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Literature for peptidase S01.215: coagulation factor VIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Broderick,J.P., Naidech,A.M., Elm,J.J., Toyoda,K., Dowlatshahi,D., Demchuk,A.M., Khatri,P., Steiner,T., Bath,P.M., Audebert,H.J., Vagal,A., Yoshimura,S., Mayer,S.A., Wang,L.L., Sabagha,N., Mocco,J.D., Molina,C., Aviv,R., Stinson,E., Quadri,S.A., Carrozzella,J., Huynh,T., Phan,A., Beall,J., Davis,I., Sakai,N., Ohta,T., Yokosawa,M., Hara,T., Sangha,N., Morita,K., Dominc Tse,M.Y., Streib,C.D., Miyashita,F., Silva,Y., Nagakane,Y., Gheorghiu,T., Sun,C.H., Hirano,T., Poli,S., Izumo,T., Fukuda-Doi,M., Ihara,M., Koga,M., Buck,B., Walsh,K.B., Spokovny,I. and Grotta,J.C.<br>Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial<br>Lancet (2026) 407, 773-783. PubMed  Europe PubMed DOI
  2. Champagne,P.S., Seneci,L., Casewell,N.R. and Fry,B.G.<br>Hemostatic hellfire: Rhabdophis helleri (Red-necked Keelback) snake venom pathophysiologically activates Factor VII and Factor X through novel uses of the clotting cofactors calcium, phospholipid, and Factor Va<br>Toxicon (2026) 271, 108970-108970. PubMed  Europe PubMed DOI
    3. 2025
  3. [YEAR:15-7-2025]No,a.l.<br>Coagulation Factor VIIa<br> (15-7-2025) PubMed  Europe PubMed
    4. 2024
  4. Abdi Ghavidel,A., Bandehpour,M., Noori,E., Jajarmi,V. and Kazemi,B.<br>Comparing the Yield of Recombinant Human Factor VII Protein Expressed by the rDNA-Promoter with the CMV-Promoter in Iranian Lizard Leishmania<br>Iran J Parasitol (2024) 19, 192-202. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Nakajima,Y. and Nogami,K.<br>The role of proteolytic cleavage at Arg(336) and Arg(372) of the A1 domain in factor VIIa/tissue factor-catalyzed reactions of B domain-deleted factor VIII<br>Biochim Biophys Acta Gen Subj (2024) 1868, 130501-130501. PubMed  Europe PubMed DOI
  6. Preisler,B., Pezeshkpoor,B., Merzenich,A., Ohlenforst,S., Ruhl,H., Ivaskevicius,V., Scholz,U., Bonigk,H., Eberl,W., Zieger,B., Pavlova,A. and Oldenburg,J.<br>Genetic Landscape of Factor VII Deficiency: Insights from a Comprehensive Analysis of Pathogenic Variants and Their Impact on Coagulation Activity<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  7. Ramezanpour,N., Khanaki,K., Dorgalaleh,A., Shams,M., Elmi,A. and Zaker,F.<br>Interleukin 10, but not tumor necrosis factor-alpha, gene variations are associated with factor VII inhibitor development<br>Lab Med (2024) 55, 8-12. PubMed  Europe PubMed DOI
  8. Rosati,G., Camerlo,S., Fornari,A., Marci,V., Montaruli,B. and Morotti,A.<br>Factor VII Deficiency in Systemic Mastocytosis with an Associated Myeloid Neoplasm<br>Hematol Rep (2024) 16, 132-139. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2023
  9. Das,K., Keshava,S., Mukherjee,T., Wang,J., Magisetty,J., Kolesnick,R., Pendurthi,U.R. and Rao,L.V.M.<br>Factor VIIa releases phosphatidylserine-enriched extracellular vesicles from endothelial cells by activating acid sphingomyelinase<br>J Thromb Haemost (2023) 21, 3414-3431. PubMed  Europe PubMed DOI
