Literature for peptidase M02.006: angiotensin-converting enzyme-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Kaiser-Graf,D., Domenig,O., Poglitsch,M., Kreutz,R. and Bolbrinker,J. Upregulation of angiotensin-(1-7) formation in human podocytes - enzyme activity assay upon fluid flow shear stress PLoS ONE (2026) 21, e0339874-e0339874. PubMed Europe PubMed DOI PMC EPMC
Pan,X., Shao,Y., Wu,F., Wang,Y., Xiong,R., Zheng,J., Tian,H., Wang,B., Wang,Y., Zhang,Y., Han,Z., Qu,A., Xu,H., Lu,A., Yang,T., Li,X., Xu,A., Du,J. and Lin,Z. FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice Cell Metab (2026) PubMed Europe PubMed DOI

2025

Akkan,C., Das,M., Bardakci,O., Sehitoglu,M.H., Akdur,G., Akman,C., Akdur,O. and Beyazit,Y. A prediction model for lung involvement using circulating angiotensin converting enzyme-2 and renin levels in COVID-19 patients J Infect Dev Ctries (2025) 19, 1432-1442. PubMed Europe PubMed DOI
AmeliMojarad,M. and AmeliMojarad,M. The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities J Neurovirol (2025) PubMed Europe PubMed DOI
Bach,M.L. and Jensen,B.L. Effects and regulation of ACE2 and TMPRSS2 abundance in healthy humans and in patients with SARS-CoV-2 Biochem Soc Trans (2025) PubMed Europe PubMed DOI
Bangaru,M.L.Y. and Raghavendra,N.K. Helix alpha1 of human ACE2 mimics dsDNA and Spike of SARS-CoV-2 binds DNA Biochem Biophys Res Commun (2025) 793, 153020-153020. PubMed Europe PubMed DOI
Campagnole-Santos,M.J., Peliky Fontes,M.A., Verano-Braga,T., Haibara,A.S., Bader,M. and Santos,R.A.S. ACE2/Angiotensin-(1-7)/Mas and the brain Brain Res (2025) 1863, 149739-149739. PubMed Europe PubMed DOI V
Catanzaro,N.J., Wu,Z., Fan,C., Jefferson,V., Abdelgadir,A., Schafer,A., Yount,B.L., Bjorkman,P.J., Baric,R. and Letko,M. ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses Nat Commun (2025) 16, 4932-4932. PubMed Europe PubMed DOI PMC EPMC
Chau,L.F., Lillico,S., Opriessnig,T., Blake,R., Tardy,L., Lee,C.H., Maxwell,S., Warren,C., Thornton,E., Mclaughlin,C.L., McLachlan,G., Tait-Burkard,C., Fletcher,S., Anderson,S., Brown,S., Gibbard,L., Tzelos,T., MacMillan-Christensen,D., Baillie,J.K., Dorward,D.A., Griffiths,D.J. and Grey,F. Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease Nat Commun (2025) 16, 766-766. PubMed Europe PubMed DOI PMC EPMC
Chen,J., Zhang,W., Li,Y., Liu,C., Dong,T., Chen,H., Wu,C., Su,J., Li,B., Zhang,W., Hu,B., Jia,J., Ma,C.B., Zhu,Y., He,X., Li,A., Pan,K., Lin,H., Guo,Z., Li,C., Zhang,L., Yan,H., Zhou,P., Peng,W. and Shi,Z.L. Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor Cell (2025) PubMed Europe PubMed DOI
Chhabra,K.H., Shoemaker,R., Herath,C.B., Thomas,M.C., Filipeanu,C.M. and Lazartigues,E. Molecular Dissection of the Role of ACE2 in Glucose Homeostasis Physiol Rev (2025) PubMed Europe PubMed DOI V
Huang,Y., Zhang,X., Wu,S., Zhang,S. and Bao,W. Porcine angiotensin-converting enzyme 2 serves as an auxiliary receptor to enhance transmissible gastroenteritis virus invasion and replication Vet Microbiol (2025) 310, 110691-110691. PubMed Europe PubMed DOI
Jiang,S. and Wu,F. Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk Cell (2025) 188, 1465-1468. PubMed Europe PubMed DOI
Liao,W., Zhang,T., Cao,J., Wang,S. and Zhang,Y. Long non-coding RNA enhances SARS-CoV-2-mediated apoptosis through epigenetic repression of angiotensin-converting enzyme 2 J Biol Chem (2025) , 110812-110812. PubMed Europe PubMed DOI
Liu,C., Park,Y.J., Ma,C.B., Gen,R., Stewart,C., Sun,Y.C., Yang,X., Lin,M.Y., Xiong,Q., Si,J.Y., Liu,P., Veesler,D. and Yan,H. HKU25 clade MERS-related coronaviruses use ACE2 as a functional receptor Nat Microbiol (2025) 10, 2860-2874. PubMed Europe PubMed DOI PMC EPMC
Lu,J., Tang,Y., Li,H., Chen,X., Qin,P., Xu,J., Li,W. and Chen,L. Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC V
Lusvarghi,S., Vassell,R., Williams,B., Baha,H., Neerukonda,S.N. and Weiss,C.D. Capture of fusion-intermediate conformations of SARS-CoV-2 spike requires receptor binding and cleavage at either the S1/S2 or S2' site PLoS Pathog (2025) 21, e1012808-e1012808. PubMed Europe PubMed DOI
Ma,C.B., Liu,C., Park,Y.J., Tang,J., Chen,J., Xiong,Q., Lee,J., Stewart,C., Asarnow,D., Brown,J., Tortorici,M.A., Yang,X., Sun,Y.H., Chen,Y.M., Yu,X., Si,J.Y., Liu,P., Tong,F., Huang,M.L., Li,J., Shi,Z.L., Deng,Z., Veesler,D. and Yan,H. Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses Cell (2025) PubMed Europe PubMed DOI
Madel Alfajaro,M., Keeler,E.L., Li,N., Catanzaro,N.J., Teng,I.T., Zhao,Z., Grunst,M.W., Yount,B., Schafer,A., Wang,D., Kim,A.S., Synowiec,A., Pena-Hernandez,M.A., Zepeda,S., Arinola,R., Kaur,R., Menasche,B.L., Wei,J., Russell,G.A., Huck,J., Song,J., Ring,A., Iwasaki,A., Jangra,R.K., Lee,S., Martinez,D.R., Mothes,W., Uchil,P.D., Doench,J.G., Spaulding,A.B., Baric,R.S., Serebryannyy,L., Tsybovsky,Y., Zhou,T., Douek,D.C. and Wilen,C.B. HKU5 bat merbecoviruses engage bat and mink ACE2 as entry receptors Nat Commun (2025) 16, 6822-6822. PubMed Europe PubMed DOI PMC EPMC
Noettger,S., Zech,F., Nchioua,R., Pastorio,C., Jung,C., Jacob,T., Stenger,S. and Kirchhoff,F. Role of N-linked glycosylation sites in human ACE2 in SARS-CoV-2 and hCoV-NL63 infection J Virol (2025) , e0220224-e0220224. PubMed Europe PubMed DOI
Okal,E.F., Romero,P.A. and Heinzelman,P. Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity J Biol Eng (2025) 19, 12-12. PubMed Europe PubMed DOI PMC EPMC
Park,Y.J., Liu,C., Lee,J., Brown,J.T., Ma,C.B., Liu,P., Gen,R., Xiong,Q., Zepeda,S.K., Stewart,C., Addetia,A., Craig,C.J., Tortorici,M.A., Alshukairi,A.N., Starr,T.N., Yan,H. and Veesler,D. Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses Cell (2025) PubMed Europe PubMed DOI
Rizopoulos,T. and Assimakopoulou,M. Angiotensinƒ_'converting enzyme 2 expression in human tumors: Implications for prognosis and therapy (Review) Oncol Rep (2025) 54 PubMed Europe PubMed DOI PMC EPMC
Tang,C., Lupala,C.S., Wang,D., Li,X., Tang,L.H. and Li,X. Structural and Energetic Insights into SARS-CoV-2 Evolution: Analysis of hACE2-RBD Binding in Wild-Type, Delta, and Omicron Subvariants Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC
Tang,X., Lu,L., Li,X. and Huang,P. Bridging Cancer and COVID-19: The Complex Interplay of ACE2 and TMPRSS2 Cancer Med (2025) 14, e70829-e70829. PubMed Europe PubMed DOI PMC EPMC V
Teratake,Y., Okamura,T. and Ishizaka,Y. SMAD5 phosphorylation by ALK1 is modulated by the interaction of the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2 Antiviral Res (2025) 242, 106261-106261. PubMed Europe PubMed DOI
Vergoten,G. and Bailly,C. Interaction of Asparagusic Acid, Asparaptines and Related Dithiolane Derivatives With Angiotensin-Converting Enzyme-2 (ACE-2): A Molecular Docking Study J Biochem Mol Toxicol (2025) 39, e70236-e70236. PubMed Europe PubMed DOI PMC EPMC
Wang,N., Ji,W., Jiao,H., Veit,M., Sun,J., Wang,Y., Ma,X., Wang,Y., Wang,Y., Li,X.X., Zhang,X., Chen,J., Wei,J., Xu,Y., Guo,D., Zhai,X., Merits,A., Li,C., Rey,F.A., Dobrikov,G.M., Gao,G.F., Zhang,S., Bi,Y. and Su,S. A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor Nature (2025) PubMed Europe PubMed DOI
Xia,J., Shen,L., Liu,Y., Wang,L. and Liu,F. Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis Proc Natl Acad Sci U S A (2025) 122, e2515641122-e2515641122. PubMed Europe PubMed DOI PMC EPMC K
Xing,L., Liu,Z., Wang,X., Liu,Q., Xu,W., Mao,Q., Zhang,X., Hao,A., Xia,S., Liu,Z., Sun,L., Zhang,G., Wang,Q., Chen,Z., Jiang,S., Sun,L. and Lu,L. Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target Cell (2025) PubMed Europe PubMed DOI
Zhang,C., Yang,M., An,Y., Liu,M., Li,H., Zhao,R., Yang,X., Huang,L., Zhang,Y., Peng,R., Zhong,H., Yan,X., Wei,C. and Wan,L. Real-Time Monitoring of Secretory Protein Traffic for Investigating Trafficking Regulators of ACE2 in Living Cells J Biol Chem (2025) , 110593-110593. PubMed Europe PubMed DOI
Zhang,Y., Tan,R., Wu,L., Zhao,D., Zhong,C., Luo,C., Chung,J.Y., Tang,P.M. and Yu,C. Epithelial DPP4 promotes Ang II-driven renal fibrosis by targeting ACE2 activity in the renin-angiotensin system Int J Biol Sci (2025) 21, 3901-3916. PubMed Europe PubMed DOI PMC EPMC
Zhou,Y. and Wang,T. Dynamic insights into the structural evolution of ACE2-RBD interactions through molecular dynamics simulation, Markov state modeling, and large language model mutation prediction J Chem Phys (2025) 163 PubMed Europe PubMed DOI

2024

Al-Saigh,N.N., Harb,A.A. and Abdalla,S. Receptors Involved in COVID-19-Related Anosmia: An Update on the Pathophysiology and the Mechanistic Aspects Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC V
Arppo,A., Barker,H. and Parkkila,S. Bioinformatic characterization of ENPEP, the gene encoding a potential cofactor for SARS-CoV-2 infection PLoS ONE (2024) 19, e0307731-e0307731. PubMed Europe PubMed DOI PMC EPMC
Ayyubova,G., Gychka,S.G., Nikolaienko,S.I., Alghenaim,F.A., Teramoto,T., Shults,N.V. and Suzuki,Y.J. The Role of Furin in the Pathogenesis of COVID-19-Associated Neurological Disorders Life (Basel) (2024) 14 PubMed Europe PubMed DOI PMC EPMC
Bach,M.L., Laftih,S., Andresen,J.K., Pedersen,R.M., Andersen,T.E., Madsen,L.W., Madsen,K., Hinrichs,G.R., Zachar,R., Svenningsen,P., Lund,L., Johansen,I.S., Hansen,L.F., Palarasah,Y. and Jensen,B.L. ACE2 and TMPRSS2 in human kidney tissue and urine extracellular vesicles with age, sex, and COVID-19 Pflugers Arch (2024) PubMed Europe PubMed DOI
Bader,M., Steckelings,U.M., Alenina,N., Santos,R.A.S. and Ferrario,C.M. Alternative Renin-Angiotensin System Hypertension (2024) 81, 964-976. PubMed Europe PubMed DOI V
Broer,A., Hu,Z., Kukulowicz,J., Yadav,A., Zhang,T., Dai,L., Bajda,M., Yan,R. and Broer,S. Cryo-EM structure of ACE2-SIT1 in complex with Tiagabine J Biol Chem (2024) , 107687-107687. PubMed Europe PubMed DOI
Ding,J., Zhang,Q., Jiang,J., Zhou,N., Yu,Z., Wang,Z., Meng,X., Daggumati,L., Liu,T., Wang,F., Lu,Z., Yang,X., Yang,Z., Zhang,H., Thorek,D.L.J., Du,P. and Zhu,H. Preclinical Evaluation and Pilot Clinical Study of (18)F-Labeled Inhibitor Peptide for Noninvasive Positron Emission Tomography Mapping of Angiotensin Converting Enzyme 2 ACS Pharmacol Transl Sci (2024) 7, 1758-1769. PubMed Europe PubMed DOI PMC EPMC
Elgazzaz,M., Filipeanu,C. and Lazartigues,E. The 2023 Lewis K. Dahl Memorial Lecture: Angiotensin-Converting Enzyme 2 Posttranslational Modifications-Implications for Hypertension and SARS-CoV-2 Infection Hypertension (2024) 81, 1438-1449. PubMed Europe PubMed DOI V
Ghahramani,M., Shahsavani,M.B., Khaleghinejad,S.H., Niazi,A., Moosavi-Movahedi,A.A. and Yousefi,R. Efficient Expression in the Prokaryotic Host System, Purification and Structural Analyses of the Recombinant Human ACE2 Catalytic Subunit as a Hybrid Protein with the B Subunit of Cholera Toxin (CTB-ACE2) Protein J (2024) 43, 24-38. PubMed Europe PubMed DOI
Guo,Y.T., Jiang,J.B., Qiao,G.R., Luo,R.H., Zhou,X., Hua,R., Zheng,C.B. and Liu,Z. Pleiotropy of positive selection in ancient ACE2 suggests an alternative hypothesis for bat-specific adaptations to host coronaviruses Proc Natl Acad Sci U S A (2024) 121, e2321619121-e2321619121. PubMed Europe PubMed DOI
Han,H., Luo,R.H., Long,X.Y., Wang,L.Q., Zhu,Q., Tang,X.Y., Zhu,R., Ma,Y.C., Zheng,Y.T. and Zou,C.G. Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1 elife (2024) 13 PubMed Europe PubMed DOI PMC EPMC
Heindl,M.R., Rupp,A.L., Schwerdtner,M., Bestle,D., Harbig,A., De Rocher,A., Schmacke,L.C., Staker,B., Steinmetzer,T., Stein,D.A., Moulton,H.M. and Bottcher-Friebertshauser,E. ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells J Virol (2024) 98, e0010224-e0010224. PubMed Europe PubMed DOI PMC EPMC K
Li,H.Z., Pike,A.C.W., Lotsaris,I., Chi,G., Hansen,J.S., Lee,S.C., Rodstrom,K.E.J., Bushell,S.R., Speedman,D., Evans,A., Wang,D., He,D., Shrestha,L., Nasrallah,C., Burgess-Brown,N.A., Vandenberg,R.J., Dafforn,T.R., Carpenter,E.P. and Sauer,D.B. Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2 Nat Commun (2024) 15, 5503-5503. PubMed Europe PubMed DOI PMC EPMC
Li,R., Li,F. and Yuan,L. ACE2 Regulates Glycolipid Metabolism in Multiple Tissues Front Biosci (Landmark Ed) (2024) 29, 17-17. PubMed Europe PubMed DOI V
Li,Z., Chen,X., Ma,C., Du,X. and Zhang,Y. Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation Virus Res (2024) 340, 199300-199300. PubMed Europe PubMed DOI PMC EPMC
Liao,Y., Zhang,Y., Li,H., Hu,H., Li,M. and Liao,C. ACE2: the node connecting the lung cancer and COVID-19 Am J Cancer Res (2024) 14, 1466-1481. PubMed Europe PubMed DOI PMC EPMC V
Luo,D., Bai,M., Zhang,W. and Wang,J. The possible mechanism and research progress of ACE2 involved in cardiovascular injury caused by COVID-19: a review Front Cardiovasc Med (2024) 11, 1409723-1409723. PubMed Europe PubMed DOI PMC EPMC
Mizutani,S., Mizutani,H., Mizutani,E., Arita,H. and Kajiyama,H. The Fate of Angiotensin II in Placental Tissue and Blood Horm Metab Res (2024) 56, 477-481. PubMed Europe PubMed DOI
Mondal,A., Das,S., Das,M., Chakraborty,S. and Sengupta,A. YAP1-mediated dysregulation of ACE-ACE2 activity augments cardiac fibrosis upon induction of hyperglycemic stress Biochim Biophys Acta Gen Subj (2024) 1868, 130666-130666. PubMed Europe PubMed DOI
