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Literature for peptidase S01.161: kallikrein-related peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, M Mutation, R Splicing, I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Oliveira,J.R., Lacerda,J.T., Sellani,T.A., Rodrigues,E.G., Travassos,L.R., Juliano,M.A. and Juliano,L.
    Extracellular Domain of IL-10 Receptor Chain-2 (IL-10R2) and Its Arginine-Containing Peptides Are Susceptible Substrates for Human Prostate Kallikrein-2 (KLK2)
    Biochemistry63, 2023-2029. PubMed  Europe PubMed DOI
  2. Pandit-Taskar,N., O'Donoghue,J.A., Chetty,D., Max,S., Wanik,D., Ilovich,O., Russell,M., Nyima,T., Divgi,C.R., Yu,M. and Morris,M.J.
    A Phase 0 Study to Assess the Biodistribution and Pharmacokinetics of a Radiolabeled Antibody Targeting Human Kallikrein 2 in Participants with Metastatic Castration-Resistant Prostate Cancer
    J Nucl Med65, 1051-1056. PubMed  Europe PubMed DOI
    3. 2023
  3. Lehto,T.K., Kovanen,R.M., Lintula,S., Malen,A., Sturenberg,C., Erickson,A., Pulkka,O.P., Stenman,U.H., Diamandis,E.P., Rannikko,A., Mirtti,T. and Koistinen,H.
    Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer
    Int J Cancer153, 867-881. PubMed  Europe PubMed DOI
  4. Meng,G., Li,P., Li,M., Wu,Y., Ma,Y., Sun,T. and Ji,C.
    KLK2 single-nucleotide polymorphism rs198977 is associated with increased susceptibility and hyperleukocytosis in AML
    Front Genet14, 1218523-1218523. PubMed  Europe PubMed DOI
    5. 2020
  5. Bonk,S., Kluth,M., Jansen,K., Hube-Magg,C., Makrypidi-Fraune,G., Hoflmayer,D., Weidemann,S., Moller,K., Uhlig,R., Buscheck,F., Luebke,A.M., Burandt,E., Clauditz,T.S., Steurer,S., Schlomm,T., Huland,H., Heinzer,H., Sauter,G., Simon,R. and Dum,D.
    Reduced KLK2 expression is a strong and independent predictor of poor prognosis in ERG-negative prostate cancer
    Prostate PubMed  Europe PubMed DOI
    6. 2019
  6. Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.
    Discovery of novel transcripts of the human tissue kallikrein (KLK1) and kallikrein-related peptidase 2 (KLK2) in human cancer cells, exploiting Next-Generation Sequencing technology
    Genomics111, 642-652. PubMed  Europe PubMed DOI  M
    7. 2016
  7. Guo,S., Skala,W., Magdolen,V., Briza,P., Biniossek,M.L., Schilling,O., Kellermann,J., Brandstetter,H. and Goettig,P.
    A single glycan at the 99-loop of human kallikrein-related peptidase 2 regulates activation and enzymatic activity
    J Biol Chem291, 593-604. PubMed  Europe PubMed DOI
  8. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics15, 2863-2876. PubMed  Europe PubMed DOI  A
    9. 2014
  9. Koistinen,H., Hekim,C., Wu,P., Narvanen,A. and Stenman,U.-H.
    Evaluation of peptides as protease inhibitors and stimulators
    Methods Mol Biol1088, 147-158. PubMed  Europe PubMed DOI
  10. Skala,W., Utzschneider,D.T., Magdolen,V., Debela,M., Guo,S., Craik,C.S., Brandstetter,H. and Goettig,P.
    Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity
    J Biol Chem289, 34267-34283. PubMed  Europe PubMed DOI
    11. 2013
  11. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost110, 469-475. PubMed  Europe PubMed DOI  V
  12. Thorek,D.L., Evans,M.J., Carlsson,S.V., Ulmert,D. and Lilja,H.
    Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection. Established relevance and emerging roles
