Substrates for peptidase S01.193: complement component activated C1s

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Abz-Gly-Leu-Gln-Arg-Ala-Leu-Glu-IleLys(DNP)-NH2			Abz-Gly-Leu-Gln-Arg+Ala-Leu-Glu-IleLys(DNP)-NH2	S		Gly	Leu	Gln	Arg	Ala	Leu	Glu	Ile	Kerr et al., 2005
Abz-Gly-Tyr-Leu-Gly-Arg-Ser-Tyr-Lys-Val-Gly-Lys(DNP)-OH			Abz-Gly-Tyr-Leu-Gly-Arg+Ser-Tyr-Lys-Val-Gly-Lys(DNP)-OH	S		Tyr	Leu	Gly	Arg	Ser	Tyr	Lys	Val	Kerr et al., 2005
Abz-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile-Lys(DNP)-NH2			Abz-Ser-Leu-Gly-Arg+Lys-Ile-Gln-Ile-Lys(DNP)-NH2	S		Ser	Leu	Gly	Arg	Lys	Ile	Gln	Ile	Kerr et al., 2005
Abz-Ser-Val-Ala-Arg-Thr-leu-Leu-ValLys(DNP)-NH2			Abz-Ser-Val-Ala-Arg+Thr-leu-Leu-ValLys(DNP)-NH2	S		Ser	Val	Ala	Arg	Thr	Leu	Leu	Val	Kerr et al., 2005
beta-2-microglobulin	P61769	21-119	peptide-Lys78+Asp-peptide	P	NT	Ser	Phe	Ser	Lys	Asp	Trp	Ser	Phe	Nissen et al., 1990
complement component C2	P06681	21-752	peptide-Arg223+Lys-peptide	P		Ser	Leu	Gly	Arg	Lys	Ile	Gln	Ile	Arlaud et al., 2004	17322
complement component C4	P0C0L4	20-1744	peptide-Arg76+Ala-peptide	P		Gly	Leu	Gln	Arg	Ala	Leu	Glu	Ile	Sim & Tsiftsoglou, 2004	20372
erythrocyte membrane protein 1	A3R6S0	1-3274	peptide-Arg714+Ser-peptide	P	MS	Ser	Ser	Gly	Arg	Ser	Leu	Asn	Pro	Azasi et al., 2021
phage display peptide ALFRAPRA			phage display peptide ALFR+APRA	S		Ala	Leu	Phe	Arg	Ala	Pro	Arg	Ala	Kerr et al., 2005
phage display peptide NVARALYA			phage display peptide NVAR+ALYA	S		Asn	Val	Ala	Arg	Ala	Leu	Tyr	Ala	Kerr et al., 2005
phage display peptide RPARILAV			phage display peptide RPAR+ILAV	S		Arg	Pro	Ala	Arg	Ile	Leu	Ala	Val	Kerr et al., 2005
phage display peptide SLRRNWSK			phage display peptide SLRR+NWSK	S		Ser	Leu	Arg	Arg	Asn	Trp	Ser	Lys	Kerr et al., 2005
phage display peptide YLGRIGVY			phage display peptide YLGR+IGVY	S		Tyr	Leu	Gly	Arg	Ile	Gly	Val	Tyr	Kerr et al., 2005
phage display peptide YLGRSYKV			phage display peptide YLGR+SYKV	S		Tyr	Leu	Gly	Arg	Ser	Tyr	Lys	Val	Kerr et al., 2005
phage display peptide YMGRVLIR			phage display peptide YMGR+VLIR	S		Tyr	Met	Gly	Arg	Val	Leu	Ile	Arg	Kerr et al., 2005
phage display peptide YVGRLLRG			phage display peptide YVGR+LLRG	S		Tyr	Val	Gly	Arg	Leu	Leu	Arg	Gly	Kerr et al., 2005
Plasma protease C1 inhibitor	P05155	23-500	peptide-Arg466+Thr-peptide	P		Ser	Val	Ala	Arg	Thr	Leu	Leu	Val	Duncan et al., 2008	3288
Tos-Arg-OMe (TAME)			Tos-Arg+OMe	S		-	-	Tos	Arg	OME	-	-	-	Arlaud & Thielens, 1993
Z-Gly-Arg-SBzl			Z-Gly-Arg+SBzl	S		-	Z	Gly	Arg	SBz	-	-	-	Arlaud & Thielens, 1993
Z-Tyr-OPhNO2			Z-Tyr+OPhNO2	S		-	-	Z	Tyr	ONA	-	-	-	Arlaud & Thielens, 1993