Niu,S., Zhao,Z., Liu,Z., Rong,X., Chai,Y., Bai,B., Han,P., Shang,G., Ren,J., Wang,Y., Zhao,X., Liu,K., Tian,W., Wang,Q. and Gao,G.F. Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs J Virol (2024) 98, e0115723-e0115723. PubMed Europe PubMed DOI PMC EPMC
Paiardi,G., Ferraz,M., Rusnati,M. and Wade,R.C. The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming Proc Natl Acad Sci U S A (2024) 121, e2404892121-e2404892121. PubMed Europe PubMed DOI
Saulnier,N.M., Thorne,D.M., Bablu,F.E., Suzuki,A.M., Khan,R.L., Oliveira,K.X. and Suzuki,Y.J. Characterizations of angiotensin-converting enzyme-2 (ACE2) peptidase activity Arch Biochem Biophys (2024) 761, 110167-110167. PubMed Europe PubMed DOI
Su,C., Li,C., Hu,X., Wang,J., Liu,L., Zhang,X. and Tong,Y. Association Between ACE2 and Lung Diseases Infect Drug Resist (2024) 17, 1771-1780. PubMed Europe PubMed DOI PMC EPMC V
Tanriverdi,O., Alkan,A., Karaoglu,T., Kitapli,S. and Yildiz,A. COVID-19 and Carcinogenesis: Exploring the Hidden Links Cureus (2024) 16, e68303-e68303. PubMed Europe PubMed DOI PMC EPMC V
Teng,F., Gang,O. and Freimuth,P. Overexpression of human ACE2 protein in mouse fibroblasts stably transfected with the intact ACE2 gene Virology (2024) 592, 109988-109988. PubMed Europe PubMed DOI
Wan,T.T., Li,Y., Li,J.X., Xiao,X., Liu,L., Li,H.H. and Guo,S.B. ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis Arch Biochem Biophys (2024) 752, 109855-109855. PubMed Europe PubMed DOI
Wang,Z., Fan,H. and Wu,J. Food-Derived Up-Regulators and Activators of Angiotensin Converting Enzyme 2: A Review J Agric Food Chem (2024) 72, 12896-12914. PubMed Europe PubMed DOI
Wu,A., Shi,K., Wang,J., Zhang,R. and Wang,Y. Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors Eur J Med Chem (2024) 263, 115923-115923. PubMed Europe PubMed DOI V
Xiong,Q., Ma,C., Liu,C., Tong,F., Huang,M. and Yan,H. ACE2-using merbecoviruses: Further evidence of convergent evolution of ACE2 recognition by NeoCoV and other MERS-CoV related viruses Cell Insight (2024) 3, 100145-100145. PubMed Europe PubMed DOI PMC EPMC V
Xu,W., Langhans,S.A., Johnson,D.K., Stauff,E., Kandula,V.V.R., Kecskemethy,H.H., Averill,L.W. and Yue,X. Radiotracers for Molecular Imaging of Angiotensin-Converting Enzyme 2 Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC V
Yang,H., Zhou,J.N., Zhang,X.M., Ling,D.D., Sun,Y.B., Li,C.Y., Zhou,Q.Q., Shi,G.N., Wang,S.H., Lin,X.S., Fan,T., Wang,H.Y., Zeng,Q., Jia,Y.L., Xi,J.F., Jin,Y.G., Pei,X.T. and Yue,W. Nanoengineered Red Blood Cells Loaded with TMPRSS2 and Cathepsin L Inhibitors Block SARS-CoV-2 Pseudovirus Entry into Lung ACE2(+) Cells Adv Mater (2024) , e2310306-e2310306. PubMed Europe PubMed DOI
Zhang,H., Wang,Z., Nguyen,H.T.T., Cornejo Pontelli,M., Qi,W., Rao,L., Liu,Z., Whelan,S.P.J. and Zhu,J. Facilitating and restraining virus infection using cell-attachable soluble viral receptors Proc Natl Acad Sci U S A (2024) 121, e2414583121-e2414583121. PubMed Europe PubMed DOI PMC EPMC
Zhang,W., Shi,K., Hsueh,F.C., Mendoza,A., Ye,G., Huang,L., Perlman,S., Aihara,H. and Li,F. Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses Proc Natl Acad Sci U S A (2024) 121, e2322600121-e2322600121. PubMed Europe PubMed DOI
Zhou,L., Chen,S., Wei,Y., Sun,Y., Yang,Y., Lin,B., Li,Y. and Wang,C. Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis Eur J Pharmacol (2024) 967, 176365-176365. PubMed Europe PubMed DOI
Zhou,P., Li,Z., Li,D., Xue,S., Li,R., Zhang,L., Bai,Q. and Li,X. [(99m)Tc]Tc-labeled cyc-DX600-HYNIC as a SPECT probe for ACE2-specific pancreatic cancer imaging Am J Nucl Med Mol Imaging (2024) 14, 122-133. PubMed Europe PubMed DOI PMC EPMC
Zorad,S., Skrabanova,M., Zilkova,M., Cente,M., Turic Csokova,N., Kovacech,B., Cizkova,D. and Filipcik,P. Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS Physiol Res (2024) 73, 27-35. PubMed Europe PubMed DOI PMC EPMC

2023

Bednash,J.S., Johns,F., Farkas,D., Elhance,A., Adair,J., Cress,K., Yount,J.S., Kenney,A.D., Londino,J.D. and Mallampalli,R.K. Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2 Am J Respir Cell Mol Biol (2023) 68, 566-576. PubMed Europe PubMed DOI PMC EPMC K
Beyer,D., Vaccarin,C., Deupi,X., Mapanao,A.K., Cohrs,S., Sozzi-Guo,F., Grundler,P.V., van der Meulen,N.P., Wang,J., Tanriver,M., Bode,J.W., Schibli,R. and Muller,C. A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides EJNMMI Res (2023) 13, 32-32. PubMed Europe PubMed DOI PMC EPMC
Bhullar,K.S., Fan,H., Nael,M.A., Elokely,K.M. and Wu,J. ACE2 Activation by Tripeptide IRW (Ile-Arg-Trp) Depends on the G Protein-Coupled Receptor 30 Signaling Cascade J Agric Food Chem (2023) 71, 8071-8082. PubMed Europe PubMed DOI K
Bradley,T., Geanes,E., McLennan,R. and LeMaster,C. Autoantibodies against Angiotensin-converting enzyme 2 and immune molecules are associated with COVID-19 disease severity Res Sq (2023) PubMed Europe PubMed DOI PMC EPMC
Brevini,T., Maes,M., Webb,G.J., John,B.V., Fuchs,C.D., Buescher,G., Wang,L., Griffiths,C., Brown,M.L., Scott,W.E., III, Pereyra-Gerber,P., Gelson,W.T.H., Brown,S., Dillon,S., Muraro,D., Sharp,J., Neary,M., Box,H., Tatham,L., Stewart,J., Curley,P., Pertinez,H., Forrest,S., Mlcochova,P., Varankar,S.S., Darvish-Damavandi,M., Mulcahy,V.L., Kuc,R.E., Williams,T.L., Heslop,J.A., Rossetti,D., Tysoe,O.C., Galanakis,V., Vila-Gonzalez,M., Crozier,T.W.M., Bargehr,J., Sinha,S., Upponi,S.S., Fear,C., Swift,L., Saeb-Parsy,K., Davies,S.E., Wester,A., Hagstrom,H., Melum,E., Clements,D., Humphreys,P., Herriott,J., Kijak,E., Cox,H., Bramwell,C., Valentijn,A., Illingworth,C.J.R., Dahman,B., Bastaich,D.R., Ferreira,R.D., Marjot,T., Barnes,E., Moon,A.M., Barritt,A.S., Gupta,R.K., Baker,S., Davenport,A.P., Corbett,G., Gorgoulis,V.G., Buczacki,S.J.A., Lee,J.H., Matheson,N.J., Trauner,M., Fisher,A.J., Gibbs,P., Butler,A.J., Watson,C.J.E., Mells,G.F., Dougan,G., Owen,A., Lohse,A.W., Vallier,L. and Sampaziotis,F. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 Nature (2023) 615, 134-142. PubMed Europe PubMed DOI PMC EPMC
Dang,F., Bai,L., Dong,J., Hu,X., Wang,J., Paulo,J.A., Xiong,Y., Liang,X., Sun,Y., Chen,Y., Guo,M., Wang,X., Huang,Z., Inuzuka,H., Chen,L., Chu,C., Liu,J., Zhang,T., Rezaeian,A.H., Liu,J., Kaniskan,H.U., Zhong,B., Zhang,J., Letko,M., Jin,J., Lan,K. and Wei,W. USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice Sci Transl Med (2023) 15, eadh7668-eadh7668. PubMed Europe PubMed DOI PMC EPMC I
Ferreira-Duarte,M., Oliveira,L.C.G., Quintas,C., Esteves-Monteiro,M., Duarte-Araujo,M., Sousa,T., Casarini,D.E. and Morato,M. ACE and ACE2 catalytic activity in the fecal content along the gut Neurogastroenterol Motil (2023) , e14598-e14598. PubMed Europe PubMed DOI
Gupta,P. and Rani,V. The Surging Mechanistic Role of Angiotensin Converting Enzyme 2 in Human Pathologies: A Potential Approach for Herbal Therapeutics Curr Drug Targets (2023) 24, 1046-1054. PubMed Europe PubMed DOI V
Harman,M.A.J., Stanway,S.J., Scott,H., Demydchuk,Y., Bezerra,G.A., Pellegrino,S., Chen,L., Brear,P., Lulla,A., Hyvonen,M., Beswick,P.J. and Skynner,M.J. Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2 J Med Chem (2023) 66, 9881-9893. PubMed Europe PubMed DOI I
Jami,G., Ataee,M., Esmaeili,V., Chamani,S., Rezaei,A. and Naghizadeh,A. Characterization of the angiotensin-converting enzyme 2 (ACE2), the main receptor for the SARS-CoV-2 virus Am J Clin Exp Immunol (2023) 12, 24-44. PubMed Europe PubMed PMC EPMC
Kamthe,D.D., Sarangkar,S.D., Dalvi,M.S., Gosavi,N.A. and Nikam,V.S. Angiotensin converting enzyme 2 level and its significance in COVID-19 and other diseases patients Eur J Clin Invest (2023) 53, e13891-e13891. PubMed Europe PubMed DOI PMC EPMC
Kralova,E., Hadova,K., Cinakova,A., Krenek,P. and Klimas,J. Pioglitazone Alters Ace/Ace 2 Balance to Favour Ace2 Independently Of Glycaemia Levels in Diabetic Rat Heart Pharmazie (2023) 78, 122-127. PubMed Europe PubMed DOI
Kunvariya,A.D., Dave,S.A., Modi,Z.J., Patel,P.K. and Sagar,S.R. Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases Heliyon (2023) 9, e15644-e15644. PubMed Europe PubMed DOI PMC EPMC V
Li,Z., Hasson,A., Daggumati,L., Zhang,H. and Thorek,D.L.J. Molecular Imaging of ACE2 Expression in Infectious Disease and Cancer Viruses (2023) 15 PubMed Europe PubMed DOI PMC EPMC V
Magazine,R., Chogtu,B. and Bhat,A. Role of Angiotensin Converting Enzyme-2 and its modulation in disease: exploring new frontiers Med Pharm Rep (2023) 96, 146-153. PubMed Europe PubMed DOI PMC EPMC V
Meyers,W.M., Hong,R.J., Sin,W.C., Kim,C.S. and Haas,K. A cell-based assay for rapid assessment of ACE2 catalytic function Sci Rep (2023) 13, 14123-14123. PubMed Europe PubMed DOI PMC EPMC
Mohammed,M., Ogunlade,B., Elgazzaz,M., Berdasco,C., Lakkappa,N., Ghita,I., Guidry,J.J., Sriramula,S., Xu,J., Restivo,L., Mendiola Pla,M.A., Bowles,D.E., Beyer,A.M., Yue,X., Lazartigues,E. and Filipeanu,C.M. Nedd4-2 upregulation is associated with ACE2 ubiquitination in hypertension Cardiovasc Res (2023) 119, 2130-2141. PubMed Europe PubMed DOI
Pan,Y. Angiotensin-converting enzyme 2 G8790A polymorphisms are associated with COVID-19 severity J Infect Dev Ctries (2023) 17, 819-825. PubMed Europe PubMed DOI V
Reveret,L., Leclerc,M., Emond,V., Tremblay,C., Loiselle,A., Bourassa,P., Bennett,D.A., Hebert,S.S. and Calon,F. Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease Acta Neuropathol Commun (2023) 11, 159-159. PubMed Europe PubMed DOI PMC EPMC
Shovlin,C.L. and Vizcaychipi,M.P. Vascular inflammation and endothelial injury in SARS-CoV-2 infection: The overlooked regulatory cascades implicated by the ACE2 gene cluster QJM (2023) 116, 629-634. PubMed Europe PubMed DOI PMC EPMC
Song,X., Hu,W., Yu,H., Zhao,L., Zhao,Y., Zhao,X., Xue,H.H. and Zhao,Y. Little to no expression of angiotensin-converting enzyme-2 on most human peripheral blood immune cells but highly expressed on tissue macrophages Cytometry A (2023) 103, 136-145. PubMed Europe PubMed DOI
Wang,C.W., Chuang,H.C. and Tan,T.H. ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification J Biomed Sci (2023) 30, 71-71. PubMed Europe PubMed DOI PMC EPMC V
Wang,Z., Fan,H., Bao,X. and Wu,J. Angiotensin-Converting Enzyme 2 Activation Is Not a Common Feature of Angiotensin-Converting Enzyme Inhibitory Peptides J Agric Food Chem (2023) 71, 8867-8876. PubMed Europe PubMed DOI
Wei,L., Chen,Y., Feng,X., Yao,J., Zhang,L., Zhou,X., Yan,G., Qiu,H., Wang,C. and Lu,H. Elucidation of N-/O-glycosylation and site-specific mapping of sialic acid linkage isomers of SARS-CoV-2 human receptor angiotensin-converting enzyme 2 Analyst (2023) 148, 5002-5011. PubMed Europe PubMed DOI
Wrobel,A.G. Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike Curr Opin Struct Biol (2023) 81, 102619-102619. PubMed Europe PubMed DOI PMC EPMC V
Xiao,Y., Chang,L., Ji,H., Sun,H., Song,S., Feng,K., Nuermaimaiti,A., Halemubieke,S., Mei,L., Lu,Z., Yan,Y. and Wang,L. Posttranslational modifications of ACE2 protein: Implications for SARS-CoV-2 infection and beyond J Med Virol (2023) 95, e29304-e29304. PubMed Europe PubMed DOI
Zhang,W., Golynker,I., Brosh,R., Fajardo,A., Zhu,Y., Wudzinska,A.M., Ordonez,R., Ribeiro-Dos-Santos,A.M., Carrau,L., Damani-Yokota,P., Yeung,S.T., Khairallah,C., Vela Gartner,A., Chalhoub,N., Huang,E., Ashe,H.J., Khanna,K.M., Maurano,M.T., Kim,S.Y., tenOever,B.R. and Boeke,J.D. Mouse genome rewriting and tailoring of three important disease loci Nature (2023) 623, 423-431. PubMed Europe PubMed DOI PMC EPMC
Zhou,G. and Liu,J. Prognostic value of elevated plasma angiotensin-converting enzyme 2 in cardiometabolic diseases: A review Medicine (Baltimore) (2023) 102, e33251-e33251. PubMed Europe PubMed DOI PMC EPMC
Zhu,Y., Zhang,S., Wang,Z., Wang,Z. and Zhu,S. ACE2 Receptor: A Potential Pharmacological Target in COVID-19 Curr Protein Pept Sci (2023) 24, 701-710. PubMed Europe PubMed DOI

2022

Alfaleh,M.A., Zawawi,A., Al-Amri,S.S. and Hashem,A.M. David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors MAbs (2022) 14, 2057832-2057832. PubMed Europe PubMed DOI PMC EPMC V
Alfaro,E., Diaz-Garcia,E., Garcia-Tovar,S., Zamarron,E., Mangas,A., Galera,R., Nanwani-Nanwani,K., Perez-de-Diego,R., Lopez-Collazo,E., Garcia-Rio,F. and Cubillos-Zapata,C. Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity Front Immunol (2022) 13, 909342-909342. PubMed Europe PubMed DOI PMC EPMC
Badawi,S., Mohamed,F.E., Alkhofash,N.R., John,A., Ali,A. and Ali,B.R. Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking Hum Genomics (2022) 16, 35-35. PubMed Europe PubMed DOI PMC EPMC
Baharin,A., Ting,T.Y. and Goh,H.H. Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications Plants (Basel) (2022) 11 PubMed Europe PubMed DOI PMC EPMC V
Batlle,D., Monteil,V., Garreta,E., Hassler,L., Wysocki,J., Chandar,V., Schwartz,R.E., Mirazimi,A., Montserrat,N., Bader,M. and Penninger,J.M. Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity Cell (2022) 185, 1837-1839. PubMed Europe PubMed DOI PMC EPMC
Bauer,M.S., Gruber,S., Hausch,A., Gomes,P.S.F.C., Milles,L.F., Nicolaus,T., Schendel,L.C., Navajas,P.L., Procko,E., Lietha,D., Melo,M.C.R., Bernardi,R.C., Gaub,H.E. and Lipfert,J. A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions Proc Natl Acad Sci U S A (2022) 119, e2114397119-e2114397119. PubMed Europe PubMed DOI
