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Literature for peptidase S01.215: coagulation factor VIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Abdi Ghavidel,A., Bandehpour,M., Noori,E., Jajarmi,V. and Kazemi,B.
    Comparing the Yield of Recombinant Human Factor VII Protein Expressed by the rDNA-Promoter with the CMV-Promoter in Iranian Lizard Leishmania
    Iran J Parasitol19, 192-202. PubMed  Europe PubMed DOI
  2. Nakajima,Y. and Nogami,K.
    The role of proteolytic cleavage at Arg(336) and Arg(372) of the A1 domain in factor VIIa/tissue factor-catalyzed reactions of B domain-deleted factor VIII
    Biochim Biophys Acta Gen Subj1868, 130501-130501. PubMed  Europe PubMed DOI
  3. Preisler,B., Pezeshkpoor,B., Merzenich,A., Ohlenforst,S., Ruhl,H., Ivaskevicius,V., Scholz,U., Bonigk,H., Eberl,W., Zieger,B., Pavlova,A. and Oldenburg,J.
    Genetic Landscape of Factor VII Deficiency: Insights from a Comprehensive Analysis of Pathogenic Variants and Their Impact on Coagulation Activity
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  4. Ramezanpour,N., Khanaki,K., Dorgalaleh,A., Shams,M., Elmi,A. and Zaker,F.
    Interleukin 10, but not tumor necrosis factor-alpha, gene variations are associated with factor VII inhibitor development
    Lab Med55, 8-12. PubMed  Europe PubMed DOI
  5. Rosati,G., Camerlo,S., Fornari,A., Marci,V., Montaruli,B. and Morotti,A.
    Factor VII Deficiency in Systemic Mastocytosis with an Associated Myeloid Neoplasm
    Hematol Rep16, 132-139. PubMed  Europe PubMed DOI
    6. 2023
  6. Das,K., Keshava,S., Mukherjee,T., Wang,J., Magisetty,J., Kolesnick,R., Pendurthi,U.R. and Rao,L.V.M.
    Factor VIIa releases phosphatidylserine-enriched extracellular vesicles from endothelial cells by activating acid sphingomyelinase
    J Thromb Haemost21, 3414-3431. PubMed  Europe PubMed DOI
  7. Feng,H., Yao,L., Zeng,Z., Jiang,L., Shang,Y., Wang,H., Li,L., Wang,Z., Wang,X., Yang,H., Zhao,Q., Ren,X., Zhang,T., Zhang,R., Guo,Y., Lu,Q., Hu,Q., Zhang,W., Ding,C., Shao,H., Cheng,G., Luo,Q. and Wen,G.
    Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine
    J Virol97, e0032423-e0032423. PubMed  Europe PubMed DOI
  8. Furlan,A., Sartori,F. and Gherlinzoni,F.
    Acquired Isolated Factor VII Deficiency in Plasma Cell Dyscrasias: A Brief Presentation of Two Plasma-Cell-Leukemia-Related Cases and Review of Literature
    J Clin Med12, PubMed  Europe PubMed DOI  V
  9. Gopal,R., Md Shakhih,M.F., Sahalan,M., Lee,T.C., Hermawan,H., Sivalingam,S., Kadiman,S. and Saidin,S.
    Immobilization of blood coagulant factor VII on polycaprolactone membrane through polydopamine grafting
    Colloids Surf B Biointerfaces228, 113390-113390. PubMed  Europe PubMed DOI
  10. Hampshire,D.J.
    Factor VII deficiency: A cause of (or risk factor for) bleeding?
