X 5D0X 5D0X 5D0X 5D0X
yeast 20s proteasome beta5-t1s mutant in complex with carfilzomib 2.90 Å 5D0Z 5D0Z 5D0Z 5D0Z 5D0Z 5D0Z
20S proteasome; complex with alkyne-PI 2.80 Å 5DKI 5DKI 5DKI 5DKI 5DKI 5DKI
20S proteasome; complex with octreotide-PI 2.80 Å 5DKJ 5DKJ 5DKJ 5DKJ 5DKJ 5DKJ
yeast 20s proteasome beta2-t1a mutant 2.70 Å 5FG7 5FG7 5FG7 5FG7 5FG7 5FG7
yeast 20s proteasome beta2-t(-2)v mutant 2.60 Å 5FG9 5FG9 5FG9 5FG9 5FG9 5FG9
yeast 20s proteasome beta5-k33a mutant (propeptide expressed in trans) 2.70 Å 5FGA 5FGA 5FGA 5FGA 5FGA 5FGA
yeast 20s proteasome beta5-h(-2)l-t1a double mutant in complex with carfilzomib 2.80 Å 5FGD 5FGD 5FGD 5FGD 5FGD 5FGD
yeast 20s proteasome beta5-h(-2)t-t1a double mutant in complex with carfilzomib 2.60 Å 5FGE 5FGE 5FGE 5FGE 5FGE 5FGE
yeast 20s proteasome beta5-h(-2)a-t1a-k81r triple mutant in complex with carfilzomib 2.60 Å 5FGF 5FGF 5FGF 5FGF 5FGF 5FGF
yeast 20s proteasome beta5-l(-49s)_d17n double mutant in complex with carfilzomib 2.70 Å 5FGG 5FGG 5FGG 5FGG 5FGG 5FGG
yeast 20s proteasome beta5-k33a mutant (propeptide expressed in trans)in complex with mg132 2.80 Å 5FGH 5FGH 5FGH 5FGH 5FGH 5FGH
yeast 20s proteasome beta1-t1a beta2-t1a double mutant in complex withcarfilzomib 2.90 Å 5FGI 5FGI 5FGI 5FGI 5FGI 5FGI
yeast 20s proteasome beta5-k33a mutant (propeptide expressed in trans)in complex with carfilzomib 2.70 Å 5FHS 5FHS 5FHS 5FHS 5FHS 5FHS
20s proteasome; complex with the peptidic epoxyketone inhibitor 27 2.90 Å 5JHR 5JHR 5JHR 5JHR 5JHR 5JHR
20s proteasome; complex with the peptidic epoxyketone inhibitor 15 3.00 Å 5JHS 5JHS 5JHS 5JHS 5JHS 5JHS
yeast 20s proteasome in complex with epoxyketone inhibitor 14 2.70 Å 5L52 5L52 5L52 5L52 5L52 5L52
yeast 20s proteasome in complex with epoxyketone inhibitor 16 2.80 Å 5L54 5L54 5L54 5L54 5L54 5L54
yeast 20s proteasome in complex with epoxyketone inhibitor 18 2.90 Å 5L55 5L55 5L55 5L55 5L55 5L55
yeast 20s proteasome with human beta5i (1-138; r57t) 2.40 Å 5L5A 5L5A 5L5A 5L5A 5L5A 5L5A
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) 2.80 Å 5L5B 5L5B 5L5B 5L5B 5L5B 5L5B
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with onx 0914 2.80 Å 5L5D 5L5D 5L5D 5L5D 5L5D 5L5D
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with carfilzomib 2.90 Å 5L5E 5L5E 5L5E 5L5E 5L5E 5L5E
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with bortezomib 2.50 Å 5L5F 5L5F 5L5F 5L5F 5L5F 5L5F
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with pr-924 2.60 Å 5L5H 5L5H 5L5H 5L5H 5L5H 5L5H
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 9 2.90 Å 5L5I 5L5I 5L5I 5L5I 5L5I 5L5I
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 14 2.90 Å 5L5J 5L5J 5L5J 5L5J 5L5J 5L5J
