Literature for peptidase S01.161: kallikrein-related peptidase 2
(Topics flags: A Assay, M Mutation, R Splicing, I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)
- Shen,F., Smith,R., McDevitt,T., Menard,K., Tian,S., Chu,G., Chaudhary,R., McCann,J., Oyer,H., Wang,S., Max,S., Francis,P., Kelly,W.K. and Drake,C.G.<br>Human kallikrein 2: A novel lineage-specific surface target in prostate cancer<br>Clin Cancer Res (2025) PubMed Europe PubMed DOI
- Oliveira,J.R., Lacerda,J.T., Sellani,T.A., Rodrigues,E.G., Travassos,L.R., Juliano,M.A. and Juliano,L.<br>Extracellular Domain of IL-10 Receptor Chain-2 (IL-10R2) and Its Arginine-Containing Peptides Are Susceptible Substrates for Human Prostate Kallikrein-2 (KLK2)<br>Biochemistry (2024) 63, 2023-2029. PubMed Europe PubMed DOI
- Pandit-Taskar,N., O'Donoghue,J.A., Chetty,D., Max,S., Wanik,D., Ilovich,O., Russell,M., Nyima,T., Divgi,C.R., Yu,M. and Morris,M.J.<br>A Phase 0 Study to Assess the Biodistribution and Pharmacokinetics of a Radiolabeled Antibody Targeting Human Kallikrein 2 in Participants with Metastatic Castration-Resistant Prostate Cancer<br>J Nucl Med (2024) 65, 1051-1056. PubMed Europe PubMed DOI
- Lehto,T.K., Kovanen,R.M., Lintula,S., Malen,A., Sturenberg,C., Erickson,A., Pulkka,O.P., Stenman,U.H., Diamandis,E.P., Rannikko,A., Mirtti,T. and Koistinen,H.<br>Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer<br>Int J Cancer (2023) 153, 867-881. PubMed Europe PubMed DOI
- Meng,G., Li,P., Li,M., Wu,Y., Ma,Y., Sun,T. and Ji,C.<br>KLK2 single-nucleotide polymorphism rs198977 is associated with increased susceptibility and hyperleukocytosis in AML<br>Front Genet (2023) 14, 1218523-1218523. PubMed Europe PubMed DOI PMC EPMC
- Bonk,S., Kluth,M., Jansen,K., Hube-Magg,C., Makrypidi-Fraune,G., Hoflmayer,D., Weidemann,S., Moller,K., Uhlig,R., Buscheck,F., Luebke,A.M., Burandt,E., Clauditz,T.S., Steurer,S., Schlomm,T., Huland,H., Heinzer,H., Sauter,G., Simon,R. and Dum,D.<br>Reduced KLK2 expression is a strong and independent predictor of poor prognosis in ERG-negative prostate cancer<br>Prostate (2020) PubMed Europe PubMed DOI
- Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.<br>Discovery of novel transcripts of the human tissue kallikrein (KLK1) and kallikrein-related peptidase 2 (KLK2) in human cancer cells, exploiting Next-Generation Sequencing technology<br>Genomics (2019) 111, 642-652. PubMed Europe PubMed DOI M
- Guo,S., Skala,W., Magdolen,V., Briza,P., Biniossek,M.L., Schilling,O., Kellermann,J., Brandstetter,H. and Goettig,P.<br>A single glycan at the 99-loop of human kallikrein-related peptidase 2 regulates activation and enzymatic activity<br>J Biol Chem (2016) 291, 593-604. PubMed Europe PubMed DOI
- Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.<br>Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays<br>Mol Cell Proteomics (2016) 15, 2863-2876. PubMed Europe PubMed DOI A
- Koistinen,H., Hekim,C., Wu,P., Narvanen,A. and Stenman,U.-H.<br>Evaluation of peptides as protease inhibitors and stimulators<br>Methods Mol Biol (2014) 1088, 147-158. PubMed Europe PubMed DOI
- Skala,W., Utzschneider,D.T., Magdolen,V., Debela,M., Guo,S., Craik,C.S., Brandstetter,H. and Goettig,P.<br>Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity<br>J Biol Chem (2014) 289, 34267-34283. PubMed Europe PubMed DOI
- Lundwall,A.<br>Old genes and new genes: The evolution of the kallikrein locus<br>Thromb Haemost (2013) 110, 469-475. PubMed Europe PubMed DOI V