  10. Feng,H., Yao,L., Zeng,Z., Jiang,L., Shang,Y., Wang,H., Li,L., Wang,Z., Wang,X., Yang,H., Zhao,Q., Ren,X., Zhang,T., Zhang,R., Guo,Y., Lu,Q., Hu,Q., Zhang,W., Ding,C., Shao,H., Cheng,G., Luo,Q. and Wen,G.<br>Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine<br>J Virol (2023) 97, e0032423-e0032423. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Furlan,A., Sartori,F. and Gherlinzoni,F.<br>Acquired Isolated Factor VII Deficiency in Plasma Cell Dyscrasias: A Brief Presentation of Two Plasma-Cell-Leukemia-Related Cases and Review of Literature<br>J Clin Med (2023) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
  12. Gopal,R., Md Shakhih,M.F., Sahalan,M., Lee,T.C., Hermawan,H., Sivalingam,S., Kadiman,S. and Saidin,S.<br>Immobilization of blood coagulant factor VII on polycaprolactone membrane through polydopamine grafting<br>Colloids Surf B Biointerfaces (2023) 228, 113390-113390. PubMed  Europe PubMed DOI
  13. Hampshire,D.J.<br>Factor VII deficiency: A cause of (or risk factor for) bleeding?<br>Br J Haematol (2023) 202, 457-458. PubMed  Europe PubMed DOI
  14. Kohler,J., Maletzki,C., Revenko,A.S., Mikkat,S., Kreikemeyer,B. and Oehmcke-Hecht,S.<br>Knockdown of coagulation factor VII has potential anticoagulant and anti-inflammatory effects in a mouse model of group A streptococcal sepsis<br>Microbes Infect (2023) , 105178-105178. PubMed  Europe PubMed DOI  K
  15. Lou,C., Jiang,J., Chen,W., Zhang,Z., Xu,G., Liu,Y., Dai,J., Ding,Q., Wang,X., Wei,H., Wu,Y., Xu,Q. and Wu,W.<br>Structural and functional characterization of novel F7 mutations identified in Chinese factor VII-deficient patients<br>Br J Haematol (2023) 202, 623-635. PubMed  Europe PubMed DOI
  16. Newman,K., Daldal,F. and Dancis,A.<br>A thrombophilic allele of clotting Factor VII/VIIa promoting recurrent pulmonary emboli, clinical details, and a structural model of the altered protein: a case report<br>J Med Case Rep (2023) 17, 161-161. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Qu,C., Liu,W., Chen,L., Zhang,L., Xue,F. and Yang,R.<br>Factor VII deficiency in China: Phenotype, genotype and current status of management<br>Br J Haematol (2023) 200, 344-352. PubMed  Europe PubMed DOI
  18. Wolf,E.B., Li,D., Fernandez,A.J., Gardner,L.B., Rivera,C.E., Wysokinska,E.M., Shaikh,M.E., Tun,H.W., Roy,V. and Alhaj Moustafa,M.<br>Acquired Factor VII Deficiency Associated With Chronic Myeloid Leukemia Blast Crisis<br>J Investig Med High Impact Case Rep (2023) 11, 23247096231209543-23247096231209543. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2022
  19. Abdul-Kadir,R. and Gomez,K.<br>Reproductive health and hemostatic issues in women and girls with congenital factor VII deficiency: A systematic review<br>J Thromb Haemost (2022) 20, 2758-2772. PubMed  Europe PubMed DOI
