Literature for peptidase S01.229: mannan-binding lectin-associated serine peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, R Splicing, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Bongoni,A.K., Kiss,B., McRae,J.L., Salvaris,E.J., Fisicaro,N., Muntz,F., Nemeth,B.Z., Nagy,Z.A., Kocsis,A., Gal,P., Cowan,P.J. and Pal,G. Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury Proc Natl Acad Sci U S A (2025) 122, e2424754122-e2424754122. PubMed Europe PubMed DOI
Cao,Y., Zhou,Y. and Jia,T. [Study on the correlation between MASP-2 and diseases] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2025) 41, 661-666. PubMed Europe PubMed
Nakhla,M.C., Comita,J., Shapiro,A.B., Moussa,S.H., Chen,A., Eyermann,C.J., O'Donnell,J.P., Miller,A.A. and Granger,B.A. Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3 Eur J Med Chem (2025) 289, 117238-117238. PubMed Europe PubMed DOI

2024

Rosbjerg,A., Plchova,T.A., Bayarri-Olmos,R., Holm,B.E., Pedersen,I.S., Skjoedt,M.O. and Garred,P. C1q/MASP Complexes-Hybrid Complexes of Classical and Lectin Pathway Proteins Are Found in the Circulation J Immunol (2024) PubMed Europe PubMed DOI

2022

Aghamohammadi,A., Rafatpanah,H., Maghsoodlu,M., Tohidi,N., Mollahosseini,F. and Shahabi,M. Mannose binding lectin-associated serine protease 2 (MASP2) gene polymorphism and susceptibility to human T-lymphotropic virus type 1 (HTLV-1) infection in blood donors from Mashhad, Iran Microbiol Immunol (2022) 66, 460-464. PubMed Europe PubMed DOI
Gotz,M.P., Skjoedt,M.O., Bayarri-Olmos,R., Hansen,C.B., Perez-Alos,L., Jarlhelt,I., Benfield,T., Rosbjerg,A. and Garred,P. Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19 J Innate Immun (2022) , 1-14. PubMed Europe PubMed DOI
Nagy,Z.A., Heja,D., Bencze,D., Kiss,B., Boros,E., Szakacs,D., Fodor,K., Wilmanns,M., Kocsis,A., Dobo,J., Gal,P., Harmat,V. and Pal,G. Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation J Biol Chem (2022) 298, 101985-101985. PubMed Europe PubMed DOI PMC EPMC
Wu,F.W.B., Chen,Y.Y., Huang,J.X., Wang,K.Y., Xu,H.S. and Lin,D. Significance of Mannan Binding Lectin-Associated Serine Protease 2 in Urinary Extracellular Vesicles in IgA Nephropathy Clin Invest Med (2022) 45, E47-E54. PubMed Europe PubMed DOI
Zachar,R., Thiel,S., Hansen,S., Henriksen,M.L., Skjoedt,M.O., Skjodt,K., Hamzaei,Z., Madsen,K., Lund,L., Hummler,E., Svenningsen,P. and Jensen,B.L. Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel Sci Rep (2022) 12, 15955-15955. PubMed Europe PubMed DOI PMC EPMC

2021

Flude,B.M., Nannetti,G., Mitchell,P., Compton,N., Richards,C., Heurich,M., Brancale,A., Ferla,S. and Bassetto,M. Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections Viruses (2021) 13 PubMed Europe PubMed DOI PMC EPMC
Pihl,R., Jensen,R.K., Poulsen,E.C., Jensen,L., Hansen,A.G., Thogersen,I.B., Dobo,J., Gal,P., Andersen,G.R., Enghild,J.J. and Thiel,S. ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism Sci Adv (2021) 7 PubMed Europe PubMed DOI PMC EPMC

