Substrates for peptidase C14.010: caspase-9

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Val-Glu-His-Asp-NHMec			Ac-Val-Glu-His-Asp-NHMec	S		Val	Glu	His	Asp	AMC	-	-	-	Garcia-Calvo et al., 1999
apoptosis regulator Bcl-2	Q9JJV8	1-236	peptide-Asp64+Met-peptide	N		Val	His	Arg	Asp	Met	Ala	Ala	Arg		16253
caspase-3 precursor	P42574		peptide-Asp175+Ser-peptide	P		Ile	Glu	Thr	Asp	Ser	Gly	Val	Asp	Zou et al., 1997	18037
caspase-9 precursor	P55211	1-416	peptide-Asp315+Ala-peptide	P		Pro	Glu	Pro	Asp	Ala	Thr	Pro	Phe	Chua et al., 2000	3994
caspase-9 precursor	Q53Y70	1-416	peptide-Glu306+Ser-peptide	P		Pro	Glu	Asp	Glu	Ser	Pro	Gly	Ser	Srinivasula et al., 2001	19303
choline-phosphate cytidylyltransferase A	P49585	1-367	peptide-Asp28+Gly-peptide	P		Thr	Glu	Glu	Asp	Gly	Val	Pro	Ser	Lagace et al., 2002
erythroid transcription factor	P15976	1-413	peptide-Asp125+Gly-peptide	P		Glu	Asp	Leu	Asp	Gly	Lys	Gly	Ser	Maria et al., 1999
N-acetylserotonin O-methyltransferase-like protein	O95671	1-621	peptide-Glu236+Asp-peptide	N		Asp	Thr	Phe	Glu	Asp	Leu	Ser	Asp	Checinska et al., 2009	25771
N-acetylserotonin O-methyltransferase-like protein	O95671	1-621	peptide-Asp240+Val-peptide	P		Asp	Leu	Ser	Asp	Val	Glu	Gly	Gly	Checinska et al., 2009	25772
Protein kinase C epsilon type	Q02156	1-737	Peptide-Asp451+Cys-Peptide	P	MU	Asp	Asp	Val	Asp	Cys	Thr	Met	Thr	Basu et al., 2002
Protein kinase C epsilon type	Q02156	1-737	Peptide-Asp383+Gly-Peptide	P	MU	Ser	Ser	Pro	Asp	Gly	Gln	Leu	Met	Basu et al., 2002
RAF proto-oncogene serine/threonine-protein kinase	P04049	1-648	peptide-Asp279+Ala-peptide	P		Met	Ile	Glu	Asp	Ala	Ile	Arg	Ser	Cornelis et al., 2005	19516
retinoblastoma-associated protein	P06400	1-928	peptide-Asp270+Thr-peptide	P		Leu	Glu	Asn	Asp	Thr	Arg	Ile	Ile	Lemaire et al., 2005	19665
vimentin	P08670	2-466	peptide-Asp258+Val-peptide	P		Ile	Asp	Val	Asp	Val	Ser	Lys	Pro	Nakanishi et al., 2001	3991