Substrates for peptidase C15.010: pyroglutamyl-peptidase I (chordate)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Glp-NHMec Glp+NHMec S - - - Glp AMC - - - Dando et al., 2003
Glp-NHNap Glp+NHNap S - - - Glp NAP - - - De Gandarias et al., 1994
Glp-NHPhNO2 Glp+NHPhNO2 S - - - Glp NAN - - -
gonadoliberin-1 P01148 24-33 Glp+His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 N - - - Glp His Trp Ser Tyr De Gandarias et al., 1994
neurotensin P30990 151-163 Glp+Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu N - - - Glp Leu Tyr Glu Asn De Gandarias et al., 1994
thyroliberin Glp+His-Pro N - - - Glp His Pro - - De Gandarias et al., 1994