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Substrates for peptidase S10.014: carboxypeptidase O

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Alpha-S1-casein P02662 209-212 Thr-Thr-Met211+Pro N AA - Thr Thr Met Pro - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 209-213 Thr-Thr-Met-Pro212+Leu N AA Thr Thr Met Pro Leu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 209-214 Thr-Met-Pro-Leu213+Trp N AA Thr Met Pro Leu Trp - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 58-73 Peptide-Ile72+Lys N AA Met Glu Asp Ile Lys - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 23-28 His-Gln-Gly-Leu-Pro+Gln N AA Gln Gly Leu Pro Gln - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 23-33 His-Gln-Gly-Leu-Pro-Gln-Glu-Val-Leu-Asn+Glu N AA Glu Val Leu Asn Glu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 23-34 His-Gln-Gly-Leu-Pro-Gln-Glu-Val-Leu-Asn-Glu+Asn N AA Val Leu Asn Glu Asn - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 151-163 Ile-Gly-Val-Asn-Gln-Glu-Leu-Ala-Tyr-Phe-Tyr-Pro+Glu N AA Tyr Phe Tyr Pro Glu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 151-166 Peptide-Phe165+Arg N AA Pro Glu Leu Phe Arg - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 38-48 Peptide-Phe47+Gly N AA Pro Glu Val Phe Gly - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 38-49 Peptide-Gly48+Lys N AA Glu Val Phe Gly Lys - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 119-133 Tyr-Lys-Val-Pro-Gln-Leu-Glu-Ile-Val-Pro-Asn-Ser-Ala-Glu+Glu N AA Asn Ser Ala Glu Glu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 58-65 Asp-Ile-Gly-Ser-Glu-Ser-Thr+Glu N AA Ser Glu Ser Thr Glu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 58-68 Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp-Gln+Ala N AA Thr Glu Asp Gln Ala - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 23-29 His-Gln-Gly-Leu-Pro-Gln+Glu N AA Gly Leu Pro Gln Glu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 23-35 His-Gln-Gly-Leu-Pro-Gln-Glu-Val-Leu-Asn-Glu-Asn+Leu N AA Leu Asn Glu Asn Leu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 151-156 Ile-Gly-Val-Asn-Gln+Glu N AA Gly Val Asn Gln Glu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 151-164 Ile-Gly-Val-Asn-Gln-Glu-Leu-Ala-Tyr-Phe-Tyr-Pro-Glu+Leu N AA Phe Tyr Pro Glu Leu - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 38-44 Phe-Phe-Val-Ala-Pro-Phe+Pro N AA Val Ala Pro Phe Pro - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 38-46 Phe-Phe-Val-Ala-Pro-Phe-Pro-Glu+Val N AA Pro Phe Pro Glu Val - - - Dal Degan et al., 1992
Alpha-S1-casein P02662 38-40 Phe-Phe+Val N AA - - Phe Phe Val - - - Dal Degan et al., 1992
alpha-S1-casein P02662 23-30 His-Gln-Gly-Leu-Pro-Gln-Glu+Val N Leu Pro Gln Glu Val - - - Dal Degan et al., 1992
alpha-S1-casein P02662 23-30 His-Gln-Gly-Leu-Pro-Gln-Glu+Val N AA Leu Pro Gln Glu Val - - - Dal Degan et al., 1992
alpha-S1-casein P02662 23-31 His-Gln-Gly-Leu-Pro-Gln-Glu-Val+Leu N AA Pro Gln Glu Val Leu - - - Dal Degan et al., 1992
alpha-S1-casein P02662 23-32 His-Gln-Gly-Leu-Pro-Gln-Glu-Val-Leu+Asn N AA Gln Glu Val Leu Asn - - - Dal Degan et al., 1992
alpha-S1-casein P02662 23-36 His-Gln-Gly-Leu-Pro-Gln-Glu-Val-Leu-Asn-Glu-Asn-Leu+Leu N AA Asn Glu Asn Leu Leu - - - Dal Degan et al., 1992
alpha-S1-casein P02662 23-37 His-Gln-Gly-Leu-Pro-Gln-Glu-Val-Leu-Asn-Glu-Asn-Leu-Leu+Arg N AA Glu Asn Leu Leu Arg - - - Dal Degan et al., 1992
alpha-S1-casein P02662 38-41 Phe-Phe-Val+Ala N AA - Phe Phe Val Ala - - - Dal Degan et al., 1992