2020

Cedzynski,M. and Swierzko,A.S. Components of the Lectin Pathway of Complement in Haematologic Malignancies Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI
Fuentes-Prior,P. Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection J Biol Chem (2020) PubMed Europe PubMed DOI V
Mercurio,D., Oggioni,M., Fumagalli,S., Lynch,N.J., Roscher,S., Minuta,D., Perego,C., Ippati,S., Wallis,R., Schwaeble,W.J. and De Simoni,M.G. Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role Acta Neuropathol Commun (2020) 8, 174-174. PubMed Europe PubMed DOI PMC EPMC
Talsma,D.T., Poppelaars,F., Dam,W., Meter-Arkema,A.H., Vives,R.R., Gal,P., Boons,G.J., Chopra,P., Naggi,A., Seelen,M.A., Berger,S.P., Daha,M.R., Stegeman,C.A. and Van den Born,J. MASP-2 is a heparin-binding protease; identification of blocking oligosaccharides Front Immunol (2020) 11, 732-732. PubMed Europe PubMed DOI PMC EPMC

2019

Bibert,S., Piret,J., Quinodoz,M., Collinet,E., Zoete,V., Michielin,O., Menasria,R., Meylan,P., Bihl,T., Erard,V., Fellmann,F., Rivolta,C., Boivin,G. and Bochud,P.Y. Herpes simplex encephalitis in adult patients with MASP-2 deficiency PLoS Pathog (2019) 15, e1008168-e1008168. PubMed Europe PubMed DOI M
Szakacs,D., Kocsis,A., Szasz,R., Gal,P. and Pal,G. Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors J Biol Chem (2019) 294, 8227-8237. PubMed Europe PubMed DOI

2017

Yaseen,S., Demopulos,G., Dudler,T., Yabuki,M., Wood,C.L., Cummings,W.J., Tjoelker,L.W., Fujita,T., Sacks,S., Garred,P., Andrew,P., Sim,R.B., Lachmann,P.J., Wallis,R., Lynch,N. and Schwaeble,W.J. Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2 FASEB J (2017) 31, 2210-2219. PubMed Europe PubMed DOI

2016

Dobo,J., Pal,G., Cervenak,L. and Gal,P. The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond Immunol Rev (2016) 274, 98-111. PubMed Europe PubMed DOI
Orsini,F., Chrysanthou,E., Dudler,T., Cummings,W.J., Takahashi,M., Fujita,T., Demopulos,G., De Simoni,M.G. and Schwaeble,W. Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1 J Neuroinflammation (2016) 13, 213-213. PubMed Europe PubMed DOI PMC EPMC

2015

Keizer,M.P., Pouw,R.B., Kamp,A.M., Patiwael,S., Marsman,G., Hart,M.H., Zeerleder,S., Kuijpers,T.W. and Wouters,D. TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2 Eur J Immunol (2015) 45, 544-550. PubMed Europe PubMed DOI

2014

Asgari,E., Farrar,C.A., Lynch,N., Ali,Y.M., Roscher,S., Stover,C., Zhou,W., Schwaeble,W.J. and Sacks,S.H. Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4 FASEB J (2014) 28, 3996-4003. PubMed Europe PubMed DOI

2012

Duncan,R.C., Bergstrom,F., Coetzer,T.H., Blom,A.M., Wijeyewickrema,L.C. and Pike,R.N. Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4 Mol Immunol (2012) 49, 593-600. PubMed Europe PubMed DOI
Heja,D., Harmat,V., Fodor,K., Wilmanns,M., Dobo,J., Kekesi,K.A., Zavodszky,P., Gal,P. and Pal,G. Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2 J Biol Chem (2012) 287, 20290-20300. PubMed Europe PubMed DOI
Schwaeble,W.J., Lynch,N.J., Gal,P. and Zavodszky,P. Mannan-binding lectin-associated serine proteases [ISSN:978-0-12-407742-3] (2012) 3, 2857-2863. DOI
Yongqing,T., Drentin,N., Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N. Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions? Biochim Biophys Acta (2012) 1824, 253-262. PubMed Europe PubMed DOI V R

