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Literature for peptidase S01.193: complement component activated C1s

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Garrigues,R.J., Garrison,M.P. and Garcia,B.L.<br>The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation<br>J Immunol (2024) 213, 718-729. PubMed  Europe PubMed DOI
  2. Thomas,S., Schulz,A.M., Leong,J.M., Zeczycki,T.N. and Garcia,B.L.<br>The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi<br>J Biol Chem (2024) , 107236-107236. PubMed  Europe PubMed DOI
  3. Xu,X., Herdendorf,T.J., Duan,H., Rohlik,D.L., Roy,S., Zhou,H., Alkhateeb,H., Khandelwal,S., Zhou,Q., Li,P., Arepally,G.M., Walker,J.K., Garcia,B.L. and Geisbrecht,B.V.<br>Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs<br>J Immunol (2024) 212, 689-701. PubMed  Europe PubMed DOI  PMC  EPMC  I
    4. 2023
  4. Amberger,A., Pertoll,J., Traunfellner,P., Kapferer-Seebacher,I., Stoiber,H., Klimaschewski,L., Thielens,N., Gaboriaud,C. and Zschocke,J.<br>Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome<br>Front Immunol (2023) 14, 1157421-1157421. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Ikeda,Z., Kamei,T., Sasaki,Y., Reynolds,M., Sakai,N., Yoshikawa,M., Tawada,M., Morishita,N., Dougan,D.R., Chen,C.H., Levin,I., Zou,H., Kuno,M., Arimura,N., Kikukawa,Y., Kondo,M., Tohyama,K. and Sato,K.<br>Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway<br>J Med Chem (2023) 66, 6354-6371. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Lorvellec,M., Chouquet,A., Koch,J., Bally,I., Signor,L., Vigne,J., Dalonneau,F., Thielens,N.M., Rabilloud,T., Dalzon,B., Rossi,V. and Gaboriaud,C.<br>HMGB1 cleavage by complement C1s and its potent anti-inflammatory product<br>Front Immunol (2023) 14, 1151731-1151731. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Wu,S., Chen,J., Teo,B.H.D., Wee,S.Y.K., Wong,M.H.M., Cui,J., Chen,J., Leong,K.P. and Lu,J.<br>The axis of complement C1 and nucleolus in antinuclear autoimmunity<br>Front Immunol (2023) 14, 1196544-1196544. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2022
  8. Garrigues,R.J., Thomas,S., Leong,J.M. and Garcia,B.L.<br>Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s<br>J Biol Chem (2022) 298, 102557-102557. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Hurler,L., Toonen,E.J.M., Kajdacsi,E., van Bree,B., Brandwijk,R.J.M.G., de Bruin,W., Lyons,P.A., Bergamaschi,L., Sinkovits,G., Cervenak,L., Wurzner,R. and Prohaszka,Z.<br>Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs<br>Front Immunol (2022) 13, 1039765-1039765. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Azasi,Y., Low,L.M., Just,A.N., Raghavan,S.S.R., Wang,C.W., Valenzuela-Leon,P., Rowe,J.A., Smith,J.D., Lavstsen,T., Turner,L., Calvo,E. and Miller,L.H.<br>Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence<br>Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2019
  11. Li,S.W., Yu,B., Byrne,G., Wright,M., O'Rourke,S., Mesa,K. and Berman,P.W.<br>Identification and CRISPR/Cas9 inactivation of the C1s protease responsible for proteolysis of recombinant proteins produced in CHO cells<br>Biotechnol Bioeng (2019) 116, 2130-2145. PubMed  Europe PubMed DOI  K