    Thromb Haemost110, 484-492. PubMed  Europe PubMed DOI  V
  13. Vegvari,A., Sjodin,K., Rezeli,M. and Marko-Varga,G.
    Quantification of human kallikrein-2 in clinical samples by selected reaction monitoring
    J Proteome Res12, 4612-4616. PubMed  Europe PubMed DOI  A
    14. 2012
  14. Chao,J., Chen,L.M. and Chai,K.X.
    Human kallikrein-related peptidase 2
    [ISSN:978-0-12-407742-3]3, 2762-2765. DOI
  15. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3]3, 2747-2756. DOI
  16. Yu,H.Z., Xie,L.D., Zhu,P.L., Xu,C.S. and Wang,H.J.
    Human tissue kallikrein 1 gene delivery inhibits PDGF-BB-induced vascular smooth muscle cells proliferation and upregulates the expressions of p27Kip1 and p2lCip1
    Mol Cell Biochem360, 363-371. PubMed  Europe PubMed DOI  U
    17. 2011
  17. Lee,S.H. and Lee,S.
    Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility
    Clin Exp Reprod Med38, 6-9. PubMed  Europe PubMed DOI  M
    18. 2010
  18. Hekim,C., Riipi,T., Weisell,J., Narvanen,A., Koistinen,R., Stenman,U.H. and Koistinen,H.
    Identification of IGFBP-3 fragments generated by KLK2 and prevention of fragmentation by KLK2-inhibiting peptides
    Biol Chem391, 475-479. PubMed  Europe PubMed DOI
  19. Pavlopoulou,A., Pampalakis,G., Michalopoulos,I. and Sotiropoulou,G.
    Evolutionary history of tissue kallikreins
    PLoS ONE5, e13781-e13781. PubMed  Europe PubMed DOI
  20. Williams,S.A., Xu,Y., De Marzo,A.M., Isaacs,J.T. and Denmeade,S.R.
    Prostate-specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate-targeted PSA/KLK2 double transgenic mice
    Prostate70, 788-796. PubMed  Europe PubMed DOI
    21. 2008
  21. Alapont Alacreu,J.M., Navarro Rosales,S., Budia Alba,A., Espana Furio,F., Morera Martinez,F. and Jimenez Cruz,J.F.
    [PSA and hK2 in the diagnosis of prostate cancer]
    Actas Urol Esp32, 575-588. PubMed  Europe PubMed
  22. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem389, 1447-1454. PubMed  Europe PubMed DOI  V
  23. Koistinen,H., Narvanen,A., Pakkala,M., Hekim,C., Mattsson,J.M., Zhu,L., Laakkonen,P. and Stenman,U.H.
    Development of peptides specifically modulating the activity of KLK2 and KLK3
    Biol Chem389, 633-642. PubMed  Europe PubMed DOI
    24. 2007
  24. Steuber,T., Vickers,A.J., Serio,A.M., Vaisanen,V., Haese,A., Pettersson,K., Eastham,J.A., Scardino,P.T., Huland,H. and Lilja,H.
    Comparison of free and total forms of serum human kallikrein 2 and prostate-specific antigen for prediction of locally advanced and recurrent prostate cancer
    Clin Chem53, 233-240. PubMed  Europe PubMed DOI
  25. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem282, 31852-31864. PubMed  Europe PubMed DOI  V
    26. 2006
  26. [YEAR:9-3-2006]Hekim,C., Leinonen,J., Narvanen,A., Koistinen,H., Zhu,L., Koivunen,E., Vaisanen,V. and Stenman,U.H.
    Novel peptide inhibitors of human kallikrein 2
    J Biol Chem281, 12555-12560. PubMed  Europe PubMed DOI  I
  27. Lundwall,A., Clauss,A. and Olsson,A.Y.
    Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitors
    Biol Chem387, 243-249. PubMed  Europe PubMed DOI
    28. 2005
  28. Chiang,C.H., Hong,C.J., Chang,Y.H., Chang,L.S. and Chen,K.K.
    Human kallikrein-2 gene polymorphism is associated with the occurrence of prostate cancer
    J Urol173, 429-432. PubMed  Europe PubMed DOI  M
  29. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta1755, 1-14. PubMed  Europe PubMed DOI  R
  30. [YEAR:13-1-2005]Michael,I.P., Kurlender,L., Memari,N., Yousef,G.M., Du,D., Grass,L., Stephan,C., Jung,K. and Diamandis,E.P.
