Substrates for peptidase M12.178: brevilysin L6

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
gonadoliberin-1 P01148 24-33 Glp-His-Trp-Ser-Tyr+Gly-Leu-Arg-Pro-Gly-NH2 N His Ser Trp Tyr Gly Leu Arg Pro Komori & Nikai, 2004
gonadoliberin-1 P01148 24-33 Glp-His-Trp-Ser-Tyr+Gly-Leu-Arg-Pro-Gly-NH2 N His Trp Ser Tyr Gly Leu Arg Pro Komori & Nikai, 2004
insulin A chain (oxidized) P01317 85-105 Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser-Leu-Tyr+Gln-Leu-Glu-Asn-Tyr-Cya-Asn N Cya Ser Leu Tyr Gln Leu Glu Asn Komori & Nikai, 2004
insulin A chain (oxidized) P01317 85-105 Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser+Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn N Ser Val Cya Ser Leu Tyr Gln Leu Komori & Nikai, 2004
insulin A chain (oxidized) P01317 85-105 Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser+Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cya-Asn N Ser Val Cya Ser Leu Tyr Gln Leu Komori & Nikai, 2004
insulin A chain (oxidized) P01317 85-105 Gly-Ile-Val-Glu-Gln-Cya-Cya-Ala-Ser-Val-Cya-Ser-Leu-Tyr+Gln-Leu-Glu-Asn-Tyr-Cya-Asn N Cya Ser Leu Tyr Gln Leu Glu Asn Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln+His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Phe Val Asn Gln His Leu Cya Gly Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser+His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Cya Gly Ser His Leu Val Glu Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+LeuTyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln+His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Phe Val Asn Gln His Leu Cya Gly Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser+His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Cya Gly Ser His Leu Val Glu Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Ser His Leu Val Glu Ala Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Komori & Nikai, 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Glu Ala Leu Tyr Leu Val Cya Gly Komori & Nikai, 2004