  12. Nikitin,P.A., Rose,E.L., Byun,T.S., Parry,G.C. and Panicker,S.<br>C1s Inhibition by BIVV009 (Sutimlimab) prevents complement-enhanced activation of autoimmune human B cells in vitro<br>J Immunol (2019) 202, 1200-1209. PubMed  Europe PubMed DOI
  13. Szilagyi,K., Hajdu,I., Flachner,B., Lorincz,Z., Balczer,J., Gal,P., Zavodszky,P., Pirli,C., Balogh,B., Mandity,I.M., Cseh,S. and Dorman,G.<br>Design and selection of novel C1s inhibitors by in silico and in vitro approaches<br>Molecules (2019) 24 PubMed  Europe PubMed DOI  I
    14. 2018
  14. Almitairi,J.O.M., Venkatraman Girija,U., Furze,C.M., Simpson-Gray,X., Badakshi,F., Marshall,J.E., Schwaeble,W.J., Mitchell,D.A., Moody,P.C.E. and Wallis,R.<br>Structure of the C1r-C1s interaction of the C1 complex of complement activation<br>Proc Natl Acad Sci U S A (2018) 115, 768-773. PubMed  Europe PubMed DOI  S
  15. Almitairi,J.O.M., Venkatraman Girija,U., Furze,C.M., Simpson-Gray,X., Badakshi,F., Marshall,J.E., Schwaeble,W.J., Mitchell,D.A., Moody,P.C.E. and Wallis,R.<br>Reply to Mortensen et al.: The zymogen form of complement component C1<br>Proc Natl Acad Sci U S A (2018) 115, E3867-E3867. PubMed  Europe PubMed DOI
  16. Habib,A., Sawmiller,D., Hou,H., Kanithi,M., Tian,J., Zeng,J., Zi,D., He,Z.X., Sanberg,P.R. and Tan,J.<br>Human cord blood serum-derived APP alpha-secretase cleavage activity is mediated by C1 complement<br>Cell Transplant (2018) 27, 666-676. PubMed  Europe PubMed DOI
    17. 2017
  17. Lu,J. and Kishore,U.<br>C1 complex: an adaptable proteolytic module for complement and non-complement functions<br>Front Immunol (2017) 8, 592-592. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Nilojan,J., Bathige,S.D.N.K., Kugapreethan,R., Yang,H., Kim,M.J., Nam,B.H. and Lee,J.<br>Molecular features and the transcriptional and functional delineation of complement system activators C1r and C1s from Sebastes schlegelii<br>Dev Comp Immunol (2017) 81, 279-290. PubMed  Europe PubMed DOI
    19. 2016
  19. Yeo,J.G., Leong,J., Arkachaisri,T., Cai,Y., Teo,B.H., Tan,J.H., Das,L. and Lu,J.<br>Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosis<br>Cell Death Discov (2016) 2, 16069-16069. PubMed  Europe PubMed DOI  PMC  EPMC  P
    20. 2014
  20. Shi,J., Rose,E.L., Singh,A., Hussain,S., Stagliano,N.E., Parry,G.C. and Panicker,S.<br>TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins<br>Blood (2014) 123, 4015-4022. PubMed  Europe PubMed DOI
  21. Wijeyewickrema,L.C., Duncan,R.C. and Pike,R.N.<br>The role of the Lys628 (192) residue of the complement protease, C1s, in interacting with peptide and protein substrates<br>Front Immunol (2014) 5, 444-444. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 2013
  22. Perry,A.J., Wijeyewickrema,L.C., Wilmann,P.G., Gunzburg,M.J., D'Andrea,L., Irving,J.A., Pang,S.S., Duncan,R.C., Wilce,J.A., Whisstock,J.C. and Pike,R.N.<br>A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4<br>J Biol Chem (2013) 288, 15821-15829. PubMed  Europe PubMed DOI  S
    23. 2012
  23. Arlaud,G.J., Rossi,V., Gaboriaud,C. and Thielens,N.M.<br>Complement component C1s<br>[ISSN:978-0-12-407742-3] (2012) 3, 2853-2857. DOI
  24. Duncan,R.C., Mohlin,F., Taleski,D., Coetzer,T.H., Huntington,J.A., Payne,R.J., Blom,A.M., Pike,R.N. and Wijeyewickrema,L.C.<br>Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s<br>J Immunol (2012) 189, 2365-2373. PubMed  Europe PubMed DOI