- Thorek,D.L., Evans,M.J., Carlsson,S.V., Ulmert,D. and Lilja,H.<br>Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection. Established relevance and emerging roles<br>Thromb Haemost (2013) 110, 484-492. PubMed Europe PubMed DOI V
- Vegvari,A., Sjodin,K., Rezeli,M. and Marko-Varga,G.<br>Quantification of human kallikrein-2 in clinical samples by selected reaction monitoring<br>J Proteome Res (2013) 12, 4612-4616. PubMed Europe PubMed DOI A
- Chao,J., Chen,L.M. and Chai,K.X.<br>Human kallikrein-related peptidase 2<br>[ISSN:978-0-12-407742-3] (2012) 3, 2762-2765. DOI
- Clements,J.A., Hooper,J.D. and Dong,Y.<br>The human tissue kallikrein and kallikrein-related peptidase family<br>[ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
- Yu,H.Z., Xie,L.D., Zhu,P.L., Xu,C.S. and Wang,H.J.<br>Human tissue kallikrein 1 gene delivery inhibits PDGF-BB-induced vascular smooth muscle cells proliferation and upregulates the expressions of p27Kip1 and p2lCip1<br>Mol Cell Biochem (2012) 360, 363-371. PubMed Europe PubMed DOI U
- Lee,S.H. and Lee,S.<br>Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility<br>Clin Exp Reprod Med (2011) 38, 6-9. PubMed Europe PubMed DOI PMC EPMC M
- Hekim,C., Riipi,T., Weisell,J., Narvanen,A., Koistinen,R., Stenman,U.H. and Koistinen,H.<br>Identification of IGFBP-3 fragments generated by KLK2 and prevention of fragmentation by KLK2-inhibiting peptides<br>Biol Chem (2010) 391, 475-479. PubMed Europe PubMed DOI
- Pavlopoulou,A., Pampalakis,G., Michalopoulos,I. and Sotiropoulou,G.<br>Evolutionary history of tissue kallikreins<br>PLoS ONE (2010) 5, e13781-e13781. PubMed Europe PubMed DOI PMC EPMC
- Williams,S.A., Xu,Y., De Marzo,A.M., Isaacs,J.T. and Denmeade,S.R.<br>Prostate-specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate-targeted PSA/KLK2 double transgenic mice<br>Prostate (2010) 70, 788-796. PubMed Europe PubMed DOI
- Alapont Alacreu,J.M., Navarro Rosales,S., Budia Alba,A., Espana Furio,F., Morera Martinez,F. and Jimenez Cruz,J.F.<br>[PSA and hK2 in the diagnosis of prostate cancer]<br>Actas Urol Esp (2008) 32, 575-588. PubMed Europe PubMed
- Clements,J.A.<br>Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?<br>Biol Chem (2008) 389, 1447-1454. PubMed Europe PubMed DOI V
- Koistinen,H., Narvanen,A., Pakkala,M., Hekim,C., Mattsson,J.M., Zhu,L., Laakkonen,P. and Stenman,U.H.<br>Development of peptides specifically modulating the activity of KLK2 and KLK3<br>Biol Chem (2008) 389, 633-642. PubMed Europe PubMed DOI
- Steuber,T., Vickers,A.J., Serio,A.M., Vaisanen,V., Haese,A., Pettersson,K., Eastham,J.A., Scardino,P.T., Huland,H. and Lilja,H.<br>Comparison of free and total forms of serum human kallikrein 2 and prostate-specific antigen for prediction of locally advanced and recurrent prostate cancer<br>Clin Chem (2007) 53, 233-240. PubMed Europe PubMed DOI
- Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.<br>Activation profiles and regulatory cascades of the human kallikrein-related peptidases<br>J Biol Chem (2007) 282, 31852-31864. PubMed Europe PubMed DOI V
- [YEAR:9-3-2006]Hekim,C., Leinonen,J., Narvanen,A., Koistinen,H., Zhu,L., Koivunen,E., Vaisanen,V. and Stenman,U.H.<br>Novel peptide inhibitors of human kallikrein 2<br>J Biol Chem (9-3-2006) 281, 12555-12560. PubMed Europe PubMed DOI I
- Lundwall,A., Clauss,A. and Olsson,A.Y.<br>Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitors<br>Biol Chem (2006) 387, 243-249. PubMed Europe PubMed DOI