2011

Boldt,A.B., Grisbach,C., Steffensen,R., Thiel,S., Kun,J.F., Jensenius,J.C. and Messias-Reason,I.J. Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels Hum Immunol (2011) 72, 753-760. PubMed Europe PubMed DOI M
Degn,S.E., Thiel,S., Nielsen,O., Hansen,A.G., Steffensen,R. and Jensenius,J.C. MAp19, the alternative splice product of the MASP2 gene J Immunol Methods (2011) 373, 89-101. PubMed Europe PubMed DOI
Schwaeble,W.J., Lynch,N.J., Clark,J.E., Marber,M., Samani,N.J., Ali,Y.M., Dudler,T., Parent,B., Lhotta,K., Wallis,R., Farrar,C.A., Sacks,S., Lee,H., Zhang,M., Iwaki,D., Takahashi,M., Fujita,T., Tedford,C.E. and Stover,C.M. Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury Proc Natl Acad Sci U S A (2011) 108, 7523-7528. PubMed Europe PubMed DOI PMC EPMC K
Takahashi,K., Chang,W.C., Takahashi,M., Pavlov,V., Ishida,Y., La Bonte,L., Shi,L., Fujita,T., Stahl,G.L. and Van Cott,E.M. Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation Immunobiology (2011) 216, 96-102. PubMed Europe PubMed DOI

2010

Gulla,K.C., Gupta,K., Krarup,A., Gal,P., Schwaeble,W.J., Sim,R.B., O'Connor,C.D. and Hajela,K. Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot Immunology (2010) 129, 482-495. PubMed Europe PubMed DOI
Kocsis,A., Kekesi,K.A., Szasz,R., Vegh,B.M., Balczer,J., Dobo,J., Zavodszky,P., Gal,P. and Pal,G. Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation J Immunol (2010) 185, 4169-4178. PubMed Europe PubMed DOI I
Skjoedt,M.O., Hummelshoj,T., Palarasah,Y., Honore,C., Koch,C., Skjodt,K. and Garred,P. A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation J Biol Chem (2010) 285, 8234-8243. PubMed Europe PubMed DOI PMC EPMC

2009

Degn,S.E., Hansen,A.G., Steffensen,R., Jacobsen,C., Jensenius,J.C. and Thiel,S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation J Immunol (2009) 183, 7371-7378. PubMed Europe PubMed DOI
Gal,P., Dobo,J., Zavodszky,P. and Sim,R.B. Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions Mol Immunol (2009) 46, 2745-2752. PubMed Europe PubMed DOI V
Thiel,S., Kolev,M., Degn,S., Steffensen,R., Hansen,A.G., Ruseva,M. and Jensenius,J.C. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity J Immunol (2009) 182, 2939-2947. PubMed Europe PubMed DOI M

2008

Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N. The initiating proteases of the complement system: controlling the cleavage Biochimie (2008) 90, 387-395. PubMed Europe PubMed DOI V
Kerr,F.K., Thomas,A.R., Wijeyewickrema,L.C., Whisstock,J.C., Boyd,S.E., Kaiserman,D., Matthews,A.Y., Bird,P.I., Thielens,N.M., Rossi,V. and Pike,R.N. Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor Mol Immunol (2008) 45, 670-677. PubMed Europe PubMed DOI P