  20. Loft,M., Christensen,C., Clausen,M.M., Carlsen,E.A., Hansen,C.P., Kroman,N., Langer,S.W., Hoegdall,C., Madsen,J., Gillings,N., Nielsen,C.H., Klausen,T.L., Holm,S., Loft,A., Berthelsen,A.K. and Kjaer,A.<br>First-in-Human PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using (18)F-labeled Active-Site Inhibited Factor VII ((18)F-ASIS): Potential as Companion Diagnostic<br>J Nucl Med (2022) 63, 1871-1879. PubMed  Europe PubMed DOI
  21. Marshalek,J.P., Yashar,D., Huynh,K. and Tomassetti,S.<br>Case of concurrent factor VII and factor XI deficiencies manifesting as spontaneous lower extremity compartment syndrome<br>Clin Case Rep (2022) 10, e05710-e05710. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2021
  22. Bernardi,F. and Mariani,G.<br>Biochemical, molecular and clinical aspects of coagulation factor VII and its role in hemostasis and thrombosis<br>Haematologica (2021) PubMed  Europe PubMed DOI  V
  23. Escobar,M., Luck,J., Averianov,Y., Ducore,J., Fernandez,M.F.L., Giermasz,A., Hart,D.P., Journeycake,J., Kessler,C., Leissinger,C., Mahlangu,J., Martinez,L.V., Miesbach,W., Mitha,I.H., Quon,D., Reding,M.T., Schved,J.F., Stasyshyn,O., Vilchevska,K.V., Wang,M., Windyga,J., Alexander,W.A., Al-Sabbagh,A., Bonzo,D., Mitchell,I.S., Wilkinson,T.A. and Hermans,C.<br>PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors<br>Haemophilia (2021) 27, 911-920. PubMed  Europe PubMed DOI
  24. Madsen,J.J. and Olsen,O.H.<br>Conformational Plasticity-Rigidity Axis of the Coagulation Factor VII Zymogen Elucidated by Atomistic Simulations of the N-Terminally Truncated Factor VIIa Protease Domain<br>Biomolecules (2021) 11 PubMed  Europe PubMed DOI  PMC  EPMC
  25. Vadivel,K., Schmidt,A.E., Cascio,D., Padmanabhan,K., Krishnaswamy,S., Brandstetter,H. and Bajaj,S.P.<br>Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium<br>Acta Crystallogr D Struct Biol (2021) 77, 809-819. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Wood,J.P.<br>Factor VIIa is not just a factor X activator<br>Blood (2021) 137, 3324-3325. PubMed  Europe PubMed DOI
    27. 2020
  27. Girolami,A., Paoletti,M., Ferrari,S. and Garcia,D.<br>Peculiar congenital factor VII defect with the proposita and her mother showing the same compound heterozygosity for Thr384Met and Arg413Gln<br>Acta Haematol (2020) , 1-5. PubMed  Europe PubMed DOI  M
  28. Osterud,B.<br>Commentary on "Therapeutic doses of recombinant factor VIIa in hemophilia generates thrombin in platelet-dependent and -independent mechanisms"<br>J Thromb Haemost (2020) 18, 1853-1854. PubMed  Europe PubMed DOI
  29. Sorensen,A.B., Tuneew,I., Svensson,L.A., Persson,E., Ostergaard,H., Overgaard,M.T., Olsen,O.H. and Gandhi,P.S.<br>Beating tissue factor at its own game: design and properties of a soluble tissue factor-independent coagulation factor VIIa<br>J Biol Chem (2020) 295, 517-528. PubMed  Europe PubMed DOI
  30. Tibesar,E.E.<br>Bleeding Gastric Heterotopic Polyp in the Duodenum of a Teenager with Severe Factor VII Deficiency<br>Case Rep Gastroenterol (2020) 14, 467-471. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Zink,J., Spigel,Z.A., Ibarra,C., Gottlieb,E.A., Adachi,I., Mery,C.M., Imamura,M., Heinle,J.S., McKenzie,E.D., Fraser,C.D. and Binsalamah,Z.M.<br>The intraoperative use of recombinant activated factor VII in arterial switch operations<br>Cardiol Young (2020) , 1-5. PubMed  Europe PubMed DOI
