Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P02679

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-453	P	release of an initiating methionine	MS	Adamski et al., 2005
26	unknown peptidase	1-453	P	release of a signal peptide		Hiller et al., 2000
84	unknown peptidase	1-453	P		NT	<%Agarwal et al., 2012[]%>
87	carboxypeptidase N	79-88	N		NT	Myles et al., 2003
87	carboxypeptidase B2	79-88	N		NT	Myles et al., 2003
88	plasmin	27-453	P			Yuan et al., 2009
91	membrane-type matrix metallopeptidase-1	27-453	P			Hiller et al., 2000
102	unknown peptidase	1-453	P		NT	<%Agarwal et al., 2012[]%>
103	matrix metallopeptidase-26	27-453	P			Park et al., 2002
104	membrane-type matrix metallopeptidase-1	27-453	P			Bini et al., 1999
109	matrix metallopeptidase-3	27-453	P			Bini et al., 1999
109	matrix metallopeptidase-7	27-453	P			Bini et al., 1999
109	membrane-type matrix metallopeptidase-1	27-453	P			Bini et al., 1999
110	carboxypeptidase N	102-111	N		NT	Myles et al., 2003
110	carboxypeptidase B2	102-111	N		NT	Myles et al., 2003
111	plasmin	27-453	P			Yuan et al., 2009
382	plasmin	27-453	P			Yuan et al., 2009
399	plasmin	27-453	P			Yuan et al., 2009
430	matrix metallopeptidase-3	27-453	P	normal turnover		Bini et al., 1996
430	staphylolysin	27-453	P			Loewy et al., 1993
430	Mername-AA291 peptidase	27-453	P			Kessler & Ohman, 2004