2007

Gal,P., Barna,L., Kocsis,A. and Zavodszky,P. Serine proteases of the classical and lectin pathways: similarities and differences Immunobiology (2007) 212, 267-277. PubMed Europe PubMed DOI V
Girija,U.V., Dodds,A.W., Roscher,S., Reid,K.B. and Wallis,R. Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins J Immunol (2007) 179, 455-462. PubMed Europe PubMed PMC EPMC
Krarup,A., Wallis,R., Presanis,J.S., Gal,P. and Sim,R.B. Simultaneous activation of complement and coagulation by MBL-associated serine protease 2 PLoS ONE (2007) 2, e623-e623. PubMed Europe PubMed DOI PMC EPMC
Moller-Kristensen,M., Thiel,S., Sjoholm,A., Matsushita,M. and Jensenius,J.C. Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway Int Immunol (2007) 19, 141-149. PubMed Europe PubMed DOI
Schlapbach,L.J., Aebi,C., Otth,M., Leibundgut,K., Hirt,A. and Ammann,R.A. Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients Pediatr Infect Dis J (2007) 26, 989-994. PubMed Europe PubMed DOI M
Sorensen,G.L., Petersen,I., Thiel,S., Fenger,M., Christensen,K., Kyvik,K.O., Sorensen,T.I., Holmskov,U. and Jensenius,J.C. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity Genet Epidemiol (2007) 31, 31-41. PubMed Europe PubMed DOI M
Takahashi,M., Mori,S., Shigeta,S. and Fujita,T. Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway Adv Exp Med Biol (2007) 598, 93-104. PubMed Europe PubMed DOI V
Thiel,S., Steffensen,R., Christensen,I.J., Ip,W.K., Lau,Y.L., Reason,I.J., Eiberg,H., Gadjeva,M., Ruseva,M. and Jensenius,J.C. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms Genes Immun (2007) 8, 154-163. PubMed Europe PubMed DOI M
Unterberger,C., Hanson,S., Klingenhoff,A., Oesterle,D., Frankenberger,M., Endo,Y., Matsushita,M., Fujita,T., Schwaeble,W., Weiss,E.H., Ziegler-Heitbrock,L. and Stover,C. Stat3 is involved in control of MASP2 gene expression Biochem Biophys Res Commun (2007) 364, 1022-1025. PubMed Europe PubMed DOI
Wallis,R., Dodds,A.W., Mitchell,D.A., Sim,R.B., Reid,K.B. and Schwaeble,W.J. Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway J Biol Chem (2007) 282, 7844-7851. PubMed Europe PubMed DOI

2006

Granell,M., Urbano-Ispizua,A., Suarez,B., Rovira,M., Fernandez-Aviles,F., Martinez,C., Ortega,M., Uriburu,C., Gaya,A., Roncero,J.M., Navarro,A., Carreras,E., Mensa,J., Vives,J., Rozman,C., Montserrat,E. and Lozano,F. Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneic stem cell transplantation Exp Hematol (2006) 34, 1435-1441. PubMed Europe PubMed DOI M
[YEAR:15-10-2006]Nakao,M., Kajiya,T., Sato,Y., Somamoto,T., Kato-Unoki,Y., Matsushita,M., Nakata,M., Fujita,T. and Yano,T. Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio) J Immunol (15-10-2006) 177, 5471-5479. PubMed Europe PubMed
[YEAR:11-10-2006]Olesen,H.V., Jensenius,J.C., Steffensen,R., Thiel,S. and Schiotz,P.O. The mannan-binding lectin pathway and lung disease in cystic fibrosis - disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier Clin Immunol (11-10-2006) 121, 324-331. PubMed Europe PubMed DOI M

2005

[YEAR:21-7-2005]Gal,P., Harmat,V., Kocsis,A., Bian,T., Barna,L., Ambrus,G., Vegh,B., Balczer,J., Sim,R.B., Naray-Szabo,G. and Zavodszky,P. A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations J Biol Chem (21-7-2005) 280, 33435-33444. PubMed Europe PubMed DOI S
Iwaki,D. and Fujita,T. Production and purification of recombinants of mouse MASP-2 and sMAP J Endotoxin Res (2005) 11, 47-50. PubMed Europe PubMed DOI
Lozano,F., Suarez,B., Munoz,A., Jensenius,J.C., Mensa,J., Vives,J. and Horcajada,J.P. Novel MASP2 variants detected among North African and Sub-Saharan individuals Tissue Antigens (2005) 66, 131-135. PubMed Europe PubMed DOI M
[YEAR:14-10-2005]Rossi,V., Teillet,F., Thielens,N.M., Bally,I. and Arlaud,G.J. Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules J Biol Chem (14-10-2005) 280, 41811-41818. PubMed Europe PubMed DOI
Stover,C., Barrett,S., Lynch,N.J., Barker,J.N., Burden,D., Trembath,R., Schwaeble,W. and Veal,C. Functional MASP2 single nucleotide polymorphism plays no role in psoriasis Br J Dermatol (2005) 152, 1313-1315. PubMed Europe PubMed DOI

