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Literature for peptidase S01.229: mannan-binding lectin-associated serine peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, R Splicing, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bongoni,A.K., Kiss,B., McRae,J.L., Salvaris,E.J., Fisicaro,N., Muntz,F., Nemeth,B.Z., Nagy,Z.A., Kocsis,A., Gal,P., Cowan,P.J. and Pal,G.
    Targeting the complement lectin pathway with a highly specific MASP-2 inhibitor protects against renal ischemia-reperfusion injury
    Proc Natl Acad Sci U S A (2025) 122, e2424754122-e2424754122. PubMed  Europe PubMed DOI
  2. Cao,Y., Zhou,Y. and Jia,T.
    [Study on the correlation between MASP-2 and diseases]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2025) 41, 661-666. PubMed  Europe PubMed
  3. Nakhla,M.C., Comita,J., Shapiro,A.B., Moussa,S.H., Chen,A., Eyermann,C.J., O'Donnell,J.P., Miller,A.A. and Granger,B.A.
    Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3
    Eur J Med Chem (2025) 289, 117238-117238. PubMed  Europe PubMed DOI
    4. 2024
  4. Rosbjerg,A., Plchova,T.A., Bayarri-Olmos,R., Holm,B.E., Pedersen,I.S., Skjoedt,M.O. and Garred,P.
    C1q/MASP Complexes-Hybrid Complexes of Classical and Lectin Pathway Proteins Are Found in the Circulation
    J Immunol (2024) PubMed  Europe PubMed DOI
    5. 2022
  5. Aghamohammadi,A., Rafatpanah,H., Maghsoodlu,M., Tohidi,N., Mollahosseini,F. and Shahabi,M.
    Mannose binding lectin-associated serine protease 2 (MASP2) gene polymorphism and susceptibility to human T-lymphotropic virus type 1 (HTLV-1) infection in blood donors from Mashhad, Iran
    Microbiol Immunol (2022) 66, 460-464. PubMed  Europe PubMed DOI
  6. Gotz,M.P., Skjoedt,M.O., Bayarri-Olmos,R., Hansen,C.B., Perez-Alos,L., Jarlhelt,I., Benfield,T., Rosbjerg,A. and Garred,P.
    Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
    J Innate Immun (2022) , 1-14. PubMed  Europe PubMed DOI
  7. Nagy,Z.A., Heja,D., Bencze,D., Kiss,B., Boros,E., Szakacs,D., Fodor,K., Wilmanns,M., Kocsis,A., Dobo,J., Gal,P., Harmat,V. and Pal,G.
    Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation
    J Biol Chem (2022) 298, 101985-101985. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Wu,F.W.B., Chen,Y.Y., Huang,J.X., Wang,K.Y., Xu,H.S. and Lin,D.
    Significance of Mannan Binding Lectin-Associated Serine Protease 2 in Urinary Extracellular Vesicles in IgA Nephropathy
    Clin Invest Med (2022) 45, E47-E54. PubMed  Europe PubMed DOI
  9. Zachar,R., Thiel,S., Hansen,S., Henriksen,M.L., Skjoedt,M.O., Skjodt,K., Hamzaei,Z., Madsen,K., Lund,L., Hummler,E., Svenningsen,P. and Jensen,B.L.
    Mannan-binding lectin serine protease-2 (MASP-2) in human kidney and its relevance for proteolytic activation of the epithelial sodium channel
    Sci Rep (2022) 12, 15955-15955. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Flude,B.M., Nannetti,G., Mitchell,P., Compton,N., Richards,C., Heurich,M., Brancale,A., Ferla,S. and Bassetto,M.
    Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus Infections
    Viruses (2021) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  11. Pihl,R., Jensen,R.K., Poulsen,E.C., Jensen,L., Hansen,A.G., Thogersen,I.B., Dobo,J., Gal,P., Andersen,G.R., Enghild,J.J. and Thiel,S.
    ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism
    Sci Adv (2021) 7 PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2020
  12. Cedzynski,M. and Swierzko,A.S.
    Components of the Lectin Pathway of Complement in Haematologic Malignancies
    Cancers (Basel) (2020) 12 PubMed  Europe PubMed DOI
  13. Fuentes-Prior,P.
    Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection
    J Biol Chem (2020) PubMed  Europe PubMed DOI  V
  14. Mercurio,D., Oggioni,M., Fumagalli,S., Lynch,N.J., Roscher,S., Minuta,D., Perego,C., Ippati,S., Wallis,R., Schwaeble,W.J. and De Simoni,M.G.
