$VAR1 = undef;
Summary for peptidase S01.161: kallikrein-related peptidase 2
| Names | |
|---|---|
| MEROPS Name | kallikrein-related peptidase 2 |
| Other names | kallikrein 2, kallikrein hk2 (Homo sapiens), KLK2 g.p. (Homo sapiens), human glandular kallikrein 1 [obs.], hGK1 |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.161 |
| Holotype | kallikrein-related peptidase 2 (Homo sapiens), Uniprot accession P20151 (peptidase unit: 25-260), MERNUM MER0000094 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00290 | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (28 cleavages) | ||
| Biotechnology | Possible use as diagnostic in detection of prostate cancer has been proposed (Finlay et al., 2001). | ||
| Pathways | KEGG | Endocrine and other factor-regulated calcium reabsorption | |
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/KLK2 | |
| Cleavage site specificity | Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here. | ||
| Cleavage pattern | g/-/-/R -/-/-/gst (based on 66 cleavages) | ||
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| Specificity matrix | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Specificity from combinatorial peptides | ||||||||||||||||||||||||||||||||||||||||
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xxxx| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| KLK2 | 19q13.2-q13.4 | ENSG00000167751 | 3817 | KLK2 | 147960 | |