Bhushan,S., Xiao,Z., Gao,K., Mao,L., Chen,J., Ping,W., Hong,W. and Zhang,Z. Role and Interaction Between ACE1, ACE2 and Their Related Genes in Cardiovascular Disorders Curr Probl Cardiol (2022) , 101162-101162. PubMed Europe PubMed DOI
Chakraborty,S., Ghosh,S. and Mondal,T. Decoding molecular factors shaping human angiotensin converting enzyme 2 receptor usage by spike glycoprotein in lineage B beta-coronaviruses Biochim Biophys Acta Mol Basis Dis (2022) 1868, 166514-166514. PubMed Europe PubMed DOI PMC EPMC
Devaux,C.A. and Camoin-Jau,L. An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019: Implications for vascular and coagulation disease associated with severe acute respiratory syndrome coronavirus infection Front Microbiol (2022) 13, 1042200-1042200. PubMed Europe PubMed DOI PMC EPMC V
Fast,L., Agren,R. and Zeberg,H. Fluorescence-Based Measurements of Membrane-Bound Angiotensin Converting Enzyme 2 Activity Using Xenopus Laevis Oocytes Biosensors (Basel) (2022) 12 PubMed Europe PubMed DOI PMC EPMC
Govender,N., Khaliq,O., Moodley,J. and Naicker,T. Unravelling the Mechanistic Role of ACE2 and TMPRSS2 in Hypertension: A Risk Factor for COVID-19 Curr Hypertens Rev (2022) 18, 130-137. PubMed Europe PubMed DOI V
Han,P., Li,L., Liu,S., Wang,Q., Zhang,D., Xu,Z., Han,P., Li,X., Peng,Q., Su,C., Huang,B., Li,D., Zhang,R., Tian,M., Fu,L., Gao,Y., Zhao,X., Liu,K., Qi,J., Gao,G.F. and Wang,P. Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2 Cell (2022) 185, 630-640. PubMed Europe PubMed DOI PMC EPMC
Healy,E.F. How tetraspanin-mediated cell entry of SARS-CoV-2 can dysregulate the shedding of the ACE2 receptor by ADAM17 Biochem Biophys Res Commun (2022) 593, 52-56. PubMed Europe PubMed DOI PMC EPMC
Hong,Q., Han,W., Li,J., Xu,S., Wang,Y., Xu,C., Li,Z., Wang,Y., Zhang,C., Huang,Z. and Cong,Y. Molecular basis of receptor binding and antibody neutralization of Omicron Nature (2022) 604, 546-552. PubMed Europe PubMed DOI
Huang,G., Wang,Y., Qin,L., Huang,B. and Yu,X. Association and functional analysis of angiotensin-converting enzyme 2 genetic variants with the pathogenesis of pre-eclampsia Front Endocrinol (Lausanne) (2022) 13, 926512-926512. PubMed Europe PubMed DOI PMC EPMC
Jin,S., He,X., Ma,L., Zhuang,Z., Wang,Y., Lin,M., Cai,S., Wei,L., Wang,Z., Zhao,Z., Wu,Y., Sun,L., Li,C., Xie,W., Zhao,Y., Songyang,Z., Peng,K., Zhao,J. and Cui,J. Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy Nat Commun (2022) 13, 5204-5204. PubMed Europe PubMed DOI PMC EPMC
Lee,J.H., Lee,C.E., Yoo,Y., Shin,E., An,J., Park,S.Y., Song,W.J., Kwon,H.S., Cho,Y.S., Moon,H.B. and Kim,T.B. Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients J Korean Med Sci (2022) 37, e65-e65. PubMed Europe PubMed DOI PMC EPMC
Li,L., Liao,H., Meng,Y., Li,W., Han,P., Liu,K., Wang,Q., Li,D., Zhang,Y., Wang,L., Fan,Z., Zhang,Y., Wang,Q., Zhao,X., Sun,Y., Huang,N., Qi,J. and Gao,G.F. Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1 Cell (2022) 185, 2952-2960. PubMed Europe PubMed DOI PMC EPMC
Ling,J., Peng,N. and Luo,L. ACE2 maybe serve as a prognostic biomarker in breast invasive carcinoma J Clin Lab Anal (2022) 36, e24362-e24362. PubMed Europe PubMed DOI PMC EPMC
Liu,P., Zhang,Y., Li,Z., Huang,J., Wang,T. and Chen,C. Structural insights revealed by crystal structure of B38-CAP, an isoenzyme of carboxypeptidase ACE2, the receptor of SARS-CoV-2 Biochem Biophys Res Commun (2022) 606, 17-22. PubMed Europe PubMed DOI PMC EPMC
MacGowan,S.A., Barton,M.I., Kutuzov,M., Dushek,O., van der Merwe,P.A. and Barton,G.J. Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants PLoS Comput Biol (2022) 18, e1009922-e1009922. PubMed Europe PubMed DOI PMC EPMC
Mariappan,V., Ranganadin,P., Shanmugam,L., Rao,S.R. and Balakrishna Pillai,A. Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2 Biochimie (2022) 201, 139-147. PubMed Europe PubMed DOI PMC EPMC
Moreira,G., Casso-Hartmann,L., Datta,S.P.A., Dean,D., McLamore,E. and Vanegas,D. Development of a Biosensor Based on Angiotensin-Converting Enzyme II for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Human Saliva Front Sens (Lausanne) (2022) 3 PubMed Europe PubMed DOI PMC EPMC
Shatizadeh Malekshahi,S., Yavarian,J. and Shafiei-Jandaghi,N.Z. Usage of peptidases by SARS-CoV-2 and several human coronaviruses as receptors: A mysterious story Biotechnol Appl Biochem (2022) 69, 124-128. PubMed Europe PubMed DOI
Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I. The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology Crit Rev Clin Lab Sci (2022) , 1-16. PubMed Europe PubMed DOI V
Song,J., Hu,B., Qu,H., Wang,L., Huang,X., Li,M. and Zhang,M. Corrigendum to "Upregulation of angiotensin converting enzyme 2 by shear stress reduced inflammation and proliferation in vascular endothelial cells" [Biochem. Biophys. Res. Commun. 525(3) (2020) 812-818] Biochem Biophys Res Commun (2022) 632, 204-205. PubMed Europe PubMed DOI
Starr,T.N., Zepeda,S.K., Walls,A.C., Greaney,A.J., Alkhovsky,S., Veesler,D. and Bloom,J.D. ACE2 binding is an ancestral and evolvable trait of sarbecoviruses Nature (2022) 603, 913-918. PubMed Europe PubMed DOI
Wang,Y., Zhang,Y., Zhang,L., Li,M., Zhu,P., Ji,W., Liang,R., Qiin,L., Wu,W., Feng,F. and Jin,Y. [Angiotensin-converting enzyme 2 particapates in ozone-induced lung inflammation and airway remodeling in mice] Nan Fang Yi Ke Da Xue Xue Bao (2022) 42, 860-867. PubMed Europe PubMed DOI PMC EPMC
Xiong,Q., Cao,L., Ma,C., Tortorici,M.A., Liu,C., Si,J., Liu,P., Gu,M., Walls,A.C., Wang,C., Shi,L., Tong,F., Huang,M., Li,J., Zhao,C., Shen,C., Chen,Y., Zhao,H., Lan,K., Corti,D., Veesler,D., Wang,X. and Yan,H. Close relatives of MERS-CoV in bats use ACE2 as their functional receptors Nature (2022) 612, 748-757. PubMed Europe PubMed DOI PMC EPMC
Xu,J. and Lazartigues,E. Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus Cell Mol Neurobiol (2022) 42, 305-309. PubMed Europe PubMed DOI PMC EPMC
Yang,G., Wang,W., Han,S., Xu,S. and Liu,H. Effect of microRNA-181b on the biological characteristics and clinical drug resistance of small-cell lung cancer by targeting angiotensin converting enzyme 2 Thorac Cancer (2022) 13, 742-749. PubMed Europe PubMed DOI PMC EPMC
Yang,Z., Macdonald-Dunlop,E., Chen,J., Zhai,R., Li,T., Richmond,A., Klaric,L., Pirastu,N., Ning,Z., Zheng,C., Wang,Y., Huang,T., He,Y., Guo,H., Ying,K., Gustafsson,S., Prins,B., Ramisch,A., Dermitzakis,E.T., Png,G., Eriksson,N., Haessler,J., Hu,X., Zanetti,D., Boutin,T., Hwang,S.J., Wheeler,E., Pietzner,M., Raffield,L.M., Kalnapenkis,A., Peters,J.E., Vinuela,A., Gilly,A., Elmstahl,S., Dedoussis,G., Petrie,J.R., Polasek,O., Folkersen,L., Chen,Y., Yao,C., Vosa,U., Pairo-Castineira,E., Clohisey,S., Bretherick,A.D., Rawlik,K., Esko,T., Enroth,S., Johansson,A., Gyllensten,U., Langenberg,C., Levy,D., Hayward,C., Assimes,T.L., Kooperberg,C., Manichaikul,A.W., Siegbahn,A., Wallentin,L., Lind,L., Zeggini,E., Schwenk,J.M., Butterworth,A.S., Michaelsson,K., Pawitan,Y., Joshi,P.K., Baillie,J.K., Malarstig,A., Reiner,A.P., Wilson,J.F. and Shen,X. Genetic Landscape of the ACE2 Coronavirus Receptor Circulation (2022) 145, 1398-1411. PubMed Europe PubMed DOI PMC EPMC
Yeung,M.L., Teng,J.L.L. and Yuen,K.Y. Response to Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity Cell (2022) 185, 1840-1841. PubMed Europe PubMed DOI PMC EPMC
Yin,W., Xu,Y., Xu,P., Cao,X., Wu,C., Gu,C., He,X., Wang,X., Huang,S., Yuan,Q., Wu,K., Hu,W., Huang,Z., Liu,J., Wang,Z., Jia,F., Xia,K., Liu,P., Wang,X., Song,B., Zheng,J., Jiang,H., Cheng,X., Jiang,Y., Deng,S.J. and Xu,H.E. Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody Science (2022) 375, 1048-1053. PubMed Europe PubMed DOI PMC EPMC
Yousif,A., Mir,R., Javid,J., Barnawi,J., Jalal,M.M., Altayar,M.A., Albalawi,S.O. and Abuduhier,F.M. Clinical Utility of Amplification Refractory Mutation System-Based PCR and Mutation-Specific PCR for Precise and Rapid Genotyping of Angiotensin-Converting Enzyme 1 (ACE1-rs4646996 D>I) and Angiotensin-Converting Enzyme 2 (ACE2-rs4240157T>C) Gene Variations in Coronary Artery Disease and Their Strong Association with Its Disease Susceptibility and Progression Diagnostics (Basel) (2022) 12 PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Yan,R. and Zhou,Q. ACE2, B(0)AT1, and SARS-CoV-2 spike protein: Structural and functional implications Curr Opin Struct Biol (2022) 74, 102388-102388. PubMed Europe PubMed DOI PMC EPMC V
Zheng,M. ACE2 and COVID-19 Susceptibility and Severity Aging Dis (2022) 13, 360-372. PubMed Europe PubMed DOI PMC EPMC

2021

Ahsan,T. and Sajib,A.A. Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptor Biochem Biophys Rep (2021) 26, 100982-100982. PubMed Europe PubMed DOI PMC EPMC
Al-Benna,S. Gene Expression of Angiotensin-Converting Enzyme 2 Receptor in Skin and the Implications for COVID-19 Adv Skin Wound Care (2021) 34, 31-35. PubMed Europe PubMed DOI
Al-Mulla,F., Mohammad,A., Al Madhoun,A., Haddad,D., Ali,H., Eaaswarkhanth,M., John,S.E., Nizam,R., Channanath,A., Abu-Farha,M., Ahmad,R., Abubaker,J. and Thanaraj,T.A. ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19 Heliyon (2021) 7, e06133-e06133. PubMed Europe PubMed DOI PMC EPMC
Albashir,A.A.D. Renin-Angiotensin-Aldosterone System (RAAS) Inhibitors and Coronavirus Disease 2019 (COVID-19) South Med J (2021) 114, 51-56. PubMed Europe PubMed DOI PMC EPMC V
Aleksova,A., Gagno,G., Sinagra,G., Beltrami,A.P., Janjusevic,M., Ippolito,G., Zumla,A., Fluca,A.L. and Ferro,F. Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Alexandre,J. and Cracowski,J.L. Outcome of patients hospitalized for Covid-19 and exposure to angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in France: Results of the ACECoV study Fundam Clin Pharmacol (2021) 35, 192-193. PubMed Europe PubMed DOI
Ali,M.Y., Zaib,S., Jannat,S. and Khan,I. Inhibition of Angiotensin-I Converting Enzyme by Ginsenosides: Structure-Activity Relationships and Inhibitory Mechanism J Agric Food Chem (2021) 69, 6073-6086. PubMed Europe PubMed DOI
Allison,S. Soluble ACE2 in SARS-CoV-2 infection Nat Rev Nephrol (2021) 17, 297-297. PubMed Europe PubMed DOI PMC EPMC
Almasi,F. and Mohammadipanah,F. Hypothetical targets and plausible drugs of coronavirus infection caused by SARS-CoV-2 Transbound Emerg Dis (2021) 68, 318-332. PubMed Europe PubMed DOI PMC EPMC
Aloufi,N., Traboulsi,H., Ding,J., Fonseca,G.J., Nair,P., Huang,S.K., Hussain,S.N.A., Eidelman,D.H. and Baglole,C.J. Angiotensin-converting enzyme 2 (ACE2) expression in COPD and IPF fibroblasts- the forgotten cell in COVID-19 Am J Physiol Lung Cell Mol Physiol (2021) 320, L152-L157. PubMed Europe PubMed DOI
Andrews,P.L.R., Cai,W., Rudd,J.A. and Sanger,G.J. COVID-19, nausea, and vomiting J Gastroenterol Hepatol (2021) 36, 646-656. PubMed Europe PubMed DOI PMC EPMC
Arce,V.M. and Costoya,J.A. SARS-CoV-2 infection in K18-ACE2 transgenic mice replicates human pulmonary disease in COVID-19 Cell Mol Immunol (2021) PubMed Europe PubMed DOI PMC EPMC
Ayipo,Y.O., Yahaya,S.N., Alananzeh,W.A., Babamale,H.F. and Mordi,M.N. Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside Infect Genet Evol (2021) 93, 104944-104944. PubMed Europe PubMed DOI PMC EPMC V I
Badawi,S. and Ali,B.R. ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues Hum Genomics (2021) 15, 8-8. PubMed Europe PubMed DOI PMC EPMC V
Bakhshandeh,B., Sorboni,S.G., Javanmard,A.R., Mottaghi,S.S., Mehrabi,M.R., Sorouri,F., Abbasi,A. and Jahanafrooz,Z. Variants in ACE2; potential influences on virus infection and COVID-19 severity Infect Genet Evol (2021) 90, 104773-104773. PubMed Europe PubMed DOI PMC EPMC V
Berdowska,I. and Matusiewicz,M. Cathepsin L, transmembrane peptidase/serine subfamily member 2/4, and other host proteases in COVID-19 pathogenesis - with impact on gastrointestinal tract World J Gastroenterol (2021) 27, 6590-6600. PubMed Europe PubMed DOI PMC EPMC
Bertoglio,F., Meier,D., Langreder,N., Steinke,S., Rand,U., Simonelli,L., Heine,P.A., Ballmann,R., Schneider,K.T., Roth,K.D.R., Ruschig,M., Riese,P., Eschke,K., Kim,Y., Schackermann,D., Pedotti,M., Kuhn,P., Zock-Emmenthal,S., Wohrle,J., Kilb,N., Herz,T., Becker,M., Grasshoff,M., Wenzel,E.V., Russo,G., Kroger,A., Brunotte,L., Ludwig,S., Fuhner,V., Kramer,S.D., Dubel,S., Varani,L., Roth,G., Cicin-Sain,L., Schubert,M. and Hust,M. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface Nat Commun (2021) 12, 1577-1577. PubMed Europe PubMed DOI PMC EPMC
Beumer,J., Geurts,M.H., Lamers,M.M., Puschhof,J., Zhang,J., van der Vaart,J., Mykytyn,A.Z., Breugem,T.I., Riesebosch,S., Schipper,D., van den Doel,P.B., de Lau,W., Pleguezuelos-Manzano,C., Busslinger,G., Haagmans,B.L. and Clevers,H. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses Nat Commun (2021) 12, 5498-5498. PubMed Europe PubMed DOI PMC EPMC
Beyerstedt,S., Casaro,E.B. and Rangel,E.B. COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection Eur J Clin Microbiol Infect Dis (2021) PubMed Europe PubMed DOI PMC EPMC
Bhattacharya,R., Gupta,A.M., Mitra,S., Mandal,S. and Biswas,S.R. A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2 Virology (2021) 552, 107-111. PubMed Europe PubMed DOI PMC EPMC
Bitossi,C., Frasca,F., Viscido,A., Oliveto,G., Scordio,M., Belloni,L., Cimino,G., Pietropaolo,V., Gentile,M., d'Ettorre,G., Midulla,F., Trancassini,M., Antonelli,G., Pierangeli,A. and Scagnolari,C. SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients Microorganisms (2021) 9 PubMed Europe PubMed DOI PMC EPMC