    Targeted deletions of complement lectin pathway genes improve outcome in traumatic brain injury, with MASP-2 playing a major role
    Acta Neuropathol Commun (2020) 8, 174-174. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Talsma,D.T., Poppelaars,F., Dam,W., Meter-Arkema,A.H., Vives,R.R., Gal,P., Boons,G.J., Chopra,P., Naggi,A., Seelen,M.A., Berger,S.P., Daha,M.R., Stegeman,C.A. and Van den Born,J.
    MASP-2 is a heparin-binding protease; identification of blocking oligosaccharides
    Front Immunol (2020) 11, 732-732. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2019
  16. Bibert,S., Piret,J., Quinodoz,M., Collinet,E., Zoete,V., Michielin,O., Menasria,R., Meylan,P., Bihl,T., Erard,V., Fellmann,F., Rivolta,C., Boivin,G. and Bochud,P.Y.
    Herpes simplex encephalitis in adult patients with MASP-2 deficiency
    PLoS Pathog (2019) 15, e1008168-e1008168. PubMed  Europe PubMed DOI  M
  17. Szakacs,D., Kocsis,A., Szasz,R., Gal,P. and Pal,G.
    Novel MASP-2 inhibitors developed via directed evolution of human TFPI1 are potent lectin pathway inhibitors
    J Biol Chem (2019) 294, 8227-8237. PubMed  Europe PubMed DOI
    18. 2017
  18. Yaseen,S., Demopulos,G., Dudler,T., Yabuki,M., Wood,C.L., Cummings,W.J., Tjoelker,L.W., Fujita,T., Sacks,S., Garred,P., Andrew,P., Sim,R.B., Lachmann,P.J., Wallis,R., Lynch,N. and Schwaeble,W.J.
    Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2
    FASEB J (2017) 31, 2210-2219. PubMed  Europe PubMed DOI
    19. 2016
  19. Dobo,J., Pal,G., Cervenak,L. and Gal,P.
    The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond
    Immunol Rev (2016) 274, 98-111. PubMed  Europe PubMed DOI
  20. Orsini,F., Chrysanthou,E., Dudler,T., Cummings,W.J., Takahashi,M., Fujita,T., Demopulos,G., De Simoni,M.G. and Schwaeble,W.
    Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1
    J Neuroinflammation (2016) 13, 213-213. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2015
  21. Keizer,M.P., Pouw,R.B., Kamp,A.M., Patiwael,S., Marsman,G., Hart,M.H., Zeerleder,S., Kuijpers,T.W. and Wouters,D.
    TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2
    Eur J Immunol (2015) 45, 544-550. PubMed  Europe PubMed DOI
    22. 2014
  22. Asgari,E., Farrar,C.A., Lynch,N., Ali,Y.M., Roscher,S., Stover,C., Zhou,W., Schwaeble,W.J. and Sacks,S.H.
    Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4
    FASEB J (2014) 28, 3996-4003. PubMed  Europe PubMed DOI
    23. 2012
  23. Duncan,R.C., Bergstrom,F., Coetzer,T.H., Blom,A.M., Wijeyewickrema,L.C. and Pike,R.N.
    Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4
    Mol Immunol (2012) 49, 593-600. PubMed  Europe PubMed DOI
  24. Heja,D., Harmat,V., Fodor,K., Wilmanns,M., Dobo,J., Kekesi,K.A., Zavodszky,P., Gal,P. and Pal,G.
    Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2
    J Biol Chem (2012) 287, 20290-20300. PubMed  Europe PubMed DOI
  25. Schwaeble,W.J., Lynch,N.J., Gal,P. and Zavodszky,P.
    Mannan-binding lectin-associated serine proteases
    [ISSN:978-0-12-407742-3] (2012) 3, 2857-2863. DOI
  26. Yongqing,T., Drentin,N., Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.
    Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?
    Biochim Biophys Acta (2012) 1824, 253-262. PubMed  Europe PubMed DOI  V  R
    27. 2011
  27. Boldt,A.B., Grisbach,C., Steffensen,R., Thiel,S., Kun,J.F., Jensenius,J.C. and Messias-Reason,I.J.
    Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels
    Hum Immunol (2011) 72, 753-760. PubMed  Europe PubMed DOI  M
  28. Degn,S.E., Thiel,S., Nielsen,O., Hansen,A.G., Steffensen,R. and Jensenius,J.C.
    MAp19, the alternative splice product of the MASP2 gene
    J Immunol Methods (2011) 373, 89-101. PubMed  Europe PubMed DOI
  29. Schwaeble,W.J., Lynch,N.J., Clark,J.E., Marber,M., Samani,N.J., Ali,Y.M., Dudler,T., Parent,B., Lhotta,K., Wallis,R., Farrar,C.A., Sacks,S., Lee,H., Zhang,M., Iwaki,D., Takahashi,M., Fujita,T., Tedford,C.E. and Stover,C.M.
    Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury
    Proc Natl Acad Sci U S A (2011) 108, 7523-7528. PubMed  Europe PubMed DOI  PMC  EPMC  K
  30. Takahashi,K., Chang,W.C., Takahashi,M., Pavlov,V., Ishida,Y., La Bonte,L., Shi,L., Fujita,T., Stahl,G.L. and Van Cott,E.M.
    Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
    Immunobiology (2011) 216, 96-102. PubMed  Europe PubMed DOI
    31. 2010
  31. Gulla,K.C., Gupta,K., Krarup,A., Gal,P., Schwaeble,W.J., Sim,R.B., O'Connor,C.D. and Hajela,K.
    Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot
    Immunology (2010) 129, 482-495. PubMed  Europe PubMed DOI
  32. Kocsis,A., Kekesi,K.A., Szasz,R., Vegh,B.M., Balczer,J., Dobo,J., Zavodszky,P., Gal,P. and Pal,G.
    Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation
    J Immunol (2010) 185, 4169-4178. PubMed  Europe PubMed DOI  I
  33. Skjoedt,M.O., Hummelshoj,T., Palarasah,Y., Honore,C., Koch,C., Skjodt,K. and Garred,P.
    A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    J Biol Chem (2010) 285, 8234-8243. PubMed  Europe PubMed DOI  PMC  EPMC
    34. 2009
  34. Degn,S.E., Hansen,A.G., Steffensen,R., Jacobsen,C., Jensenius,J.C. and Thiel,S.
    MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation
    J Immunol (2009) 183, 7371-7378. PubMed  Europe PubMed DOI
  35. Gal,P., Dobo,J., Zavodszky,P. and Sim,R.B.
    Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions
    Mol Immunol (2009) 46, 2745-2752. PubMed  Europe PubMed DOI  V
  36. Thiel,S., Kolev,M., Degn,S., Steffensen,R., Hansen,A.G., Ruseva,M. and Jensenius,J.C.
    Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity
    J Immunol (2009) 182, 2939-2947. PubMed  Europe PubMed DOI  M
    37. 2008
  37. Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.
    The initiating proteases of the complement system: controlling the cleavage
    Biochimie (2008) 90, 387-395. PubMed  Europe PubMed DOI  V
  38. Kerr,F.K., Thomas,A.R., Wijeyewickrema,L.C., Whisstock,J.C., Boyd,S.E., Kaiserman,D., Matthews,A.Y., Bird,P.I., Thielens,N.M., Rossi,V. and Pike,R.N.
    Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
    Mol Immunol (2008) 45, 670-677. PubMed  Europe PubMed DOI  P
    39. 2007
  39. Gal,P., Barna,L., Kocsis,A. and Zavodszky,P.
    Serine proteases of the classical and lectin pathways: similarities and differences
    Immunobiology (2007) 212, 267-277. PubMed  Europe PubMed DOI  V
  40. Girija,U.V., Dodds,A.W., Roscher,S., Reid,K.B. and Wallis,R.
    Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins
    J Immunol (2007) 179, 455-462. PubMed  Europe PubMed  PMC  EPMC
  41. Krarup,A., Wallis,R., Presanis,J.S., Gal,P. and Sim,R.B.
    Simultaneous activation of complement and coagulation by MBL-associated serine protease 2
    PLoS ONE (2007) 2, e623-e623. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Moller-Kristensen,M., Thiel,S., Sjoholm,A., Matsushita,M. and Jensenius,J.C.
    Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
    Int Immunol (2007) 19, 141-149. PubMed  Europe PubMed DOI
  43. Schlapbach,L.J., Aebi,C., Otth,M., Leibundgut,K., Hirt,A. and Ammann,R.A.
    Deficiency of mannose-binding lectin-associated serine protease-2 associated with increased risk of fever and neutropenia in pediatric cancer patients
    Pediatr Infect Dis J (2007) 26, 989-994. PubMed  Europe PubMed DOI  M
  44. Sorensen,G.L., Petersen,I., Thiel,S., Fenger,M., Christensen,K., Kyvik,K.O., Sorensen,T.I., Holmskov,U. and Jensenius,J.C.
    Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
    Genet Epidemiol (2007) 31, 31-41. PubMed  Europe PubMed DOI  M
  45. Takahashi,M., Mori,S., Shigeta,S. and Fujita,T.
    Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway
    Adv Exp Med Biol (2007) 598, 93-104. PubMed  Europe PubMed DOI  V
  46. Thiel,S., Steffensen,R., Christensen,I.J., Ip,W.K., Lau,Y.L., Reason,I.J., Eiberg,H., Gadjeva,M., Ruseva,M. and Jensenius,J.C.
    Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms
    Genes Immun (2007) 8, 154-163. PubMed  Europe PubMed DOI  M
  47. Unterberger,C., Hanson,S., Klingenhoff,A., Oesterle,D., Frankenberger,M., Endo,Y., Matsushita,M., Fujita,T., Schwaeble,W., Weiss,E.H., Ziegler-Heitbrock,L. and Stover,C.
    Stat3 is involved in control of MASP2 gene expression
    Biochem Biophys Res Commun (2007) 364, 1022-1025. PubMed  Europe PubMed DOI
  48. Wallis,R., Dodds,A.W., Mitchell,D.A., Sim,R.B., Reid,K.B. and Schwaeble,W.J.
    Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway
    J Biol Chem (2007) 282, 7844-7851. PubMed  Europe PubMed DOI
    49. 2006
  49. Granell,M., Urbano-Ispizua,A., Suarez,B., Rovira,M., Fernandez-Aviles,F., Martinez,C., Ortega,M., Uriburu,C., Gaya,A., Roncero,J.M., Navarro,A., Carreras,E., Mensa,J., Vives,J., Rozman,C., Montserrat,E. and Lozano,F.
    Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneic stem cell transplantation
    Exp Hematol (2006) 34, 1435-1441. PubMed  Europe PubMed DOI  M
  50. [YEAR:15-10-2006]Nakao,M., Kajiya,T., Sato,Y., Somamoto,T., Kato-Unoki,Y., Matsushita,M., Nakata,M., Fujita,T. and Yano,T.
    Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio)
    J Immunol (15-10-2006) 177, 5471-5479. PubMed  Europe PubMed
  51. [YEAR:11-10-2006]Olesen,H.V., Jensenius,J.C., Steffensen,R., Thiel,S. and Schiotz,P.O.
    The mannan-binding lectin pathway and lung disease in cystic fibrosis - disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier
    Clin Immunol (11-10-2006) 121, 324-331. PubMed  Europe PubMed DOI  M
    52. 2005
  52. [YEAR:21-7-2005]Gal,P., Harmat,V., Kocsis,A., Bian,T., Barna,L., Ambrus,G., Vegh,B., Balczer,J., Sim,R.B., Naray-Szabo,G. and Zavodszky,P.
    A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations
    J Biol Chem (21-7-2005) 280, 33435-33444. PubMed  Europe PubMed DOI  S
  53. Iwaki,D. and Fujita,T.
    Production and purification of recombinants of mouse MASP-2 and sMAP
    J Endotoxin Res (2005) 11, 47-50. PubMed  Europe PubMed DOI
  54. Lozano,F., Suarez,B., Munoz,A., Jensenius,J.C., Mensa,J., Vives,J. and Horcajada,J.P.
    Novel MASP2 variants detected among North African and Sub-Saharan individuals
    Tissue Antigens (2005) 66, 131-135. PubMed  Europe PubMed DOI  M
  55. [YEAR:14-10-2005]Rossi,V., Teillet,F., Thielens,N.M., Bally,I. and Arlaud,G.J.
    Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules
    J Biol Chem (14-10-2005) 280, 41811-41818. PubMed  Europe PubMed DOI
  56. Stover,C., Barrett,S., Lynch,N.J., Barker,J.N., Burden,D., Trembath,R., Schwaeble,W. and Veal,C.
    Functional MASP2 single nucleotide polymorphism plays no role in psoriasis
    Br J Dermatol (2005) 152, 1313-1315. PubMed  Europe PubMed DOI
    57. 2004
  57. [YEAR:18-6-2004]Chen,C.B. and Wallis,R.
    Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases
    J Biol Chem (18-6-2004) 279, 26058-26065. PubMed  Europe PubMed DOI
  58. [YEAR:1-10-2004]Harmat,V., Gal,P., Kardos,J., Szilagyi,K., Ambrus,G., Vegh,B., Naray-Szabo,G. and Zavodszky,P.
    The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
    J Mol Biol (1-10-2004) 342, 1533-1546. PubMed  Europe PubMed DOI  S
  59. Presanis,J.S., Hajela,K., Ambrus,G., Gal,P. and Sim,R.B.
    Differential substrate and inhibitor profiles for human MASP-1 and MASP-2
    Mol Immunol (2004) 40, 921-929. PubMed  Europe PubMed DOI
  60. Schwaeble,W.J., Stover,C. and Reid,K.B.M.
    Mannan-binding lectin-associated serine proteases
    [ISSN:0-12-079610-4] (2004) 2, 1623-1627.  V
    61. 2003
  61. [YEAR:1-2-2003]Ambrus,G., Gal,P., Kojima,M., Szilagyi,K., Balczer,J., Antal,J., Graf,L., Laich,A., Moffatt,B.E., Schwaeble,W., Sim,R.B. and Zavodszky,P.
    Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    J Immunol (1-2-2003) 170, 1374-1382. PubMed  Europe PubMed
  62. [YEAR:15-5-2003]Feinberg,H., Uitdehaag,J.C., Davies,J.M., Wallis,R., Drickamer,K. and Weis,W.I.
    Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2
    EMBO J (15-5-2003) 22, 2348-2359. PubMed  Europe PubMed DOI  PMC  EPMC  S
  63. Moller-Kristensen,M., Jensenius,J.C., Jensen,L., Thielens,N., Rossi,V., Arlaud,G. and Thiel,S.
    Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals
    J Immunol Methods (2003) 282, 159-167. PubMed  Europe PubMed DOI
  64. Presanis,J.S., Kojima,M. and Sim,R.B.
    Biochemistry and genetics of mannan-binding lectin (MBL)
    Biochem Soc Trans (2003) 31, 748-752. PubMed  Europe PubMed DOI
  65. [YEAR:7-8-2003]Stengaard-Pedersen,K., Thiel,S., Gadjeva,M., Moller-Kristensen,M., Sorensen,R., Jensen,L.T., Sjoholm,A.G., Fugger,L. and Jensenius,J.C.
    Inherited deficiency of mannan-binding lectin-associated serine protease 2
    N Engl J Med (7-8-2003) 349, 554-560. PubMed  Europe PubMed DOI
    66. 2002
  66. [YEAR:15-11-2002]Cseh,S., Vera,L., Matsushita,M., Fujita,T., Arlaud,G.J. and Thielens,N.M.
    Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2
    J Immunol (15-11-2002) 169, 5735-5743. PubMed  Europe PubMed
  67. Endo,Y., Takahashi,M., Kuraya,M., Matsushita,M., Stover,C.M., Schwaeble,W.J. and Fujita,T.
    Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter
    Int Immunol (2002) 14, 1193-1201. PubMed  Europe PubMed
  68. Fujita,T.
    Evolution of the lectin-complement pathway and its role in innate immunity
    Nat Rev Immunol (2002) 2, 346-353. PubMed  Europe PubMed DOI
  69. Hajela,K., Kojima,M., Ambrus,G., Wong,K.H., Moffatt,B.E., Ferluga,J., Hajela,S., Gal,P. and Sim,R.B.
    The biological functions of MBL-associated serine proteases (MASPs)
    Immunobiology (2002) 205, 467-475. PubMed  Europe PubMed
  70. [YEAR:15-10-2002]Neth,O., Jack,D.L., Johnson,M., Klein,N.J. and Turner,M.W.
    Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus
    J Immunol (15-10-2002) 169, 4430-4436. PubMed  Europe PubMed
  71. Nonaka,M. and Miyazawa,S.
    Evolution of the initiating enzymes of the complement system
    Genome Biol (2002) 3, REVIEWS1001-REVIEWS1001. PubMed  Europe PubMed  PMC  EPMC
  72. Schwaeble,W., Dahl,M.R., Thiel,S., Stover,C. and Jensenius,J.C.
    The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes
    Immunobiology (2002) 205, 455-466. PubMed  Europe PubMed DOI  R
    73. 2001
  73. [YEAR:13-7-2001]Chen,C.B. and Wallis,R.
    Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation
    J Biol Chem (13-7-2001) 276, 25894-25902. PubMed  Europe PubMed DOI
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