    Intron retention: a common splicing event within the human kallikrein gene family
    Clin Chem51, 506-515. PubMed  Europe PubMed DOI  R
    31. 2004
  31. Chao,J.
    Human kallikrein 2
    [ISSN:0-12-079610-4]2, 1581-1582.  V
  32. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4]2, 1569-1577.  V
  33. Cloutier,S.M., Kundig,C., Felber,L.M., Fattah,O.M., Chagas,J.R., Gygi,C.M., Jichlinski,P., Leisinger,H.J. and Deperthes,D.
    Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates
    Eur J Biochem271, 607-613. PubMed  Europe PubMed DOI
  34. Janssen,S., Jakobsen,C.M., Rosen,D.M., Ricklis,R.M., Reineke,U., Christensen,S.B., Lilja,H. and Denmeade,S.R.
    Screening a combinatorial peptide library to develop a human glandular kallikrein 2-activated prodrug as targeted therapy for prostate cancer
    Mol Cancer Ther3, 1439-1450. PubMed  Europe PubMed
  35. Tsui,K.H., Wu,L., Chang,P.L., Hsieh,M.L. and Juang,H.H.
    Identifying the combination of the transcriptional regulatory sequences on prostate specific antigen and human glandular kallikrein genes
    J Urol172, 2029-2034. PubMed  Europe PubMed DOI
    36. 2003
  36. [YEAR:15-6-2003]Nam,R.K., Zhang,W.W., Trachtenberg,J., Diamandis,E., Toi,A., Emami,M., Ho,M., Sweet,J., Evans,A., Jewett,M.A. and Narod,S.A.
    Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection
    J Clin Oncol21, 2312-2319. PubMed  Europe PubMed DOI  M
    37. 2002
  37. Cloutier,S.M., Chagas,J.R., Mach,J.P., Gygi,C.M., Leisinger,H.J. and Deperthes,D.
    Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology
    Eur J Biochem269, 2747-2754. PubMed  Europe PubMed DOI
    38. 2001
  38. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem382, 5-14. PubMed  Europe PubMed DOI  V
  39. [YEAR:1-7-2001]Denmeade,S.R., Lovgren,J., Khan,S.R., Lilja,H. and Isaacs,J.T.
    Activation of latent protease function of Pro-HK2, but not Pro-PSA, involves autoprocessing
    Prostate48, 122-126. PubMed  Europe PubMed DOI
  40. Finlay,J.A., Day,J.R., Evans,C.L., Carlson,R., Kuus-Reichel,K., Millar,L.S., Mikolajczyk,S.D., Goodmanson,M., Klee,G.G. and Rittenhouse,H.G.
    Development of a dual monoclonal antibody immunoassay for total human kallikrein 2
    Clin Chem47, 1218-1224. PubMed  Europe PubMed  A
  41. Rehault,S., Monget,P., Mazerbourg,S., Tremblay,R., Gutman,N., Gauthier,F. and Moreau,T.
    Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3
    Eur J Biochem268, 2960-2968. PubMed  Europe PubMed DOI
  42. Saedi,M.S., Zhu,Z., Marker,K., Liu,R.S., Carpenter,P.M., Rittenhouse,H. and Mikolajczyk,S.D.
    Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells
    Int J Cancer94, 558-563. PubMed  Europe PubMed DOI
    43. 2000
  43. Becker,C., Piironen,T., Pettersson,K., Bjork,T., Wojno,K.J., Oesterling,J.E. and Lilja,H.
    Discrimination of men with prostate cancer from those with benign disease by measurements of human glandular kallikrein 2 (hK2) in serum
    J Urol163, 311-316. PubMed  Europe PubMed
  44. Black,M.H., Magklara,A., Obiezu,C., Levesque,M.A., Sutherland,D.J., Tindall,D.J., Young,C.Y., Sauter,E.R. and Diamandis,E.P.
