Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P61769

,


Click here to display alignment and conservation of cleavage sites of this sequence with close homologues.  This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site Peptidase Residue range Cleavage type Description Evidence Reference
20 unknown peptidase 1-119 P release of a signal peptide NT Argiles et al., 1992
21 unknown peptidase 1-119 P NT <%Agarwal et al., 2012[]%>
78 complement component activated C1s 21-119 P NT Nissen et al., 1990
90 meprin alpha subunit 21-119 N MS Becker-Pauly et al., 2011