Blume,C., Jackson,C.L., Spalluto,C.M., Legebeke,J., Nazlamova,L., Conforti,F., Perotin,J.M., Frank,M., Butler,J., Crispin,M., Coles,J., Thompson,J., Ridley,R.A., Dean,L.S.N., Loxham,M., Reikine,S., Azim,A., Tariq,K., Johnston,D.A., Skipp,P.J., Djukanovic,R., Baralle,D., McCormick,C.J., Davies,D.E., Lucas,J.S., Wheway,G. and Mennella,V. A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection Nat Genet (2021) 53, 205-214. PubMed Europe PubMed DOI
Bozgeyik,I. Therapeutic potential of miRNAs targeting SARS-CoV-2 host cell receptor ACE2 Meta Gene (2021) 27, 100831-100831. PubMed Europe PubMed DOI PMC EPMC
Buitron-Gonzalez,I., Aguilera-Duran,G. and Romo-Mancillas,A. In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex Results Chem (2021) 3, 100094-100094. PubMed Europe PubMed DOI PMC EPMC I
Cao,W., Dong,C., Kim,S., Hou,D., Tai,W., Du,L., Im,W. and Zhang,X.F. Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction Biophys J (2021) PubMed Europe PubMed DOI PMC EPMC
Cao,X., Song,L.N. and Yang,J.K. ACE2 and energy metabolism: the connection between COVID-19 and chronic metabolic disorders Clin Sci (Lond) (2021) 135, 535-554. PubMed Europe PubMed DOI
Chakraborty,S. Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity Biochem Biophys Res Commun (2021) 538, 97-103. PubMed Europe PubMed DOI PMC EPMC
Chen,C., Boorla,V.S., Banerjee,D., Chowdhury,R., Cavener,V.S., Nissly,R.H., Gontu,A., Boyle,N.R., Vandegrift,K., Nair,M.S., Kuchipudi,S.V. and Maranas,C.D. Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike RBD and human ACE2 Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI
Choudhary,S., Sreenivasulu,K., Mitra,P., Misra,S. and Sharma,P. Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19 Ann Lab Med (2021) 41, 129-138. PubMed Europe PubMed DOI PMC EPMC
Cubuk,H. and Ozbil,M. Comparison of clinically approved molecules on SARS-CoV-2 drug target proteins: a molecular docking study Turk J Chem (2021) 45, 35-41. PubMed Europe PubMed DOI PMC EPMC I
Dash,P., Turuk,J., Behera,S.K., Palo,S.K., Raghav,S.K., Ghosh,A., Sabat,J., Rath,S., Subhadra,S., Rana,K., Bhattacharya,D., Kanungo,S., Kshatri,J.S., Mishra,B.K., Dash,S., Parida,A. and Pati,S. Sequence analysis of Indian SARS-CoV-2 isolates shows a stronger interaction of mutated receptor binding domain with ACE2 receptor Int J Infect Dis (2021) PubMed Europe PubMed DOI PMC EPMC
Deng,Q., Rasool,R.U., Russell,R.M., Natesan,R. and Asangani,I.A. Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19 iScience (2021) 24, 102254-102254. PubMed Europe PubMed DOI PMC EPMC
Du,Y., Shi,R., Zhang,Y., Duan,X., Li,L., Zhang,J., Wang,F., Zhang,R., Shen,H., Wang,Y., Wu,Z., Peng,Q., Pan,T., Sun,W., Huang,W., Feng,Y., Feng,H., Xiao,J., Tan,W., Wang,Y., Wang,C. and Yan,J. A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants Nat Commun (2021) 12, 5000-5000. PubMed Europe PubMed DOI PMC EPMC
Egieyeh,S., Egieyeh,E., Malan,S., Christofells,A. and Fielding,B. Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2) PLoS ONE (2021) 16, e0245258-e0245258. PubMed Europe PubMed DOI
Evans,J.P. and Liu,S.L. Role of host factors in SARS-CoV-2 entry J Biol Chem (2021) 297, 100847-100847. PubMed Europe PubMed DOI PMC EPMC
Flinn,B., Royce,N., Gress,T., Chowdhury,N. and Santanam,N. Dual role for angiotensin-converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat Obes Rev (2021) PubMed Europe PubMed DOI V
Forouzesh,N. and Mishra,N. An Effective MM/GBSA Protocol for Absolute Binding Free Energy Calculations: A Case Study on SARS-CoV-2 Spike Protein and the Human ACE2 Receptor Molecules (2021) 26 PubMed Europe PubMed DOI PMC EPMC
Freitas,F.C., Ferreira,P.H.B., Favaro,D.C. and Oliveira,R.J. Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV-2 Spike Proteins by ACE2-Designed Peptides J Chem Inf Model (2021) 61, 1226-1243. PubMed Europe PubMed DOI PMC EPMC
Gangadevi,S., Badavath,V.N., Thakur,A., Yin,N., De Jonghe,S., Acevedo,O., Jochmans,D., Leyssen,P., Wang,K., Neyts,J., Yujie,T. and Blum,G. Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19 J Phys Chem Lett (2021) 12, 1793-1802. PubMed Europe PubMed DOI PMC EPMC
Garcia-Escobar,A., Jimenez-Valero,S., Galeote,G., Jurado-Roman,A., Garcia-Rodriguez,J. and Moreno,R. The soluble catalytic ectodomain of ACE2 a biomarker of cardiac remodelling: new insights for heart failure and COVID19 Heart Fail Rev (2021) PubMed Europe PubMed DOI PMC EPMC V
Ge,J., Wang,R., Ju,B., Zhang,Q., Sun,J., Chen,P., Zhang,S., Tian,Y., Shan,S., Cheng,L., Zhou,B., Song,S., Zhao,J., Wang,H., Shi,X., Ding,Q., Liu,L., Zhao,J., Zhang,Z., Wang,X. and Zhang,L. Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry Nat Commun (2021) 12, 250-250. PubMed Europe PubMed DOI PMC EPMC
Ge,S., Lu,J., Hou,Y., Lv,Y., Wang,C. and He,H. Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2 Virology (2021) 560, 110-115. PubMed Europe PubMed DOI PMC EPMC
Getachew,B. and Tizabi,Y. Vitamin D and COVID-19: Role of ACE2, age, gender, and ethnicity J Med Virol (2021) PubMed Europe PubMed DOI V
Glasgow,J., Glasgow,A., Kortemme,T. and Wells,J.A. Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2 Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC
Gomez-Zorita,S., Milton-Laskibar,I., Garcia-Arellano,L., Gonzalez,M. and Portillo,M.P. An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC V
Gottschalk,G., Knox,K. and Roy,A. ACE2: At the crossroad of COVID-19 and lung cancer Gene Rep (2021) 23, 101077-101077. PubMed Europe PubMed DOI PMC EPMC V
Graier,T., Golob-Schwarzl,N., Weger,W., Benezeder,T., Painsi,C., Salmhofer,W. and Wolf,P. Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2? Front Med (Lausanne) (2021) 8, 624462-624462. PubMed Europe PubMed DOI PMC EPMC
Guo,Y., Wang,B., Gao,H., Gao,L., Hua,R. and Xu,J.D. ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology Front Mol Biosci (2021) 8, 708336-708336. PubMed Europe PubMed DOI PMC EPMC V
Hamet,P., Pausova,Z., Attaoua,R., Hishmih,C., Haloui,M., Shin,J., Paus,T., Abrhamowicz,M., Gaudet,D., Santucci,L., Kotchen,T.A., Cowley,A.W., Hussin,J. and Tremblay,J. SARS-COV-2 RECEPTOR ACE2 GENE is associated with hypertension and SEVERity of COVID 19: interaction with sex, obesity and SMOKING Am J Hypertens (2021) PubMed Europe PubMed DOI PMC EPMC
Han,P., Su,C., Zhang,Y., Bai,C., Zheng,A., Qiao,C., Wang,Q., Niu,S., Chen,Q., Zhang,Y., Li,W., Liao,H., Li,J., Zhang,Z., Cho,H., Yang,M., Rong,X., Hu,Y., Huang,N., Yan,J., Wang,Q., Zhao,X., Gao,G.F. and Qi,J. Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants Nat Commun (2021) 12, 6103-6103. PubMed Europe PubMed DOI PMC EPMC
Healy,E.F. and Lilic,M. A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17 Biochem Biophys Res Commun (2021) 573, 158-163. PubMed Europe PubMed DOI PMC EPMC
Higuchi,Y., Suzuki,T., Arimori,T., Ikemura,N., Mihara,E., Kirita,Y., Ohgitani,E., Mazda,O., Motooka,D., Nakamura,S., Sakai,Y., Itoh,Y., Sugihara,F., Matsuura,Y., Matoba,S., Okamoto,T., Takagi,J. and Hoshino,A. Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2 Nat Commun (2021) 12, 3802-3802. PubMed Europe PubMed DOI PMC EPMC
Hmazzou,R., Marc,Y., Flahault,A., Gerbier,R., de Mota,N. and Llorens-Cortes,C. Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension Clin Sci (Lond) (2021) 135, 775-791. PubMed Europe PubMed DOI
Huo,J., Bas,A.L., Ruza,R.R., Duyvesteyn,H.M.E., Mikolajek,H., Malinauskas,T., Tan,T.K., Rijal,P., Dumoux,M., Ward,P.N., Ren,J., Zhou,D., Harrison,P.J., Weckener,M., Clare,D.K., Vogirala,V.K., Radecke,J., Moynie,L., Zhao,Y., Gilbert-Jaramillo,J., Knight,M.L., Tree,J.A., Buttigieg,K.R., Coombes,N., Elmore,M.J., Carroll,M.W., Carrique,L., Shah,P.N.M., James,W., Townsend,A.R., Stuart,D.I., Owens,R.J. and Naismith,J.H. Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 Nat Struct Mol Biol (2021) PubMed Europe PubMed DOI PMC EPMC
Hussain,A., Tang,O., Sun,C., Jia,X., Selvin,E., Nambi,V., Folsom,A., Heiss,G., Zannad,F., Mosley,T., Virani,S.S., Coresh,J., Boerwinkle,E., Yu,B., Cunningham,J.W., Shah,A.M., Solomon,S.D., de Lemos,J.A., Hoogeveen,R.C. and Ballantyne,C.M. Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study) Am J Cardiol (2021) PubMed Europe PubMed DOI
Jackson,C.B., Farzan,M., Chen,B. and Choe,H. Mechanisms of SARS-CoV-2 entry into cells Nat Rev Mol Cell Biol (2021) PubMed Europe PubMed DOI PMC EPMC V
Jia,G.H. and Sowers,J.R. Management of hypertension in patients with COVID-19: Implication of angiotensin-converting enzyme 2 Cardiol Plus (2021) 6, 210-217. PubMed Europe PubMed DOI PMC EPMC V
Karakas Celik,S., Cakmak Genc,G., Piskin,N., Acikgoz,B., Altinsoy,B., Kurucu Issiz,B. and Dursun,A. Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case study J Med Virol (2021) PubMed Europe PubMed DOI
Kermani,N.Z., Song,W.J., Badi,Y., Versi,A., Guo,Y., Sun,K., Bhavsar,P., Howarth,P., Dahlen,S.E., Sterk,P.J., Djukanovic,R., Adcock,I.M. and Chung,K.F. Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma Respir Res (2021) 22, 10-10. PubMed Europe PubMed DOI PMC EPMC
Khoury,E.E., Knaney,Y., Fokra,A., Kinaneh,S., Azzam,Z., Heyman,S.N. and Abassi,Z. Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease J Cell Mol Med (2021) PubMed Europe PubMed DOI
Kiseleva,A.A., Troisi,E.M., Hensley,S.E., Kohli,R.M. and Epstein,J.A. SARS-CoV-2 spike protein binding selectively accelerates substrate-specific catalytic activity of ACE2 J Biochem (2021) PubMed Europe PubMed DOI PMC EPMC
Koehler,M., Ray,A., Moreira,R.A., Juniku,B., Poma,A.B. and Alsteens,D. Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants Nat Commun (2021) 12, 6977-6977. PubMed Europe PubMed DOI PMC EPMC
Kragstrup,T.W., Singh,H.S., Grundberg,I., Nielsen,A.L., Rivellese,F., Mehta,A., Goldberg,M.B., Filbin,M.R., Qvist,P. and Bibby,B.M. Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients PLoS ONE (2021) 16, e0252799-e0252799. PubMed Europe PubMed DOI PMC EPMC
Kumar Verma,A., Kumar,V., Singh,S., Goswami,B.C., Camps,I., Sekar,A., Yoon,S. and Lee,K.W. Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies Biomed Pharmacother (2021) 137, 111356-111356. PubMed Europe PubMed DOI PMC EPMC I
Kuriakose,J., Montezano,A.C. and Touyz,R.M. ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease Clin Sci (Lond) (2021) 135, 387-407. PubMed Europe PubMed DOI PMC EPMC V
Larue,R.C., Xing,E., Kenney,A.D., Zhang,Y., Tuazon,J.A., Li,J., Yount,J.S., Li,P.K. and Sharma,A. Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2 Bioconjug Chem (2021) 32, 215-223. PubMed Europe PubMed DOI PMC EPMC
Lee,J.H., Choi,M., Jung,Y., Lee,S.K., Lee,C.S., Kim,J., Kim,J., Kim,N.H., Kim,B.T. and Kim,H.G. A novel rapid detection for SARS-CoV-2 spike 1 antigens using human angiotensin converting enzyme 2 (ACE2) Biosens Bioelectron (2021) 171, 112715-112715. PubMed Europe PubMed DOI PMC EPMC
Letarov,A.V., Babenko,V.V. and Kulikov,E.E. Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection Biochemistry (Mosc) (2021) 86, 257-261. PubMed Europe PubMed DOI PMC EPMC
Li,S., Cai,B., Ma,W., Yang,F., Xu,Y. and Xu,B. ACE2 as a key target for treatment of COVID-19 related cardiovascular diseases: current progress and prospect Curr Drug Targets (2021) PubMed Europe PubMed DOI V
Liu,K., Tan,S., Niu,S., Wang,J., Wu,L., Sun,H., Zhang,Y., Pan,X., Qu,X., Du,P., Meng,Y., Jia,Y., Chen,Q., Deng,C., Yan,J., Wang,H.W., Wang,Q., Qi,J. and Gao,G.F. Cross-species recognition of SARS-CoV-2 to bat ACE2 Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI
Liu,K., Pan,X., Li,L., Yu,F., Zheng,A., Du,P., Han,P., Meng,Y., Zhang,Y., Wu,L., Chen,Q., Song,C., Jia,Y., Niu,S., Lu,D., Qiao,C., Chen,Z., Ma,D., Ma,X., Tan,S., Zhao,X., Qi,J., Gao,G.F. and Wang,Q. Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species Cell (2021) 184, 3438-3451. PubMed Europe PubMed DOI PMC EPMC
Liu,P., Xie,X., Gao,L. and Jin,J. His345 mutant of angiotensin-converting enzyme 2 (ACE2) remains enzymatically active against angiotensin II Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC
Liu,X., Wang,Y.L., Wu,J., Qi,J., Zeng,Z., Wan,Q., Chen,Z., Manandhar,P., Cavener,V.S., Boyle,N.R., Fu,X., Salazar,E., Kuchipudi,S.V., Kapur,V., Zhang,X., Umetani,M., Sen,M., Willson,R.C., Chen,S.H. and Zu,Y. Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection Angew Chem Int Ed Engl (2021) PubMed Europe PubMed DOI
Liu,Y., Hu,G., Wang,Y., Ren,W., Zhao,X., Ji,F., Zhu,Y., Feng,F., Gong,M., Ju,X., Zhu,Y., Cai,X., Lan,J., Guo,J., Xie,M., Dong,L., Zhu,Z., Na,J., Wu,J., Lan,X., Xie,Y., Wang,X., Yuan,Z., Zhang,R. and Ding,Q. Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2 Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI
Low-Gan,J., Huang,R., Kelley,A., Jenkins,G.W., McGregor,D. and Smider,V.V. Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain Biochem J (2021) 478, 3671-3684. PubMed Europe PubMed DOI
Luan,B., Wang,H. and Huynh,T. Enhanced binding of the N501Y-mutated SARS-CoV-2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations FEBS Lett (2021) PubMed Europe PubMed DOI
Ma,S., Li,H., Yang,J. and Yu,K. Molecular simulation studies of the interactions between the human/pangolin/cat/bat ACE2 and the receptor binding domain of the SARS-CoV-2 spike protein Biochimie (2021) 187, 1-13. PubMed Europe PubMed DOI PMC EPMC