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 16 2.60 Å 5L5O 5L5O 5L5O 5L5O 5L5O 5L5O
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 17 2.80 Å 5L5P 5L5P 5L5P 5L5P 5L5P 5L5P
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone 18 2.80 Å 5L5Q 5L5Q 5L5Q 5L5Q 5L5Q 5L5Q
yeast 20s proteasome with human beta5i (1-138;v31m) and human beta6 (97-111; 118-133) 2.90 Å 5L5R 5L5R 5L5R 5L5R 5L5R 5L5R
yeast 20s proteasome with human beta5i (1-138; v31m) and human beta6 (97-111; 118-133) in complex with pr-924 2.60 Å 5L5S 5L5S 5L5S 5L5S 5L5S 5L5S
yeast 20s proteasome with human beta5i (1-138; v31m) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 16 2.90 Å 5L5T 5L5T 5L5T 5L5T 5L5T 5L5T
yeast 20s proteasome with human beta5i (1-138; v31m) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17 ***caveat 5l5u 04c h 301 has wrong chirality at atom c27 04c k 301 has ***caveat 2 5l5u wrong chirality at atom c27 04c v 301 h 2.60 Å 5L5U 5L5U 5L5U 5L5U 5L5U 5L5U
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) 2.80 Å 5L5W 5L5W 5L5W 5L5W 5L5W 5L5W
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with onx 0914 2.90 Å 5L5X 5L5X 5L5X 5L5X 5L5X 5L5X
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with carfilzomib 2.70 Å 5L5Y 5L5Y 5L5Y 5L5Y 5L5Y 5L5Y
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with bortezomib 2.70 Å 5L5Z 5L5Z 5L5Z 5L5Z 5L5Z 5L5Z
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with pr-924 2.70 Å 5L60 5L60 5L60 5L60 5L60 5L60
yeast 20s proteasome with human beta5c (1-138) and human beta6 (99- 132) in complex with epoxyketone inhibitor 14 2.80 Å 5L61 5L61 5L61 5L61 5L61 5L61
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 16 2.80 Å 5L62 5L62 5L62 5L62 5L62 5L62
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 17 ***caveat 5l63 04c h 301 has wrong chirality at atom c27 04c k 301 has ***caveat 2 5l63 wrong chirality at atom c27 04c v 301 has wr 2.70 Å 5L63 5L63 5L63 5L63 5L63 5L63
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 18 2.70 Å 5L64 5L64 5L64 5L64 5L64 5L64
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with carfilzomib 2.90 Å 5L65 5L65 5L65 5L65 5L65 5L65
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with bortezomib 2.80 Å 5L66 5L66 5L66 5L66 5L66 5L66
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with pr-924 2.60 Å 5L67 5L67 5L67 5L67 5L67 5L67
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 14 2.80 Å 5L68 5L68 5L68 5L68 5L68 5L68
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 16 2.70 Å 5L69 5L69 5L69 5L69 5L69 5L69
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 17 2.80 Å 5L6A 5L6A 5L6A 5L6A 5L6A 5L6A
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with onx 0914 2.60 Å 5L6B 5L6B 5L6B 5L6B 5L6B 5L6B
