Substrates for peptidase S01.229: mannan-binding lectin-associated serine peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
complement C4 precursor	P08649	20-1737	peptide-Arg753+Ala-peptide	P		Gly	Leu	Ala	Arg	Ala	Gln	Asp	Met	Chen & Wallis, 2004	19511
complement component C2	P06681	21-752	peptide-Arg223+Lys224-peptide	P		Ser	Leu	Gly	Arg	Lys	Ile	Gln	Ile	Matsushita et al., 2000	17421
complement component C4	P0C0L4	20-1744	peptide-Arg76+Ala77-peptide	P		Gly	Leu	Gln	Arg	Ala	Leu	Glu	Ile	Matsushita et al., 2000	17422
mannan-binding lectin serine protease 2	O00187	1-686	peptide-Lys290+Ile-peptide	P	NT	Thr	Gly	Trp	Lys	Ile	His	Tyr	Thr	Ambrus et al., 2003
MASP2	O00187	16-686	peptide-Arg444+Ile-peptide	P		Thr	Gly	Gly	Arg	Ile	Tyr	Gly	Gly	Gal et al., 2005	18850
Plasma protease C1 inhibitor	P05155	23-500	peptide-Arg466+Thr-peptide	P		Ser	Val	Ala	Arg	Thr	Leu	Leu	Val	Duncan et al., 2008	20317
thrombin precursor	P00734	44-622	peptide-Arg327+Thr-peptide	P	NT	Phe	Asn	Pro	Arg	Thr	Phe	Gly	Ser	Krarup et al., 2007
Z-Lys-OPhNO2 (ZLNE)			Z-Lys+OPhNO2	S		-	-	Z	Lys	Ona	-	-	-	Chen & Wallis, 2004