alpha-S1-casein P02662 38-42 Phe-Phe-Val-Ala+Pro N AA Phe Phe Val Ala Pro - - - Dal Degan et al., 1992
alpha-S1-casein P02662 38-43 Phe-Phe-Val-Ala-Pro+Phe N AA Phe Val Ala Pro Phe - - - Dal Degan et al., 1992
alpha-S1-casein P02662 38-45 Phe-Phe-Val-Ala-Pro-Phe-Pro+Glu N AA Ala Pro Phe Pro Glu - - - Dal Degan et al., 1992
alpha-S1-casein P02662 38-47 Phe-Phe-Val-Ala-Pro-Phe-Pro-Glu-Val+Phe N AA Phe Pro Glu Val Phe - - - Dal Degan et al., 1992
alpha-S1-casein P02662 58-66 Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu+Asp N AA Glu Ser Thr Glu Asp - - - Dal Degan et al., 1992
alpha-S1-casein P02662 58-67 Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp+Gln N AA Ser Thr Glu Asp Gln - - - Dal Degan et al., 1992
alpha-S1-casein P02662 58-69 Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp-Gln-Ala+Met N AA Glu Asp Gln Ala Met - - - Dal Degan et al., 1992
alpha-S1-casein P02662 58-70 Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp-Gln-Ala-Met+Glu N AA Asp Gln Ala Met Glu - - - Dal Degan et al., 1992
alpha-S1-casein P02662 58-71 Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp-Gln-Ala-Met-Glu+Asp N AA Gln Ala Met Glu Asp - - - Dal Degan et al., 1992
alpha-S1-casein P02662 58-72 Asp-Ile-Gly-Ser-Glu-Ser-Thr-Glu-Asp-Gln-Ala-Met-Glu-Asp+Ile N AA Ala Met Glu Asp Ile - - - Dal Degan et al., 1992
alpha-S1-casein P02662 119-134 Tyr-Lys-Val-Pro-Gln-Leu-Glu-Ile-Val-Pro-Asn-Ser-Ala-Glu-Glu+Arg N AA Ser Ala Glu Glu Arg - - - Dal Degan et al., 1992
alpha-S1-casein P02662 119-132 Tyr-Lys-Val-Pro-Gln-Leu-Glu-Ile-Val-Pro-Asn-Ser-Ala+Glu N AA Pro Asn Ser Ala Glu - - - Dal Degan et al., 1992
alpha-S1-casein P02662 119-131 Tyr-Lys-Val-Pro-Gln-Leu-Glu-Ile-Val-Pro-Asn-Ser+Ala N AA Val Pro Asn Ser Ala - - - Dal Degan et al., 1992
alpha-S1-casein P02662 151-157 Ile-Gly-Val-Asn-Gln-Glu+Leu N AA Val Asn Gln Glu Leu - - - Dal Degan et al., 1992
alpha-S1-casein P02662 151-158 Ile-Gly-Val-Asn-Gln-Glu-Leu+Ala N AA Asn Gln Glu Leu Ala - - - Dal Degan et al., 1992
alpha-S1-casein P02662 151-159 Ile-Gly-Val-Asn-Gln-Glu-Leu-Ala+Tyr N AA Gln Glu Leu Ala Tyr - - - Dal Degan et al., 1992
alpha-S1-casein P02662 151-160 Ile-Gly-Val-Asn-Gln-Glu-Leu-Ala-Tyr+Phe N AA Glu Leu Ala Tyr Phe - - - Dal Degan et al., 1992
alpha-S1-casein P02662 151-161 Ile-Gly-Val-Asn-Gln-Glu-Leu-Ala-Tyr-Phe+Tyr N AA Leu Ala Tyr Phe Tyr - - - Dal Degan et al., 1992
alpha-S1-casein P02662 151-162 Ile-Gly-Val-Asn-Gln-Glu-Leu-Ala-Tyr-Phe-Tyr+Pro N AA Ala Tyr Phe Tyr Pro - - - Dal Degan et al., 1992
alpha-S1-casein P02662 151-165 Ile-Gly-Val-Asn-Gln-Glu-Leu-Ala-Tyr-Phe-Tyr-Pro-Glu-Leu+Phe N AA Tyr Pro Glu Leu Phe - - - Dal Degan et al., 1992
Bz-Arg-OMe Bz-Arg+OMe S - - Bz Arg OMe - - - Dal Degan et al., 1992
Bz-His-OMe Bz-His+OMe S - - Bz His OMe - - - Dal Degan et al., 1992
Bz-Lys-OMe Bz-Lys+OMe S - - Bz Lys OMe - - - Dal Degan et al., 1992
Bz-Met-OMe Bz-Met+OMe S - - Bz Met OMe - - - Dal Degan et al., 1992
Bz-Phe-OMe Bz-Phe+OMe S - - Bz Phe OMe - - - Dal Degan et al., 1992
Eledoisin P62933 7-11 Phe-Ile-Gly-Leu10+Met-NH2 N AA Phe Ile Gly Leu Met NH2 - - Lee et al., 1993
FA-Phe-Ala FA-Phe+Ala S - - FA Phe Ala - - - Dal Degan et al., 1992
FA-Phe-OMe FA-Phe+OMe S - - FA Phe OMe - - - Dal Degan et al., 1992
Gastrin P01350 89-92 Trp-Met-Asp91+Phe-NH2 N AA - Trp Met Asp Phe NH2 - - Lee et al., 1993
Glucagon P01275 53-76 Peptide-Val75+Gln N AA Gln Asp Phe Val Gln - - - Dal Degan et al., 1992
Glucagon P01275 53-77 Peptide-Gln76+Trp N AA Asp Phe Val Gln Trp - - - Dal Degan et al., 1992
