PDBsum entry 3unb

Hydrolase/hydrolase inhibitor

PDB id: 3unb

Contents

Protein chains

231 a.a.

248 a.a.

239 a.a.

233 a.a.

238 a.a.

244 a.a.

243 a.a.

220 a.a.

204 a.a.

196 a.a.

201 a.a.

213 a.a.

216 a.a.

202 a.a.

Ligands

04C ×12

Waters ×1480

PDB id:

3unb

Name:

Hydrolase/hydrolase inhibitor

Title:

Mouse constitutive 20s proteasome in complex with pr-957

Structure:

Proteasome subunit alpha type-2. Chain: a, o, c, q. Synonym: macropain subunit c3, multicatalytic endopeptidase complex subunit c3, proteasome component c3. Proteasome subunit alpha type-4. Chain: b, p, d, r. Synonym: macropain subunit c9, multicatalytic endopeptidase complex subunit c9, proteasome component c9, proteasome subunit l. Proteasome subunit alpha type-7.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Organism_taxid: 10090

Resolution:

2.90Å R-factor: 0.232 R-free: 0.273

Authors:

E.Huber,M.Basler,R.Schwab,W.Heinemeyer,C.Kirk,M.Groettrup,M.Groll

Key ref:

E.M.Huber et al. (2012). Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Cell, 148, 727-738. PubMed id: 22341445

Date:

15-Nov-11 Release date: 29-Feb-12

Protein chains

P49722  (PSA2_MOUSE) -  Proteasome subunit alpha type-2 from Mus musculus

Seq: 234 a.a.

Struc: 231 a.a.*

Protein chains

Q9R1P0  (PSA4_MOUSE) -  Proteasome subunit alpha type-4 from Mus musculus

Seq: 261 a.a.

Struc: 248 a.a.

Protein chains

Q9Z2U0  (PSA7_MOUSE) -  Proteasome subunit alpha type-7 from Mus musculus

Seq: 248 a.a.

Struc: 239 a.a.*

Protein chains

Q9Z2U1  (PSA5_MOUSE) -  Proteasome subunit alpha type-5 from Mus musculus

Seq: 241 a.a.

Struc: 233 a.a.

Protein chains

Q9R1P4  (PSA1_MOUSE) -  Proteasome subunit alpha type-1 from Mus musculus

Seq: 263 a.a.

Struc: 238 a.a.

Protein chains

O70435  (PSA3_MOUSE) -  Proteasome subunit alpha type-3 from Mus musculus

Seq: 255 a.a.

Struc: 244 a.a.

Protein chains

Q9QUM9  (PSA6_MOUSE) -  Proteasome subunit alpha type-6 from Mus musculus

Seq: 246 a.a.

Struc: 243 a.a.

Protein chains

P70195  (PSB7_MOUSE) -  Proteasome subunit beta type-7 from Mus musculus

Seq: 277 a.a.

Struc: 220 a.a.

Protein chains

Q9R1P1  (PSB3_MOUSE) -  Proteasome subunit beta type-3 from Mus musculus

Seq: 205 a.a.

Struc: 204 a.a.

Protein chains

Q9R1P3  (PSB2_MOUSE) -  Proteasome subunit beta type-2 from Mus musculus

Seq: 201 a.a.

Struc: 196 a.a.

Protein chains

O55234  (PSB5_MOUSE) -  Proteasome subunit beta type-5 from Mus musculus

Seq: 264 a.a.

Struc: 201 a.a.

Protein chains

O09061  (PSB1_MOUSE) -  Proteasome subunit beta type-1 from Mus musculus

Seq: 240 a.a.

Struc: 213 a.a.

Protein chains

P99026  (PSB4_MOUSE) -  Proteasome subunit beta type-4 from Mus musculus

Seq: 264 a.a.

Struc: 216 a.a.

Protein chains

Q60692  (PSB6_MOUSE) -  Proteasome subunit beta type-6 from Mus musculus

Seq: 238 a.a.

Struc: 202 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z, 1, 2, 3, 4: E.C.3.4.25.1 - proteasome endopeptidase complex.
• Reaction: Cleavage at peptide bonds with very broad specificity.

Cell 148:727-738 (2012)

PubMed id: 22341445

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

E.M.Huber, M.Basler, R.Schwab, W.Heinemeyer, C.J.Kirk, M.Groettrup, M.Groll.

ABSTRACT

No abstract given.