  25. Forneris,F., Wu,J. and Gros,P.<br>The modular serine proteases of the complement cascade<br>Curr Opin Struct Biol (2012) 22, 333-341. PubMed  Europe PubMed DOI  V
  26. Subasinghe,N.L., Khalil,E., Travins,J.M., Ali,F., Ballentine,S.K., Hufnagel,H.R., Pan,W., Leonard,K., Bone,R.F., Soll,R.M., Crysler,C.S., Ninan,N., Kirkpatrick,J., Kolpak,M.X., Diloreto,K.A., Eisennagel,S.H., Huebert,N.D., Molloy,C.J., Tomczuk,B.E. and Gaul,M.D.<br>Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s<br>Bioorg Med Chem Lett (2012) 22, 5303-5307. PubMed  Europe PubMed DOI  I
    27. 2010
  27. Brier,S., Pflieger,D., Le Mignon,M., Bally,I., Gaboriaud,C., Arlaud,G.J. and Daniel,R.<br>Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex<br>J Biol Chem (2010) 285, 32251-32263. PubMed  Europe PubMed DOI
    28. 2009
  28. Abe,K., Endo,Y., Nakazawa,N., Kanno,K., Okubo,M., Hoshino,T. and Fujita,T.<br>Unique phenotypes of C1s deficiency and abnormality caused by two compound heterozygosities in a Japanese family<br>J Immunol (2009) 182, 1681-1688. PubMed  Europe PubMed  M
  29. Bally,I., Rossi,V., Lunardi,T., Thielens,N.M., Gaboriaud,C. and Arlaud,G.J.<br>Identification of the C1q-binding sites of human C1r and C1s: a refined three-dimensional model of the C1 complex of complement<br>J Biol Chem (2009) 284, 19340-19348. PubMed  Europe PubMed DOI  PMC  EPMC  S
  30. Boyd,S.E., Kerr,F.K., Albrecht,D.W., de la Banda,M.G., Ng,N. and Pike,R.N.<br>Cooperative effects in the substrate specificity of the complement protease C1s<br>Biol Chem (2009) 390, 503-507. PubMed  Europe PubMed DOI  P
  31. Busby,W.H., Jr., Yocum,S.A., Rowland,M., Kellner,D., Lazerwith,S., Sverdrup,F., Yates,M., Radabaugh,M. and Clemmons,D.R.<br>Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid<br>Osteoarthritis Cartilage (2009) 17, 547-555. PubMed  Europe PubMed DOI
  32. Gal,P., Dobo,J., Zavodszky,P. and Sim,R.B.<br>Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions<br>Mol Immunol (2009) 46, 2745-2752. PubMed  Europe PubMed DOI  V
  33. Murray-Rust,T.A., Kerr,F.K., Thomas,A.R., Wu,T., Yongqing,T., Ong,P.C., Quinsey,N.S., Whisstock,J.C., Wagenaar-Bos,I.C., Freeman,C. and Pike,R.N.<br>Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1<br>Biochem J (2009) 422, 295-303. PubMed  Europe PubMed DOI
  34. Phillips,A.E., Toth,J., Dodds,A.W., Girija,U.V., Furze,C.M., Pala,E., Sim,R.B., Reid,K.B., Schwaeble,W.J., Schmid,R., Keeble,A.H. and Wallis,R.<br>Analogous interactions in initiating complexes of the classical and lectin pathways of complement<br>J Immunol (2009) 182, 7708-7717. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2008
  35. Amano,M.T., Ferriani,V.P., Florido,M.P., Reis,E.S., Delcolli,M.I., Azzolini,A.E., Assis-Pandochi,A.I., Sjoholm,A.G., Farah,C.S., Jensenius,J.C. and Isaac,L.<br>Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene<br>Mol Immunol (2008) 45, 1693-1702. PubMed  Europe PubMed DOI  M
  36. Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.<br>The initiating proteases of the complement system: controlling the cleavage<br>Biochimie (2008) 90, 387-395. PubMed  Europe PubMed DOI  V
