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Literature for peptidase S01.193: complement component activated C1s

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Garrigues,R.J., Garrison,M.P. and Garcia,B.L.
    The Crystal Structure of the Michaelis-Menten Complex of C1 Esterase Inhibitor and C1s Reveals Novel Insights into Complement Regulation
    J Immunol213, 718-729. PubMed  Europe PubMed DOI
  2. Thomas,S., Schulz,A.M., Leong,J.M., Zeczycki,T.N. and Garcia,B.L.
    The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi
    J Biol Chem107236-107236. PubMed  Europe PubMed DOI
  3. Xu,X., Herdendorf,T.J., Duan,H., Rohlik,D.L., Roy,S., Zhou,H., Alkhateeb,H., Khandelwal,S., Zhou,Q., Li,P., Arepally,G.M., Walker,J.K., Garcia,B.L. and Geisbrecht,B.V.
    Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs
    J Immunol212, 689-701. PubMed  Europe PubMed DOI  I
    4. 2023
  4. Amberger,A., Pertoll,J., Traunfellner,P., Kapferer-Seebacher,I., Stoiber,H., Klimaschewski,L., Thielens,N., Gaboriaud,C. and Zschocke,J.
    Degradation of collagen I by activated C1s in periodontal Ehlers-Danlos Syndrome
    Front Immunol14, 1157421-1157421. PubMed  Europe PubMed DOI
  5. Ikeda,Z., Kamei,T., Sasaki,Y., Reynolds,M., Sakai,N., Yoshikawa,M., Tawada,M., Morishita,N., Dougan,D.R., Chen,C.H., Levin,I., Zou,H., Kuno,M., Arimura,N., Kikukawa,Y., Kondo,M., Tohyama,K. and Sato,K.
    Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway
    J Med Chem66, 6354-6371. PubMed  Europe PubMed DOI
  6. Lorvellec,M., Chouquet,A., Koch,J., Bally,I., Signor,L., Vigne,J., Dalonneau,F., Thielens,N.M., Rabilloud,T., Dalzon,B., Rossi,V. and Gaboriaud,C.
    HMGB1 cleavage by complement C1s and its potent anti-inflammatory product
    Front Immunol14, 1151731-1151731. PubMed  Europe PubMed DOI
  7. Wu,S., Chen,J., Teo,B.H.D., Wee,S.Y.K., Wong,M.H.M., Cui,J., Chen,J., Leong,K.P. and Lu,J.
    The axis of complement C1 and nucleolus in antinuclear autoimmunity
    Front Immunol14, 1196544-1196544. PubMed  Europe PubMed DOI
    8. 2022
  8. Garrigues,R.J., Thomas,S., Leong,J.M. and Garcia,B.L.
    Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s
    J Biol Chem298, 102557-102557. PubMed  Europe PubMed DOI
    9. 2021
  9. Azasi,Y., Low,L.M., Just,A.N., Raghavan,S.S.R., Wang,C.W., Valenzuela-Leon,P., Rowe,J.A., Smith,J.D., Lavstsen,T., Turner,L., Calvo,E. and Miller,L.H.
    Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
    10. 2019
  10. Li,S.W., Yu,B., Byrne,G., Wright,M., O'Rourke,S., Mesa,K. and Berman,P.W.
    Identification and CRISPR/Cas9 inactivation of the C1s protease responsible for proteolysis of recombinant proteins produced in CHO cells
    Biotechnol Bioeng116, 2130-2145. PubMed  Europe PubMed DOI  K
  11. Nikitin,P.A., Rose,E.L., Byun,T.S., Parry,G.C. and Panicker,S.
    C1s Inhibition by BIVV009 (Sutimlimab) prevents complement-enhanced activation of autoimmune human B cells in vitro
    J Immunol202, 1200-1209. PubMed  Europe PubMed DOI
  12. Szilagyi,K., Hajdu,I., Flachner,B., Lorincz,Z., Balczer,J., Gal,P., Zavodszky,P., Pirli,C., Balogh,B., Mandity,I.M., Cseh,S. and Dorman,G.