    32. 2019
  32. de Vries,P.S., Sabater-Lleal,M., Huffman,J.E., Marten,J., Song,C., Pankratz,N., Bartz,T.M., de Haan,H.G., Delgado,G.E., Eicher,J.D., Martinez-Perez,A., Ward-Caviness,C.K., Brody,J.A., Chen,M.H., de Maat,M.P.M., Franberg,M., Gill,D., Kleber,M.E., Rivadeneira,F., Soria,J.M., Tang,W., Tofler,G.H., Uitterlinden,A.G., van Hylckama Vlieg,A., Seshadri,S., Boerwinkle,E., Davies,N.M., Giese,A.K., Ikram,M.K., Kittner,S.J., McKnight,B., Psaty,B.M., Reiner,A.P., Sargurupremraj,M., Taylor,K.D., Fornage,M., Hamsten,A., Marz,W., Rosendaal,F.R., Souto,J.C., Dehghan,A., Johnson,A.D., Morrison,A.C., O'Donnell,C.J. and Smith,N.L.<br>A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology<br>Blood (2019) 133, 967-977. PubMed  Europe PubMed DOI  M
  33. Girolami,A., Cosi,E., Ferrari,S., Girolami,B. and Randi,M.L.<br>Thrombotic events in homozygotes with a proven or highly probable Arg304Gln factor VII mutation (FVII Padua): only limited replacement therapy is needed in case of surgery<br>Cardiovasc Hematol Disord Drug Targets (2019) 19, 233-238. PubMed  Europe PubMed DOI  M
  34. Jiang,L., Xie,X., Li,J., Persson,E. and Huang,M.<br>Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism<br>Res Pract Thromb Haemost (2019) 3, 412-419. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Li,M., Jin,Y., Wang,M. and Ding,H.<br>Analysis of phenotype and genotype in an inherited coagulation factor VII deficiency pedigree<br>Clin Lab (2019) 65 PubMed  Europe PubMed DOI  M
  36. Misenheimer,T.M., Kumfer,K.T., Bates,B.E., Nettesheim,E.R. and Schwartz,B.S.<br>A candidate activation pathway for coagulation factor VII<br>Biochem J (2019) 476, 2909-2926. PubMed  Europe PubMed DOI
  37. Robinson,K.S.<br>An overview of inherited factor VII deficiency<br>Transfus Apher Sci (2019) 58, 569-571. PubMed  Europe PubMed DOI  M
  38. Shahbazi,S. and Mahdian,R.<br>Factor VII gene defects: review of functional studies and their clinical implications<br>Iran Biomed J (2019) 23, 165-174. PubMed  Europe PubMed  M
  39. Shaul,C., Blotnick,S., Deutsch,L., Rosenberg,G. and Caraco,Y.<br>The impact of R353Q genetic polymorphism in coagulation factor VII on the initial anticoagulant effect exerted by warfarin<br>Eur J Clin Pharmacol (2019) 75, 343-350. PubMed  Europe PubMed DOI  M
  40. Sorensen,A.B., Madsen,J.J., Frimurer,T.M., Overgaard,M.T., Gandhi,P.S., Persson,E. and Olsen,O.H.<br>Allostery in coagulation factor VIIa revealed by ensemble refinement of crystallographic structures<br>Biophys J (2019) 116, 1823-1835. PubMed  Europe PubMed DOI  S
    41. 2018
  41. Augustsson,C., Svensson,A., Kjaer,B., Chao,T.Y., Wenjuan,X., Krogh,B.O., Breinholt,J., Clausen,J.T., Hilden,I., Petersen,H.H. and Petersen,L.C.<br>Factor Xa and VIIa inhibition by tissue factor pathway Inhibitor is prevented by a monoclonal antibody to its Kunitz-1 domain<br>J Thromb Haemost (2018) 16, 893-904. PubMed  Europe PubMed DOI