- Chiang,C.H., Hong,C.J., Chang,Y.H., Chang,L.S. and Chen,K.K.<br>Human kallikrein-2 gene polymorphism is associated with the occurrence of prostate cancer<br>J Urol (2005) 173, 429-432. PubMed Europe PubMed DOI M
- [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.<br>A survey of alternative transcripts of human tissue kallikrein genes<br>Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed Europe PubMed DOI R
- [YEAR:13-1-2005]Michael,I.P., Kurlender,L., Memari,N., Yousef,G.M., Du,D., Grass,L., Stephan,C., Jung,K. and Diamandis,E.P.<br>Intron retention: a common splicing event within the human kallikrein gene family<br>Clin Chem (13-1-2005) 51, 506-515. PubMed Europe PubMed DOI R
- Chao,J.<br>Human kallikrein 2<br>[ISSN:0-12-079610-4] (2004) 2, 1581-1582. V
- Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.<br>The tissue kallikrein gene cluster<br>[ISSN:0-12-079610-4] (2004) 2, 1569-1577. V
- Cloutier,S.M., Kundig,C., Felber,L.M., Fattah,O.M., Chagas,J.R., Gygi,C.M., Jichlinski,P., Leisinger,H.J. and Deperthes,D.<br>Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates<br>Eur J Biochem (2004) 271, 607-613. PubMed Europe PubMed DOI
- Janssen,S., Jakobsen,C.M., Rosen,D.M., Ricklis,R.M., Reineke,U., Christensen,S.B., Lilja,H. and Denmeade,S.R.<br>Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer<br>Mol Cancer Ther (2004) 3, 1439-1450. PubMed Europe PubMed
- Tsui,K.H., Wu,L., Chang,P.L., Hsieh,M.L. and Juang,H.H.<br>Identifying the combination of the transcriptional regulatory sequences on prostate specific antigen and human glandular kallikrein genes<br>J Urol (2004) 172, 2029-2034. PubMed Europe PubMed DOI
- [YEAR:15-6-2003]Nam,R.K., Zhang,W.W., Trachtenberg,J., Diamandis,E., Toi,A., Emami,M., Ho,M., Sweet,J., Evans,A., Jewett,M.A. and Narod,S.A.<br>Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection<br>J Clin Oncol (15-6-2003) 21, 2312-2319. PubMed Europe PubMed DOI M
- Cloutier,S.M., Chagas,J.R., Mach,J.P., Gygi,C.M., Leisinger,H.J. and Deperthes,D.<br>Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology<br>Eur J Biochem (2002) 269, 2747-2754. PubMed Europe PubMed DOI
- Clements,J., Hooper,J., Dong,Y. and Harvey,T.<br>The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions<br>Biol Chem (2001) 382, 5-14. PubMed Europe PubMed DOI V
- [YEAR:1-7-2001]Denmeade,S.R., Lovgren,J., Khan,S.R., Lilja,H. and Isaacs,J.T.<br>Activation of latent protease function of Pro-HK2, but not Pro-PSA, involves autoprocessing<br>Prostate (1-7-2001) 48, 122-126. PubMed Europe PubMed DOI
- Finlay,J.A., Day,J.R., Evans,C.L., Carlson,R., Kuus-Reichel,K., Millar,L.S., Mikolajczyk,S.D., Goodmanson,M., Klee,G.G. and Rittenhouse,H.G.<br>Development of a dual monoclonal antibody immunoassay for total human kallikrein 2<br>Clin Chem (2001) 47, 1218-1224. PubMed Europe PubMed A
- Rehault,S., Monget,P., Mazerbourg,S., Tremblay,R., Gutman,N., Gauthier,F. and Moreau,T.<br>Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3<br>Eur J Biochem (2001) 268, 2960-2968. PubMed Europe PubMed DOI
- Saedi,M.S., Zhu,Z., Marker,K., Liu,R.S., Carpenter,P.M., Rittenhouse,H. and Mikolajczyk,S.D.<br>Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells<br>Int J Cancer (2001) 94, 558-563. PubMed Europe PubMed DOI
- Becker,C., Piironen,T., Pettersson,K., Bjork,T., Wojno,K.J., Oesterling,J.E. and Lilja,H.<br>Discrimination of men with prostate cancer from those with benign disease by measurements of human glandular kallikrein 2 (hK2) in serum<br>J Urol (2000) 163, 311-316. PubMed Europe PubMed
