Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00740

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
28	unknown peptidase	1-461	P		NT	<%Agarwal et al., 2012[]%>
46	russellysin	29-461	N			Kawabata & Iwanaga, 2004
46	furin	29-461	P			Wasley et al., 1993
186	elastase-2	47-461	P			Samis et al., 1998
188	thermolysin	47-461	N			Narasaki et al., 2005
190	elastase-2	47-461	P			Samis et al., 1998
191	gingipain RgpA	47-461	N			Imamura et al., 2001
191	coagulation factor XIa	29-461	P			Walsh, 2004
191	coagulation factor VIIa	29-461	P			Morrissey, 2004
210	elastase-2	47-461	P			Samis et al., 1998
218	elastase-2	47-461	P	release of an amino acid		Samis et al., 1998
223	thermolysin	47-461	N			Narasaki et al., 2005
226	gingipain RgpA	47-461	N			Imamura et al., 2001
226	russellysin	222-230	N		MS	Siigur et al., 2001
226	coagulation factor XIa	29-461	P			Walsh, 2004
226	coagulation factor VIIa	29-461	P			Morrissey, 2004
226	hepsin	47-461	P			Herter et al., 2005
226	kallikrein-related peptidase 4	1-461	P		CS	Matsumura et al., 2005
227	elastase-2	47-461	P			Samis et al., 1998
364	thrombin	47-461	P	normal turnover		Kisiel et al., 1986
373	thrombin	47-461	P	normal turnover		Kisiel et al., 1986
384	thrombin	47-461	P	normal turnover		Kisiel et al., 1986