  37. Travins,J.M., Ali,F., Huang,H., Ballentine,S.K., Khalil,E., Hufnagel,H.R., Pan,W., Gushue,J., Leonard,K., Bone,R.F., Soll,R.M., DesJarlais,R.L., Crysler,C.S., Ninan,N., Kirkpatrick,J., Cummings,M.D., Huebert,N., Molloy,C.J., Gaul,M., Tomczuk,B.E. and Subasinghe,N.L.<br>Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s<br>Bioorg Med Chem Lett (2008) 18, 1603-1606. PubMed  Europe PubMed DOI  I
    38. 2007
  38. Gaboriaud,C., Teillet,F., Gregory,L.A., Thielens,N.M. and Arlaud,G.J.<br>Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights<br>Immunobiology (2007) 212, 279-288. PubMed  Europe PubMed DOI
    39. 2006
  39. [YEAR:2-2-2006]Subasinghe,N.L., Travins,J.M., Ali,F., Huang,H., Ballentine,S.K., Marugan,J.J., Khalil,E., Hufnagel,H.R., Bone,R.F., DesJarlais,R.L., Crysler,C.S., Ninan,N., Cummings,M.D., Molloy,C.J. and Tomczuk,B.E.<br>A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s<br>Bioorg Med Chem Lett (2-2-2006) 16, 2200-2204. PubMed  Europe PubMed DOI  I
    40. 2005
  40. [YEAR:1-10-2005]Bally,I., Rossi,V., Thielens,N.M., Gaboriaud,C. and Arlaud,G.J.<br>Functional role of the linker between the complement control protein modules of complement protease C1s<br>J Immunol (1-10-2005) 175, 4536-4542. PubMed  Europe PubMed
  41. [YEAR:16-9-2005]Kerr,F.K., O'Brien,G., Quinsey,N.S., Whisstock,J.C., Boyd,S., de la Banda,M.G., Kaiserman,D., Matthews,A.Y., Bird,P.I. and Pike,R.N.<br>Elucidation of the substrate specificity of the C1s protease of the classical complement pathway<br>J Biol Chem (16-9-2005) 280, 39510-39514. PubMed  Europe PubMed DOI  P
  42. [YEAR:14-10-2005]Rossi,V., Teillet,F., Thielens,N.M., Bally,I. and Arlaud,G.J.<br>Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules<br>J Biol Chem (14-10-2005) 280, 41811-41818. PubMed  Europe PubMed DOI
    43. 2004
  43. Arlaud,G.J., Rossi,V., Gaboriaud,C. and Thielens,N.M.<br>Complement component C1s<br>[ISSN:0-12-079610-4] (2004) 2, 1620-1623.  V
  44. [YEAR:1-7-2004]Gaboriaud,C., Thielens,N.M., Gregory,L.A., Rossi,V., Fontecilla-Camps,J.C. and Arlaud,G.J.<br>Structure and activation of the C1 complex of complement: unraveling the puzzle<br>Trends Immunol (1-7-2004) 25, 368-373. PubMed  Europe PubMed DOI
  45. [YEAR:21-6-2004]Subasinghe,N.L., Ali,F., Illig,C.R., Jonathan Rudolph,M., Klein,S., Khalil,E., Soll,R.M., Bone,R.F., Spurlino,J.C., DesJarlais,R.L., Crysler,C.S., Cummings,M.D., Morris,P.E., Jr., Kilpatrick,J.M. and Sudhakara Babu,Y.<br>A novel series of potent and selective small molecule inhibitors of the complement component C1s<br>Bioorg Med Chem Lett (21-6-2004) 14, 3043-3047. PubMed  Europe PubMed DOI  I
    46. 2003
  46. [YEAR:15-4-2003]Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.<br>Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system<br>Biochem J (15-4-2003) 371, 631-640. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Gregory,L.A., Thielens,N.M., Arlaud,G.J., Fontecilla-Camps,J.C. and Gaboriaud,C.<br>X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement<br>J Biol Chem (2003) 278, 32157-32164. PubMed  Europe PubMed DOI
  48. Moralez,A., Busby,W.H., Jr. and Clemmons,D.<br>Control of insulin-like growth factor binding protein-5 protease synthesis and secretion by human fibroblasts and porcine aortic smooth muscle cells<br>Endocrinology (2003) 144, 2489-2495. PubMed  Europe PubMed DOI
  49. [YEAR:23-12-2003]O'Brien,G., Quinsey,N.S., Whisstock,J.C. and Pike,R.N.<br>Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates<br>Biochemistry (23-12-2003) 42, 14939-14945. PubMed  Europe PubMed DOI