- Black,M.H., Magklara,A., Obiezu,C., Levesque,M.A., Sutherland,D.J., Tindall,D.J., Young,C.Y., Sauter,E.R. and Diamandis,E.P.<br>Expression of a prostate-associated protein, human glandular kallikrein (hK2), in breast tumours and in normal breast secretions<br>Br J Cancer (2000) 82, 361-367. PubMed Europe PubMed DOI PMC EPMC
- Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.<br>The new human kallikrein gene family: implications in carcinogenesis<br>Trends Endocrinol Metab (2000) 11, 54-60. PubMed Europe PubMed DOI
- [YEAR:17-10-2000]Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J., Moss,P., Paeper,B. and Wang,K.<br>Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region<br>Gene (17-10-2000) 257, 119-130. PubMed Europe PubMed DOI
- Potter,S.R. and Partin,A.W.<br>Tumor markers: an update on human kallikrein 2<br>Rev Urol (2000) 2, 221-222. PubMed Europe PubMed PMC EPMC
- Black,M.H., Magklara,A., Obiezu,C.V., Melegos,D.N. and Diamandis,E.P.<br>Development of an ultrasensitive immunoassay for human glandular kallikrein with no cross-reactivity from prostate-specific antigen<br>Clin Chem (1999) 45, 790-799. PubMed Europe PubMed A
- Charlesworth,M.C., Young,C.Y., Miller,V.M. and Tindall,D.J.<br>Kininogenase activity of prostate-derived human glandular kallikrein (hK2) purified from seminal fluid<br>J Androl (1999) 20, 220-229. PubMed Europe PubMed
- Fiedler,F., Betz,G., Hinz,H., Lottspeich,F., Raidoo,D.M. and Bhoola,K.D.<br>Not more than three tissue kallikreins identified from organs of the guinea pig<br>Biol Chem (1999) 380, 63-73. PubMed Europe PubMed DOI
- Klee,G.G., Goodmanson,M.K., Jacobsen,S.J., Young,C.Y., Finlay,J.A., Rittenhouse,H.G., Wolfert,R.L. and Tindall,D.J.<br>Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein-2<br>Clin Chem (1999) 45, 800-806. PubMed Europe PubMed A
- Kumar,A., Goel,A.S., Payne,J.K., Evans,C., Mikolajczyk,S.D., Kuus-Reichel,K. and Saedi,M.S.<br>Large-scale propagation of recombinant adherent cells that secrete a stable form of human glandular kallikrein, hK2<br>Protein Expr Purif (1999) 15, 62-68. PubMed Europe PubMed DOI E
- Leinonen,J., Leinimaa,M., Zhang,W.M., Piironen,T., Pettersson,K., Lilja,H., Dowell,B. and Stenman,U.H.<br>Reactivity of anti-PSA monoclonal antibodies with recombinant human kallikrein-2<br>Tumour Biol (1999) 20 Suppl 1, 35-37. PubMed Europe PubMed
- Lovgren,J., Airas,K. and Lilja,H.<br>Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors<br>Eur J Biochem (1999) 262, 781-789. PubMed Europe PubMed DOI
- Lovgren,J., Tian,S., Lundwall,A., Karp,M. and Lilja,H.<br>Production and activation of recombinant hK2 with propeptide mutations resulting in high expression levels<br>Eur J Biochem (1999) 266, 1050-1055. PubMed Europe PubMed DOI
- [YEAR:15-8-1999]Mikolajczyk,S.D., Millar,L.S., Marker,K.M., Rittenhouse,H.G., Wolfert,R.L., Marks,L.S., Charlesworth,M.C. and Tindall,D.J.<br>Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue<br>Cancer Res (15-8-1999) 59, 3927-3930. PubMed Europe PubMed
- [YEAR:5-5-1999]Mikolajczyk,S.D., Millar,L.S., Kumar,A. and Saedi,M.S.<br>Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1<br>Int J Cancer (5-5-1999) 81, 438-442. PubMed Europe PubMed DOI
- Rae,F., Bulmer,B., Nicol,D. and Clements,J.<br>The human tissue kallikreins (KLKs 1-3) and a novel KLK1 mRNA transcript are expressed in a renal cell carcinoma cDNA library<br>Immunopharmacology (1999) 45, 83-88. PubMed Europe PubMed DOI