    Br J Haematol202, 457-458. PubMed  Europe PubMed DOI
  11. Kohler,J., Maletzki,C., Revenko,A.S., Mikkat,S., Kreikemeyer,B. and Oehmcke-Hecht,S.
    Knockdown of coagulation factor VII has potential anticoagulant and anti-inflammatory effects in a mouse model of group A streptococcal sepsis
    Microbes Infect105178-105178. PubMed  Europe PubMed DOI  K
  12. Lou,C., Jiang,J., Chen,W., Zhang,Z., Xu,G., Liu,Y., Dai,J., Ding,Q., Wang,X., Wei,H., Wu,Y., Xu,Q. and Wu,W.
    Structural and functional characterization of novel F7 mutations identified in Chinese factor VII-deficient patients
    Br J Haematol202, 623-635. PubMed  Europe PubMed DOI
  13. Newman,K., Daldal,F. and Dancis,A.
    A thrombophilic allele of clotting Factor VII/VIIa promoting recurrent pulmonary emboli, clinical details, and a structural model of the altered protein: a case report
    J Med Case Rep17, 161-161. PubMed  Europe PubMed DOI
  14. Qu,C., Liu,W., Chen,L., Zhang,L., Xue,F. and Yang,R.
    Factor VII deficiency in China: Phenotype, genotype and current status of management
    Br J Haematol200, 344-352. PubMed  Europe PubMed DOI
  15. Wolf,E.B., Li,D., Fernandez,A.J., Gardner,L.B., Rivera,C.E., Wysokinska,E.M., Shaikh,M.E., Tun,H.W., Roy,V. and Alhaj Moustafa,M.
    Acquired Factor VII Deficiency Associated With Chronic Myeloid Leukemia Blast Crisis
    J Investig Med High Impact Case Rep11, 23247096231209543-23247096231209543. PubMed  Europe PubMed DOI
    16. 2022
  16. Abdul-Kadir,R. and Gomez,K.
    Reproductive health and hemostatic issues in women and girls with congenital factor VII deficiency: A systematic review
    J Thromb Haemost20, 2758-2772. PubMed  Europe PubMed DOI
  17. Loft,M., Christensen,C., Clausen,M.M., Carlsen,E.A., Hansen,C.P., Kroman,N., Langer,S.W., Hoegdall,C., Madsen,J., Gillings,N., Nielsen,C.H., Klausen,T.L., Holm,S., Loft,A., Berthelsen,A.K. and Kjaer,A.
    First-in-Human PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using (18)F-labeled Active-Site Inhibited Factor VII ((18)F-ASIS): Potential as Companion Diagnostic
    J Nucl Med63, 1871-1879. PubMed  Europe PubMed DOI
  18. Marshalek,J.P., Yashar,D., Huynh,K. and Tomassetti,S.
    Case of concurrent factor VII and factor XI deficiencies manifesting as spontaneous lower extremity compartment syndrome
    Clin Case Rep10, e05710-e05710. PubMed  Europe PubMed DOI
    19. 2021
  19. Bernardi,F. and Mariani,G.
    Biochemical, molecular and clinical aspects of coagulation factor VII and its role in hemostasis and thrombosis
    Haematologica PubMed  Europe PubMed DOI  V
  20. Escobar,M., Luck,J., Averianov,Y., Ducore,J., Fernandez,M.F.L., Giermasz,A., Hart,D.P., Journeycake,J., Kessler,C., Leissinger,C., Mahlangu,J., Martinez,L.V., Miesbach,W., Mitha,I.H., Quon,D., Reding,M.T., Schved,J.F., Stasyshyn,O., Vilchevska,K.V., Wang,M., Windyga,J., Alexander,W.A., Al-Sabbagh,A., Bonzo,D., Mitchell,I.S., Wilkinson,T.A. and Hermans,C.
    PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors
    Haemophilia27, 911-920. PubMed  Europe PubMed DOI
  21. Madsen,J.J. and Olsen,O.H.
    Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain
    Biomolecules11, PubMed  Europe PubMed DOI
  22. Vadivel,K., Schmidt,A.E., Cascio,D., Padmanabhan,K., Krishnaswamy,S., Brandstetter,H. and Bajaj,S.P.
    Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium
    Acta Crystallogr D Struct Biol77, 809-819. PubMed  Europe PubMed DOI
  23. Wood,J.P.
    Factor VIIa is not just a factor X activator
    Blood137, 3324-3325. PubMed  Europe PubMed DOI
    24. 2020
  24. Girolami,A., Paoletti,M., Ferrari,S. and Garcia,D.
    Peculiar congenital factor VII defect with the proposita and her mother showing the same compound heterozygosity for Thr384Met and Arg413Gln
    Acta Haematol1-5. PubMed  Europe PubMed DOI  M
  25. Osterud,B.
    Commentary on "Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet-dependent and -independent mechanisms"
    J Thromb Haemost18, 1853-1854. PubMed  Europe PubMed DOI
  26. Sorensen,A.B., Tuneew,I., Svensson,L.A., Persson,E., Ostergaard,H., Overgaard,M.T., Olsen,O.H. and Gandhi,P.S.
    Beating tissue factor at its own game: design and properties of a soluble tissue factor-independent coagulation factor VIIa
    J Biol Chem295, 517-528. PubMed  Europe PubMed DOI
  27. Tibesar,E.E.
    Bleeding Gastric Heterotopic Polyp in the Duodenum of a Teenager with Severe Factor VII Deficiency
    Case Rep Gastroenterol14, 467-471. PubMed  Europe PubMed DOI
  28. Zink,J., Spigel,Z.A., Ibarra,C., Gottlieb,E.A., Adachi,I., Mery,C.M., Imamura,M., Heinle,J.S., McKenzie,E.D., Fraser,C.D. and Binsalamah,Z.M.
    The intraoperative use of recombinant activated factor VII in arterial switch operations
    Cardiol Young1-5. PubMed  Europe PubMed DOI
    29. 2019
  29. de Vries,P.S., Sabater-Lleal,M., Huffman,J.E., Marten,J., Song,C., Pankratz,N., Bartz,T.M., de Haan,H.G., Delgado,G.E., Eicher,J.D., Martinez-Perez,A., Ward-Caviness,C.K., Brody,J.A., Chen,M.H., de Maat,M.P.M., Franberg,M., Gill,D., Kleber,M.E., Rivadeneira,F., Soria,J.M., Tang,W., Tofler,G.H., Uitterlinden,A.G., van Hylckama Vlieg,A., Seshadri,S., Boerwinkle,E., Davies,N.M., Giese,A.K., Ikram,M.K., Kittner,S.J., McKnight,B., Psaty,B.M., Reiner,A.P., Sargurupremraj,M., Taylor,K.D., Fornage,M., Hamsten,A., Marz,W., Rosendaal,F.R., Souto,J.C., Dehghan,A., Johnson,A.D., Morrison,A.C., O'Donnell,C.J. and Smith,N.L.
    A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology
    Blood133, 967-977. PubMed  Europe PubMed DOI  M
  30. Girolami,A., Cosi,E., Ferrari,S., Girolami,B. and Randi,M.L.
    Thrombotic events in homozygotes with a proven or highly probable Arg304Gln factor VII mutation (FVII Padua): only limited replacement therapy is needed in case of surgery
    Cardiovasc Hematol Disord Drug Targets19, 233-238. PubMed  Europe PubMed DOI  M
  31. Jiang,L., Xie,X., Li,J., Persson,E. and Huang,M.
    Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism
    Res Pract Thromb Haemost3, 412-419. PubMed  Europe PubMed DOI
  32. Li,M., Jin,Y., Wang,M. and Ding,H.
    Analysis of phenotype and genotype in an inherited coagulation factor VII deficiency pedigree
