Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P68871

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site Peptidase Residue range Cleavage type Description Evidence Reference
1 unknown peptidase 1-147 P NT <%Agarwal et al., 2012[]%>
2 falcipain-2 2-147 N Subramanian et al., 2009
3 cathepsin D 2-147 N normal turnover Brindley et al., 2001
3 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
3 falcipain-2 2-147 N Subramanian et al., 2009
3 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
4 cathepsin D 2-147 P normal turnover
6 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
7 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
8 necepsin-1 1-147 N NT Williamson et al., 2003
8 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
8 falcipain-2 2-147 N Subramanian et al., 2009
8 CPG70 carboxypeptidase (Porphyromonas gingivalis) 2-9 N Chen et al., 2002
9 necepsin-2 1-147 N MS Ranjit et al., 2009
9 falcipain-2 2-147 N Subramanian et al., 2009
9 falcipain-3 2-147 N Subramanian et al., 2009
10 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
11 falcipain-2 2-147 N Subramanian et al., 2009
12 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
13 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
13 falcipain-2 2-147 N Subramanian et al., 2009
13 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
14 cathepsin D 2-147 N normal turnover Brindley et al., 2001
14 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
14 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
14 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
15 cathepsin D 2-147 N normal turnover Brindley et al., 2001
15 necepsin-2 1-147 N MS Ranjit et al., 2009
15 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
15 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
15 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
16 necepsin-2 1-147 N MS Ranjit et al., 2009
16 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
16 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
16 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
17 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
17 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
17 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
17 CPG70 carboxypeptidase (Porphyromonas gingivalis) 10-18 N Chen et al., 2002
19 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
19 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
20 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
20 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
21 necepsin-2 1-147 N MS Ranjit et al., 2009
21 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
22 necepsin-2 1-147 N MS Ranjit et al., 2009
22 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
23 necepsin-2 1-147 N MS Ranjit et al., 2009
23 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
23 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
23 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
24 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
25 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
26 necepsin-1 1-147 N NT Williamson et al., 2003
27 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
28 necepsin-2 1-147 N MS Ranjit et al., 2009
28 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
28 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
29 necepsin-2 1-147 N MS Ranjit et al., 2009
29 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
29 falcipain-2 2-147 N Subramanian et al., 2009
30 necepsin-1 1-147 N NT Williamson et al., 2003
30 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
30 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
30 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
30 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
31 cathepsin D 2-147 N normal turnover Brindley et al., 2001
31 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
32 cathepsin D 2-147 N normal turnover Brindley et al., 2001
32 plasmepsin-1 2-147 P NT Gluzman et al., 1994
32 necepsin-2 1-147 N MS Ranjit et al., 2009
33 plasmepsin-2 2-147 P MS Gluzman et al., 1994
33 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
33 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
33 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
34 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
34 falcipain-2 2-147 N Subramanian et al., 2009
35 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
35 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
35 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
36 necepsin-1 1-147 N NT Williamson et al., 2003
37 necepsin-1 2-147 N normal turnover MS Williamson et al., 2003
37 falcipain-2 2-147 N Subramanian et al., 2009
37 falcipain-3 2-147 N Subramanian et al., 2009
38 necepsin-1 1-147 N NT Williamson et al., 2003
38 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
39 falcipain-2 2-147 N Subramanian et al., 2009
40 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
40 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
40 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
40 CPG70 carboxypeptidase (Porphyromonas gingivalis) 32-41 N Chen et al., 2002
41 cathepsin D 2-147 N normal turnover Brindley et al., 2001
41 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
41 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
42 plasmepsin-1 2-147 P NT Gluzman et al., 1994
42 necepsin-2 1-147 N MS Ranjit et al., 2009
42 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
42 falcipain-2 2-147 N Subramanian et al., 2009
42 falcipain-3 2-147 N Subramanian et al., 2009
43 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
43 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
43 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
44 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
44 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
44 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
44 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
45 cathepsin D 2-147 N normal turnover Brindley et al., 2001
45 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
46 necepsin-1 1-147 N NT Williamson et al., 2003
46 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
46 falcipain-2 2-147 N Subramanian et al., 2009
46 falcipain-3 2-147 N Subramanian et al., 2009
47 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
47 falcipain-2 2-147 N Subramanian et al., 2009
47 falcipain-3 2-147 N Subramanian et al., 2009
49 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
49 falcipain-2 2-147 N Subramanian et al., 2009
49 falcipain-3 2-147 N Subramanian et al., 2009
50 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
50 falcipain-2 2-147 N Subramanian et al., 2009
50 falcipain-3 2-147 N Subramanian et al., 2009
51 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
51 falcipain-3 2-147 N Subramanian et al., 2009
53 necepsin-1 1-147 N NT Williamson et al., 2003
53 falcipain-2 2-147 N Subramanian et al., 2009
53 falcipain-3 2-147 N Subramanian et al., 2009
55 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
56 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
57 necepsin-1 1-147 N NT Williamson et al., 2003
57 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
57 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
57 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
57 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
58 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
59 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
61 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
61 falcipain-3 2-147 N Subramanian et al., 2009
62 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
62 falcipain-2 2-147 N Subramanian et al., 2009
62 falcipain-3 2-147 N Subramanian et al., 2009
64 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
66 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