- Yousef,G.M., Luo,L.Y. and Diamandis,E.P.<br>Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4<br>Anticancer Res (1999) 19, 2843-2852. PubMed Europe PubMed
- [YEAR:15-10-1998]Heeb,M.J. and Espana,F.<br>alpha2-Macroglobulin and C1-inactivator are plasma inhibitors of human glandular kallikrein<br>Blood Cells Mol Dis (15-10-1998) 24, 412-419. PubMed Europe PubMed DOI
- [YEAR:1-1-1998]Mikolajczyk,S.D., Millar,L.S., Kumar,A. and Saedi,M.S.<br>Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors<br>Prostate (1-1-1998) 34, 44-50. PubMed Europe PubMed DOI
- [YEAR:21-11-1997]Bourgeois,L., Brillard-Bourdet,M., Deperthes,D., Juliano,M.A., Juliano,L., Tremblay,R.R., Dube,J.Y. and Gauthier,F.<br>Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2<br>J Biol Chem (21-11-1997) 272, 29590-29595. PubMed Europe PubMed DOI
- [YEAR:14-11-1997]Deperthes,D., Marceau,F., Frenette,G., Lazure,C., Tremblay,R.R. and Dube,J.Y.<br>Human kallikrein hK2 has low kininogenase activity while prostate-specific antigen (hK3) has none<br>Biochim Biophys Acta (14-11-1997) 1343, 102-106. PubMed Europe PubMed DOI
- Frenette,G., Deperthes,D., Tremblay,R.R., Lazure,C. and Dube,J.Y.<br>Purification of enzymatically active kallikrein hK2 from human seminal plasma<br>Biochim Biophys Acta (1997) 1334, 109-115. PubMed Europe PubMed DOI
- Lovgren,J., Rajakoski,K., Karp,M., Lundwall a and Lilja,H.<br>Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2<br>Biochem Biophys Res Commun (1997) 238, 549-555. PubMed Europe PubMed DOI
- Deperthes,D., Frenette,G., Brillard-Bourdet,M., Bourgeois,L., Gauthier,F., Tremblay,R.R. and Dube,J.Y.<br>Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation<br>J Androl (1996) 17, 659-665. PubMed Europe PubMed
- Grauer,L.S., Charlesworth,M.C., Saedi,M.S., Finlay,J.A., Liu,R.S., Kuus-Reichel,K., Young,C.Y. and Tindall,D.J.<br>Identification of human glandular kallikrein hK2 from LNCaP cells<br>J Androl (1996) 17, 353-359. PubMed Europe PubMed
- Piironen,T., Lovgren,J., Karp,M., Eerola,R., Lundwall,A., Dowell,B., Lovgren,T., Lilja,H. and Pettersson,K.<br>Immunofluorometric assay for sensitive and specific measurement of human prostatic glandular kallikrein (hK2) in serum<br>Clin Chem (1996) 42, 1034-1041. PubMed Europe PubMed A
- [YEAR:24-8-1995]Lovgren,J., Piironen,T., Overmo,C., Dowell,B., Karp,M., Pettersson,K., Lilja,H. and Lundwall,A.<br>Production of recombinant PSA and HK2 and analysis of their immunologic cross-reactivity<br>Biochem Biophys Res Commun (24-8-1995) 213, 888-895. PubMed Europe PubMed DOI
- Richards,G.P., Chao,J., Chung,P. and Chao,L.<br>Purification and characterization of tissue kallikrein-like proteinases from the black sea bass (Centropristis striata) and the southern frog (Rana berlandieri)<br>Comp Biochem Physiol C Pharmacol Toxicol Endocrinol (1995) 111, 69-82. PubMed Europe PubMed DOI
- Saedi,M.S., Cass,M.M., Goel,A.S., Grauer,L., Hogen,K.L., Okaneya,T., Griffin,B.Y., Klee,G.G., Young,C.Y. and Tindall,D.J.<br>Overexpression of a human prostate-specific glandular kallikrein, hK2, in E. coli and generation of antibodies<br>Mol Cell Endocrinol (1995) 109, 237-241. PubMed Europe PubMed DOI E
- [YEAR:29-6-1993]Murtha,P., Tindall,D.J. and Young,C.Y.<br>Androgen induction of a human prostate-specific kallikrein, hKLK2: characterization of an androgen response element in the 5' promoter region of the gene<br>Biochemistry (29-6-1993) 32, 6459-6464. PubMed Europe PubMed
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