yeast 20s proteasome with mouse beta5i (1-138) and mouse beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 18 2.60 Å 5L6C 5L6C 5L6C 5L6C 5L6C 5L6C
ligand-induced aziridine-formation at the yeast proteasomal subunit beta5 by sulfonate esters 2.50 Å 5LAI 5LAI 5LAI 5LAI 5LAI 5LAI
ligand-induced lys33-thr1 crosslinking at the yeast proteasomal subunit beta5 by sulfonate esters 2.90 Å 5LAJ 5LAJ 5LAJ 5LAJ 5LAJ 5LAJ
yeast 20s proteasome with human beta5i (1-138; r57t)in complex with pr-924 2.70 Å 5LTT 5LTT 5LTT 5LTT 5LTT 5LTT
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with thiazole based inhibitor ro19 2.70 Å 5M2B 5M2B 5M2B 5M2B 5M2B 5M2B
26s proteasome in presence of atp (s1) 4.10 Å 5MP9 5MP9 5MP9 5MP9 5MP9 5MP9
26s proteasome in presence of atp (s2) 4.50 Å 5MPA 5MPA 5MPA 5MPA 5MPA 5MPA
yeast 20s proteasome in complex with blm-pep activator 3.00 Å 5NIF 5NIF 5NIF 5NIF 5NIF 5NIF
yeast 26s proteasome bound to ubiquitinated substrate (1d* motor state) 4.43 Å 6EF0 6EF0 6EF0 6EF0 6EF0 6EF0
yeast 26s proteasome bound to ubiquitinated substrate (5d motor state) 4.73 Å 6EF1 6EF1 6EF1 6EF1 6EF1 6EF1
yeast 26s proteasome bound to ubiquitinated substrate (5t motor state) 4.27 Å 6EF2 6EF2 6EF2 6EF2 6EF2 6EF2
yeast 26s proteasome bound to ubiquitinated substrate (4d motor state) 4.17 Å 6EF3 6EF3 6EF3 6EF3 6EF3 6EF3
yeast 20s proteasome in complex with cystargolide b 2.70 Å 6G7F 6G7F 6G7F 6G7F 6G7F 6G7F
yeast 20s proteasome in complex with cystargolide b derivative 1 2.70 Å 6G8M 6G8M 6G8M 6G8M 6G8M 6G8M
yeast 20s proteasome in complex with cystargolide b derivative 2 3.00 Å 6G8N 6G8N 6G8N 6G8N 6G8N 6G8N
yeast 20s proteasome in complex with homosalinosporamide a 2.90 Å 6GOP 6GOP 6GOP 6GOP 6GOP 6GOP
yeast 20s proteasome in complex with the peptidic non-covalent bindinginhibitor rts-v5 2.50 Å 6H39 6H39 6H39 6H39 6H39 6H39
yeast 20s proteasome with human beta2c (s171g) 2.70 Å 6HTB 6HTB 6HTB 6HTB 6HTB 6HTB
yeast 20s proteasome with human beta2c (s171g) in complex with onx 0914 2.80 Å 6HTC 6HTC 6HTC 6HTC 6HTC 6HTC
yeast 20s proteasome with human beta2c (s171g) in complex with 4 3.00 Å 6HTD 6HTD 6HTD 6HTD 6HTD 6HTD
yeast 20s proteasome with human beta2c (s171g) in complex with 7 3.00 Å 6HTP 6HTP 6HTP 6HTP 6HTP 6HTP
yeast 20s proteasome with human beta2c (s171g) in complex with 13 2.60 Å 6HTR 6HTR 6HTR 6HTR 6HTR 6HTR
yeast 20s proteasome with human beta2c (s171g) in complex with 16 2.90 Å 6HUB 6HUB 6HUB 6HUB 6HUB 6HUB
yeast 20s proteasome with human beta2c (s171g) in complex with 18 3.00 Å 6HUC 6HUC 6HUC 6HUC 6HUC 6HUC
yeast 20s proteasome with human beta2c (s171g) in complex with 20 3.00 Å 6HUQ 6HUQ 6HUQ 6HUQ 6HUQ 6HUQ