    Clin Lab65, PubMed  Europe PubMed DOI  M
  33. Misenheimer,T.M., Kumfer,K.T., Bates,B.E., Nettesheim,E.R. and Schwartz,B.S.
    A candidate activation pathway for coagulation factor VII
    Biochem J476, 2909-2926. PubMed  Europe PubMed DOI
  34. Robinson,K.S.
    An overview of inherited factor VII deficiency
    Transfus Apher Sci58, 569-571. PubMed  Europe PubMed DOI  M
  35. Shahbazi,S. and Mahdian,R.
    Factor VII gene defects: review of functional studies and their clinical implications
    Iran Biomed J23, 165-174. PubMed  Europe PubMed  M
  36. Shaul,C., Blotnick,S., Deutsch,L., Rosenberg,G. and Caraco,Y.
    The impact of R353Q genetic polymorphism in coagulation factor VII on the initial anticoagulant effect exerted by warfarin
    Eur J Clin Pharmacol75, 343-350. PubMed  Europe PubMed DOI  M
  37. Sorensen,A.B., Madsen,J.J., Frimurer,T.M., Overgaard,M.T., Gandhi,P.S., Persson,E. and Olsen,O.H.
    Allostery in coagulation factor VIIa revealed by ensemble refinement of crystallographic structures
    Biophys J116, 1823-1835. PubMed  Europe PubMed DOI  S
    38. 2018
  38. Augustsson,C., Svensson,A., Kjaer,B., Chao,T.Y., Wenjuan,X., Krogh,B.O., Breinholt,J., Clausen,J.T., Hilden,I., Petersen,H.H. and Petersen,L.C.
    Factor Xa and VIIa inhibition by tissue factor pathway Inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain
    J Thromb Haemost16, 893-904. PubMed  Europe PubMed DOI
  39. Granovski,V., Freitas,M.C.C., Abreu-Neto,M.S. and Covas,D.T.
    Purification and autoactivation method for recombinant coagulation factor VII
    Methods Mol Biol1674, 221-226. PubMed  Europe PubMed DOI  E
  40. Habib,A.M., Calafiore,A.M., Cargoni,M., Foschi,M. and Di Mauro,M.
    Recombinant activated factor VII is associated with postoperative thromboembolic adverse events in bleeding after coronary surgery
    Interact Cardiovasc Thorac Surg27, 350-356. PubMed  Europe PubMed DOI  U
  41. Madsen,J.J., Persson,E. and Olsen,O.H.
    Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: comment
    J Thromb Haemost16, 1450-1454. PubMed  Europe PubMed DOI
  42. Mashayekhi,A., Shahbazi,S. and Omrani,M.
    Functional and molecular characterization of C91S mutation in the second epidermal growth factor-like domain of factor VII
    Iran J Biotechnol16, e1813-e1813. PubMed  Europe PubMed DOI  M
  43. Mashayekhi,A., Shahbazi,S., Omrani,M. and Mahdian,R.
    In vitro expression of mutant factor VII proteins and characterization of their clinical significance
    Mol Med Rep17, 2738-2742. PubMed  Europe PubMed DOI  E
  44. Rajpurkar,M. and Cooper,D.L.
    Continuous infusion of recombinant activated factor VII: a review of data in congenital hemophilia with inhibitors and congenital factor VII deficiency
    J Blood Med9, 227-239. PubMed  Europe PubMed DOI  U
  45. Umakanthan,J.M., Dhakal,P., Gundabolu,K., Koepsell,S.A. and Baljevic,M.
    Serendipitous discovery of factor VII deficiency and the ensuing dilemma
    Maedica (Buchar)13, 71-73. PubMed  Europe PubMed  M
    46. 2017
  46. Chollet,M.E., Andersen,E., Skarpen,E., Myklebust,C.F., Koehler,C., Morth,J.P., Chuansumrit,A., Pinotti,M., Bernardi,F., Thiede,B., Sandset,P.M. and Skretting,G.