  42. Granovski,V., Freitas,M.C.C., Abreu-Neto,M.S. and Covas,D.T.<br>Purification and autoactivation method for recombinant coagulation factor VII<br>Methods Mol Biol (2018) 1674, 221-226. PubMed  Europe PubMed DOI  E
  43. Habib,A.M., Calafiore,A.M., Cargoni,M., Foschi,M. and Di Mauro,M.<br>Recombinant activated factor VII is associated with postoperative thromboembolic adverse events in bleeding after coronary surgery<br>Interact Cardiovasc Thorac Surg (2018) 27, 350-356. PubMed  Europe PubMed DOI  U
  44. Madsen,J.J., Persson,E. and Olsen,O.H.<br>Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: comment<br>J Thromb Haemost (2018) 16, 1450-1454. PubMed  Europe PubMed DOI
  45. Mashayekhi,A., Shahbazi,S., Omrani,M. and Mahdian,R.<br>In vitro expression of mutant factor VII proteins and characterization of their clinical significance<br>Mol Med Rep (2018) 17, 2738-2742. PubMed  Europe PubMed DOI  E
  46. Mashayekhi,A., Shahbazi,S. and Omrani,M.<br>Functional and molecular characterization of C91S mutation in the second epidermal growth factor-like domain of factor VII<br>Iran J Biotechnol (2018) 16, e1813-e1813. PubMed  Europe PubMed DOI  PMC  EPMC  M
  47. Rajpurkar,M. and Cooper,D.L.<br>Continuous infusion of recombinant activated factor VII: a review of data in congenital hemophilia with inhibitors and congenital factor VII deficiency<br>J Blood Med (2018) 9, 227-239. PubMed  Europe PubMed DOI  PMC  EPMC  U
  48. Umakanthan,J.M., Dhakal,P., Gundabolu,K., Koepsell,S.A. and Baljevic,M.<br>Serendipitous discovery of factor VII deficiency and the ensuing dilemma<br>Maedica (Buchar) (2018) 13, 71-73. PubMed  Europe PubMed  PMC  EPMC  M
    49. 2017
  49. Chollet,M.E., Andersen,E., Skarpen,E., Myklebust,C.F., Koehler,C., Morth,J.P., Chuansumrit,A., Pinotti,M., Bernardi,F., Thiede,B., Sandset,P.M. and Skretting,G.<br>Factor VII deficiency: unveiling the cellular and molecular mechanisms underlying three model alterations of the enzyme catalytic domain<br>Biochim Biophys Acta (2017) 1864, 660-667. PubMed  Europe PubMed DOI  M
  50. Correa de Freitas,M.C., Bomfim,A.S., Mizukami,A., Picanco-Castro,V., Swiech,K. and Covas,D.T.<br>Production of coagulation factor VII in human cell lines Sk-Hep-1 and HKB-11<br>Protein Expr Purif (2017) 137, 26-33. PubMed  Europe PubMed DOI  E
  51. Di Minno,M.N.D., Ambrosino,P., Myasoedova,V., Amato,M., Ventre,I., Tremoli,E. and Minno,A.D.<br>Recombinant activated factor VII (eptacog alfa activated NovoSeven (R) ) in patients with rare congenital bleeding disorders. A systematic review on its use in surgical procedures<br>Curr Pharm Des (2017) 23, 1125-1131. PubMed  Europe PubMed  V  U
  52. Lynch,M., McGrath,K., Raj,K., McLaren,P., Payne,K., McCoy,R. and Giger,U.<br>Hereditary factor VII deficiency in the Asian elephant (Elephas maximus) caused by a F7 missense mutation<br>J Wildl Dis (2017) 53, 248-257. PubMed  Europe PubMed DOI  M
