Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M10.017: membrane-type matrix metallopeptidase-4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Munoz-Saez,E., Moracho,N., Learte,A.I.R., Collignon,A., Arroyo,A.G., Noel,A., Sounni,N.E. and Sanchez-Camacho,C.<br>Molecular Mechanisms Driven by MT4-MMP in Cancer Progression<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
    2. 2018
  2. Clemente,C., Rius,C., Alonso-Herranz,L., Martin-Alonso,M., Pollan,A., Camafeita,E., Martinez,F., Mota,R.A., Nunez,V., Rodriguez,C., Seiki,M., Martinez-Gonzalez,J., Andres,V., Ricote,M. and Arroyo,A.G.<br>MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis<br>Nat Commun (2018) 9, 910-910. PubMed  Europe PubMed DOI  PMC  EPMC  K
    3. 2016
  3. Truong,A., Yip,C., Paye,A., Blacher,S., Munaut,C., Deroanne,C., Noel,A. and Sounni,N.E.<br>Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells<br>FEBS J (2016) 283, 704-722. PubMed  Europe PubMed DOI
    4. 2014
  4. Crawford,B.D., Po,M.D., Saranyan,P.V., Forsberg,D., Schulz,R. and Pilgrim,D.B.<br>Mmp25beta facilitates elongation of sensory neurons during zebrafish development<br>Genesis (2014) 52, 833-848. PubMed  Europe PubMed DOI
  5. Paye,A., Truong,A., Yip,C., Cimino,J., Blacher,S., Munaut,C., Cataldo,D., Foidart,J.M., Maquoi,E., Collignon,J., Delvenne,P., Jerusalem,G., Noel,A. and Sounni,N.E.<br>EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP<br>Cancer Res (2014) 74, 6758-6770. PubMed  Europe PubMed DOI
    6. 2012
  6. Host,L., Paye,A., Detry,B., Blacher,S., Munaut,C., Foidart,J.M., Seiki,M., Sounni,N.E. and Noel,A.<br>The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects<br>Int J Cancer (2012) 131, 1537-1548. PubMed  Europe PubMed DOI
  7. Itoh,Y. and Seiki,M.<br>Membrane-type matrix metalloproteinase 4<br>[ISSN:978-0-12-407744-7] (2012) 3, 823-826. DOI
    8. 2011
  8. Clements,K.M., Flannelly,J.K., Tart,J., Brockbank,S.M., Wardale,J., Freeth,J., Parker,A.E. and Newham,P.<br>Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment<br>Ann Rheum Dis (2011) 70, 683-689. PubMed  Europe PubMed DOI
  9. Sohail,A., Marco,M., Zhao,H., Shi,Q., Merriman,S., Mobashery,S. and Fridman,R.<br>Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase<br>J Biol Chem (2011) 286, 33178-33189. PubMed  Europe PubMed DOI
  10. Srichai,M.B., Colleta,H., Gewin,L., Matrisian,L., Abel,T.W., Koshikawa,N., Seiki,M., Pozzi,A., Harris,R.C. and Zent,R.<br>Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice<br>PLoS ONE (2011) 6, e17099-e17099. PubMed  Europe PubMed DOI  PMC  EPMC  K
    11. 2009
  11. Chabottaux,V., Ricaud,S., Host,L., Blacher,S., Paye,A., Thiry,M., Garofalakis,A., Pestourie,C., Gombert,K., Bruyere,F., Lewandowsky,D., Tavitian,B., Foidart,J.M., Duconge,F. and Noel,A.<br>Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture<br>J Cell Mol Med (2009) 13, 4002-4013. PubMed  Europe PubMed DOI
    12. 2008
  12. Sohail,A., Sun,Q., Zhao,H., Bernardo,M.M., Cho,J.A. and Fridman,R.<br>MT4-(MMP17) and MT6-MMP (MMP25), a unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer<br>Cancer Metastasis Rev (2008) 27, 289-302. PubMed  Europe PubMed DOI
    13. 2007
  13. Rikimaru,A., Komori,K., Sakamoto,T., Ichise,H., Yoshida,N., Yana,I. and Seiki,M.<br>Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase<br>Genes Cells (2007) 12, 1091-1100. PubMed  Europe PubMed DOI  K
    14. 2005
  14. Patwari,P., Gao,G., Lee,J.H., Grodzinsky,A.J. and Sandy,J.D.<br>Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage<br>Osteoarthritis Cartilage (2005) 13, 269-277. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2004
  15. [YEAR:29-12-2004]Gao,G., Plaas,A., Thompson,V.P., Jin,S., Zuo,F. and Sandy,J.D.<br>ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1<br>J Biol Chem (29-12-2004) 279, 10042-10051. PubMed  Europe PubMed DOI
  16. Itoh,Y. and Seiki,M.<br>Membrane-type matrix metalloproteinase 4<br>[ISSN:0-12-079610-4] (2004) 2, 553-555.  V
    17. 2001
  17. Dong,Z., Katar,M., Alousi,S. and Berk,R.S.<br>Expression of membrane-type matrix metalloproteinases 4, 5, and 6 in mouse corneas infected with P. aeruginosa<br>Invest Ophthalmol Vis Sci (2001) 42, 3223-3227. PubMed  Europe PubMed
    18. 2000
  18. [YEAR:12-5-2000]English,W.R., Puente,X.S., Freije,J.M., Knauper,V., Amour,A., Merryweather,A., Lopez-Otin,C. and Murphy,G.<br>Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2<br>J Biol Chem (12-5-2000) 275, 14046-14055. PubMed  Europe PubMed DOI
    19. 1999
  19. [YEAR:26-11-1999]Itoh,Y., Kajita,M., Kinoh,H., Mori,H., Okada,A. and Seiki,M.<br>Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase<br>J Biol Chem (26-11-1999) 274, 34260-34266. PubMed  Europe PubMed DOI
  20. [YEAR:3-9-1999]Kajita,M., Kinoh,H., Ito,N., Takamura,A., Itoh,Y., Okada,A., Sato,H. and Seiki,M.<br>Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts<br>FEBS Lett (3-9-1999) 457, 353-356. PubMed  Europe PubMed DOI
  21. Kinoh,H., Hayashita,H., Kajita,M., Okada,A. and Seiki,M.<br>Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2 - >q12, respectively, by radiation hybrid and in situ hybridization<br>Cytogenet Cell Genet (1999) 87, 97-98. PubMed  Europe PubMed
  22. Kolkenbrock,H., Essers,L., Ulbrich,N. and Will,H.<br>Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase<br>Biol Chem (1999) 380, 1103-1108. PubMed  Europe PubMed DOI
  23. [YEAR:12-11-1999]Wang,Y., Johnson,A.R., Ye,Q.Z. and Dyer,R.D.<br>Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain<br>J Biol Chem (12-11-1999) 274, 33043-33049. PubMed  Europe PubMed DOI
    24. 1998
  24. [YEAR:15-12-1998]Puente,X.S., Pendas,A.M., Llano,E. and Lopez-Otin,C.<br>Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24<br>Genomics (15-12-1998) 54, 578-579. PubMed  Europe PubMed DOI
    25. 1996
  25. Puente,X.S., Pendas,A.M., Llano,E., Velasco,G. and Lopez-Otin,C.<br>Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma<br>Cancer Res (1996) 56, 944-949. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use