Structure for peptidase M02.006: angiotensin-converting enzyme-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
2AJF_A	Homo sapiens	2.90 Å	structure of sars coronavirus spike receptor-binding domain complexed with its receptor
The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His374 in purple, His378 in purple and Glu402 in blue. The catalytic Glu375 is shown in blue ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
mature peptidase	2.20 Å	1R42	1R42	1R42	1R42	1R42	1R42	Towler et al., 2004
inhibitor bound human angiotensin converting enzyme-related carboxypeptidase (ace2)	3.00 Å	1R4L	1R4L	1R4L	1R4L	1R4L	1R4L	Towler et al., 2004
mature peptidase	0.00 Å	1XJP	1XJP	1XJP	1XJP	1XJP	1XJP
structure of sars coronavirus spike receptor-binding domain complexed with its receptor	2.90 Å	2AJF	2AJF	2AJF	2AJF	2AJF	2AJF	Li et al., 2005
crystal structure of spike protein receptor-binding domain from the 2002-2003 sars coronavirus human strain complexed with human-civet chimeric receptor ace2	2.80 Å	3D0G	3D0G	3D0G	3D0G	3D0G	3D0G	Li, 2008
crystal structure of spike protein receptor-binding domain from the 2002-2003 sars coronavirus civet strain complexed with human-civet chimeric receptor ace2	3.10 Å	3D0H	3D0H	3D0H	3D0H	3D0H	3D0H	Li, 2008
crystal structure of spike protein receptor-binding domain from the 2005-2006 sars coronavirus civet strain complexed with human-civet chimeric receptor ace2	2.90 Å	3D0I	3D0I	3D0I	3D0I	3D0I	3D0I	Li, 2008
mature peptidase	3.31 Å	3KBH	3KBH	3KBH	3KBH	3KBH	3KBH	Wu et al., 2009
mature peptidase	2.90 Å	3SCI	3SCI	3SCI	3SCI	3SCI	3SCI
mature peptidase	3.00 Å	3SCJ	3SCJ	3SCJ	3SCJ	3SCJ	3SCJ
mature peptidase	3.00 Å	3SCK	3SCK	3SCK	3SCK	3SCK	3SCK
mature peptidase	3.00 Å	3SCL	3SCL	3SCL	3SCL	3SCL	3SCL
trypsin-cleaved and low ph-treated sars-cov spike glycoprotein and ace2 complex, ace2-bound conformation 1	5.40 Å	6ACG	6ACG	6ACG	6ACG	6ACG	6ACG
trypsin-cleaved and low ph-treated sars-cov spike glycoprotein and ace2 complex, ace2-bound conformation 2	4.20 Å	6ACJ	6ACJ	6ACJ	6ACJ	6ACJ	6ACJ
trypsin-cleaved and low ph-treated sars-cov spike glycoprotein and ace2 complex, ace2-bound conformation 3	4.50 Å	6ACK	6ACK	6ACK	6ACK	6ACK	6ACK
sars spike glycoprotein - human ace2 complex, stabilized variant, all ace2-bound particles	4.40 Å	6CS2	6CS2	6CS2	6CS2	6CS2	6CS2
Paguma larvata
crystal structure of spike protein receptor-binding domain from the 2002-2003 sars coronavirus human strain complexed with human-civet chimeric receptor ace2	2.80 Å	3D0G	3D0G	3D0G	3D0G	3D0G	3D0G	Li, 2008
crystal structure of spike protein receptor-binding domain from the 2002-2003 sars coronavirus civet strain complexed with human-civet chimeric receptor ace2	3.10 Å	3D0H	3D0H	3D0H	3D0H	3D0H	3D0H	Li, 2008
crystal structure of spike protein receptor-binding domain from the 2005-2006 sars coronavirus civet strain complexed with human-civet chimeric receptor ace2	2.90 Å	3D0I	3D0I	3D0I	3D0I	3D0I	3D0I	Li, 2008
mature peptidase	3.00 Å	3SCK	3SCK	3SCK	3SCK	3SCK	3SCK
mature peptidase	3.00 Å	3SCL	3SCL	3SCL	3SCL	3SCL	3SCL