    50. 2002
  50. Arlaud,G.J., Gaboriaud,C., Thielens,N.M., Budayova-Spano,M., Rossi,V. and Fontecilla-Camps,J.C.<br>Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity<br>Mol Immunol (2002) 39, 383-394. PubMed  Europe PubMed DOI
  51. Arlaud,G.J., Gaboriaud,C., Thielens,N.M. and Rossi,V.<br>Structural biology of C1<br>Biochem Soc Trans (2002) 30, 1001-1006. PubMed  Europe PubMed DOI
  52. Gal,P., Ambrus,G. and Zavodszky,P.<br>C1s, the protease messenger of C1. Structure, function and physiological significance<br>Immunobiology (2002) 205, 383-394. PubMed  Europe PubMed
    53. 2001
  53. [YEAR:15-6-2001]Dragon-Durey,M.A., Quartier,P., Fremeaux-Bacchi,V., Blouin,J., de Barace,C., Prieur,A.M., Weiss,L. and Fridman,W.H.<br>Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases<br>J Immunol (15-6-2001) 166, 7612-7616. PubMed  Europe PubMed  K
  54. Nakao,M., Osaka,K., Kato,Y., Fujiki,K. and Yano,T.<br>Molecular cloning of the complement C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)<br>Immunogenetics (2001) 52, 255-263. PubMed  Europe PubMed DOI
    55. 2000
  55. [YEAR:1-12-2000]Busby,W.H., Jr., Nam,T.J., Moralez,A., Smith,C., Jennings,M. and Clemmons,D.R.<br>The complement component C1s is the protease that accounts for cleavage of insulin-like growth factor-binding protein-5 in fibroblast medium<br>J Biol Chem (1-12-2000) 275, 37638-37644. PubMed  Europe PubMed DOI
  56. Sim,R.B. and Laich,A.<br>Serine proteases of the complement system<br>Biochem Soc Trans (2000) 28, 545-550. PubMed  Europe PubMed
    57. 1999
  57. Thielens,N.M., Bersch,B., Hernandez,J.F. and Arlaud,G.J.<br>Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex<br>Immunopharmacology (1999) 42, 3-13. PubMed  Europe PubMed DOI
    58. 1998
  58. Arlaud,G.J., Volanakis,J.E., Thielens,N.M., Narayana,S.V., Rossi,V. and Xu,Y.<br>The atypical serine proteases of the complement system<br>Adv Immunol (1998) 69, 249-307. PubMed  Europe PubMed
  59. Gans,P., Rossi,V., Gaboriaud,C., Bally,I., Hernandez,J.F., Blackledge,M.J. and Arlaud,G.J.<br>NMR structures of the C-terminal end of human complement serine protease C1s<br>Cell Mol Life Sci (1998) 54, 171-178. PubMed  Europe PubMed DOI
  60. [YEAR:9-1-1998]Rossi,V., Bally,I., Thielens,N.M., Esser,A.F. and Arlaud,G.J.<br>Baculovirus-mediated expression of truncated modular fragments from the catalytic region of human complement serine protease C1s. Evidence for the involvement of both complement control protein modules in the recognition of the C4 protein substrate<br>J Biol Chem (9-1-1998) 273, 1232-1239. PubMed  Europe PubMed DOI
  61. [YEAR:16-3-1998]Sakai,H., Nakashima,S., Yoshimura,S., Nishimura,Y., Sakai,N. and Nozawa,Y.<br>Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation<br>Gene (16-3-1998) 209, 87-94. PubMed  Europe PubMed DOI
    62. 1995
  62. Ogata,R.T. and Low,P.J.<br>Complement component C5: engineering of a mutant that is specifically cleaved by the C4-specific C1s protease<br>J Immunol (1995) 155, 2642-2651. PubMed  Europe PubMed
  63. [YEAR:30-1-1995]Petillot,Y., Thibault,P., Thielens,N.M., Rossi,V., Lacroix,M., Coddeville,B., Spik,G., Schumaker,V.N., Gagnon,J. and Arlaud,G.J.<br>Analysis of the N-linked oligosaccharides of human C1s using electrospray ionisation mass spectrometry<br>FEBS Lett (30-1-1995) 358, 323-328. PubMed  Europe PubMed DOI