2004

[YEAR:18-6-2004]Chen,C.B. and Wallis,R. Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases J Biol Chem (18-6-2004) 279, 26058-26065. PubMed Europe PubMed DOI
[YEAR:1-10-2004]Harmat,V., Gal,P., Kardos,J., Szilagyi,K., Ambrus,G., Vegh,B., Naray-Szabo,G. and Zavodszky,P. The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions J Mol Biol (1-10-2004) 342, 1533-1546. PubMed Europe PubMed DOI S
Presanis,J.S., Hajela,K., Ambrus,G., Gal,P. and Sim,R.B. Differential substrate and inhibitor profiles for human MASP-1 and MASP-2 Mol Immunol (2004) 40, 921-929. PubMed Europe PubMed DOI
Schwaeble,W.J., Stover,C. and Reid,K.B.M. Mannan-binding lectin-associated serine proteases [ISSN:0-12-079610-4] (2004) 2, 1623-1627. V

2003

[YEAR:1-2-2003]Ambrus,G., Gal,P., Kojima,M., Szilagyi,K., Balczer,J., Antal,J., Graf,L., Laich,A., Moffatt,B.E., Schwaeble,W., Sim,R.B. and Zavodszky,P. Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments J Immunol (1-2-2003) 170, 1374-1382. PubMed Europe PubMed
[YEAR:15-5-2003]Feinberg,H., Uitdehaag,J.C., Davies,J.M., Wallis,R., Drickamer,K. and Weis,W.I. Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2 EMBO J (15-5-2003) 22, 2348-2359. PubMed Europe PubMed DOI PMC EPMC S
Moller-Kristensen,M., Jensenius,J.C., Jensen,L., Thielens,N., Rossi,V., Arlaud,G. and Thiel,S. Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals J Immunol Methods (2003) 282, 159-167. PubMed Europe PubMed DOI
Presanis,J.S., Kojima,M. and Sim,R.B. Biochemistry and genetics of mannan-binding lectin (MBL) Biochem Soc Trans (2003) 31, 748-752. PubMed Europe PubMed DOI
[YEAR:7-8-2003]Stengaard-Pedersen,K., Thiel,S., Gadjeva,M., Moller-Kristensen,M., Sorensen,R., Jensen,L.T., Sjoholm,A.G., Fugger,L. and Jensenius,J.C. Inherited deficiency of mannan-binding lectin-associated serine protease 2 N Engl J Med (7-8-2003) 349, 554-560. PubMed Europe PubMed DOI

2002

[YEAR:15-11-2002]Cseh,S., Vera,L., Matsushita,M., Fujita,T., Arlaud,G.J. and Thielens,N.M. Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2 J Immunol (15-11-2002) 169, 5735-5743. PubMed Europe PubMed
Endo,Y., Takahashi,M., Kuraya,M., Matsushita,M., Stover,C.M., Schwaeble,W.J. and Fujita,T. Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter Int Immunol (2002) 14, 1193-1201. PubMed Europe PubMed
Fujita,T. Evolution of the lectin-complement pathway and its role in innate immunity Nat Rev Immunol (2002) 2, 346-353. PubMed Europe PubMed DOI
Hajela,K., Kojima,M., Ambrus,G., Wong,K.H., Moffatt,B.E., Ferluga,J., Hajela,S., Gal,P. and Sim,R.B. The biological functions of MBL-associated serine proteases (MASPs) Immunobiology (2002) 205, 467-475. PubMed Europe PubMed
[YEAR:15-10-2002]Neth,O., Jack,D.L., Johnson,M., Klein,N.J. and Turner,M.W. Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus J Immunol (15-10-2002) 169, 4430-4436. PubMed Europe PubMed
Nonaka,M. and Miyazawa,S. Evolution of the initiating enzymes of the complement system Genome Biol (2002) 3, REVIEWS1001-REVIEWS1001. PubMed Europe PubMed PMC EPMC
Schwaeble,W., Dahl,M.R., Thiel,S., Stover,C. and Jensenius,J.C. The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes Immunobiology (2002) 205, 455-466. PubMed Europe PubMed DOI R