  53. Napolitano,M., Siragusa,S. and Mariani,G.<br>Factor VII deficiency: clinical phenotype, genotype and therapy<br>J Clin Med (2017) 6 PubMed  Europe PubMed DOI  M
  54. Nielsen,A.L., Sorensen,A.B., Holmberg,H.L., Gandhi,P.S., Karlsson,J., Buchardt,J., Lamberth,K., Kjelgaard-Hansen,M., Ley,C.D., Sorensen,B.B., Ruf,W., Olsen,O.H. and Ostergaard,H.<br>Engineering of a membrane-triggered activity switch in coagulation factor VIIa<br>Proc Natl Acad Sci U S A (2017) 114, 12454-12459. PubMed  Europe PubMed DOI
  55. Richter,J.M., Cheney,D.L., Bates,J.A., Wei,A., Luettgen,J.M., Rendina,A.R., Harper,T.M., Narayanan,R., Wong,P.C., Seiffert,D., Wexler,R.R. and Priestley,E.S.<br>Design and synthesis of novel meta-linked phenylglycine macrocyclic FVIIa inhibitors<br>ACS Med Chem Lett (2017) 8, 67-72. PubMed  Europe PubMed DOI  PMC  EPMC  I
  56. Wurtz,N.R., Parkhurst,B.L., DeLucca,I., Glunz,P.W., Jiang,W., Zhang,X., Cheney,D.L., Bozarth,J.M., Rendina,A.R., Wei,A., Harper,T., Luettgen,J.M., Wu,Y., Wong,P.C., Seiffert,D.A., Wexler,R.R. and Priestley,E.S.<br>Neutral macrocyclic factor VIIa inhibitors<br>Bioorg Med Chem Lett (2017) 27, 2650-2654. PubMed  Europe PubMed DOI  I
    57. 2016
  57. Faranoush,M., Abolghasemi,H., Mahboudi,F., Toogeh,G., Karimi,M., Eshghi,P., Managhchi,M., Hoorfar,H., Dehdezi,B.K., Mehrvar,A., Khoeiny,B., Vaziri,B., Kamyar,K., Heshmat,R., Baghaeipour,M.R., Mirbehbahani,N.B., Fayazfar,R., Ahmadinejad,M. and Naderi,M.<br>A comparison of efficacy between recombinant activated factor VII (Aryoseven) and Novoseven in patients with hereditary FVIII deficiency with inhibitor<br>Clin Appl Thromb Hemost (2016) 22, 184-190. PubMed  Europe PubMed DOI  U
  58. Glunz,P.W., Mueller,L., Cheney,D.L., Ladziata,V., Zou,Y., Wurtz,N.R., Wei,A., Wong,P.C., Wexler,R.R. and Priestley,E.S.<br>Atropisomer control in macrocyclic factor VIIa inhibitors<br>J Med Chem (2016) 59, 4007-4018. PubMed  Europe PubMed DOI  I
  59. Habib,A.M., Mousa,A.Y. and Al-Halees,Z.<br>Recombinant activated factor VII for uncontrolled bleeding postcardiac surgery<br>J Saudi Heart Assoc (2016) 28, 222-231. PubMed  Europe PubMed DOI  PMC  EPMC  U
  60. Hao,X., Cheng,X., Ye,J., Wang,Y., Yang,L., Wang,M. and Jin,Y.<br>Severe coagulation factor VII deficiency caused by a novel homozygous mutation (p. Trp284Gly) in loop 140s<br>Blood Coagul Fibrinolysis (2016) 27, 461-463. PubMed  Europe PubMed DOI  M
  61. Ladziata,V.U., Glunz,P.W., Zou,Y., Zhang,X., Jiang,W., Jacutin-Porte,S., Cheney,D.L., Wei,A., Luettgen,J.M., Harper,T.M., Wong,P.C., Seiffert,D., Wexler,R.R. and Priestley,E.S.<br>Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors<br>Bioorg Med Chem Lett (2016) 26, 5051-5057. PubMed  Europe PubMed DOI  I
  62. Ma,A.D., Kessler,C.M., Al-Mondhiry,H.A., Gut,R.Z. and Cooper,D.L.<br>Use of recombinant activated factor VII for acute bleeding episodes in acquired hemophilia: final analysis from the Hemostasis and Thrombosis Research Society Registry acquired hemophilia study<br>Blood Coagul Fibrinolysis (2016) 27, 753-760. PubMed  Europe PubMed DOI  U