Mao,Q., Chu,S., Shapiro,S., Bliss,J.M. and De Paepe,M.E. Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS) Placenta (2021) 105, 7-13. PubMed Europe PubMed DOI PMC EPMC
Mehdipour,A.R. and Hummer,G. Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC
Muus,C., Luecken,M.D., Eraslan,G., Sikkema,L., Waghray,A., Heimberg,G., Kobayashi,Y., Vaishnav,E.D., Subramanian,A., Smillie,C., Jagadeesh,K.A., Duong,E.T., Fiskin,E., Triglia,E.T., Ansari,M., Cai,P., Lin,B., Buchanan,J., Chen,S., Shu,J., Haber,A.L., Chung,H., Montoro,D.T., Adams,T., Aliee,H., Allon,S.J., Andrusivova,Z., Angelidis,I., Ashenberg,O., Bassler,K., Becavin,C., Benhar,I., Bergenstrahle,J., Bergenstrahle,L., Bolt,L., Braun,E., Bui,L.T., Callori,S., Chaffin,M., Chichelnitskiy,E., Chiou,J., Conlon,T.M., Cuoco,M.S., Cuomo,A.S.E., Deprez,M., Duclos,G., Fine,D., Fischer,D.S., Ghazanfar,S., Gillich,A., Giotti,B., Gould,J., Guo,M., Gutierrez,A.J., Habermann,A.C., Harvey,T., He,P., Hou,X., Hu,L., Hu,Y., Jaiswal,A., Ji,L., Jiang,P., Kapellos,T.S., Kuo,C.S., Larsson,L., Leney-Greene,M.A., Lim,K., Litvinukova,M., Ludwig,L.S., Lukassen,S., Luo,W., Maatz,H., Madissoon,E., Mamanova,L., Manakongtreecheep,K., Leroy,S., Mayr,C.H., Mbano,I.M., McAdams,A.M., Nabhan,A.N., Nyquist,S.K., Penland,L., Poirion,O.B., Poli,S., Qi,C., Queen,R., Reichart,D., Rosas,I., Schupp,J.C., Shea,C.V., Shi,X., Sinha,R., Sit,R.V., Slowikowski,K., Slyper,M., Smith,N.P., Sountoulidis,A., Strunz,M., Sullivan,T.B., Sun,D., Talavera-Lopez,C., Tan,P., Tantivit,J., Travaglini,K.J., Tucker,N.R., Vernon,K.A., Wadsworth,M.H., Waldman,J., Wang,X., Xu,K., Yan,W., Zhao,W. and Ziegler,C.G.K. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics Nat Med (2021) 27, 546-559. PubMed Europe PubMed DOI
Nath,K.A., Singh,R.D., Grande,J.P., Garovic,V.D., Croatt,A.J., Ackerman,A.W., Barry,M.A. and Agarwal,A. Expression of ACE2 in the Intact and Acutely Injured Kidney Kidney360 (2021) 2, 1095-1106. PubMed Europe PubMed DOI PMC EPMC
Nomura,H., Kuruppu,S. and Rajapakse,N.W. Stimulation of Angiotensin Converting Enzyme 2: A Novel Treatment Strategy for Diabetic Nephropathy Front Physiol (2021) 12, 813012-813012. PubMed Europe PubMed DOI PMC EPMC V
Ozono,S., Zhang,Y., Ode,H., Sano,K., Tan,T.S., Imai,K., Miyoshi,K., Kishigami,S., Ueno,T., Iwatani,Y., Suzuki,T. and Tokunaga,K. SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity Nat Commun (2021) 12, 848-848. PubMed Europe PubMed DOI PMC EPMC
Pagliaro,P., Thairi,C., Alloatti,G. and Penna,C. Angiotensin-converting enzyme 2: a key enzyme in key organs J Cardiovasc Med (Hagerstown) (2021) PubMed Europe PubMed DOI V
Paniri,A., Hosseini,M.M., Moballegh-Eslam,M. and Akhavan-Niaki,H. Comprehensive in silico identification of impacts of ACE2 SNPs on COVID-19 susceptibility in different populations Gene Rep (2021) 22, 100979-100979. PubMed Europe PubMed DOI PMC EPMC
Perico,L., Benigni,A. and Remuzzi,G. Angiotensin-converting enzyme 2: from a vasoactive peptide to the gatekeeper of a global pandemic Curr Opin Nephrol Hypertens (2021) 30, 252-263. PubMed Europe PubMed DOI V
Polak,Y. and Speth,R.C. Metabolism of angiotensin peptides by angiotensin converting enzyme 2 (ACE2) and analysis of the effect of excess zinc on ACE2 enzymatic activity Peptides (2021) 137, 170477-170477. PubMed Europe PubMed DOI
Prevost,J., Richard,J., Gasser,R., Ding,S., Fage,C., Anand,S.P., Adam,D., Vergara,N.G., Tauzin,A., Benlarbi,M., Gong,S.Y., Goyette,G., Prive,A., Moreira,S., Charest,H., Roger,M., Mothes,W., Pazgier,M., Brochiero,E., Boivin,G., Abrams,C.F., Schon,A. and Finzi,A. Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2 J Biol Chem (2021) , 101151-101151. PubMed Europe PubMed DOI PMC EPMC
Qi,J., Zhou,Y., Hua,J., Zhang,L., Bian,J., Liu,B., Zhao,Z. and Jin,S. The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection Int J Environ Res Public Health (2021) 18 PubMed Europe PubMed DOI PMC EPMC
Raghuvamsi,P.V., Tulsian,N.K., Samsudin,F., Qian,X., Purushotorman,K., Yue,G., Kozma,M.M., Hwa,W.Y., Lescar,J., Bond,P.J., MacAry,P.A. and Anand,G.S. SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets elife (2021) 10 PubMed Europe PubMed DOI
Rahman,M.M., Hasan,M. and Ahmed,A. Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients Rev Med Virol (2021) 31, 1-12. PubMed Europe PubMed DOI V
Rathi,H., Burman,V., Datta,S.K., Rana,S.V., Mirza,A.A., Saha,S., Kumar,R. and Naithani,M. Review on COVID-19 Etiopathogenesis, Clinical Presentation and Treatment Available with Emphasis on ACE2 Indian J Clin Biochem (2021) , 1-20. PubMed Europe PubMed DOI PMC EPMC V
Refaey,R.H., El-Ashrey,M.K. and Nissan,Y.M. Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study Virology (2021) 554, 48-54. PubMed Europe PubMed DOI PMC EPMC I
Sahu,T., Mehta,A., Ratre,Y.K., Jaiswal,A., Vishvakarma,N.K., Bhaskar,L.V.K.S. and Verma,H.K. Current understanding of the impact of COVID-19 on gastrointestinal disease: Challenges and openings World J Gastroenterol (2021) 27, 449-469. PubMed Europe PubMed DOI PMC EPMC V
Samtani,R. and Krishna,K. ACE2 and COVID-19: An anthropological perspective Anthropol Anz (2021) PubMed Europe PubMed DOI V
Sarver,D.C. and Wong,G.W. Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19 Biochem Biophys Res Commun (2021) 538, 92-96-96. PubMed Europe PubMed DOI PMC EPMC
Sato,T., Ueha,R., Goto,T., Yamauchi,A., Kondo,K. and Yamasoba,T. Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower Aerodigestive Tracts of Rats: Implications on COVID 19 Infections Laryngoscope (2021) 131, E932-E939. PubMed Europe PubMed DOI
Sawa,Y., Ibaragi,S., Okui,T., Yamashita,J., Ikebe,T. and Harada,H. Expression of SARS-CoV-2 entry factors in human oral tissue J Anat (2021) PubMed Europe PubMed DOI
Scagnolari,C., Bitossi,C., Viscido,A., Frasca,F., Oliveto,G., Scordio,M., Petrarca,L., Mancino,E., Nenna,R., Riva,E., De Vito,C., Midulla,F., Antonelli,G. and Pierangeli,A. ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry? Cytokine (2021) 140, 155430-155430. PubMed Europe PubMed DOI PMC EPMC
Schnichels,S., Rohrbach,J.M., Bayyoud,T., Thaler,S., Ziemssen,F. and Hurst,J. Can SARS-CoV-2 infect the eye? An overview of the receptor status in ocular tissue Ophthalmologe (2021) 118, 81-84. PubMed Europe PubMed DOI PMC EPMC V
Seyedpour,S., Khodaei,B., Loghman,A.H., Seyedpour,N., Kisomi,M.F., Balibegloo,M., Nezamabadi,S.S., Gholami,B., Saghazadeh,A. and Rezaei,N. Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms: A systematic review of in vitro and in vivo studies J Cell Physiol (2021) 236, 2364-2392. PubMed Europe PubMed DOI
Seyran,M., Takayama,K., Uversky,V.N., Lundstrom,K., Palu,G., Sherchan,S.P., Attrish,D., Rezaei,N., Aljabali,A.A.A., Ghosh,S., Pizzol,D., Chauhan,G., Adadi,P., Mohamed Abd El-Aziz,T., Soares,A.G., Kandimalla,R., Tambuwala,M., Hassan,S.S., Azad,G.K., Pal Choudhury,P., Baetas-da-Cruz,W., Serrano-Aroca,A., Brufsky,A.M. and Uhal,B.D. The structural basis of accelerated host cell entry by SARS-CoV-2dagger FEBS J (2021) 288, 5010-5020. PubMed Europe PubMed DOI
Shah,A., Patel,V. and Parmar,B. Discovery of Some Antiviral Natural products to fight against Novel Corona Virus (SARS-CoV-2) using Insilico approach Comb Chem High Throughput Screen (2021) 24, 1271-1280. PubMed Europe PubMed DOI I
Shajahan,A., Archer-Hartmann,S., Supekar,N.T., Gleinich,A.S., Heiss,C. and Azadi,P. Comprehensive characterization of N- and O- glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2 Glycobiology (2021) 31, 410-424. PubMed Europe PubMed DOI PMC EPMC
Sharma,R.K., Li,J., Krishnan,S., Richards,E.M., Raizada,M.K. and Mohandas,R. Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases Clin Sci (Lond) (2021) 135, 1-17. PubMed Europe PubMed DOI PMC EPMC V
Soni,S., Jiang,Y., Tesfaigzi,Y., Hornick,J.L. and Cataltepe,S. Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis PLoS ONE (2021) 16, e0247510-e0247510. PubMed Europe PubMed DOI PMC EPMC
Sriram,K. and Insel,P.A. Inflammation and thrombosis in COVID-19 pathophysiology: Proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets Physiol Rev (2021) 101, 545-567. PubMed Europe PubMed DOI
Stone,L. An ACE2 in the kidney Nat Rev Urol (2021) 18, 132-132. PubMed Europe PubMed DOI
Suh,S.H., Ma,S.K., Kim,S.W. and Bae,E.H. Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019 Korean J Intern Med (2021) 36, 247-262. PubMed Europe PubMed DOI V
Sun,K., Gu,L., Ma,L. and Duan,Y. Atlas of ACE2 gene expression reveals novel insights into transmission of SARS-CoV-2 Heliyon (2021) 7, e05850-e05850. PubMed Europe PubMed DOI PMC EPMC
Sun,Z., Ren,K., Zhang,X., Chen,J., Jiang,Z., Jiang,J., Ji,F., Ouyang,X. and Li,L. Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications Engineering (Beijing) (2021) 7, 1441-1451. PubMed Europe PubMed DOI PMC EPMC
Taha,M.M., Shahy,E.M., Mahdy-Abdallah,H., Ibrahim,K.S. and El Tahlawy,E.M. Evaluation of the effect of serum cystatin-C and ACE I/D and ACE G2350A polymorphisms on kidney function among hypertensive sewage workers Environ Sci Pollut Res Int (2021) 28, 1619-1626. PubMed Europe PubMed DOI
Tamanna,S., Lumbers,E.R., Morosin,S.K., Delforce,S.J. and Pringle,K.G. ACE2: A key modulator of RAS and pregnancy Am J Physiol Regul Integr Comp Physiol (2021) PubMed Europe PubMed DOI V
Tembhre,M.K., Parihar,A.S., Sharma,V.K., Imran,S., Bhari,N., Lakshmy,R. and Bhalla,A. Enhanced expression of ACE2 in psoriatic skin and its upregulation in keratinocytes by interferon-gamma: Implication of inflammatory milieu in skin tropism of SARS-CoV-2 Br J Dermatol (2021) 184, 577-579. PubMed Europe PubMed DOI
Torre-Fuentes,L., Matias-Guiu,J., Hernandez-Lorenzo,L., Montero-Escribano,P., Pytel,V., Porta-Etessam,J., Gomez-Pinedo,U. and Matias-Guiu,J.A. ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain J Med Virol (2021) 93, 863-869. PubMed Europe PubMed DOI PMC EPMC
Triposkiadis,F., Starling,R.C., Xanthopoulos,A., Butler,J. and Boudoulas,H. Renin-angiotensin-system inhibition in the context of corona virus disease-19: experimental evidence, observational studies, and clinical implications Heart Fail Rev (2021) 26, 381-389. PubMed Europe PubMed DOI PMC EPMC
Tuli,H.S., Sood,S., Kaur,J., Kumar,P., Seth,P., Punia,S., Yadav,P., Sharma,A.K., Aggarwal,D. and Sak,K. Mechanistic insight into anti-COVID-19 drugs: recent trends and advancements 3 Biotech (2021) 11, 110-110. PubMed Europe PubMed DOI PMC EPMC V I
Upreti,S., Prusty,J.S., Pandey,S.C., Kumar,A. and Samant,M. Identification of novel inhibitors of angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19) Mol Divers (2021) PubMed Europe PubMed DOI PMC EPMC
Uranaka,T., Kashio,A., Ueha,R., Sato,T., Bing,H., Ying,G., Kinoshita,M., Kondo,K. and Yamasoba,T. Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection Laryngoscope (2021) 131, E2013-E2017. PubMed Europe PubMed DOI
Virant-Klun,I. and Strle,F. Human Oocytes Express Both ACE2 and BSG Genes and Corresponding Proteins: Is SARS-CoV-2 Infection Possible? Stem Cell Rev Rep (2021) PubMed Europe PubMed DOI PMC EPMC
Viveiros,A., Rasmuson,J., Vu,J., Mulvagh,S.L., Yip,C.Y.Y., Norris,C.M. and Oudit,G.Y. Sex Differences in COVID-19: Candidate Pathways, Genetics of ACE2, and Sex Hormones Am J Physiol Heart Circ Physiol (2021) 320, H296-H304. PubMed Europe PubMed DOI
Wang,G., Yang,M.L., Duan,Z.L., Liu,F.L., Jin,L., Long,C.B., Zhang,M., Tang,X.P., Xu,L., Li,Y.C., Kamau,P.M., Yang,L., Liu,H.Q., Xu,J.W., Chen,J.K., Zheng,Y.T., Peng,X.Z. and Lai,R. Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models Cell Res (2021) 31, 17-24. PubMed Europe PubMed DOI PMC EPMC
Wang,H., Song,J., Yao,Y., Deng,Y.K., Wang,Z.C., Liao,B., Ma,J., He,C., Pan,L., Liu,Y., Xie,J.G., Zeng,M. and Liu,Z. Angiotensin-converting enzyme II expression and its implication in the association between COVID-19 and allergic rhinitis Allergy (2021) 76, 906-910. PubMed Europe PubMed DOI PMC EPMC
Wang,L.F., Sun,Y.Y., Pan,Q., Yin,Y.Q., Tian,X.M., Liu,Y., Bu,T., Zhang,Q., Wang,Y.A., Zhao,J. and Luo,Y. Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding Front Pharmacol (2021) 12, 713632-713632. PubMed Europe PubMed DOI PMC EPMC
Wang,M., Bu,X., Fang,G., Luan,G., Huang,Y., Akdis,C.A., Wang,C. and Zhang,L. Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps Allergy (2021) 76, 789-803. PubMed Europe PubMed DOI
Wang,Q., Qiu,Y., Li,J.Y., Liao,C.H., Zhou,Z.J. and Ge,X.Y. Receptor utilization of angiotensin-converting enzyme 2 (ACE2) indicates a narrower host range of SARS-CoV-2 than that of SARS-CoV Transbound Emerg Dis (2021) 68, 1046-1053. PubMed Europe PubMed DOI PMC EPMC
Wang,X.S. Angiotensin-converting enzyme 2 connects COVID-19 with cancer and cancer immunotherapy World J Gastrointest Oncol (2021) 13, 157-160. PubMed Europe PubMed DOI PMC EPMC
Wiese,O., Zemlin,A.E. and Pillay,T.S. Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2) J Clin Pathol (2021) 74, 285-290. PubMed Europe PubMed DOI PMC EPMC T
Wong,L.M. and Jiang,G. A Plausible Link of TMPRSS2/ACE2/AR Signaling to Male Mortality during the COVID-19 Pandemic in the United States Pathogens (2021) 10 PubMed Europe PubMed DOI PMC EPMC
Xiao,K., Song,L., Bai,Y., Liu,P., Liu,Y., Xie,F. and Xie,L. Decipering the Molecular Mechanism of ACE2 Regulating A549 Cells Front Genet (2021) 12, 653725-653725. PubMed Europe PubMed DOI PMC EPMC