yeast 20s proteasome with human beta2c (s171g) in complex with 29 2.80 Å 6HUU 6HUU 6HUU 6HUU 6HUU 6HUU
yeast 20s proteasome with human beta2c (s171g) in complex with 39 3.10 Å 6HUV 6HUV 6HUV 6HUV 6HUV 6HUV
yeast 20s proteasome with human beta2i (1-53) 2.70 Å 6HV3 6HV3 6HV3 6HV3 6HV3 6HV3
yeast 20s proteasome with human beta2i (1-53) in complex with onx 0914 3.00 Å 6HV4 6HV4 6HV4 6HV4 6HV4 6HV4
yeast 20s proteasome with human beta2i (1-53) in complex with 4 3.00 Å 6HV5 6HV5 6HV5 6HV5 6HV5 6HV5
yeast 20s proteasome with human beta2i (1-53) in complex with 7 3.40 Å 6HV7 6HV7 6HV7 6HV7 6HV7 6HV7
yeast 20s proteasome with human beta2i (1-53) in complex with 13 2.90 Å 6HVA 6HVA 6HVA 6HVA 6HVA 6HVA
yeast 20s proteasome with human beta2i (1-53) in complex with 16 2.70 Å 6HVR 6HVR 6HVR 6HVR 6HVR 6HVR
yeast 20s proteasome with human beta2i (1-53) in complex with 18 3.10 Å 6HVS 6HVS 6HVS 6HVS 6HVS 6HVS
yeast 20s proteasome with human beta2i (1-53) in complex with 20 2.90 Å 6HVT 6HVT 6HVT 6HVT 6HVT 6HVT
yeast 20s proteasome with human beta2i (1-53) in complex with 29 2.90 Å 6HVU 6HVU 6HVU 6HVU 6HVU 6HVU
yeast 20s proteasome with human beta2i (1-53) in complex with 39 2.70 Å 6HVV 6HVV 6HVV 6HVV 6HVV 6HVV
yeast 20s proteasome with human beta2i (1-53) in complex with 43 3.00 Å 6HVW 6HVW 6HVW 6HVW 6HVW 6HVW
yeast 20s proteasome in complex with 4 2.80 Å 6HVX 6HVX 6HVX 6HVX 6HVX 6HVX
yeast 20s proteasome in complex with 5 (7- and 6-membered ring) 2.70 Å 6HVY 6HVY 6HVY 6HVY 6HVY 6HVY
yeast 20s proteasome in complex with 7 2.80 Å 6HW0 6HW0 6HW0 6HW0 6HW0 6HW0
yeast 20s proteasome in complex with 13 2.60 Å 6HW3 6HW3 6HW3 6HW3 6HW3 6HW3
yeast 20s proteasome in complex with 16 2.90 Å 6HW4 6HW4 6HW4 6HW4 6HW4 6HW4
yeast 20s proteasome in complex with 18 2.90 Å 6HW5 6HW5 6HW5 6HW5 6HW5 6HW5
yeast 20s proteasome in complex with 20 2.70 Å 6HW6 6HW6 6HW6 6HW6 6HW6 6HW6
yeast 20s proteasome in complex with 29 2.70 Å 6HW7 6HW7 6HW7 6HW7 6HW7 6HW7
yeast 20s proteasome in complex with 39 2.80 Å 6HW8 6HW8 6HW8 6HW8 6HW8 6HW8
yeast 20s proteasome in complex with 41b 2.80 Å 6HW9 6HW9 6HW9 6HW9 6HW9 6HW9
yeast 20s proteasome in complex with 43 2.80 Å 6HWA 6HWA 6HWA 6HWA 6HWA 6HWA
yeast 20s proteasome in complex with 44b 2.60 Å 6HWB 6HWB 6HWB 6HWB 6HWB 6HWB
yeast 20s proteasome beta2-g45a mutant 2.80 Å 6HWC 6HWC 6HWC 6HWC 6HWC 6HWC
yeast 20s proteasome beta2-g45a mutant in complex with bortezomib 2.80 Å 6HWD 6HWD 6HWD 6HWD 6HWD 6HWD
yeast 20s proteasome beta2-g45a mutant in complex with carfilzomib 2.30 Å 6HWE 6HWE 6HWE 6HWE 6HWE 6HWE
yeast 20s proteasome beta2-g45a mutant in complex with onx 0914 2.50 Å 6HWF 6HWF 6HWF 6HWF 6HWF 6HWF

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use