Sequence features for peptidase S01.193: complement component activated C1s

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

MERNUM	Species	Sequence length	Peptidase unit	Active site residues	Source
MER0216663	Ailuropoda melanoleuca	695	444-689	H481, D535, S638	GENBANK:XP_002922266
MER0236780	Alligator mississippiensis	702	449-693	H486, D542, S644	GENBANK:XP_006273467
MER0295296	Alligator sinensis	693	440-684	H477, D533, S635	GENBANK:XP_006037097
MER0607376	Anolis carolinensis	449	207-446	Q244, D296, S397	GENBANK:XP_008113508
MER0391069	Balaenoptera acutorostrata	784	533-778	H570, D624, S727	GENBANK:XP_007170183
MER0089053	Bos taurus	695	444-688	H481, D535, S638	GENBANK:DAA29246
MER0089053	Bos taurus	695	444-688	H481, D535, S638	GENBANK:DAA29246
MER0089053	Bos taurus	695	444-688	H481, D535, S638	GENBANK:DAA29246
MER0089053	Bos taurus	695	444-688	H481, D535, S638	GENBANK:DAA29246
MER0580206	Bubalus bubalis	695	444-688	H481, D535, S638	GENBANK:XP_006065922
MER0368179	Callithrix jacchus	688	438-682	H475, D529, S632	UNIPROT:F6VJE5
MER0368179	Callithrix jacchus	688	438-682	H475, D529, S632	UNIPROT:F6VJE5
MER0439571	Camelus ferus	695	444-689	H481, D535, S638	GENBANK:XP_006173069
MER0163458	Canis lupus familiaris	695	444-687	H481, D535, S638	GENBANK:XP_853320
MER0539596	Capra hircus	701	450-694	H487, D541, S644	GENBANK:XP_005680979
MER0545605	Ceratotherium simum	695	444-689	H481, D535, S638	GENBANK:XP_004438738
MER0586723	Cercopithecus sabaeus	534	294-519	H331, D385, S488	GENBANK:XP_007966334
MER0586725	Cercopithecus sabaeus	616	366-610	H403, D457, S560	GENBANK:XP_007965643
MER0592257	Chelonia mydas	697	445-686	H482, D538, S639	GENBANK:XP_007072391
MER0568521	Chrysemys picta	693	441-682	H354, H478, D534, missing, missing, G635	GENBANK:XP_008175769
MER0578140	Chrysemys picta	697	445-686	H482, D538, S639	GENBANK:XP_005312090
MER0574795	Chrysochloris asiatica	828	576-822	H613, D667, S770	GENBANK:XP_006862816
MER0573512	Condylura cristata	697	444-691	H481, D535, S640	GENBANK:XP_004692625
MER0572647	Corvus brachyrhynchos	689	440-681	H477, D531, S631	GENBANK:XP_008630051
MER0565160	Elephantulus edwardii	690	438-684	H475, D529, S633	GENBANK:XP_006891305
MER0563813	Eptesicus fuscus	696	445-690	H482, D536, S639	GENBANK:XP_008143102
MER0098431	Equus caballus	695	444-687	H481, D535, S638	GENBANK:XP_001492637
MER0562182	Equus przewalskii	695	444-687	H481, D535, S638	GENBANK:XP_008537371
MER0104068	Erinaceus europaeus	692	444-686	H482, D535, S635	GENBANK:XP_007535915
MER0568515	Ficedula albicollis	689	440-681	H477, D531, S631	UNIPROT:U3JPU3
MER0568515	Ficedula albicollis	689	440-681	H477, D531, S631	UNIPROT:U3JPU3
MER0557969	Galeopterus variegatus	689	438-683	H475, D529, S632	GENBANK:XP_008577475
MER0053997	Gallus gallus	690	440-681	H477, D531, S631	UNIPROT:Q5F3N3
MER0053997	Gallus gallus	690	440-681	H477, D531, S631	UNIPROT:Q5F3N3
MER0558836	Geospiza fortis	689	440-681	H477, D531, S631	GENBANK:XP_005420667
MER0609441	Gorilla gorilla	688	438-682	H475, D529, S632	GENBANK:XP_004052668
MER0000239	Homo sapiens	688	438-682	H475, D529, S632	UNIPROT:Q9UCV3
MER0000239	Homo sapiens	688	438-682	H475, D529, S632	UNIPROT:Q9UCV3
MER0000239	Homo sapiens	688	438-682	H475, D529, S632	UNIPROT:Q9UCV3
MER0106690	Ictidomys tridecemlineatus	695	444-689	H481, D535, S638	GENBANK:XP_005338362
MER0552563	Leptonychotes weddellii	695	444-689	H481, D535, S638	GENBANK:XP_006737933
MER0550029	Lipotes vexillifer	793	542-787	H579, D633, S736	GENBANK:XP_007469445
MER0604380	Macaca fascicularis	791	543-787	H580, D634, S737	GENBANK:XP_005570608
MER0160444	Macaca mulatta	688	438-682	H475, D529, S632	UNIPROT:H9FZ52
MER0160444	Macaca mulatta	688	438-682	H475, D529, S632	UNIPROT:H9FZ52
MER0486693	Meleagris gallopavo	700	450-692	H487, D542, S642	GENBANK:XP_003202698
MER0000240	Mesocricetus auratus	695	445-689	H482, D536, S638	GENBANK:XP_005066079