  64. Rossi,V., Gaboriaud,C., Lacroix,M., Ulrich,J., Fontecilla-Camps,J.C., Gagnon,J. and Arlaud,G.J.<br>Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling<br>Biochemistry (1995) 34, 7311-7321. PubMed  Europe PubMed DOI
  65. [YEAR:3-7-1995]Toyoguchi,T., Yamaguchi,K., Imajoh-Ohmi,S., Kato,N., Kusunoki,M., Kageyama,H., Sakiyama,S., Nagasawa,S., Moriya,H. and Sakiyama,H.<br>Purification and characterization of recombinant hamster tissue complement C1s<br>Biochim Biophys Acta (3-7-1995) 1250, 90-96. PubMed  Europe PubMed DOI
    66. 1993
  66. Arlaud,G.J. and Thielens,N.M.<br>Human complement serine proteases C1r and C1s and their proenzymes<br>Methods Enzymol (1993) 223, 61-82. PubMed  Europe PubMed DOI  V
  67. Lomas,D.A., Evans,D.L., Upton,C., McFadden,G. and Carrell,R.W.<br>Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1s by a myxoma virus serine proteinase inhibitor<br>J Biol Chem (1993) 268, 516-521. PubMed  Europe PubMed
    68. 1992
  68. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.<br>Substituted isocoumarins as inhibitors of complement serine proteases<br>J Immunol (1992) 149, 163-168. PubMed  Europe PubMed  I
  69. [YEAR:5-5-1992]Luo,C., Thielens,N.M., Gagnon,J., Gal,P., Sarvari,M., Tseng,Y., Tosi,M., Zavodszky,P., Arlaud,G.J. and Schumaker,V.N.<br>Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex<br>Biochemistry (5-5-1992) 31, 4254-4262. PubMed  Europe PubMed DOI
    70. 1991
  70. Bork,P.<br>Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats<br>FEBS Lett (1991) 282, 9-12. PubMed  Europe PubMed DOI
    71. 1990
  71. Nissen,M.H., Roepstorff,P., Thim,L., Dunbar,B. and Fothergill,J.E.<br>Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1s<br>Eur J Biochem (1990) 189, 423-429. PubMed  Europe PubMed  P
  72. Rawlings,N.D. and Barrett,A.J.<br>Bone morphogenetic protein 1 is homologous in part with calcium-dependent serine proteinase<br>Biochem J (1990) 266, 622-624. PubMed  Europe PubMed  PMC  EPMC
  73. [YEAR:10-4-1990]Thielens,N.M., Van Dorsselaer,A., Gagnon,J. and Arlaud,G.J.<br>Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region<br>Biochemistry (10-4-1990) 29, 3570-3578. PubMed  Europe PubMed
    74. 1989
  74. Kinoshita,H., Sakiyama,H., Tokunaga,K., Imajoh-Ohmi,S., Hamada,Y., Isono,K. and Sakiyama,S.<br>Complete primary structure of calcium-dependent serine proteinase capable of degrading extracellular matrix proteins<br>FEBS Lett (1989) 250, 411-415. PubMed  Europe PubMed
  75. Skoog,M.T., Mehdi,S., Wiseman,J.S. and Bey,P.<br>The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates<br>Biochim Biophys Acta (1989) 996, 89-94. PubMed  Europe PubMed
    76. 1988
  76. Kusumoto,H., Hirosawa,S., Salier,J.P., Hagen,F.S. and Kurachi,K.<br>Human genes for complement components c1r and c1s in a close tail-to- tail arrangement<br>Proc Natl Acad Sci U S A (1988) 85, 7307-7311. PubMed  Europe PubMed  PMC  EPMC
  77. Muller-Eberhard,H.J.<br>Molecular organization and function of the complement system<br>Annu Rev Biochem (1988) 57, 321-347. PubMed  Europe PubMed DOI