    Factor VII deficiency: unveiling the cellular and molecular mechanisms underlying three model alterations of the enzyme catalytic domain
    Biochim Biophys Acta1864, 660-667. PubMed  Europe PubMed DOI  M
  47. Correa de Freitas,M.C., Bomfim,A.S., Mizukami,A., Picanco-Castro,V., Swiech,K. and Covas,D.T.
    Production of coagulation factor VII in human cell lines Sk-Hep-1 and HKB-11
    Protein Expr Purif137, 26-33. PubMed  Europe PubMed DOI  E
  48. Di Minno,M.N.D., Ambrosino,P., Myasoedova,V., Amato,M., Ventre,I., Tremoli,E. and Minno,A.D.
    Recombinant activated factor VII (eptacog alfa activated NovoSeven (R) ) in patients with rare congenital bleeding disorders. A systematic review on its use in surgical procedures
    Curr Pharm Des23, 1125-1131. PubMed  Europe PubMed  V  U
  49. Lynch,M., McGrath,K., Raj,K., McLaren,P., Payne,K., McCoy,R. and Giger,U.
    Hereditary factor VII deficiency in the Asian elephant (Elephas maximus) caused by a F7 missense mutation
    J Wildl Dis53, 248-257. PubMed  Europe PubMed DOI  M
  50. Napolitano,M., Siragusa,S. and Mariani,G.
    Factor VII deficiency: clinical phenotype, genotype and therapy
    J Clin Med6, PubMed  Europe PubMed DOI  M
  51. Nielsen,A.L., Sorensen,A.B., Holmberg,H.L., Gandhi,P.S., Karlsson,J., Buchardt,J., Lamberth,K., Kjelgaard-Hansen,M., Ley,C.D., Sorensen,B.B., Ruf,W., Olsen,O.H. and Ostergaard,H.
    Engineering of a membrane-triggered activity switch in coagulation factor VIIa
    Proc Natl Acad Sci U S A114, 12454-12459. PubMed  Europe PubMed DOI
  52. Richter,J.M., Cheney,D.L., Bates,J.A., Wei,A., Luettgen,J.M., Rendina,A.R., Harper,T.M., Narayanan,R., Wong,P.C., Seiffert,D., Wexler,R.R. and Priestley,E.S.
    Design and synthesis of novel meta-linked phenylglycine macrocyclic FVIIa inhibitors
    ACS Med Chem Lett8, 67-72. PubMed  Europe PubMed DOI  I
  53. Wurtz,N.R., Parkhurst,B.L., DeLucca,I., Glunz,P.W., Jiang,W., Zhang,X., Cheney,D.L., Bozarth,J.M., Rendina,A.R., Wei,A., Harper,T., Luettgen,J.M., Wu,Y., Wong,P.C., Seiffert,D.A., Wexler,R.R. and Priestley,E.S.
    Neutral macrocyclic factor VIIa inhibitors
    Bioorg Med Chem Lett27, 2650-2654. PubMed  Europe PubMed DOI  I
    54. 2016
  54. Faranoush,M., Abolghasemi,H., Mahboudi,F., Toogeh,G., Karimi,M., Eshghi,P., Managhchi,M., Hoorfar,H., Dehdezi,B.K., Mehrvar,A., Khoeiny,B., Vaziri,B., Kamyar,K., Heshmat,R., Baghaeipour,M.R., Mirbehbahani,N.B., Fayazfar,R., Ahmadinejad,M. and Naderi,M.
    A comparison of efficacy between recombinant activated factor VII (Aryoseven) and Novoseven in patients with hereditary FVIII deficiency with inhibitor
    Clin Appl Thromb Hemost22, 184-190. PubMed  Europe PubMed DOI  U
  55. Glunz,P.W., Mueller,L., Cheney,D.L., Ladziata,V., Zou,Y., Wurtz,N.R., Wei,A., Wong,P.C., Wexler,R.R. and Priestley,E.S.