  63. Peng,L., Yu,X., Li,C., Cai,Y., Chen,Y., He,Y., Yang,J., Jin,J. and Li,H.<br>Enhanced recombinant factor VII expression in Chinese hamster ovary cells by optimizing signal peptides and fed-batch medium<br>Bioengineered (2016) 7, 189-197. PubMed  Europe PubMed DOI  E
  64. Sheffield,W.P. and Bhakta,V.<br>The M358R variant of alpha(1)-proteinase inhibitor inhibits coagulation factor VIIa<br>Biochem Biophys Res Commun (2016) 470, 710-713. PubMed  Europe PubMed DOI  M
  65. Sorensen,A.B., Madsen,J.J., Svensson,L.A., Pedersen,A.A., Ostergaard,H., Overgaard,M.T., Olsen,O.H. and Gandhi,P.S.<br>Molecular basis of enhanced activity in factor VIIa-trypsin variants conveys insights into tissue factor-mediated allosteric regulation of factor VIIa activity<br>J Biol Chem (2016) 291, 4671-4683. PubMed  Europe PubMed DOI
  66. Toogeh,G., Abolghasemi,H., Eshghi,P., Managhchi,M., Shaverdi-Niasari,M., Karimi,K., Roostaei,S., Emran,N. and Abdollahi,A.<br>Evaluation of AryoSeven safety (recombinant activated factor VII) in patients with bleeding disorders (an observational post-marketing surveillance study)<br>Iran J Pathol (2016) 11, 204-209. PubMed  Europe PubMed  PMC  EPMC
  67. Wurtz,N.R., Parkhurst,B.L., Jiang,W., DeLucca,I., Zhang,X., Ladziata,V., Cheney,D.L., Bozarth,J.R., Rendina,A.R., Wei,A., Luettgen,J.M., Wu,Y., Wong,P.C., Seiffert,D.A., Wexler,R.R. and Priestley,E.S.<br>Discovery of phenylglycine lactams as potent neutral factor VIIa inhibitors<br>ACS Med Chem Lett (2016) 7, 1077-1081. PubMed  Europe PubMed DOI  PMC  EPMC  I
  68. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.<br>A plasma proteolysis pathway comprising blood coagulation proteases<br>Oncotarget (2016) 7, 40919-40938. PubMed  Europe PubMed DOI
  69. Zhang,X., Glunz,P.W., Johnson,J.A., Jiang,W., Jacutin-Porte,S., Ladziata,V., Zou,Y., Phillips,M.S., Wurtz,N.R., Parkhurst,B., Rendina,A.R., Harper,T.M., Cheney,D.L., Luettgen,J.M., Wong,P.C., Seiffert,D., Wexler,R.R. and Priestley,E.S.<br>Discovery of a highly potent, selective, and orally bioavailable macrocyclic inhibitor of blood coagulation factor VIIa-tissue factor complex<br>J Med Chem (2016) 59, 7125-7137. PubMed  Europe PubMed DOI  I
    70. 2015
  70. Bohm,E., Seyfried,B.K., Dockal,M., Graninger,M., Hasslacher,M., Neurath,M., Konetschny,C., Matthiessen,P., Mitterer,A. and Scheiflinger,F.<br>Differences in N-glycosylation of recombinant human coagulation factor VII derived from BHK, CHO, and HEK293 cells<br>BMC Biotechnol (2015) 15, 87-87. PubMed  Europe PubMed DOI  PMC  EPMC  E
  71. Cheney,D.L., Bozarth,J.M., Metzler,W.J., Morin,P.E., Mueller,L., Newitt,J.A., Nirschl,A.H., Rendina,A.R., Tamura,J.K., Wei,A., Wen,X., Wurtz,N.R., Seiffert,D.A., Wexler,R.R. and Priestley,E.S.<br>Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening<br>J Med Chem (2015) 58, 2799-2808. PubMed  Europe PubMed DOI  I
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