PDBe 2r9p

X-ray diffraction
1.4Å resolution

Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor(BPTI)


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Trypsin-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 224 amino acids
Theoretical weight: 24.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P35030 (Residues: 81-304; Coverage: 74%)
Gene names: PRSS3, PRSS4, TRY3, TRY4
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Pancreatic trypsin inhibitor Chains: E, F, G, I
Molecule details ›
Chains: E, F, G, I
Length: 58 amino acids
Theoretical weight: 6.53 KDa
Source organism: Bos taurus
  • Canonical: P00974 (Residues: 36-93; Coverage: 73%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P21
Unit cell:
a: 74.222Å b: 109.717Å c: 81.171Å
α: 90° β: 117.15° γ: 90°
R R work R free
0.17 0.17 0.224
Expression system: Escherichia coli