    Atropisomer control in macrocyclic factor VIIa inhibitors
    J Med Chem59, 4007-4018. PubMed  Europe PubMed DOI  I
  56. Habib,A.M., Mousa,A.Y. and Al-Halees,Z.
    Recombinant activated factor VII for uncontrolled bleeding postcardiac surgery
    J Saudi Heart Assoc28, 222-231. PubMed  Europe PubMed DOI  U
  57. Hao,X., Cheng,X., Ye,J., Wang,Y., Yang,L., Wang,M. and Jin,Y.
    Severe coagulation factor VII deficiency caused by a novel homozygous mutation (p. Trp284Gly) in loop 140s
    Blood Coagul Fibrinolysis27, 461-463. PubMed  Europe PubMed DOI  M
  58. Ladziata,V.U., Glunz,P.W., Zou,Y., Zhang,X., Jiang,W., Jacutin-Porte,S., Cheney,D.L., Wei,A., Luettgen,J.M., Harper,T.M., Wong,P.C., Seiffert,D., Wexler,R.R. and Priestley,E.S.
    Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors
    Bioorg Med Chem Lett26, 5051-5057. PubMed  Europe PubMed DOI  I
  59. Ma,A.D., Kessler,C.M., Al-Mondhiry,H.A., Gut,R.Z. and Cooper,D.L.
    Use of recombinant activated factor VII for acute bleeding episodes in acquired hemophilia: final analysis from the Hemostasis and Thrombosis Research Society Registry acquired hemophilia study
    Blood Coagul Fibrinolysis27, 753-760. PubMed  Europe PubMed DOI  U
  60. Peng,L., Yu,X., Li,C., Cai,Y., Chen,Y., He,Y., Yang,J., Jin,J. and Li,H.
    Enhanced recombinant factor VII expression in Chinese hamster ovary cells by optimizing signal peptides and fed-batch medium
    Bioengineered7, 189-197. PubMed  Europe PubMed DOI  E
  61. Sheffield,W.P. and Bhakta,V.
    The M358R variant of alpha(1)-proteinase inhibitor inhibits coagulation factor VIIa
    Biochem Biophys Res Commun470, 710-713. PubMed  Europe PubMed DOI  M
  62. Sorensen,A.B., Madsen,J.J., Svensson,L.A., Pedersen,A.A., Ostergaard,H., Overgaard,M.T., Olsen,O.H. and Gandhi,P.S.
    Molecular basis of enhanced activity in factor VIIa-trypsin variants conveys insights into tissue factor-mediated allosteric regulation of factor VIIa activity
    J Biol Chem291, 4671-4683. PubMed  Europe PubMed DOI
  63. Toogeh,G., Abolghasemi,H., Eshghi,P., Managhchi,M., Shaverdi-Niasari,M., Karimi,K., Roostaei,S., Emran,N. and Abdollahi,A.
    Evaluation of AryoSeven safety (recombinant activated factor VII) in patients with bleeding disorders (an observational post-marketing surveillance study)
    Iran J Pathol11, 204-209. PubMed  Europe PubMed
  64. Wurtz,N.R., Parkhurst,B.L., Jiang,W., DeLucca,I., Zhang,X., Ladziata,V., Cheney,D.L., Bozarth,J.R., Rendina,A.R., Wei,A., Luettgen,J.M., Wu,Y., Wong,P.C., Seiffert,D.A., Wexler,R.R. and Priestley,E.S.
    Discovery of phenylglycine lactams as potent neutral factor VIIa inhibitors
    ACS Med Chem Lett7, 1077-1081. PubMed  Europe PubMed DOI  I
  65. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.
    A plasma proteolysis pathway comprising blood coagulation proteases
    Oncotarget7, 40919-40938. PubMed  Europe PubMed DOI
  66. Zhang,X., Glunz,P.W., Johnson,J.A., Jiang,W., Jacutin-Porte,S., Ladziata,V., Zou,Y., Phillips,M.S., Wurtz,N.R., Parkhurst,B., Rendina,A.R., Harper,T.M., Cheney,D.L., Luettgen,J.M., Wong,P.C., Seiffert,D., Wexler,R.R. and Priestley,E.S.