Xiao,T., Lu,J., Zhang,J., Johnson,R.I., McKay,L.G.A., Storm,N., Lavine,C.L., Peng,H., Cai,Y., Rits-Volloch,S., Lu,S., Quinlan,B.D., Farzan,M., Seaman,M.S., Griffiths,A. and Chen,B. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent Nat Struct Mol Biol (2021) 28, 202-209. PubMed Europe PubMed DOI
Xu,F., Gao,J., Orgil,B.O., Bajpai,A.K., Gu,Q., Purevjav,E., Davenport,A.S., Li,K., Towbin,J.A., Black,D.D., Pierre,J.F. and Lu,L. Ace2 and Tmprss2 Expressions Are Regulated by Dhx32 and Influence the Gastrointestinal Symptoms Caused by SARS-CoV-2 J Pers Med (2021) 11 PubMed Europe PubMed DOI PMC EPMC
Yadav,D.K., Singh,D.D., Han,I., Kumar,Y. and Choi,E.H. Current Potential Therapeutic Approaches against SARS-CoV-2: A Review Biomedicines (2021) 9 PubMed Europe PubMed DOI PMC EPMC I
Yalcin,H.C., Sukumaran,V., Al-Ruweidi,M.K.A.A. and Shurbaji,S. Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC V
Yan,H., Jiao,H., Liu,Q., Zhang,Z., Xiong,Q., Wang,B.J., Wang,X., Guo,M., Wang,L.F., Lan,K., Chen,Y. and Zhao,H. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species Nat Ecol Evol (2021) 5, 600-608. PubMed Europe PubMed DOI
Yang,J., Chen,T. and Zhou,Y. Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes Hereditas (2021) 158, 4-4. PubMed Europe PubMed DOI PMC EPMC
Yang,J., Petitjean,S.J.L., Koehler,M., Zhang,Q., Dumitru,A.C., Chen,W., Derclaye,S., Vincent,S.P., Soumillion,P. and Alsteens,D. Author Correction: Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor Nat Commun (2021) 12, 2996-2996. PubMed Europe PubMed DOI PMC EPMC
Yang,W., Li,L., Zhang,K., Ma,K., Xie,H., Gong,Y., Zhou,J. and Gong,K. ACE2 Correlated With Immune Infiltration Serves As A Novel Prognostic Biomarker In Clear Cell Renal Cell Carcinoma: Implication For COVID-19 Int J Biol Sci (2021) 17, 20-31. PubMed Europe PubMed DOI PMC EPMC
Yao,Y., Ma,D., Xu,Y., Yuan,X.L., Liang,J.J., Chen,S.L., Jhanji,V. and Ng,T.K. Hydroxychloroquine treatment on SARS-CoV-2 receptor ACE2, TMPRSS2 and NRP1 expression in human primary pterygium and conjunctival cells Exp Eye Res (2021) 214, 108864-108864. PubMed Europe PubMed DOI PMC EPMC
Ye,S., Zhang,G. and Jiang,J. AI-based spectroscopic monitoring of real-time interactions between SARS-CoV-2 and human ACE2 Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC
Yeung,M.L., Teng,J.L.L., Jia,L., Zhang,C., Huang,C., Cai,J.P., Zhou,R., Chan,K.H., Zhao,H., Zhu,L., Siu,K.L., Fung,S.Y., Yung,S., Chan,T.M., To,K.K., Chan,J.F., Cai,Z., Lau,S.K.P., Chen,Z., Jin,D.Y., Woo,P.C.Y. and Yuen,K.Y. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system Cell (2021) 184, 2212-2228. PubMed Europe PubMed DOI PMC EPMC
Zanganeh,S., Goodarzi,N., Doroudian,M. and Movahed,E. Potential COVID-19 therapeutic approaches targeting angiotensin-converting enzyme 2; An updated review Rev Med Virol (2021) , e2321-e2321. PubMed Europe PubMed DOI
Zhang,F., Li,W., Feng,J., Ramos da Silva,S., Ju,E., Zhang,H., Chang,Y., Moore,P.S., Guo,H. and Gao,S.J. SARS-CoV-2 pseudovirus infectivity and expression of viral entry-related factors ACE2, TMPRSS2, Kim-1, and NRP-1 in human cells from the respiratory, urinary, digestive, reproductive, and immune systems J Med Virol (2021) PubMed Europe PubMed DOI
Zhang,H.L., Li,Y.M., Sun,J., Zhang,Y.Y., Wang,T.Y., Sun,M.X., Wang,M.H., Yang,Y.L., Hu,X.L., Tang,Y.D., Zhao,J. and Cai,X. Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species J Biol Chem (2021) , 100435-100435. PubMed Europe PubMed DOI PMC EPMC
Zhang,Q., Jeppesen,D.K., Higginbotham,J.N., Franklin,J.L., Crowe,J.E., Jr. and Coffey,R.J. ACE2-containing extracellular vesicles and exomeres bind the SARS-CoV-2 spike protein Gastroenterology (2021) 160, 958-961. PubMed Europe PubMed DOI
Zhang,Y., Niu,G., Flisikowska,T., Schnieke,A. and Flisikowski,K. A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs Biochem Biophys Res Commun (2021) 553, 25-29. PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Hu,S., Wang,J., Xue,Z., Wang,C. and Wang,N. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2 Virology (2021) 554, 83-88. PubMed Europe PubMed DOI PMC EPMC
Zhang,Z., Guo,L., Huang,L., Zhang,C., Luo,R., Zeng,L., Liang,H., Li,Q., Lu,X., Wang,X., Yan Ma,C., Shao,J., Luo,W., Li,L., Liu,L., Li,Z., Zhou,X., Zhang,X., Liu,J., Yang,J., Kwan,K.Y., Liu,W., Xu,Y., Jiang,H., Liu,H., Du,H., Wu,Y., Yu,G., Chen,J., Wu,J., Zhang,J., Liao,C., Chen,H.J., Chen,Z., Tse,H.F., Xia,H. and Lian,Q. Distinct disease severity between children and older adults with COVID-19: Impacts of ACE2 expression, distribution, and lung progenitor cells Clin Infect Dis (2021) 73, e4154-e4165. PubMed Europe PubMed DOI PMC EPMC
Zhao,D., Chen,X., Han,D., Zhong,J., Zhang,S.E. and Yang,C. Pulmonary ACE2 expression in neonatal and adult rats FEBS Open Bio (2021) 11, 2266-2272. PubMed Europe PubMed DOI
Zhou,P., Wang,H., Chen,Z. and Liu,Q. Context contribution to the intermolecular recognition of human ACE2-derived peptides by SARS-CoV-2 spike protein: implications for improving the peptide affinity but not altering the peptide specificity by optimizing indirect readout Mol Omics (2021) 17, 86-94. PubMed Europe PubMed DOI
Zhou,Y., Huang,Y., Song,X., Guo,X., Pang,J., Wang,J., Zhang,S. and Wang,C. Single-cell transcriptional profile of ACE2 in healthy and failing human hearts Sci China Life Sci (2021) 64, 652-655. PubMed Europe PubMed DOI PMC EPMC
Zhou,Z., Yang,Z., Ou,J., Zhang,H., Zhang,Q., Dong,M. and Zhang,G. Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome Comput Struct Biotechnol J (2021) 19, 161-167. PubMed Europe PubMed DOI PMC EPMC
Zhu,F., Zhong,Y., Ji,H., Ge,R., Guo,L., Song,H., Wu,H., Jiao,P., Li,S., Wang,C. and Du,H. ACE2 and TMPRSS2 in human saliva can adsorb to the oral mucosal epithelium J Anat (2021) 240, 398-409. PubMed Europe PubMed DOI
Zhu,H., Zhang,L., Ma,Y., Zhai,M., Xia,L., Liu,J., Yu,S. and Duan,W. The role of SARS-CoV-2 target ACE2 in cardiovascular diseases J Cell Mol Med (2021) 25, 1342-1349. PubMed Europe PubMed DOI V

2020

Spike-ACE2 protein-protein interaction (QD) (2020) PubMed Europe PubMed
ACE2 binding (2020) PubMed Europe PubMed
ACE2 enzymatic activity (2020) PubMed Europe PubMed
Abassi,Z., Higazi,A.A.R., Kinaneh,S., Armaly,Z., Skorecki,K. and Heyman,S.N. ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle Front Physiol (2020) 11, 574753-574753. PubMed Europe PubMed DOI PMC EPMC
Abd El-Aziz,T.M., Al-Sabi,A. and Stockand,J.D. Human recombinant soluble ACE2 (hrsACE2) shows promise for treating severe COVID-19 Signal Transduct Target Ther (2020) 5, 258-258. PubMed Europe PubMed DOI PMC EPMC
Abhinand,C.S., Nair,A.S., Krishnamurthy,A., Oommen,O.V. and Sudhakaran,P.R. Potential protease inhibitors and their combinations to block SARS-CoV-2 J Biomol Struct Dyn (2020) , 1-15. PubMed Europe PubMed DOI PMC EPMC I
Adhikari,P., Li,N., Shin,M., Steinmetz,N.F., Twarock,R., Podgornik,R. and Ching,W.Y. Intra- and intermolecular atomic-scale interactions in the receptor binding domain of SARS-CoV-2 spike protein: implication for ACE2 receptor binding Phys Chem Chem Phys (2020) 22, 18272-18283. PubMed Europe PubMed DOI
Akhtar,S., Benter,I.F., Danjuma,M.I., Doi,S.A.R., Hasan,S.S. and Habib,A.M. Pharmacotherapy in COVID-19 patients: a review of ACE2-raising drugs and their clinical safety J Drug Target (2020) , 1-17. PubMed Europe PubMed DOI
Al-Benna,S. Association of high level gene expression of ACE2 in adipose tissue with mortality of COVID-19 infection in obese patients Obes Med (2020) 19, 100283-100283. PubMed Europe PubMed DOI PMC EPMC
Al-Horani,R.A., Kar,S. and Aliter,K.F. Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI V
Alazmi,M. and Motwalli,O. Molecular basis for drug repurposing to study the interface of the S protein in SARS-CoV-2 and human ACE2 through docking, characterization, and molecular dynamics for natural drug candidates J Mol Model (2020) 26, 338-338. PubMed Europe PubMed DOI PMC EPMC
Alexander,M.R., Schoeder,C.T., Brown,J.A., Smart,C.D., Moth,C., Wikswo,J.P., Capra,J.A., Meiler,J., Chen,W. and Madhur,M.S. Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species FASEB J (2020) 34, 15946-15960. PubMed Europe PubMed DOI
Alexpandi,R., De Mesquita,J.F., Pandian,S.K. and Ravi,A.V. Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico Analysis Front Microbiol (2020) 11, 1796-1796. PubMed Europe PubMed DOI PMC EPMC I
AlGhamdi,N.A., Alsuwat,H.S., Borgio,J.F. and AbdulAzeez,S. Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection: in silico approaches J Biomol Struct Dyn (2020) , 1-12. PubMed Europe PubMed DOI PMC EPMC
Ali,A. and Vijayan,R. Dynamics of the ACE2-SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms Sci Rep (2020) 10, 14214-14214. PubMed Europe PubMed DOI PMC EPMC
Ali,F., Elserafy,M., Alkordi,M.H. and Amin,M. ACE2 coding variants in different populations and their potential impact on SARS-CoV-2 binding affinity Biochem Biophys Rep (2020) 24, 100798-100798. PubMed Europe PubMed DOI PMC EPMC
Allen,J.D., Watanabe,Y., Chawla,H., Newby,M.L. and Crispin,M. Subtle Influence of ACE2 Glycan Processing on SARS-CoV-2 Recognition J Mol Biol (2020) 433, 166762-166762. PubMed Europe PubMed DOI PMC EPMC
Alsufyani,H.A. and Alrefaie,Z. Renin-Angiotensin System Implications to COVID-19 Comorbidities J Microsc Ultrastruct (2020) 8, 148-151. PubMed Europe PubMed DOI PMC EPMC V
Amano,T. Angiotensin-Converting Enzyme 2 as a Versatile Player in the Management of Coronavirus Disease 2019 J Diabetes Investig (2020) 11, 1120-1122. PubMed Europe PubMed DOI PMC EPMC
Amraei,R. and Rahimi,N. COVID-19, Renin-Angiotensin System and Endothelial Dysfunction Cells (2020) 9 PubMed Europe PubMed DOI
Armijos-Jaramillo,V., Yeager,J., Muslin,C. and Perez-Castillo,Y. SARS-CoV-2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stability Evol Appl (2020) PubMed Europe PubMed DOI PMC EPMC
Ashraf,U.M., Abokor,A.A., Edwards,J.M., Waigi,E.W., Royfman,R.S., Hasan,S.A., Smedlund,K.B., Hardy,A.M.G., Chakravarti,R. and Koch,L.G. SARS-CoV-2, ACE2 expression, and systemic organ invasion Physiol Genomics (2020) PubMed Europe PubMed DOI V
Avanzini,M.A., Mura,M., Percivalle,E., Bastaroli,F., Croce,S., Valsecchi,C., Lenta,E., Nykjaer,G., Cassaniti,I., Bagnarino,J., Baldanti,F., Zecca,M., Comoli,P. and Gnecchi,M. Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection Stem Cells Transl Med (2020) PubMed Europe PubMed DOI
Azizan,E. and Brown,M. ACE2 role in SARS-CoV-2 infectivity and Covid-19 severity Malays J Pathol (2020) 42, 363-367. PubMed Europe PubMed V
Azouz,N.P., Klingler,A.M., Callahan,V., Akhrymuk,I.V., Elez,K., Raich,L., Henry,B.M., Benoit,J.L., Benoit,S.W., Noe,F., Kehn-Hall,K. and Rothenberg,M.E. Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Bader,M. [ACE2 - the hijacked all-rounder] Nephrologe (2020) , 1-4. PubMed Europe PubMed DOI PMC EPMC
Bader,M., Turner,A.J. and Alenina,N. ACE2, a multifunctional protein - from cardiovascular regulation to COVID-19 Clin Sci (Lond) (2020) 134, 3229-3232. PubMed Europe PubMed DOI
Bala,A., Sengupta,A., Matsabisa,M.G. and Chabalala,H.P. COVID-19: Pathophysiology; Mechanism of Transmission and Possible Molecular Drug Target for Management Curr Mol Pharmacol (2020) PubMed Europe PubMed DOI V
Balkrishna,A., Pokhrel,S. and Varshney,A. Tinocordiside from Tinospora cordifolia (Giloy) May Curb SARS-CoV-2 Contagion by Disrupting the Electrostatic Interactions between Host ACE2 and Viral S-Protein Receptor Binding Domain Comb Chem High Throughput Screen (2020) PubMed Europe PubMed DOI
Bao,R., Hernandez,K., Huang,L. and Luke,J.J. ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19 J Immunother Cancer (2020) 8 PubMed Europe PubMed DOI PMC EPMC
Baral,R., White,M. and Vassiliou,V.S. Effect of Renin-Angiotensin-Aldosterone System Inhibitors in Patients with COVID-19: a Systematic Review and Meta-analysis of 28,872 Patients Curr Atheroscler Rep (2020) 22, 61-61. PubMed Europe PubMed DOI PMC EPMC V
Barash,A., Machluf,Y., Ariel,I. and Dekel,Y. The Pursuit of COVID-19 Biomarkers: Putting the Spotlight on ACE2 and TMPRSS2 Regulatory Sequences Front Med (Lausanne) (2020) 7, 582793-582793. PubMed Europe PubMed DOI PMC EPMC
Barilla,F., Bassareo,P.P., Calcaterra,G., Romeo,F. and Mehta,J.L. Focus on clinical practice: angiotensin-converting enzyme 2 and corona virus disease 2019: pathophysiology and clinical implications J Cardiovasc Med (Hagerstown) (2020) 21, 630-633. PubMed Europe PubMed DOI
Barker,H. and Parkkila,S. Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2 PLoS ONE (2020) 15, e0240647-e0240647. PubMed Europe PubMed DOI PMC EPMC
Barnett,B.P., Wahlin,K., Krawczyk,M., Spencer,D., Welsbie,D., Afshari,N. and Chao,D. Potential of Ocular Transmission of SARS-CoV-2: A Review Vision (Basel) (2020) 4 PubMed Europe PubMed DOI V
Barochiner,J. and Martinez,R. Use of inhibitors of the renin-angiotensin system in hypertensive patients and COVID-19 severity: A systematic review and meta-analysis J Clin Pharm Ther (2020) PubMed Europe PubMed DOI PMC EPMC
Barros,E.P., Casalino,L., Gaieb,Z., Dommer,A.C., Wang,Y., Fallon,L., Raguette,L., Belfon,K., Simmerling,C. and Amaro,R.E. The Flexibility of ACE2 in the Context of SARS-CoV-2 Infection Biophys J (2020) PubMed Europe PubMed DOI PMC EPMC