Glucagon P01275 53-78 Peptide-Trp77+Leu N AA Phe Val Gln Trp Leu - - - Dal Degan et al., 1992
glucagon P01275 53-81 peptide-Asn80+Thr N AA Trp Leu Met Asn Thr - - - Dal Degan et al., 1992
glucagon P01275 53-80 peptide-Met79+Asn N AA Gln Trp Leu Met Asn - - - Dal Degan et al., 1992
glucagon P01275 53-79 peptide-Leu78+Met N AA Val Gln Trp Leu Met - - - Dal Degan et al., 1992
glucagon P01275 53-75 peptide-Phe74+Val N AA Ala Gln Asp Phe Val - - - Dal Degan et al., 1992
glucagon P01275 53-74 peptide-Asp73+Phe N AA Arg Ala Gln Asp Phe - - - Dal Degan et al., 1992
glucagon P01275 53-73 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala+Asp-peptide N AA Arg Arg Ala Gln Asp - - - Dal Degan et al., 1992
glucagon P01275 53-72 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala+Gln N AA Ser Arg Arg Ala Gln - - - Dal Degan et al., 1992
glucagon P01275 53-71 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg+Ala N AA Asp Ser Arg Arg Ala - - - Dal Degan et al., 1992
glucagon P01275 53-70 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg+Arg N AA Leu Asp Ser Arg Arg - - - Dal Degan et al., 1992
glucagon P01275 53-69 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser+Arg N AA Tyr Leu Asp Ser Arg - - - Dal Degan et al., 1992
glucagon P01275 53-68 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp+Ser N AA Lys Tyr Leu Asp Ser - - - Dal Degan et al., 1992
glucagon P01275 53-67 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu+Asp N AA Ser Lys Tyr Leu Asp - - - Dal Degan et al., 1992
glucagon P01275 53-66 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr+Leu N AA Tyr Ser Lys Tyr Leu - - - Dal Degan et al., 1992
glucagon P01275 53-65 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys+Tyr N AA Asp Tyr Ser Lys Tyr - - - Dal Degan et al., 1992
glucagon P01275 53-64 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser+Lys N AA Ser Asp Tyr Ser Lys - - - Dal Degan et al., 1992
glucagon P01275 53-63 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr+Ser N AA Thr Ser Asp Tyr Ser - - - Dal Degan et al., 1992
glucagon P01275 53-62 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp+Tyr N AA Phe Thr Ser Asp Tyr - - - Dal Degan et al., 1992
Insulin B chain (oxidized) P01317 25-45 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly+Glu N AA Leu Val Cys Gly Glu - - - Dal Degan et al., 1992
Insulin B chain (oxidized) P01317 25-46 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu+Arg N AA Val Cys Gly Glu Arg - - - Dal Degan et al., 1992
Insulin B chain (oxidized) P01317 25-47 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg+Gly N AA Cys Gly Glu Arg Gly - - - Dal Degan et al., 1992
Insulin B chain (oxidized) P01317 25-48 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly+Phe N AA Gly Glu Arg Gly Phe - - - Dal Degan et al., 1992
Z-Ala-Ala Z-Ala+Ala S - - Z Ala Ala - - - Dal Degan et al., 1992
Z-Ala-Arg Z-Ala+Arg S - - Z Ala Arg - - - Dal Degan et al., 1992
Z-Ala-Asp Z-Ala+Asp S - - Z Ala Asp - - - Dal Degan et al., 1992
Z-Ala-Ile Z-Ala+Ile S - - Z Ala Ile - - - Dal Degan et al., 1992
Z-Ala-Leu Z-Ala+Leu S - - Z Ala Leu - - - Dal Degan et al., 1992
Z-Ala-Lys Z-Ala+Lys S - - Z Ala Lys - - - Dal Degan et al., 1992
Z-Ala-Met Z-Ala+Met S - - Z Ala Met - - - Dal Degan et al., 1992
Z-Ala-Phe Z-Ala+Phe S - - Z Ala Phe - - - Dal Degan et al., 1992
Z-Ala-Val Z-Ala+Val S - - Z Ala Val - - - Dal Degan et al., 1992

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