Substrates for peptidase C14.012: caspase-11

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Ile-Glu-His-Asp-NHMec			Ac-Ile-Glu-His-Asp-NHMec	S		Ile	Glu	His	Asp	AMC	-	-	-	Kang et al., 2000
Ac-Leu-Glu-Hisl-Asp-NHMec			Ac-Leu-Glu-Hisl-Asp-NHMec	S		Leu	Glu	His	Asp	AMC	-	-	-	Kang et al., 2000
Ac-Pro-Glu-His-Asp-NHMec			Ac-Pro-Glu-His-Asp-NHMec	S		Pro	Glu	His	Asp	AMC	-	-	-	Kang et al., 2000
Ac-Val-Glu-His-Asp-NHMec			Ac-Val-Glu-His-Asp-NHMec	S		Val	Glu	His	Asp	AMC	-	-	-	Kang et al., 2000
caspase-3 precursor	P70677	29-277	peptide-Asp175+Ser-peptide	P		Ile	Glu	Thr	Asp	Ser	Gly	Thr	Asp	Kang et al., 2000
caspase-3 precursor	P42574	1-277	peptide-Asp175+Ser-peptide	P		Ile	Glu	Thr	Asp	Ser	Gly	Val	Asp	Kang et al., 2000	20275
gasdermin-D	P57764	1-484	peptide-Asp275+Gly-peptide	P	MU	Phe	Leu	Thr	Asp	Gly	Val	Pro	Ala	Shi et al., 2015
presenilin 1	P49768	1-467	peptide-Asp333+Gly-peptide	P		Glu	Asn	Asp	Asp	Gly	Gly	Phe	Ser	van de Craen et al., 1999
presenilin 1	P49768	1-467	peptide-Asp345+Ser-peptide	P		Ala	Gln	Arg	Asp	Ser	His	Leu	Gly	van de Craen et al., 1999