66 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
67 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
68 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
69 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
70 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
70 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
70 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
72 necepsin-1 1-147 N NT Williamson et al., 2003
73 necepsin-2 1-147 N MS Ranjit et al., 2009
73 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
73 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
73 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
73 falcilysin 2-147 N Eggleson et al., 1999
74 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
74 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
75 necepsin-1 1-147 N NT Williamson et al., 2003
75 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
75 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
76 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
76 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
76 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
77 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
77 falcipain-3 2-147 N Subramanian et al., 2009
78 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
78 falcilysin 2-147 N Eggleson et al., 1999
80 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
80 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
81 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
81 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
82 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
82 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
82 CPG70 carboxypeptidase (Porphyromonas gingivalis) 67-83 N Chen et al., 2002
83 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
83 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
83 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
84 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
85 cathepsin D 2-147 N normal turnover Brindley et al., 2001
85 necepsin-1 1-147 N NT Williamson et al., 2003
86 necepsin-2 1-147 N MS Ranjit et al., 2009
86 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
87 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
88 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
89 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
89 falcipain-3 2-147 N Subramanian et al., 2009
90 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
91 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
92 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
93 necepsin-1 1-147 N NT Williamson et al., 2003
93 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
93 falcipain-2 2-147 N Subramanian et al., 2009
93 falcipain-3 2-147 N Subramanian et al., 2009
95 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
95 falcipain-2 2-147 N Subramanian et al., 2009
95 CPG70 carboxypeptidase (Porphyromonas gingivalis) 84-96 N Chen et al., 2002
96 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
96 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
96 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
97 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
97 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
97 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
98 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
98 falcipain-2 2-147 N Subramanian et al., 2009
100 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
100 falcipain-3 2-147 N Subramanian et al., 2009
102 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
103 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
103 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
103 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
104 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
104 CPG70 carboxypeptidase (Porphyromonas gingivalis) 84-105 N Chen et al., 2002
105 necepsin-1 1-147 N NT Williamson et al., 2003
105 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
105 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
105 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
106 falcipain-2 2-147 N Subramanian et al., 2009
106 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
107 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
107 falcipain-2 2-147 N Subramanian et al., 2009
107 falcipain-3 2-147 N Subramanian et al., 2009
108 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
108 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
108 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
110 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
111 necepsin-1 1-147 N NT Williamson et al., 2003
111 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
112 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
112 falcipain-2 2-147 N Subramanian et al., 2009
113 necepsin-2 1-147 N MS Ranjit et al., 2009
114 necepsin-2 1-147 N MS Ranjit et al., 2009
114 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
114 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
115 necepsin-2 1-147 N MS Ranjit et al., 2009
115 falcipain-2 2-147 N Subramanian et al., 2009
116 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
116 falcipain-2 2-147 N Subramanian et al., 2009
120 necepsin-1 1-147 N NT Williamson et al., 2003
120 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
120 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
120 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
120 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
120 CPG70 carboxypeptidase (Porphyromonas gingivalis) 106-121 N Chen et al., 2002
121 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
122 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
122 falcipain-2 2-147 N Subramanian et al., 2009
123 necepsin-1 1-147 N NT Williamson et al., 2003
123 necepsin-2 1-147 N MS Ranjit et al., 2009
123 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
123 falcipain-3 2-147 N normal turnover Subramanian et al., 2009
125 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
128 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
128 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
128 falcipain-3 2-147 N Subramanian et al., 2009
129 cathepsin D 2-147 N normal turnover Brindley et al., 2001
129 necepsin-1 1-147 N NT Williamson et al., 2003
129 falcipain-2 2-147 N Subramanian et al., 2009
129 falcipain-3 2-147 N Subramanian et al., 2009
130 plasmepsin-1 2-147 P NT Gluzman et al., 1994
130 necepsin-2 1-147 N MS Ranjit et al., 2009
130 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
131 MEP peptidase (nematode) 2-147 N MS Ranjit et al., 2009
132 falcipain-2 2-147 N normal turnover Subramanian et al., 2009
132 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
132 CPG70 carboxypeptidase (Porphyromonas gingivalis) 122-133 N Chen et al., 2002
132 falcilysin 2-147 N Eggleson et al., 1999
133 falcipain-2 2-147 N Subramanian et al., 2009
134 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
136 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
137 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
139 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
139 falcipain-2 2-147 N Subramanian et al., 2009
139 falcipain-3 2-147 N Subramanian et al., 2009
140 falcipain-2 2-147 N Subramanian et al., 2009
141 necepsin-1 1-147 N NT Williamson et al., 2003
141 cathepsin B-like peptidase, nematode 2-147 N MS Ranjit et al., 2009
143 necepsin-2 1-147 N MS Ranjit et al., 2009
143 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009
143 falcipain-2 2-147 N Subramanian et al., 2009
143 falcipain-3 2-147 N Subramanian et al., 2009
144 CPG70 carboxypeptidase (Porphyromonas gingivalis) 134-145 N Chen et al., 2002
145 necepsin-1 1-147 N NT Williamson et al., 2003
146 cathepsin L1 (Fasciola sp.) 2-147 N normal turnover Lowther et al., 2009