Substrates for peptidase S01.215: coagulation factor VIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
coagulation factor IX P00740 29-461 peptide-Arg145+Ala-peptide P Lys Leu Thr Arg Ala Glu Thr Val Morrissey, 2004 17369
coagulation factor IX P00740 29-461 peptide-Arg180+Val-peptide P Asp Phe Thr Arg Val Val Gly Gly Morrissey, 2004 17370
coagulation factor V P12259 29-2224 peptide-Arg707+Lys-peptide P Met Ala Thr Arg Lys Met His Asp Safa et al., 1999 3622
coagulation factor V P12259 29-2224 peptide-Arg1220+Asn-peptide P Leu Ile Gln Arg Asn Leu Ser Pro Safa et al., 1999 3621
coagulation factor V P12259 29-2224 peptide-Arg1046+Thr-peptide P Leu Ser Pro Arg Thr Phe His Pro Safa et al., 1999 3620
coagulation factor V P12259 29-2224 peptide-Arg737+Ser-peptide P Leu Gly Ile Arg Ser Phe Arg Asn Safa et al., 1999 3619
coagulation factor VII P08709 21-466 peptide-Arg194+Ile-peptide P Pro Gln Gly Arg Ile Val Gly Gly Morrissey, 2004 17371
coagulation factor X P00742 32-488 peptide-Arg51+Ile-peptide P Asn Leu Thr Arg Ile Val Gly Gly 17372
coagulation factor X P00743 24-492 peptide-Arg233+Ile-peptide N Gln Val Val Arg Ile Val Gly Gly 17373