MER0000240	Mesocricetus auratus	695	445-689	H482, D536, S638	GENBANK:XP_005066079
MER0172052	Monodelphis domestica	762	511-754	H548, D602, S705	UNIPROT:F7CCG9
MER0172052	Monodelphis domestica	762	511-754	H548, D602, S705	UNIPROT:F7CCG9
MER0485036	Mustela putorius	665	438-665	H475, D529, S632	UNIPROT:M1EGK7
MER0485036	Mustela putorius	665	438-665	H475, D529, S632	UNIPROT:M1EGK7
MER0567583	Myotis brandtii	695	444-689	H481, D535, S638	UNIPROT:S7N5F8
MER0567583	Myotis brandtii	695	444-689	H481, D535, S638	UNIPROT:S7N5F8
MER0392249	Myotis davidii	606	355-600	H392, D446, S549	UNIPROT:L5M8A6
MER0392249	Myotis davidii	606	355-600	H392, D446, S549	UNIPROT:L5M8A6
MER0243792	Myotis lucifugus	695	444-688	H481, D535, S638	GENBANK:XP_006084247
MER0531469	Odobenus rosmarus	695	444-689	H481, D535, S638	GENBANK:XP_004407687
MER0529921	Orcinus orca	695	444-689	H481, D535, S638	GENBANK:XP_004279131
MER0527747	Orycteropus afer	689	438-682	H475, D529, S632	GENBANK:XP_007935337
MER0110499	Oryctolagus cuniculus	690	444-684	H481, D535, S633	GENBANK:XP_002712892
MER0594762	Otolemur garnettii	734	484-729	H521, D575, S678	GENBANK:XP_003796518
MER0619216	Ovis aries	702	451-695	H488, D542, S645,	GENBANK:XP_004006965
MER0594054	Pan paniscus	688	438-682	H475, D529, S632	GENBANK:XP_003820311
MER0053432	Pan troglodytes	688	438-682	H475, D529, S632	UNIPROT:K7AR52
MER0053432	Pan troglodytes	688	438-682	H475, D529, S632	UNIPROT:K7AR52
MER0518144	Panthera tigris	695	444-689	H481, D535, S638	GENBANK:XP_007089642
MER0516786	Pantholops hodgsonii	701	450-694	H487, D541, S644	GENBANK:XP_005957966
MER0525862	Papio anubis	688	438-682	H475, D529, S632	GENBANK:XP_003905952
MER0524369	Pelodiscus sinensis	277	25-268	Q62, D118, S219	GENBANK:XP_006124195
MER0524370	Pelodiscus sinensis	582	330-573	H367, D423, S524	GENBANK:XP_006124243
MER0520388	Physeter catodon	695	444-689	H481, D535, S638	GENBANK:XP_007108374
MER0485017	Pipa carvalhoi	262	195-260	missing, missing, S212	UNIPROT:G5E1U4
MER0485017	Pipa carvalhoi	262	195-260	missing, missing, S212	UNIPROT:G5E1U4
MER0368214	Pongo abelii	688	438-682	H475, D529, S632	UNIPROT:H2NGB6
MER0368214	Pongo abelii	688	438-682	H475, D529, S632	UNIPROT:H2NGB6
MER0515041	Pteropus alecto	773	522-767	H559, D613, S716	GENBANK:XP_006914722
MER0440316	Python bivittatus	689	443-683	H480, D533, S634	GENBANK:XP_007420468
MER0004602	Rattus norvegicus	694	444-688	H481, D535, S637	GENBANK:NP_620255
MER0004602	Rattus norvegicus	694	444-688	H481, D535, S637	GENBANK:NP_620255
MER0004602	Rattus norvegicus	694	444-688	H481, D535, S637	GENBANK:NP_620255
MER0512912	Saimiri boliviensis	688	438-682	H475, D529, S632	GENBANK:XP_003944928
MER0484190	Siniperca chuatsi	143	6-139	missing, D14, S111	UNIPROT:Q2KKV9
MER0484190	Siniperca chuatsi	143	6-139	missing, D14, S111	UNIPROT:Q2KKV9
MER0016636	Sus scrofa	165	78-141	H128, missing, missing	UNIPROT:Q9GLE6
MER0016636	Sus scrofa	165	78-141	H128, missing, missing	UNIPROT:Q9GLE6
MER0160158	Sus scrofa	687	438-680	H475, D528, S630	GENBANK:NP_001005349
MER0160158	Sus scrofa	687	438-680	H475, D528, S630	GENBANK:NP_001005349
MER0160158	Sus scrofa	687	438-680	H475, D528, S630	GENBANK:NP_001005349
MER0160158	Sus scrofa	687	438-680	H475, D528, S630	GENBANK:NP_001005349
MER0399545	synthetic construct	688	438-682	H475, D529, S632	GENBANK:BAJ21076
MER0176422	Taeniopygia guttata	872	623-864	H660, D714, S814	GENBANK:XP_002192681
MER0265035	Takifugu rubripes	0	410-695	, ,	GENBANK:XP_003966360
MER0595862	Tarsius syrichta	664	443-656	H480, D534, G637	GENBANK:XP_008049021
MER0099079	Tetraodon nigroviridis	688	424-687	H478, D531, S633	UNIPROT:Q4SNE7
MER0099079	Tetraodon nigroviridis	688	424-687	H478, D531, S633	UNIPROT:Q4SNE7
MER0482092	Trichechus manatus	689	438-683	H475, D529, S632	GENBANK:XP_004387326
MER0598974	Tupaia chinensis	689	438-683	H475, D529, A632	GENBANK:XP_006170838
MER0598975	Tupaia chinensis	720	469-714	H506, D560, A663	GENBANK:XP_006170902