Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M10.017: membrane-type matrix metallopeptidase-4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Munoz-Saez,E., Moracho,N., Learte,A.I.R., Collignon,A., Arroyo,A.G., Noel,A., Sounni,N.E. and Sanchez-Camacho,C.
    Molecular Mechanisms Driven by MT4-MMP in Cancer Progression
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
    2. 2018
  2. Clemente,C., Rius,C., Alonso-Herranz,L., Martin-Alonso,M., Pollan,A., Camafeita,E., Martinez,F., Mota,R.A., Nunez,V., Rodriguez,C., Seiki,M., Martinez-Gonzalez,J., Andres,V., Ricote,M. and Arroyo,A.G.
    MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis
    Nat Commun (2018) 9, 910-910. PubMed  Europe PubMed DOI  PMC  EPMC  K
    3. 2016
  3. Truong,A., Yip,C., Paye,A., Blacher,S., Munaut,C., Deroanne,C., Noel,A. and Sounni,N.E.
    Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells
    FEBS J (2016) 283, 704-722. PubMed  Europe PubMed DOI
    4. 2014
  4. Crawford,B.D., Po,M.D., Saranyan,P.V., Forsberg,D., Schulz,R. and Pilgrim,D.B.
    Mmp25beta facilitates elongation of sensory neurons during zebrafish development
    Genesis (2014) 52, 833-848. PubMed  Europe PubMed DOI
  5. Paye,A., Truong,A., Yip,C., Cimino,J., Blacher,S., Munaut,C., Cataldo,D., Foidart,J.M., Maquoi,E., Collignon,J., Delvenne,P., Jerusalem,G., Noel,A. and Sounni,N.E.
    EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP
    Cancer Res (2014) 74, 6758-6770. PubMed  Europe PubMed DOI
    6. 2012
  6. Host,L., Paye,A., Detry,B., Blacher,S., Munaut,C., Foidart,J.M., Seiki,M., Sounni,N.E. and Noel,A.
    The proteolytic activity of MT4-MMP is required for its pro-angiogenic and pro-metastatic promoting effects
    Int J Cancer (2012) 131, 1537-1548. PubMed  Europe PubMed DOI
  7. Itoh,Y. and Seiki,M.
    Membrane-type matrix metalloproteinase 4
    [ISSN:978-0-12-407744-7] (2012) 3, 823-826. DOI
    8. 2011
  8. Clements,K.M., Flannelly,J.K., Tart,J., Brockbank,S.M., Wardale,J., Freeth,J., Parker,A.E. and Newham,P.
    Matrix metalloproteinase 17 is necessary for cartilage aggrecan degradation in an inflammatory environment
    Ann Rheum Dis (2011) 70, 683-689. PubMed  Europe PubMed DOI
  9. Sohail,A., Marco,M., Zhao,H., Shi,Q., Merriman,S., Mobashery,S. and Fridman,R.
    Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase
    J Biol Chem (2011) 286, 33178-33189. PubMed  Europe PubMed DOI
  10. Srichai,M.B., Colleta,H., Gewin,L., Matrisian,L., Abel,T.W., Koshikawa,N., Seiki,M., Pozzi,A., Harris,R.C. and Zent,R.
    Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice
    PLoS ONE (2011) 6, e17099-e17099. PubMed  Europe PubMed DOI  PMC  EPMC  K
    11. 2009
  11. Chabottaux,V., Ricaud,S., Host,L., Blacher,S., Paye,A., Thiry,M., Garofalakis,A., Pestourie,C., Gombert,K., Bruyere,F., Lewandowsky,D., Tavitian,B., Foidart,J.M., Duconge,F. and Noel,A.
    Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture
    J Cell Mol Med (2009) 13, 4002-4013. PubMed  Europe PubMed DOI
    12. 2008
  12. Sohail,A., Sun,Q., Zhao,H., Bernardo,M.M., Cho,J.A. and Fridman,R.
    MT4-(MMP17) and MT6-MMP (MMP25), a unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer
    Cancer Metastasis Rev (2008) 27, 289-302. PubMed  Europe PubMed DOI
    13. 2007
  13. Rikimaru,A., Komori,K., Sakamoto,T., Ichise,H., Yoshida,N., Yana,I. and Seiki,M.
    Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase
    Genes Cells (2007) 12, 1091-1100. PubMed  Europe PubMed DOI  K
    14. 2005
  14. Patwari,P., Gao,G., Lee,J.H., Grodzinsky,A.J. and Sandy,J.D.
    Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage
    Osteoarthritis Cartilage (2005) 13, 269-277. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2004
  15. [YEAR:29-12-2004]Gao,G., Plaas,A., Thompson,V.P., Jin,S., Zuo,F. and Sandy,J.D.
    ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1
    J Biol Chem (29-12-2004) 279, 10042-10051. PubMed  Europe PubMed DOI
  16. Itoh,Y. and Seiki,M.
    Membrane-type matrix metalloproteinase 4
    [ISSN:0-12-079610-4] (2004) 2, 553-555.  V
    17. 2001
  17. Dong,Z., Katar,M., Alousi,S. and Berk,R.S.
    Expression of membrane-type matrix metalloproteinases 4, 5, and 6 in mouse corneas infected with P. aeruginosa
    Invest Ophthalmol Vis Sci (2001) 42, 3223-3227. PubMed  Europe PubMed
    18. 2000
  18. [YEAR:12-5-2000]English,W.R., Puente,X.S., Freije,J.M., Knauper,V., Amour,A., Merryweather,A., Lopez-Otin,C. and Murphy,G.
    Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2
    J Biol Chem (12-5-2000) 275, 14046-14055. PubMed  Europe PubMed DOI
    19. 1999
  19. [YEAR:26-11-1999]Itoh,Y., Kajita,M., Kinoh,H., Mori,H., Okada,A. and Seiki,M.
    Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase
    J Biol Chem (26-11-1999) 274, 34260-34266. PubMed  Europe PubMed DOI
  20. [YEAR:3-9-1999]Kajita,M., Kinoh,H., Ito,N., Takamura,A., Itoh,Y., Okada,A., Sato,H. and Seiki,M.
    Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts
    FEBS Lett (3-9-1999) 457, 353-356. PubMed  Europe PubMed DOI
  21. Kinoh,H., Hayashita,H., Kajita,M., Okada,A. and Seiki,M.
    Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2 - >q12, respectively, by radiation hybrid and in situ hybridization
    Cytogenet Cell Genet (1999) 87, 97-98. PubMed  Europe PubMed
  22. Kolkenbrock,H., Essers,L., Ulbrich,N. and Will,H.
    Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase
    Biol Chem (1999) 380, 1103-1108. PubMed  Europe PubMed DOI
  23. [YEAR:12-11-1999]Wang,Y., Johnson,A.R., Ye,Q.Z. and Dyer,R.D.
    Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain
    J Biol Chem (12-11-1999) 274, 33043-33049. PubMed  Europe PubMed DOI
    24. 1998
  24. [YEAR:15-12-1998]Puente,X.S., Pendas,A.M., Llano,E. and Lopez-Otin,C.
    Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24
    Genomics (15-12-1998) 54, 578-579. PubMed  Europe PubMed DOI
    25. 1996
  25. Puente,X.S., Pendas,A.M., Llano,E., Velasco,G. and Lopez-Otin,C.
    Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma
    Cancer Res (1996) 56, 944-949. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use