    Discovery of a highly potent, selective, and orally bioavailable macrocyclic inhibitor of blood coagulation factor VIIa-tissue factor complex
    J Med Chem59, 7125-7137. PubMed  Europe PubMed DOI  I
    67. 2015
  67. Bohm,E., Seyfried,B.K., Dockal,M., Graninger,M., Hasslacher,M., Neurath,M., Konetschny,C., Matthiessen,P., Mitterer,A. and Scheiflinger,F.
    Differences in N-glycosylation of recombinant human coagulation factor VII derived from BHK, CHO, and HEK293 cells
    BMC Biotechnol15, 87-87. PubMed  Europe PubMed DOI  E
  68. Cheney,D.L., Bozarth,J.M., Metzler,W.J., Morin,P.E., Mueller,L., Newitt,J.A., Nirschl,A.H., Rendina,A.R., Tamura,J.K., Wei,A., Wen,X., Wurtz,N.R., Seiffert,D.A., Wexler,R.R. and Priestley,E.S.
    Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening
    J Med Chem58, 2799-2808. PubMed  Europe PubMed DOI  I
  69. Erlandsson,M., Nielsen,C.H., Jeppesen,T.E., Kristensen,J.B., Petersen,L.C., Madsen,J. and Kjaer,A.
    Synthesis and characterization of (18)F-labeled active site inhibited factor VII (ASIS)
    J Labelled Comp Radiopharm58, 196-201. PubMed  Europe PubMed DOI
  70. Gajsiewicz,J.M. and Morrissey,J.H.
    Structure-function relationship of the interaction between tissue factor and factor VIIa
    Semin Thromb Hemost41, 682-690. PubMed  Europe PubMed DOI
  71. Glunz,P.W., Cheng,X., Cheney,D.L., Weigelt,C.A., Wei,A., Luettgen,J.M., Wong,P.C., Wexler,R.R. and Priestley,E.S.
    Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors
    Bioorg Med Chem Lett25, 2169-2173. PubMed  Europe PubMed DOI  S  I
  72. Hao,X., Cheng,X., Wang,Y., Yang,L., Xie,Y., Wang,M. and Jin,Y.
    A novel gene insertion combined with a missense mutation causing factor VII deficiency in two unrelated Chinese families
    Blood Coagul Fibrinolysis26, 687-690. PubMed  Europe PubMed DOI  M
  73. Hedner,U.
    Recombinant activated factor VII: 30 years of research and innovation
    Blood Rev29 Suppl 1, S4-S8. PubMed  Europe PubMed DOI  U
  74. Madsen,J.J., Persson,E. and Olsen,O.H.
    Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes
    J Thromb Haemost13, 262-267. PubMed  Europe PubMed DOI
  75. Priestley,E.S., Cheney,D.L., DeLucca,I., Wei,A., Luettgen,J.M., Rendina,A.R., Wong,P.C. and Wexler,R.R.
    Structure-based design of macrocyclic coagulation factor VIIa inhibitors
    J Med Chem58, 6225-6236. PubMed  Europe PubMed DOI  I
  76. Sakakibara,K., Okayama,Y., Fukushima,K., Kaji,S., Muraoka,M., Arao,Y. and Shimada,A.
    Japanese family with congenital factor VII deficiency
    Pediatr Int57, 1023-1024. PubMed  Europe PubMed DOI  M
  77. Shigekiyo,T., Sekimoto,E., Shibata,H., Ozaki,S., Okumura,T., Fujinaga,H., Shibata,H., Aihara,K. and Akaike,M.
    Factor VII Tokushima: the first case of factor VII Cys22Gly with the development of myocardial infarction in the proband receiving recombinant factor VIIa replacement therapy
    Blood Coagul Fibrinolysis26, 956-958. PubMed  Europe PubMed DOI  M
    78. 2014
  78. Faydhi,A.A., Kassem,Y.A., Al-Shabassy,A.M., Ahmed,S. and Al-Shareef,A.
    Recombinant activated factor VII as treatment for intractable haemorrhage
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