2001

[YEAR:13-7-2001]Chen,C.B. and Wallis,R. Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation J Biol Chem (13-7-2001) 276, 25894-25902. PubMed Europe PubMed DOI
Nakao,M., Osaka,K., Kato,Y., Fujiki,K. and Yano,T. Molecular cloning of the complement C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio) Immunogenetics (2001) 52, 255-263. PubMed Europe PubMed DOI
[YEAR:2-11-2001]Rossi,V., Cseh,S., Bally,I., Thielens,N.M., Jensenius,J.C. and Arlaud,G.J. Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and-2 J Biol Chem (2-11-2001) 276, 40880-40887. PubMed Europe PubMed DOI
Stover,C., Endo,Y., Takahashi,M., Lynch,N.J., Constantinescu,C., Vorup-Jensen,T., Thiel,S., Friedl,H., Hankeln,T., Hall,R., Gregory,S., Fujita,T. and Schwaeble,W. The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3 Genes Immun (2001) 2, 119-127. PubMed Europe PubMed DOI
[YEAR:15-4-2001]Thielens,N.M., Cseh,S., Thiel,S., Vorup-Jensen,T., Rossi,V., Jensenius,J.C. and Arlaud,G.J. Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL J Immunol (15-4-2001) 166, 5068-5077. PubMed Europe PubMed

2000

[YEAR:1-3-2000]Matsushita,M., Endo,Y. and Fujita,T. Cutting edge: Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease J Immunol (1-3-2000) 164, 2281-2284. PubMed Europe PubMed
[YEAR:1-9-2000]Matsushita,M., Thiel,S., Jensenius,J.C., Terai,I. and Fujita,T. Proteolytic activities of two types of mannose-binding lectin-associated serine protease J Immunol (1-9-2000) 165, 2637-2642. PubMed Europe PubMed
Sim,R.B. and Laich,A. Serine proteases of the complement system Biochem Soc Trans (2000) 28, 545-550. PubMed Europe PubMed
[YEAR:6-10-2000]Wallis,R. and Dodd,R.B. Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations J Biol Chem (6-10-2000) 275, 30962-30969. PubMed Europe PubMed DOI

1999

Stover,C.M., Schwaeble,W.J., Lynch,N.J., Thiel,S. and Speicher,M.R. Assignment of the gene encoding mannan-binding lectin-associated serine protease 2 (MASP2) to human chromosome 1p36.3 - >p36.2 by in situ hybridization and somatic cell hybrid analysis Cytogenet Cell Genet (1999) 84, 148-149. PubMed Europe PubMed
[YEAR:15-12-1999]Stover,C.M., Thiel,S., Lynch,N.J. and Schwaeble,W.J. The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement J Immunol (15-12-1999) 163, 6848-6859. PubMed Europe PubMed
Takahashi,M., Endo,Y., Fujita,T. and Matsushita,M. A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway Int Immunol (1999) 11, 859-863. PubMed Europe PubMed DOI
Wong,N.K., Kojima,M., Dobo,J., Ambrus,G. and Sim,R.B. Activities of the MBL-associated serine proteases (MASPs) and their regulation by natural inhibitors Mol Immunol (1999) 36, 853-861. PubMed Europe PubMed DOI

1998

Vorup-Jensen,T., Jensenius,J.C. and Thiel,S. MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway Immunobiology (1998) 199, 348-357. PubMed Europe PubMed DOI

1997

Thiel,S., Vorup-Jensen,T., Stover,C.M., Schwaeble,W., Laursen,S.B., Poulsen,K., Willis,A.C., Eggleton,P., Hansen,S., Holmskov,U., Reid,K.B. and Jensenius,J.C. A second serine protease associated with mannan-binding lectin that activates complement Nature (1997) 386, 506-510. PubMed Europe PubMed DOI