    Design and selection of novel C1s inhibitors by in silico and in vitro approaches
    Molecules24, PubMed  Europe PubMed DOI  I
    13. 2018
  13. Almitairi,J.O.M., Venkatraman Girija,U., Furze,C.M., Simpson-Gray,X., Badakshi,F., Marshall,J.E., Schwaeble,W.J., Mitchell,D.A., Moody,P.C.E. and Wallis,R.
    Structure of the C1r-C1s interaction of the C1 complex of complement activation
    Proc Natl Acad Sci U S A115, 768-773. PubMed  Europe PubMed DOI  S
  14. Almitairi,J.O.M., Venkatraman Girija,U., Furze,C.M., Simpson-Gray,X., Badakshi,F., Marshall,J.E., Schwaeble,W.J., Mitchell,D.A., Moody,P.C.E. and Wallis,R.
    Reply to Mortensen et al.: The zymogen form of complement component C1
    Proc Natl Acad Sci U S A115, E3867-E3867. PubMed  Europe PubMed DOI
  15. Habib,A., Sawmiller,D., Hou,H., Kanithi,M., Tian,J., Zeng,J., Zi,D., He,Z.X., Sanberg,P.R. and Tan,J.
    Human cord blood serum-derived APP alpha-secretase cleavage activity is mediated by C1 complement
    Cell Transplant27, 666-676. PubMed  Europe PubMed DOI
    16. 2017
  16. Lu,J. and Kishore,U.
    C1 complex: an adaptable proteolytic module for complement and non-complement functions
    Front Immunol8, 592-592. PubMed  Europe PubMed DOI
  17. Nilojan,J., Bathige,S.D.N.K., Kugapreethan,R., Yang,H., Kim,M.J., Nam,B.H. and Lee,J.
    Molecular features and the transcriptional and functional delineation of complement system activators C1r and C1s from Sebastes schlegelii
    Dev Comp Immunol81, 279-290. PubMed  Europe PubMed DOI
    18. 2016
  18. Yeo,J.G., Leong,J., Arkachaisri,T., Cai,Y., Teo,B.H., Tan,J.H., Das,L. and Lu,J.
    Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosis
    Cell Death Discov2, 16069-16069. PubMed  Europe PubMed DOI  P
    19. 2014
  19. Shi,J., Rose,E.L., Singh,A., Hussain,S., Stagliano,N.E., Parry,G.C. and Panicker,S.
    TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins
    Blood123, 4015-4022. PubMed  Europe PubMed DOI
  20. Wijeyewickrema,L.C., Duncan,R.C. and Pike,R.N.
    The role of the Lys628 (192) residue of the complement protease, C1s, in interacting with peptide and protein substrates
    Front Immunol5, 444-444. PubMed  Europe PubMed DOI
    21. 2013
  21. Perry,A.J., Wijeyewickrema,L.C., Wilmann,P.G., Gunzburg,M.J., D'Andrea,L., Irving,J.A., Pang,S.S., Duncan,R.C., Wilce,J.A., Whisstock,J.C. and Pike,R.N.
    A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4
    J Biol Chem288, 15821-15829. PubMed  Europe PubMed DOI  S
    22. 2012
  22. Arlaud,G.J., Rossi,V., Gaboriaud,C. and Thielens,N.M.
    Complement component C1s
    [ISSN:978-0-12-407742-3]3, 2853-2857. DOI
  23. Duncan,R.C., Mohlin,F., Taleski,D., Coetzer,T.H., Huntington,J.A., Payne,R.J., Blom,A.M., Pike,R.N. and Wijeyewickrema,L.C.
    Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s
    J Immunol189, 2365-2373. PubMed  Europe PubMed DOI
  24. Forneris,F., Wu,J. and Gros,P.
    The modular serine proteases of the complement cascade
    Curr Opin Struct Biol22, 333-341. PubMed  Europe PubMed DOI  V
  25. Subasinghe,N.L., Khalil,E., Travins,J.M., Ali,F., Ballentine,S.K., Hufnagel,H.R., Pan,W., Leonard,K., Bone,R.F., Soll,R.M., Crysler,C.S., Ninan,N., Kirkpatrick,J., Kolpak,M.X., Diloreto,K.A., Eisennagel,S.H., Huebert,N.D., Molloy,C.J., Tomczuk,B.E. and Gaul,M.D.
    Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
    Bioorg Med Chem Lett22, 5303-5307. PubMed  Europe PubMed DOI  I
    26. 2010
  26. Brier,S., Pflieger,D., Le Mignon,M., Bally,I., Gaboriaud,C., Arlaud,G.J. and Daniel,R.
    Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex
    J Biol Chem285, 32251-32263. PubMed  Europe PubMed DOI
    27. 2009
  27. Abe,K., Endo,Y., Nakazawa,N., Kanno,K., Okubo,M., Hoshino,T. and Fujita,T.
    Unique phenotypes of C1s deficiency and abnormality caused by two compound heterozygosities in a Japanese family
    J Immunol182, 1681-1688. PubMed  Europe PubMed  M
  28. Bally,I., Rossi,V., Lunardi,T., Thielens,N.M., Gaboriaud,C. and Arlaud,G.J.
    Identification of the C1q-binding sites of human C1r and C1s: a refined three-dimensional model of the C1 complex of complement
    J Biol Chem284, 19340-19348. PubMed  Europe PubMed DOI  S
  29. Boyd,S.E., Kerr,F.K., Albrecht,D.W., de la Banda,M.G., Ng,N. and Pike,R.N.
    Cooperative effects in the substrate specificity of the complement protease C1s
    Biol Chem390, 503-507. PubMed  Europe PubMed DOI  P
  30. Busby,W.H., Jr., Yocum,S.A., Rowland,M., Kellner,D., Lazerwith,S., Sverdrup,F., Yates,M., Radabaugh,M. and Clemmons,D.R.
    Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid
    Osteoarthritis Cartilage17, 547-555. PubMed  Europe PubMed DOI
  31. Gal,P., Dobo,J., Zavodszky,P. and Sim,R.B.
    Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions
    Mol Immunol46, 2745-2752. PubMed  Europe PubMed DOI  V
  32. Murray-Rust,T.A., Kerr,F.K., Thomas,A.R., Wu,T., Yongqing,T., Ong,P.C., Quinsey,N.S., Whisstock,J.C., Wagenaar-Bos,I.C., Freeman,C. and Pike,R.N.
    Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1
    Biochem J422, 295-303. PubMed  Europe PubMed DOI
  33. Phillips,A.E., Toth,J., Dodds,A.W., Girija,U.V., Furze,C.M., Pala,E., Sim,R.B., Reid,K.B., Schwaeble,W.J., Schmid,R., Keeble,A.H. and Wallis,R.
    Analogous interactions in initiating complexes of the classical and lectin pathways of complement
    J Immunol182, 7708-7717. PubMed  Europe PubMed DOI
    34. 2008
  34. Amano,M.T., Ferriani,V.P., Florido,M.P., Reis,E.S., Delcolli,M.I., Azzolini,A.E., Assis-Pandochi,A.I., Sjoholm,A.G., Farah,C.S., Jensenius,J.C. and Isaac,L.
    Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene
    Mol Immunol45, 1693-1702. PubMed  Europe PubMed DOI  M
  35. Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.
    The initiating proteases of the complement system: controlling the cleavage
    Biochimie90, 387-395. PubMed  Europe PubMed DOI  V
  36. Travins,J.M., Ali,F., Huang,H., Ballentine,S.K., Khalil,E., Hufnagel,H.R., Pan,W., Gushue,J., Leonard,K., Bone,R.F., Soll,R.M., DesJarlais,R.L., Crysler,C.S., Ninan,N., Kirkpatrick,J., Cummings,M.D., Huebert,N., Molloy,C.J., Gaul,M., Tomczuk,B.E. and Subasinghe,N.L.
    Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
    Bioorg Med Chem Lett18, 1603-1606. PubMed  Europe PubMed DOI  I
    37. 2007
  37. Gaboriaud,C., Teillet,F., Gregory,L.A., Thielens,N.M. and Arlaud,G.J.
    Assembly of C1 and the MBL- and ficolin-MASP complexes: structural insights
    Immunobiology212, 279-288. PubMed  Europe PubMed DOI
    38. 2006
  38. [YEAR:2-2-2006]Subasinghe,N.L., Travins,J.M., Ali,F., Huang,H., Ballentine,S.K., Marugan,J.J., Khalil,E., Hufnagel,H.R., Bone,R.F., DesJarlais,R.L., Crysler,C.S., Ninan,N., Cummings,M.D., Molloy,C.J. and Tomczuk,B.E.
    A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s
    Bioorg Med Chem Lett16, 2200-2204. PubMed  Europe PubMed DOI  I
    39. 2005
  39. [YEAR:1-10-2005]Bally,I., Rossi,V., Thielens,N.M., Gaboriaud,C. and Arlaud,G.J.
    Functional role of the linker between the complement control protein modules of complement protease C1s
    J Immunol175, 4536-4542. PubMed  Europe PubMed
  40. [YEAR:16-9-2005]Kerr,F.K., O'Brien,G., Quinsey,N.S., Whisstock,J.C., Boyd,S., de la Banda,M.G., Kaiserman,D., Matthews,A.Y., Bird,P.I. and Pike,R.N.
    Elucidation of the substrate specificity of the C1s protease of the classical complement pathway
    J Biol Chem280, 39510-39514. PubMed  Europe PubMed DOI  P
  41. [YEAR:14-10-2005]Rossi,V., Teillet,F., Thielens,N.M., Bally,I. and Arlaud,G.J.
    Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules
    J Biol Chem280, 41811-41818. PubMed  Europe PubMed DOI
    42. 2004
  42. Arlaud,G.J., Rossi,V., Gaboriaud,C. and Thielens,N.M.
    Complement component C1s
    [ISSN:0-12-079610-4]2, 1620-1623.  V
  43. [YEAR:1-7-2004]Gaboriaud,C., Thielens,N.M., Gregory,L.A., Rossi,V., Fontecilla-Camps,J.C. and Arlaud,G.J.
    Structure and activation of the C1 complex of complement: unraveling the puzzle
    Trends Immunol25, 368-373. PubMed  Europe PubMed DOI
  44. [YEAR:21-6-2004]Subasinghe,N.L., Ali,F., Illig,C.R., Jonathan Rudolph,M., Klein,S., Khalil,E., Soll,R.M., Bone,R.F., Spurlino,J.C., DesJarlais,R.L., Crysler,C.S., Cummings,M.D., Morris,P.E., Jr., Kilpatrick,J.M. and Sudhakara Babu,Y.
    A novel series of potent and selective small molecule inhibitors of the complement component C1s
    Bioorg Med Chem Lett14, 3043-3047. PubMed  Europe PubMed DOI  I
    45. 2003
  45. [YEAR:15-4-2003]Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.
    Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system
    Biochem J371, 631-640. PubMed  Europe PubMed DOI
  46. Gregory,L.A., Thielens,N.M., Arlaud,G.J., Fontecilla-Camps,J.C. and Gaboriaud,C.
    X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement
    J Biol Chem278, 32157-32164. PubMed  Europe PubMed DOI
  47. Moralez,A., Busby,W.H., Jr. and Clemmons,D.
    Control of insulin-like growth factor binding protein-5 protease synthesis and secretion by human fibroblasts and porcine aortic smooth muscle cells
    Endocrinology144, 2489-2495. PubMed  Europe PubMed DOI
  48. [YEAR:23-12-2003]O'Brien,G., Quinsey,N.S., Whisstock,J.C. and Pike,R.N.
    Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates
    Biochemistry42, 14939-14945. PubMed  Europe PubMed DOI
    49. 2002
  49. Arlaud,G.J., Gaboriaud,C., Thielens,N.M., Budayova-Spano,M., Rossi,V. and Fontecilla-Camps,J.C.
    Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity
    Mol Immunol39, 383-394. PubMed  Europe PubMed DOI
  50. Arlaud,G.J., Gaboriaud,C., Thielens,N.M. and Rossi,V.
    Structural biology of C1
    Biochem Soc Trans30, 1001-1006. PubMed  Europe PubMed DOI
  51. Gal,P., Ambrus,G. and Zavodszky,P.
    C1s, the protease messenger of C1. Structure, function and physiological significance
    Immunobiology205, 383-394. PubMed  Europe PubMed
    52. 2001
  52. [YEAR:15-6-2001]Dragon-Durey,M.A., Quartier,P., Fremeaux-Bacchi,V., Blouin,J., de Barace,C., Prieur,A.M., Weiss,L. and Fridman,W.H.
    Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases
    J Immunol166, 7612-7616. PubMed  Europe PubMed  K
  53. Nakao,M., Osaka,K., Kato,Y., Fujiki,K. and Yano,T.
    Molecular cloning of the complement C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)
    Immunogenetics52, 255-263. PubMed  Europe PubMed DOI
    54. 2000
  54. [YEAR:1-12-2000]Busby,W.H., Jr., Nam,T.J., Moralez,A., Smith,C., Jennings,M. and Clemmons,D.R.
    The complement component C1s is the protease that accounts for cleavage of insulin-like growth factor-binding protein-5 in fibroblast medium
    J Biol Chem275, 37638-37644. PubMed  Europe PubMed DOI
  55. Sim,R.B. and Laich,A.
    Serine proteases of the complement system
    Biochem Soc Trans28, 545-550. PubMed  Europe PubMed
    56. 1999
  56. Thielens,N.M., Bersch,B., Hernandez,J.F. and Arlaud,G.J.
    Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex
    Immunopharmacology42, 3-13. PubMed  Europe PubMed DOI
    57. 1998
  57. Arlaud,G.J., Volanakis,J.E., Thielens,N.M., Narayana,S.V., Rossi,V. and Xu,Y.
    The atypical serine proteases of the complement system
    Adv Immunol69, 249-307. PubMed  Europe PubMed
  58. Gans,P., Rossi,V., Gaboriaud,C., Bally,I., Hernandez,J.F., Blackledge,M.J. and Arlaud,G.J.
    NMR structures of the C-terminal end of human complement serine protease C1s
    Cell Mol Life Sci54, 171-178. PubMed  Europe PubMed DOI
  59. [YEAR:9-1-1998]Rossi,V., Bally,I., Thielens,N.M., Esser,A.F. and Arlaud,G.J.
    Baculovirus-mediated expression of truncated modular fragments from the catalytic region of human complement serine protease C1s. Evidence for the involvement of both complement control protein modules in the recognition of the C4 protein substrate
    J Biol Chem273, 1232-1239. PubMed  Europe PubMed DOI
  60. [YEAR:16-3-1998]Sakai,H., Nakashima,S., Yoshimura,S., Nishimura,Y., Sakai,N. and Nozawa,Y.
    Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation
    Gene209, 87-94. PubMed  Europe PubMed DOI
    61. 1995
  61. Ogata,R.T. and Low,P.J.
    Complement component C5: engineering of a mutant that is specifically cleaved by the C4-specific C1s protease
    J Immunol155, 2642-2651. PubMed  Europe PubMed
  62. [YEAR:30-1-1995]Petillot,Y., Thibault,P., Thielens,N.M., Rossi,V., Lacroix,M., Coddeville,B., Spik,G., Schumaker,V.N., Gagnon,J. and Arlaud,G.J.