Barros,R.O., Junior,F.L.C.C., Pereira,W.S., Oliveira,N.M.N. and Ramos,R.M. Interaction of Drug Candidates with Various SARS-CoV-2 Receptors: An in Silico Study to Combat COVID-19 J Proteome Res (2020) PubMed Europe PubMed DOI I
Bartolome,A., Liang,J., Wang,P., Ho,D.D. and Pajvani,U.B. Angiotensin converting enzyme 2 is a novel target of the gamma-secretase complex bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Bartova,E., Legartova,S., Krejci,J. and Arcidiacono,O.A. Cell differentiation and aging accompanied by depletion of the ACE2 protein Aging (Albany NY) (2020) 12, 22495-22508. PubMed Europe PubMed DOI
Batchu,S.N., Kaur,H., Yerra,V.G., Advani,S.L., Kabir,M.G., Liu,Y., Klein,T. and Advani,A. Lung and Kidney ACE2 and TMPRSS2 in Renin Angiotensin System Blocker Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19 Diabetes (2020) PubMed Europe PubMed DOI I
Batlle,D., Wysocki,J. and Satchell,K. Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? Clin Sci (Lond) (2020) 134, 543-545. PubMed Europe PubMed DOI U
Baughn,L.B., Sharma,N., Elhaik,E., Sekulic,A., Bryce,A.H. and Fonseca,R. Targeting TMPRSS2 in SARS-CoV-2 Infection Mayo Clin Proc (2020) 95, 1989-1999. PubMed Europe PubMed DOI PMC EPMC
Beeraka,N.M., Sadhu,S.P., Madhunapantula,S.V., Rao Pragada,R., Svistunov,A.A., Nikolenko,V.N., Mikhaleva,L.M. and Aliev,G. Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status Front Immunol (2020) 11, 552925-552925. PubMed Europe PubMed DOI PMC EPMC V
Behl,T., Kaur,I., Bungau,S., Kumar,A., Uddin,M.S., Kumar,C., Pal,G., Sahil, Shrivastava,K., Zengin,G. and Arora,S. The dual impact of ACE2 in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions Life Sci (2020) 257, 118075-118075. PubMed Europe PubMed DOI PMC EPMC V
Bellis,A., Mauro,C., Barbato,E., Trimarco,B. and Morisco,C. The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19 Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V I
Benetti,E., Tita,R., Spiga,O., Ciolfi,A., Birolo,G., Bruselles,A., Doddato,G., Giliberti,A., Marconi,C., Musacchia,F., Pippucci,T., Torella,A., Trezza,A., Valentino,F., Baldassarri,M., Brusco,A., Asselta,R., Bruttini,M., Furini,S., Seri,M., Nigro,V., Matullo,G., Tartaglia,M., Mari,F., Renieri,A. and Pinto,A.M. ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population Eur J Hum Genet (2020) PubMed Europe PubMed DOI PMC EPMC
Bernardi,A., Huang,Y., Harris,B., Xiong,Y., Nandi,S., McDonald,K.A. and Faller,R. Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain PLoS ONE (2020) 15, e0237295-e0237295. PubMed Europe PubMed DOI PMC EPMC
Bhari,V.K., Kumar,D., Kumar,S. and Mishra,R. SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes Biochem Biophys Rep (2020) 24, 100844-100844. PubMed Europe PubMed DOI PMC EPMC
Bhattarai,A., Pawnikar,S. and Miao,Y. Mechanism of ligand recognition by human ACE2 receptor bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC I
Bloise,E., Zhang,J., Nakpu,J., Hamada,H., Dunk,C.E., Li,S., Imperio,G.E., Nadeem,L., Kibschull,M., Lye,P., Matthews,S.G. and Lye,S.J. Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia Am J Obstet Gynecol (2020) PubMed Europe PubMed DOI PMC EPMC
Borro,M., Di Girolamo,P., Gentile,G., De Luca,O., Preissner,R., Marcolongo,A., Ferracuti,S. and Simmaco,M. Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2 Int J Environ Res Public Health (2020) 17 PubMed Europe PubMed DOI
Bosso,M., Thanaraj,T.A., Abu-Farha,M., Alanbaei,M., Abubaker,J. and Al-Mulla,F. The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19 Mol Ther Methods Clin Dev (2020) 18, 321-327. PubMed Europe PubMed DOI PMC EPMC
Bouricha,E.M., Hakmi,M., Akachar,J., Belyamani,L. and Ibrahimi,A. In silico analysis of ACE2 orthologues to predict animal host range with high susceptibility to SARS-CoV-2 3 Biotech (2020) 10, 483-483. PubMed Europe PubMed DOI PMC EPMC
Br,B., Damle,H., Ganju,S. and Damle,L. In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19 F1000Res (2020) 9, 663-663. PubMed Europe PubMed DOI PMC EPMC
Branco,A.C.C.C., Sato,M.N. and Alberca,R.W. The Possible Dual Role of the ACE2 Receptor in Asthma and Coronavirus (SARS-CoV2) Infection Front Cell Infect Microbiol (2020) 10, 550571-550571. PubMed Europe PubMed DOI PMC EPMC
Braun,M., Sharon,E., Unterman,I., Miller,M., Shtern,A.M., Benenson,S., Vainstein,A. and Tabach,Y. ACE2 Co-evolutionary Pattern Suggests Targets for Pharmaceutical Intervention in the COVID-19 Pandemic iScience (2020) 23, 101384-101384. PubMed Europe PubMed DOI PMC EPMC
Braz,H.L.B., Silveira,J.A.M., Marinho,A.D., de Moraes,M.E.A., Moraes Filho,M.O., Monteiro,H.S.A. and Jorge,R.J.B. In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection Int J Antimicrob Agents (2020) , 106119-106119. PubMed Europe PubMed DOI PMC EPMC
Brenner,S.R. Erythropoietin-induced hemoglobin subunit beta may stimulate innate immune RNA virus pattern recognition, suppress reactive oxygen species, reduce ACE2 viral doorway opening, and neutrophil extracellular traps against COVID-19 J Med Virol (2020) PubMed Europe PubMed DOI PMC EPMC
Brooke,G.N. and Prischi,F. Structural and functional modelling of SARS-CoV-2 entry in animal models Sci Rep (2020) 10, 15917-15917. PubMed Europe PubMed DOI PMC EPMC
Buchrieser,J., Dufloo,J., Hubert,M., Monel,B., Planas,D., Michael Rajah,M., Planchais,C., Porrot,F., Guivel-Benhassine,F., van der Werf,S., Casartelli,N., Mouquet,H., Bruel,T. and Schwartz,O. Syncytia formation by SARS-CoV-2 infected cells EMBO J (2020) , e106267-e106267. PubMed Europe PubMed DOI
Busnadiego,I., Fernbach,S., Pohl,M.O., Karakus,U., Huber,M., Trkola,A., Stertz,S. and Hale,B.G. Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2 MBio (2020) 11 PubMed Europe PubMed DOI PMC EPMC
Cadegiani,F.A., Goren,A. and Wambier,C.G. Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS) Med Hypotheses (2020) 143, 110112-110112. PubMed Europe PubMed DOI PMC EPMC
Calcagnile,M., Forgez,P., Iannelli,A., Bucci,C., Alifano,M. and Alifano,P. Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein Biochimie (2020) 180, 143-148. PubMed Europe PubMed DOI
Calo,L.A. and Davis,P.A. Are the Clinical Presentations (Phenotypes) of Gitelman's and Bartter's Syndromes Gene Mutations Driven by Their Effects on Intracellular pH, Their "pH" Enotype? Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Camargo,S.M.R., Vuille-Dit-Bille,R.N., Meier,C.F. and Verrey,F. ACE2 and gut amino acid transport Clin Sci (Lond) (2020) 134, 2823-2833. PubMed Europe PubMed DOI
Cameron,A., Porterfield,C.A., Byron,L.D., Wang,J., Pearson,Z., Bohrhunter,J.L., Cardillo,A.B., Ryan-Muntz,L., Sorensen,R.A., Caserta,M.T., Angeloni,S., Hardy,D.J., Zand,M.S. and Pecora,N.D. A multiplex microsphere IgG assay for SARS-CoV-2 using ACE2-mediated inhibition as a surrogate for neutralization J Clin Microbiol (2020) PubMed Europe PubMed DOI V
Campbell,R.A., Boilard,E. and Rondina,M.T. Is there a role for the ACE2 receptor in SARS-CoV-2 interactions with platelets? J Thromb Haemost (2020) PubMed Europe PubMed DOI
Cao,W., Dong,C., Kim,S., Hou,D., Tai,W., Du,L., Im,W. and Zhang,X.F. Biomechanical Characterization of SARS-CoV-2 Spike RBD and Human ACE2 Protein-Protein Interaction bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Cao,Y., Sun,Y., Tian,X., Bai,Z., Gong,Y., Qi,J., Liu,D., Liu,W. and Li,J. Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species Front Vet Sci (2020) 7, 457-457. PubMed Europe PubMed DOI PMC EPMC
Carino,A., Moraca,F., Fiorillo,B., Marchiano,S., Sepe,V., Biagioli,M., Finamore,C., Bozza,S., Francisci,D., Distrutti,E., Catalanotti,B., Zampella,A. and Fiorucci,S. Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain Front Chem (2020) 8, 572885-572885. PubMed Europe PubMed DOI PMC EPMC
Carvalho,T. ACE2, the viral gateway Nat Med (2020) 26, 1807-1807. PubMed Europe PubMed DOI
Cava,C., Bertoli,G. and Castiglioni,I. A protein interaction map identifies existing drugs targeting SARS-CoV-2 BMC Pharmacol Toxicol (2020) 21, 65-65. PubMed Europe PubMed DOI PMC EPMC
Cavasotto,C. and Di Filippo,J. In silico Drug Repurposing for COVID-19: Targeting SARS-CoV-2 Proteins through Docking and Consensus Ranking Mol Inform (2020) PubMed Europe PubMed DOI
Chadchan,S.B., Maurya,V.K., Popli,P. and Kommagani,R. The SARS-CoV-2 receptor, Angiotensin converting enzyme 2 (ACE2) is required for human endometrial stromal cell decidualization bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC K
Chadchan,S.B., Popli,P., Maurya,V.K. and Kommagani,R. The SARS-CoV-2 receptor, Angiotensin converting enzyme 2 (ACE2) is required for human endometrial stromal cell decidualization Biol Reprod (2020) PubMed Europe PubMed DOI K
Chakraborty,K. and Francis,P. Callypyrones from marine Callyspongiidae sponge Callyspongia diffusa: antihypertensive bis-gamma-pyrone polypropionates attenuate angiotensin-converting enzyme Nat Prod Res (2020) , 1-12. PubMed Europe PubMed DOI I
Chakraborty,S. Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity Biochem Biophys Res Commun (2020) PubMed Europe PubMed DOI PMC EPMC
Chambers,J.P., Yu,J., Valdes,J.J. and Arulanandam,B.P. SARS-CoV-2, Early Entry Events J Pathog (2020) 2020, 9238696-9238696. PubMed Europe PubMed DOI PMC EPMC
Chan,K.K., Dorosky,D., Sharma,P., Abbasi,S.A., Dye,J.M., Kranz,D.M., Herbert,A.S. and Procko,E. Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2 Science (2020) PubMed Europe PubMed DOI
Chang,E.H., Willis,A.L., Romanoski,C.E., Cusanovich,D.A., Pouladi,N., Li,J., Lussier,Y.A. and Martinez,F.D. RV Infections in Asthmatics Increase ACE2 Expression and Cytokine Pathways Implicated in COVID-19 Am J Respir Crit Care Med (2020) PubMed Europe PubMed DOI
Chatterjee,P., Gheblawi,M., Wang,K., Vu,J., Kondaiah,P. and Oudit,G.Y. Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications Clin Sci (Lond) (2020) 134, 2319-2336. PubMed Europe PubMed DOI V
Chen,J., Jiang,Q., Xia,X., Liu,K., Yu,Z., Tao,W., Gong,W. and Han,J.J. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation Aging Cell (2020) 19 PubMed Europe PubMed DOI PMC EPMC
Chen,Y., Gong,W., Wei,H., Dai,W. and Xu,S. 2019-nCoV may create complications in colon cancer patients with ACE2 expression Int J Clin Exp Pathol (2020) 13, 2305-2311. PubMed Europe PubMed PMC EPMC
Chenna,A., Konala,V.M., Bose,S., Roy,S., Madhira,B.R., Gayam,V., Naramala,S. and Adapa,S. Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade Case Rep Nephrol (2020) 2020, 8811931-8811931. PubMed Europe PubMed DOI PMC EPMC
Chiappelli,F. Towards Neuro-CoViD-19 Bioinformation (2020) 16, 288-292. PubMed Europe PubMed DOI PMC EPMC
Chiocchetti,R., Galiazzo,G., Fracassi,F., Giancola,F. and Pietra,M. ACE2 Expression in the Cat and the Tiger Gastrointestinal Tracts Front Vet Sci (2020) 7, 514-514. PubMed Europe PubMed DOI PMC EPMC
Chuang,H.C., Chen,Y.Y., Hsiao,T.C., Chou,H.C., Kuo,H.P., Feng,P.H., Ho,S.C., Chen,J.K., Chuang,K.J. and Lee,K.Y. Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats ERJ Open Res (2020) 6 PubMed Europe PubMed DOI PMC EPMC
Chung,M.K., Karnik,S., Saef,J., Bergmann,C., Barnard,J., Lederman,M.M., Tilton,J., Cheng,F., Harding,C.V., Young,J.B., Mehta,N., Cameron,S.J., McCrae,K.R., Schmaier,A.H., Smith,J.D., Kalra,A., Gebreselassie,S.K., Thomas,G., Hawkins,E.S. and Svensson,L.G. SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy EBioMedicine (2020) 58, 102907-102907. PubMed Europe PubMed DOI PMC EPMC
Clausen,T.M., Sandoval,D.R., Spliid,C.B., Pihl,J., Painter,C.D., Thacker,B.E., Glass,C.A., Narayanan,A., Majowicz,S.A., Zhang,Y., Torres,J.L., Golden,G.J., Porell,R., Garretson,A.F., Laubach,L., Feldman,J., Yin,X., Pu,Y., Hauser,B., Caradonna,T.M., Kellman,B.P., Martino,C., Gordts,P.L.S.M., Leibel,S.L., Chanda,S.K., Schmidt,A.G., Godula,K., Jose,J., Corbett,K.D., Ward,A.B., Carlin,A.F. and Esko,J.D. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Coate,K.C., Cha,J., Shrestha,S., Wang,W., Goncalves,L.M., Almaca,J., Kapp,M.E., Fasolino,M., Morgan,A., Dai,C., Saunders,D.C., Bottino,R., Aramandla,R., Jenkins,R., Stein,R., Kaestner,K.H., Vahedi,G., Consortium,H., Brissova,M. and Powers,A.C. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Coate,K.C., Cha,J., Shrestha,S., Wang,W., Goncalves,L.M., Almaca,J., Kapp,M.E., Fasolino,M., Morgan,A., Dai,C., Saunders,D.C., Bottino,R., Aramandla,R., Jenkins,R., Stein,R., Kaestner,K.H., Vahedi,G., Brissova,M. and Powers,A.C. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in beta Cells Cell Metab (2020) 32, 1028-1040. PubMed Europe PubMed DOI PMC EPMC
Cohen,J.B., Hanff,T.C., Bress,A.P. and South,A.M. Relationship Between ACE2 and Other Components of the Renin-Angiotensin System Curr Hypertens Rep (2020) 22, 44-44. PubMed Europe PubMed DOI PMC EPMC V
Conceicao,C., Thakur,N., Human,S., Kelly,J.T., Logan,L., Bialy,D., Bhat,S., Stevenson-Leggett,P., Zagrajek,A.K., Hollinghurst,P., Varga,M., Tsirigoti,C., Tully,M., Chiu,C., Moffat,K., Silesian,A.P., Hammond,J.A., Maier,H.J., Bickerton,E., Shelton,H., Dietrich,I., Graham,S.C. and Bailey,D. The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins PLoS Biol (2020) 18, e3001016-e3001016. PubMed Europe PubMed DOI PMC EPMC
