Substrates for peptidase C14.011: caspase-10

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Val-Glu-His-Asp-NHMec			Ac-Val-Glu-His-Asp-NHMec	S	Val	Glu	His	Asp	AMC	-	-	-	Garcia-Calvo et al., 1999
AKAP1 A-kinase anchor protein 1 precursor	Q92667	30-903	peptide-Asp582+Ser-peptide	P	Asp	Ser	Val	Asp	Ser	Cys	Cys	Ser	Yoo et al., 2008	21690
Bcl2 antagonist of cell death (BAD)	Q61337	1-204	peptide-Asp61+Arg-peptide	P	Ser	Ala	Thr	Asp	Arg	Gly	Leu	Gly	Condorelli et al., 2001
Bcl2 antagonist of cell death (BAD)	Q61337	1-204	peptide-Asp56+Ala-peptide	P	Glu	Gln	Glu	Asp	Ala	Ser	Ala	Thr	Condorelli et al., 2001
caspase-10 precursor	Q92851	1-521	peptide-Asp415+Ala-peptide	P	Ile	Glu	Ala	Asp	Ala	Leu	Asn	Pro	Srinivasula et al., 1996
caspase-10 precursor	Q92851	1-521	peptide-Asp219+Val-peptide	P	Ser	Gln	Thr	Asp	Val	Lys	Thr	Phe	Srinivasula et al., 1996	3955
caspase-3 precursor	P42574	1-277	peptide-Asp9+Ser-peptide	P	Asn	Ser	Val	Asp	Ser	Lys	Ser	Ile	Fernandes-Alnemri et al., 1996	3956
caspase-3 precursor	P42574	1-277	peptide-Asp175+Ser-peptide	P	Ile	Glu	Thr	Asp	Ser	Gly	Val	Asp	Fernandes-Alnemri et al., 1996
erythroid transcription factor	P15976	1-413	peptide-Asp125+Gly-peptide	P	Glu	Asp	Leu	Asp	Gly	Lys	Gly	Ser	Maria et al., 1999
eukaryotic translation initiation factor 2 subunit 1	P05198	2-315	peptide-Asp301+Gly-peptide	P	Ala	Glu	Val	Asp	Gly	Asp	Asp	Asp	Satoh et al., 1999	3954