    Analysis of the N-linked oligosaccharides of human C1s using electrospray ionisation mass spectrometry
    FEBS Lett358, 323-328. PubMed  Europe PubMed DOI
  63. Rossi,V., Gaboriaud,C., Lacroix,M., Ulrich,J., Fontecilla-Camps,J.C., Gagnon,J. and Arlaud,G.J.
    Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling
    Biochemistry34, 7311-7321. PubMed  Europe PubMed DOI
  64. [YEAR:3-7-1995]Toyoguchi,T., Yamaguchi,K., Imajoh-Ohmi,S., Kato,N., Kusunoki,M., Kageyama,H., Sakiyama,S., Nagasawa,S., Moriya,H. and Sakiyama,H.
    Purification and characterization of recombinant hamster tissue complement C1s
    Biochim Biophys Acta1250, 90-96. PubMed  Europe PubMed DOI
    65. 1993
  65. Arlaud,G.J. and Thielens,N.M.
    Human complement serine proteases C1r and C1s and their proenzymes
    Methods Enzymol223, 61-82. PubMed  Europe PubMed DOI  V
  66. Lomas,D.A., Evans,D.L., Upton,C., McFadden,G. and Carrell,R.W.
    Inhibition of plasmin, urokinase, tissue plasminogen activator, and C1s by a myxoma virus serine proteinase inhibitor
    J Biol Chem268, 516-521. PubMed  Europe PubMed
    67. 1992
  67. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.
    Substituted isocoumarins as inhibitors of complement serine proteases
    J Immunol149, 163-168. PubMed  Europe PubMed  I
  68. [YEAR:5-5-1992]Luo,C., Thielens,N.M., Gagnon,J., Gal,P., Sarvari,M., Tseng,Y., Tosi,M., Zavodszky,P., Arlaud,G.J. and Schumaker,V.N.
    Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex
    Biochemistry31, 4254-4262. PubMed  Europe PubMed DOI
    69. 1991
  69. Bork,P.
    Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats
    FEBS Lett282, 9-12. PubMed  Europe PubMed DOI
    70. 1990
  70. Nissen,M.H., Roepstorff,P., Thim,L., Dunbar,B. and Fothergill,J.E.
    Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1s
    Eur J Biochem189, 423-429. PubMed  Europe PubMed  P
  71. Rawlings,N.D. and Barrett,A.J.
    Bone morphogenetic protein 1 is homologous in part with calcium-dependent serine proteinase
    Biochem J266, 622-624. PubMed  Europe PubMed
  72. [YEAR:10-4-1990]Thielens,N.M., Van Dorsselaer,A., Gagnon,J. and Arlaud,G.J.
    Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region
    Biochemistry29, 3570-3578. PubMed  Europe PubMed
    73. 1989
  73. Kinoshita,H., Sakiyama,H., Tokunaga,K., Imajoh-Ohmi,S., Hamada,Y., Isono,K. and Sakiyama,S.
    Complete primary structure of calcium-dependent serine proteinase capable of degrading extracellular matrix proteins
    FEBS Lett250, 411-415. PubMed  Europe PubMed
  74. Skoog,M.T., Mehdi,S., Wiseman,J.S. and Bey,P.
    The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates
    Biochim Biophys Acta996, 89-94. PubMed  Europe PubMed
    75. 1988
  75. Kusumoto,H., Hirosawa,S., Salier,J.P., Hagen,F.S. and Kurachi,K.
    Human genes for complement components c1r and c1s in a close tail-to- tail arrangement
    Proc Natl Acad Sci U S A85, 7307-7311. PubMed  Europe PubMed
  76. Muller-Eberhard,H.J.
    Molecular organization and function of the complement system
    Annu Rev Biochem57, 321-347. PubMed  Europe PubMed DOI
  77. Nguyen,V.C., Tosi,M., Gross,M.S., Cohen-Haguenauer,O., Jegou-Foubert,C., de Tand,M.F., Meo,T. and Frezal,J.
    Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13
    Hum Genet78, 363-368. PubMed  Europe PubMed
    78. 1987
  78. Keogh,S.J., Harding,D.R. and Hardman,M.J.
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