Substrates for peptidase C14.007: caspase-4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Trp-Glu-His-Asp-NHMec			Ac-Trp-Glu-His-Asp+NHMec	S		Trp	Glu	His	Asp	AMC	-	-	-	Garcia-Calvo et al., 1999
Actin, cytoplasmic 1	P60709	1-375	Peptide-Asp51+Ser-Peptide	N	MS	Gly	Gln	Lys	Asp	Ser	Tyr	Val	Gly	Agard et al., 2010
Ataxin-2	Q99700	1-1313	Peptide-Asp416+Ser-Peptide	N	MS	Ser	Thr	Tyr	Asp	Ser	Ser	Leu	Ser	Agard et al., 2010
caspase-3 precursor	P42574	29-277	peptide-Asp175+Ser-peptide	P		Ile	Glu	Thr	Asp	Ser	Gly	Val	Asp	Kamada et al., 1997	4007
Caspase-9	P55211	1-416	Peptide-Asp315+Ala-Peptide	P	MU	Pro	Glu	Pro	Asp	Ala	Thr	Pro	Phe	Yamamuro et al., 2011
gasdermin-D	P57764	1-484	peptide-Asp275+Gly-peptide	P	MU	Phe	Leu	Thr	Asp	Gly	Val	Pro	Ala	Shi et al., 2015
interleukin-1 beta precursor	P01584	1-269	peptide-Asp116+Ala-peptide	P		Tyr	Val	His	Asp	Ala	Pro	Val	Arg	Kamens et al., 1995	4005
interleukin-1 beta precursor	P01584	1-269	peptide-Asp27+Gly-peptide	P		Phe	Glu	Ala	Asp	Gly	Pro	Lys	Gln	Kamens et al., 1995	4004
Interleukin-18 precursor	Q14116	1-193	peptide-Asp36+Tyr-peptide	P	AB	Leu	Glu	Ser	Asp	Tyr	Phe	Gly	Lys	Gaggero et al., 2004
spectrin alpha chain, brain	Q13813	1-2472	peptide-Asp1185+Ser-peptide	P		Asp	Glu	Thr	Asp	Ser	Lys	Thr	Ala	Nath et al., 1996
Splicing factor U2AF 65 kDa subunit	P26368	2-475	Peptide-Asp128+Gly-Peptide	N	MS	Met	Thr	Pro	Asp	Gly	Leu	Ala	Val	Agard et al., 2010