  78. Nguyen,V.C., Tosi,M., Gross,M.S., Cohen-Haguenauer,O., Jegou-Foubert,C., de Tand,M.F., Meo,T. and Frezal,J.<br>Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13<br>Hum Genet (1988) 78, 363-368. PubMed  Europe PubMed
    79. 1987
  79. Keogh,S.J., Harding,D.R. and Hardman,M.J.<br>The complement component C1s catalysed hydrolysis of peptide 4-nitroanilide substrates<br>Biochim Biophys Acta (1987) 913, 39-44. PubMed  Europe PubMed  P
  80. Mackinnon,C.M., Carter,P.E., Smyth,S.J., Dunbar,B. and Fothergill,J.E.<br>Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence<br>Eur J Biochem (1987) 169, 547-553. PubMed  Europe PubMed
    81. 1983
  81. Nilsson,T. and Wiman,B.<br>Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s<br>Eur J Biochem (1983) 129, 663-667. PubMed  Europe PubMed
  82. [YEAR:1-9-1983]Nilsson,T., Sjoholm,I. and Wiman,B.<br>Structural and circular-dichroism studies on the interaction between human C1-esterase inhibitor and C1s<br>Biochem J (1-9-1983) 213, 617-624. PubMed  Europe PubMed  PMC  EPMC
    83. 1982
  83. [YEAR:1-1-1982]Chesne,S., Villiers,C.L., Arlaud,G.J., Lacroix,M.B. and Colomb,M.G.<br>Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1<br>Biochem J (1-1-1982) 201, 61-70. PubMed  Europe PubMed  PMC  EPMC
  84. Hitomi,Y. and Fujii,S.<br>Inhibition of various immunological reactions in vivo by a new synthetic complement inhibitor<br>Int Arch Allergy Appl Immunol (1982) 69, 262-267. PubMed  Europe PubMed  I
    85. 1981
  85. Arlaud,G.J. and Gagnon,J.<br>Clr and Cls subcomponents of human complement: two serine proteinases lacking the 'histidine-loop' disulphide bridge<br>Biosci Rep (1981) 1, 779-784. PubMed  Europe PubMed
    86. 1980
  86. Takahashi,K., Nagasawa,S. and Koyama,J.<br>Effect of C1-inhibitor, benzamidine, and heat treatment on the hydrolytic activity of a subcomponent of the first component of human complement, C1s<br>Biochim Biophys Acta (1980) 611, 196-204. PubMed  Europe PubMed  I
    87. 1979
  87. [YEAR:25-1-1979]Arlaud,G.J., Reboul,A., Sim,R.B. and Colomb,M.G.<br>Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1<br>Biochim Biophys Acta (25-1-1979) 576, 151-162. PubMed  Europe PubMed
  88. [YEAR:1-1-1979]Sim,R.B., Reboul,A., Arlaud,G.J., Villiers,C.L. and Colomb,M.G.<br>Interaction of 125I-labelled complement subcomponents C-1r and C-1s with protease inhibitors in plasma<br>FEBS Lett (1-1-1979) 97, 111-115. PubMed  Europe PubMed DOI
    89. 1977
  89. Chapuis,R.M., Isliker,H. and Assimeh,S.N.<br>Studies on the precursor form of the first component of complement. 1. Isolation of the proenzyme forms of Clr and Cls<br>Immunochemistry (1977) 14, 313-317. PubMed  Europe PubMed DOI
    90. 1976
  90. [YEAR:1-9-1976]Gigli,I., Porter,R.R. and Sim,R.B.<br>The unactivated form of the first component of human complement, C1<br>Biochem J (1-9-1976) 157, 541-548. PubMed  Europe PubMed  PMC  EPMC
    91. 1975
  91. Harpel,P.C. and Cooper,N.R.<br>Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin<br>J Clin Invest (1975) 55, 593-604. PubMed  Europe PubMed DOI  PMC  EPMC
    92. 1963
  92. Lepow,I.H., Naff,G.B., Todd,E.W., Pensky,J. and Hinz,C.F.<br>Chromatographic resolution of the first component of human complement into three activities<br>J Exp Med (1963) 117, 983-1008. PubMed  Europe PubMed  PMC  EPMC

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