    Expression of a prostate-associated protein, human glandular kallikrein (hK2), in breast tumours and in normal breast secretions
    Br J Cancer82, 361-367. PubMed  Europe PubMed DOI
  45. Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
    The new human kallikrein gene family: implications in carcinogenesis
    Trends Endocrinol Metab11, 54-60. PubMed  Europe PubMed DOI
  46. [YEAR:17-10-2000]Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J., Moss,P., Paeper,B. and Wang,K.
    Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region
    Gene257, 119-130. PubMed  Europe PubMed DOI
  47. Potter,S.R. and Partin,A.W.
    Tumor markers: an update on human kallikrein 2
    Rev Urol2, 221-222. PubMed  Europe PubMed
    48. 1999
  48. Black,M.H., Magklara,A., Obiezu,C.V., Melegos,D.N. and Diamandis,E.P.
    Development of an ultrasensitive immunoassay for human glandular kallikrein with no cross-reactivity from prostate-specific antigen
    Clin Chem45, 790-799. PubMed  Europe PubMed  A
  49. Charlesworth,M.C., Young,C.Y., Miller,V.M. and Tindall,D.J.
    Kininogenase activity of prostate-derived human glandular kallikrein (hK2) purified from seminal fluid
    J Androl20, 220-229. PubMed  Europe PubMed
  50. Fiedler,F., Betz,G., Hinz,H., Lottspeich,F., Raidoo,D.M. and Bhoola,K.D.
    Not more than three tissue kallikreins identified from organs of the guinea pig
    Biol Chem380, 63-73. PubMed  Europe PubMed DOI
  51. Klee,G.G., Goodmanson,M.K., Jacobsen,S.J., Young,C.Y., Finlay,J.A., Rittenhouse,H.G., Wolfert,R.L. and Tindall,D.J.
    Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein-2
    Clin Chem45, 800-806. PubMed  Europe PubMed  A
  52. Kumar,A., Goel,A.S., Payne,J.K., Evans,C., Mikolajczyk,S.D., Kuus-Reichel,K. and Saedi,M.S.
    Large-scale propagation of recombinant adherent cells that secrete a stable form of human glandular kallikrein, hK2
    Protein Expr Purif15, 62-68. PubMed  Europe PubMed DOI  E
  53. Leinonen,J., Leinimaa,M., Zhang,W.M., Piironen,T., Pettersson,K., Lilja,H., Dowell,B. and Stenman,U.H.
    Reactivity of anti-PSA monoclonal antibodies with recombinant human kallikrein-2
    Tumour Biol20 Suppl 1, 35-37. PubMed  Europe PubMed
  54. Lovgren,J., Tian,S., Lundwall,A., Karp,M. and Lilja,H.
    Production and activation of recombinant hK2 with propeptide mutations resulting in high expression levels
    Eur J Biochem266, 1050-1055. PubMed  Europe PubMed DOI
  55. Lovgren,J., Airas,K. and Lilja,H.
    Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors
    Eur J Biochem262, 781-789. PubMed  Europe PubMed DOI
  56. [YEAR:5-5-1999]Mikolajczyk,S.D., Millar,L.S., Kumar,A. and Saedi,M.S.
    Prostatic human kallikrein 2 inactivates and complexes with plasminogen activator inhibitor-1
    Int J Cancer81, 438-442. PubMed  Europe PubMed DOI
  57. [YEAR:15-8-1999]Mikolajczyk,S.D., Millar,L.S., Marker,K.M., Rittenhouse,H.G., Wolfert,R.L., Marks,L.S., Charlesworth,M.C. and Tindall,D.J.
    Identification of a novel complex between human kallikrein 2 and protease inhibitor-6 in prostate cancer tissue
    Cancer Res59, 3927-3930. PubMed  Europe PubMed
  58. Rae,F., Bulmer,B., Nicol,D. and Clements,J.
    The human tissue kallikreins (KLKs 1-3) and a novel KLK1 mRNA transcript are expressed in a renal cell carcinoma cDNA library
    Immunopharmacology45, 83-88. PubMed  Europe PubMed DOI
  59. Yousef,G.M., Luo,L.Y. and Diamandis,E.P.
    Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4
    Anticancer Res19, 2843-2852. PubMed  Europe PubMed
    60. 1998
  60. [YEAR:15-10-1998]Heeb,M.J. and Espana,F.
    alpha2-Macroglobulin and C1-inactivator are plasma inhibitors of human glandular kallikrein
    Blood Cells Mol Dis24, 412-419. PubMed  Europe PubMed DOI
  61. [YEAR:1-1-1998]Mikolajczyk,S.D., Millar,L.S., Kumar,A. and Saedi,M.S.
    Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors
    Prostate34, 44-50. PubMed  Europe PubMed DOI
    62. 1997
  62. [YEAR:21-11-1997]Bourgeois,L., Brillard-Bourdet,M., Deperthes,D., Juliano,M.A., Juliano,L., Tremblay,R.R., Dube,J.Y. and Gauthier,F.
    Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2
    J Biol Chem272, 29590-29595. PubMed  Europe PubMed DOI
  63. [YEAR:14-11-1997]Deperthes,D., Marceau,F., Frenette,G., Lazure,C., Tremblay,R.R. and Dube,J.Y.
    Human kallikrein hK2 has low kininogenase activity while prostate-specific antigen (hK3) has none
    Biochim Biophys Acta1343, 102-106. PubMed  Europe PubMed DOI
  64. Frenette,G., Deperthes,D., Tremblay,R.R., Lazure,C. and Dube,J.Y.
    Purification of enzymatically active kallikrein hK2 from human seminal plasma
    Biochim Biophys Acta1334, 109-115. PubMed  Europe PubMed DOI
  65. Lovgren,J., Rajakoski,K., Karp,M., Lundwall a and Lilja,H.
    Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2
    Biochem Biophys Res Commun238, 549-555. PubMed  Europe PubMed DOI
    66. 1996
  66. Deperthes,D., Frenette,G., Brillard-Bourdet,M., Bourgeois,L., Gauthier,F., Tremblay,R.R. and Dube,J.Y.
    Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation
    J Androl17, 659-665. PubMed  Europe PubMed
  67. Grauer,L.S., Charlesworth,M.C., Saedi,M.S., Finlay,J.A., Liu,R.S., Kuus-Reichel,K., Young,C.Y. and Tindall,D.J.
    Identification of human glandular kallikrein hK2 from LNCaP cells
    J Androl17, 353-359. PubMed  Europe PubMed
  68. Piironen,T., Lovgren,J., Karp,M., Eerola,R., Lundwall,A., Dowell,B., Lovgren,T., Lilja,H. and Pettersson,K.
    Immunofluorometric assay for sensitive and specific measurement of human prostatic glandular kallikrein (hK2) in serum
    Clin Chem42, 1034-1041. PubMed  Europe PubMed  A
    69. 1995
  69. [YEAR:24-8-1995]Lovgren,J., Piironen,T., Overmo,C., Dowell,B., Karp,M., Pettersson,K., Lilja,H. and Lundwall,A.
    Production of recombinant PSA and HK2 and analysis of their immunologic cross-reactivity
    Biochem Biophys Res Commun213, 888-895. PubMed  Europe PubMed DOI
  70. Richards,G.P., Chao,J., Chung,P. and Chao,L.
    Purification and characterization of tissue kallikrein-like proteinases from the black sea bass (Centropristis striata) and the southern frog (Rana berlandieri)
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol111, 69-82. PubMed  Europe PubMed DOI
  71. Saedi,M.S., Cass,M.M., Goel,A.S., Grauer,L., Hogen,K.L., Okaneya,T., Griffin,B.Y., Klee,G.G., Young,C.Y. and Tindall,D.J.
    Overexpression of a human prostate-specific glandular kallikrein, hK2, in E. coli and generation of antibodies
    Mol Cell Endocrinol109, 237-241. PubMed  Europe PubMed DOI  E
    72. 1993
  72. [YEAR:29-6-1993]Murtha,P., Tindall,D.J. and Young,C.Y.
    Androgen induction of a human prostate-specific kallikrein, hKLK2: characterization of an androgen response element in the 5' promoter region of the gene
    Biochemistry32, 6459-6464. PubMed  Europe PubMed

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