Couselo-Seijas,M., Almenglo,C., Agra-Bermejo,M., Luis Fernandez,A., Alvarez,E., Gonzalez-Juanatey,R. and Eiras,S. Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer Eur J Clin Invest (2020) , e13463-e13463. PubMed Europe PubMed DOI PMC EPMC
Cui,D., Liu,Y., Jiang,X., Ding,C., Poon,L.C., Wang,H. and Yang,H. Single-cell RNA expression profiling of ACE2 and TMPRSS2 in the human trophectoderm and placenta Ultrasound Obstet Gynecol (2020) PubMed Europe PubMed DOI PMC EPMC
Damas,J., Hughes,G.M., Keough,K.C., Painter,C.A., Persky,N.S., Corbo,M., Hiller,M., Koepfli,K.P., Pfenning,A.R., Zhao,H., Genereux,D.P., Swofford,R., Pollard,K.S., Ryder,O.A., Nweeia,M.T., Lindblad-Toh,K., Teeling,E.C., Karlsson,E.K. and Lewin,H.A. Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates Proc Natl Acad Sci U S A (2020) 117, 22311-22322. PubMed Europe PubMed DOI PMC EPMC
Dambha-Miller,H., Albasri,A., Hodgson,S., Wilcox,C., Islam,N., Khan,S., Little,P. and Griffin,S. Drug treatments affecting ACE2 in COVID-19 infection: a systematic review protocol BJGP Open (2020) PubMed Europe PubMed DOI V
Darriverre,L., Fieux,F. and de la Jonquiere,C. [Acute renal failure during COVID-19 epidemic] Prat Anesth Reanim (2020) 24, 207-211. PubMed Europe PubMed DOI PMC EPMC
Dastan,F., Abedini,A., Shahabi,S., Kiani,A., Saffaei,A. and Zare,A. Sitagliptin Repositioning in SARS-CoV-2: Effects on ACE-2, CD-26, and Inflammatory Cytokine Storms in the Lung Iran J Allergy Asthma Immunol (2020) 19, 10-12. PubMed Europe PubMed DOI I
Datta,P.K., Liu,F., Fischer,T., Rappaport,J. and Qin,X. SARS-CoV-2 pandemic and research gaps: Understanding SARS-CoV-2 interaction with the ACE2 receptor and implications for therapy Theranostics (2020) 10, 7448-7464. PubMed Europe PubMed DOI PMC EPMC
de la Cruz,A., Ashraf,S., Vittorio,T.J. and Bella,J.N. COVID-19 and renin-angiotensin system modulators: what do we know so far? Expert Rev Cardiovasc Ther (2020) , 1-6. PubMed Europe PubMed DOI
de Oliveira,A.P., Lopes,A.L.F., Pacheco,G., de Sa Guimaraes Noleto,I.R., Nicolau,L.A.D. and Medeiros,J.V.R. Premises among SARS-CoV-2, dysbiosis and diarrhea: Walking through the ACE2/mTOR/autophagy route Med Hypotheses (2020) 144, 110243-110243. PubMed Europe PubMed DOI PMC EPMC
de Vries,M., Mohamed,A.S., Prescott,R.A., Valero-Jimenez,A.M., Desvignes,L., O'Connor,R., Steppan,C., Anderson,A.S., Binder,J. and Dittmann,M. Comparative study of a 3CL (pro) inhibitor and remdesivir against both major SARS-CoV-2 clades in human airway models bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC I
Dehury,B., Raina,V., Misra,N. and Suar,M. Effect of mutation on structure, function and dynamics of receptor binding domain of human SARS-CoV-2 with host cell receptor ACE2: a molecular dynamics simulations study J Biomol Struct Dyn (2020) , 1-15. PubMed Europe PubMed DOI
DeKosky,B.J. A molecular trap against COVID-19 Science (2020) 369, 1167-1168. PubMed Europe PubMed DOI
Delgado Blanco,J., Hernandez-Alias,X., Cianferoni,D. and Serrano,L. In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species PLoS Comput Biol (2020) 16, e1008450-e1008450. PubMed Europe PubMed DOI
Descamps,G., Verset,L., Trelcat,A., Hopkins,C., Lechien,J.R., Journe,F. and Saussez,S. ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection Biology (Basel) (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Devarakonda,C.K.V., Meredith,E., Ghosh,M. and Shapiro,L.H. Coronavirus Receptors as Immune Modulators J Immunol (2020) PubMed Europe PubMed DOI V
Ding,Q., Shults,N.V., Harris,B.T. and Suzuki,Y.J. Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Divani,A.A., Andalib,S., Di Napoli,M., Lattanzi,S., Hussain,M.S., Biller,J., McCullough,L.D., Azarpazhooh,M.R., Seletska,A., Mayer,S.A. and Torbey,M. Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights J Stroke Cerebrovasc Dis (2020) 29, 104941-104941. PubMed Europe PubMed DOI PMC EPMC V
Djomkam,A.L.Z., Olwal,C.O., Sala,T.B. and Paemka,L. Commentary: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Front Oncol (2020) 10, 1448-1448. PubMed Europe PubMed DOI PMC EPMC
Do-Umehara,H.C., Chen,C., Zhang,Q., Misharin,A.V., Abdala-Valencia,H., Casalino-Matsuda,S.M., Reyfman,P.A., Anekalla,K.R., Gonzalez-Gonzalez,F.J., Sala,M.A., Peng,C., Wu,P., Wong,C.C.L., Kalhan,R., Bharat,A., Perlman,H., Ridge,K.M., Sznajder,J.I., Sporn,P.H.S., Chandel,N.S., Yu,J., Fu,X., Petrache,I., Tuder,R., Budinger,G.R.S. and Liu,J. Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice Sci Adv (2020) 6, eabb7238-eabb7238. PubMed Europe PubMed DOI PMC EPMC
Dominska,K. Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V
Drew,E.D. and Janes,R.W. Identification of a druggable binding pocket in the spike protein reveals a key site for existing drugs potentially capable of combating Covid-19 infectivity BMC Mol Cell Biol (2020) 21, 49-49. PubMed Europe PubMed DOI PMC EPMC
Du,F., Liu,B. and Zhang,S. COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness J Thromb Thrombolysis (2020) PubMed Europe PubMed DOI PMC EPMC V
Du,H., Wang,D.W. and Chen,C. The potential effects of DPP-4 inhibitors on cardiovascular system in COVID-19 patients J Cell Mol Med (2020) PubMed Europe PubMed DOI
Du,X., Zeng,X., Zhang,J., Pan,K., Song,L., Zhou,J., Zhou,L., Xie,Y., Sun,Q., Ge,W., Chen,R., Zhao,J. and Kan,H. Ambient fine particulate matter induced the elevation of blood pressure through ACE2/Ang(1-7) pathway: The evidence from urine metabolites Ecotoxicol Environ Saf (2020) 203, 111044-111044. PubMed Europe PubMed DOI
Duan,F., Guo,L., Yang,L., Han,Y., Thakur,A., Nilsson-Payant,B.E., Wang,P., Zhang,Z., Ma,C.Y., Zhou,X., Han,T., Zhang,T., Wang,X., Xu,D., Duan,X., Xiang,J., Tse,H.F., Liao,C., Luo,W., Huang,F.P., Chen,Y.W., Evans,T., Schwartz,R.E., tenOever,B., Ho,D.D., Chen,S., Lian,Q. and Chen,H.J. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq (2020) PubMed Europe PubMed DOI PMC EPMC
Duan,R., Xue,X., Zhang,Q.Q., Wang,S.Y., Gong,P.Y., E,Y., Jiang,T. and Zhang,Y.D. ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice Aging (Albany NY) (2020) 12, 14819-14829. PubMed Europe PubMed DOI I
Eapen,M.S., Lu,W., Hackett,T.L., Singhera,G.K., Thompson,I.E., McAlinden,K.D., Hardikar,A., Weber,H.C., Haug,G., Wark,P.A.B., Chia,C. and Sohal,S.S. Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections Am J Physiol Lung Cell Mol Physiol (2020) PubMed Europe PubMed DOI
Eberli,F.R. and Kurz,D. Cardiovascular aspects of COVID-19 Swiss Med Wkly (2020) 150, w20417-w20417. PubMed Europe PubMed DOI V
Edmonston,D.L., South,A.M., Sparks,M.A. and Cohen,J.B. Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System Adv Chronic Kidney Dis (2020) 27, 404-411. PubMed Europe PubMed DOI PMC EPMC V
Elmorsi,R. The therapeutic potential of targeting ACE2 in COVID-19 Eur Rev Med Pharmacol Sci (2020) 24, 9744-9747. PubMed Europe PubMed DOI
Esparza,T.J., Martin,N.P., Anderson,G.P., Goldman,E.R. and Brody,D.L. High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme Sci Rep (2020) 10, 22370-22370. PubMed Europe PubMed DOI PMC EPMC
Fang,S., Zheng,R., Lei,C., Wang,J., Zheng,R. and Li,M. Key residues influencing binding affinities of 2019-nCoV with ACE2 in different species Brief Bioinform (2020) PubMed Europe PubMed DOI
Feng,Q., Li,L. and Wang,X. Identifying Pathways and Networks Associated With the SARS-CoV-2 Cell Receptor ACE2 Based on Gene Expression Profiles in Normal and SARS-CoV-2-Infected Human Tissues Front Mol Biosci (2020) 7, 568954-568954. PubMed Europe PubMed DOI PMC EPMC
Ferrandi,P.J., Alway,S.E. and Mohamed,J.S. Last Word on Viewpoint: The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies J Appl Physiol (1985) (2020) 129, 872-872. PubMed Europe PubMed DOI
Ferrandi,P.J., Alway,S.E. and Mohamed,J.S. The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies J Appl Physiol (1985) (2020) PubMed Europe PubMed DOI
Ferrario,C.M., Ahmad,S. and Groban,L. Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease Clin Sci (Lond) (2020) 134, 2645-2664. PubMed Europe PubMed DOI V
Fignani,D., Licata,G., Brusco,N., Nigi,L., Grieco,G.E., Marselli,L., Overbergh,L., Gysemans,C., Colli,M.L., Marchetti,P., Mathieu,C., Eizirik,D.L., Sebastiani,G. and Dotta,F. SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic beta-Cells and in the Human Pancreas Microvasculature Front Endocrinol (Lausanne) (2020) 11, 596898-596898. PubMed Europe PubMed DOI PMC EPMC
Foroozanfar,E., Forouzanfar,M., Farkhondeh,T., Samarghandian,S. and Forouzanfar,F. ACE2 as a potential target for management of novel coronavirus (nCoV- 2019) Curr Drug Discov Technol (2020) PubMed Europe PubMed DOI V
Forouzesh,N. and Onufriev,A.V. MMGB/SA Consensus Estimate of the Binding Free Energy Between the Novel Coronavirus Spike Protein to the Human ACE2 Receptor bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Forssen,P., Samuelsson,J., Lacki,K. and Fornstedt,T. Advanced Analysis of Biosensor Data for SARS-CoV-2 RBD and ACE2 Interactions Anal Chem (2020) 92, 11520-11524. PubMed Europe PubMed DOI PMC EPMC
Franco,R., Rivas-Santisteban,R., Serrano-Marin,J., Rodriguez-Perez,A.I., Labandeira-Garcia,J.L. and Navarro,G. SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production J Immunol (2020) PubMed Europe PubMed DOI
Franco,R., Lillo,A., Rivas-Santisteban,R., Rodriguez-Perez,A.I., Reyes-Resina,I., Labandeira-Garcia,J.L. and Navarro,G. Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Fu,J., Jia,Q., Zhou,H., Zhang,L., Wang,S., Liang,P., Lv,Y. and Han,S. Cell membrane chromatography for the analysis of the interaction between chloroquine and hydroxychloroquine with ACE2 receptors J Chromatogr B Analyt Technol Biomed Life Sci (2020) 1162, 122469-122469. PubMed Europe PubMed DOI PMC EPMC
Fuentes-Prior,P. Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection J Biol Chem (2020) PubMed Europe PubMed DOI V
Galan,M. and Jimenez-Altayo,F. Small Resistance Artery Disease and ACE2 in Hypertension: A New Paradigm in the Context of COVID-19 Front Cardiovasc Med (2020) 7, 588692-588692. PubMed Europe PubMed DOI PMC EPMC V
Galanopoulos,M., Doukatas,A. and Gazouli,M. Origin and genomic characteristics of SARS-CoV-2 and its interaction with angiotensin converting enzyme type 2 receptors, focusing on the gastrointestinal tract World J Gastroenterol (2020) 26, 6335-6345. PubMed Europe PubMed DOI PMC EPMC V
Gan,R., Rosoman,N.P., Henshaw,D.J.E., Noble,E.P., Georgius,P. and Sommerfeld,N. COVID-19 as a viral functional ACE2 deficiency disorder with ACE2 related multi-organ disease Med Hypotheses (2020) 144, 110024-110024. PubMed Europe PubMed DOI PMC EPMC V
Gao,F., Zheng,K.I., Fan,Y.C., Targher,G., Byrne,C.D. and Zheng,M.H. ACE2: A Linkage for the Interplay Between COVID-19 and Decompensated Cirrhosis Am J Gastroenterol (2020) PubMed Europe PubMed DOI PMC EPMC
Gao,L.Q., Xu,J. and Chen,S.D. In Silico Screening of Potential Chinese Herbal Medicine Against COVID-19 by Targeting SARS-CoV-2 3CLpro and Angiotensin Converting Enzyme II Using Molecular Docking Chin J Integr Med (2020) 26, 527-532. PubMed Europe PubMed DOI PMC EPMC
Gao,S., Luan,J., Cui,H. and Zhang,L. ACE2 isoform diversity predicts the host susceptibility of SARS-CoV-2 Transbound Emerg Dis (2020) PubMed Europe PubMed DOI PMC EPMC
Gao,S. and Zhang,L. ACE2 partially dictates the host range and tropism of SARS-CoV-2 Comput Struct Biotechnol J (2020) 18, 4040-4047. PubMed Europe PubMed DOI PMC EPMC V
Gaunkar,R.B., Nagarsekar,A., Carvalho,K.M., Jodalli,P.S. and Mascarenhas,K. COVID-19 in Smokeless Tobacco Habitues: Increased Susceptibility and Transmission Cureus (2020) 12, e8824-e8824. PubMed Europe PubMed DOI PMC EPMC
Ge,J., Zhang,S., Zhang,L. and Wang,X. Structural basis of severe acute respiratory syndrome coronavirus 2 infection Curr Opin HIV AIDS (2020) PubMed Europe PubMed DOI V
Ghahestani,S.M., Mahmoudi,J., Hajebrahimi,S., Sioofy-Khojine,A.B., Salehi-Pourmehr,H., Sadeghi-Ghyassi,F. and Mostafaei,H. Bradykinin as a Probable Aspect in SARS-Cov-2 Scenarios: Is Bradykinin Sneaking out of Our Sight? Iran J Allergy Asthma Immunol (2020) 19, 13-17. PubMed Europe PubMed DOI
Gheblawi,M., Wang,K., Viveiros,A., Nguyen,Q., Zhong,J.C., Turner,A.J., Raizada,M.K., Grant,M.B. and Oudit,G.Y. Response by Gheblawi et al to Letter Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2" Circ Res (2020) 127, e46-e46. PubMed Europe PubMed DOI
Ghorbani,M., Brooks,B.R. and Klauda,J.B. Critical Sequence Hot-spots for Binding of nCOV-2019 to ACE2 as Evaluated by Molecular Simulations bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Gil-Moles,M., Basu,U., Bussing,R., Hoffmeister,H., Turck,S., Varchmin,A. and Ott,I. Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike-ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics Chemistry (2020) PubMed Europe PubMed DOI I
Gilbert,R.E., Caldwell,L., Misra,P.S., Chan,K., Burns,K.D., Wrana,J.L. and Yuen,D.A. Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019 Can J Diabetes (2020) PubMed Europe PubMed DOI PMC EPMC
Gilzad-Kohan,H. and Jamali,F. Anti-Inflammatory Properties of Drugs Used to Control COVID-19 and their Effects on the Renin-Angiotensin System and Angiotensin-Converting Enzyme-2 J Pharm Pharm Sci (2020) 23, 259-277. PubMed Europe PubMed DOI V I
Glasgow,A., Glasgow,J., Limonta,D., Solomon,P., Lui,I., Zhang,Y., Nix,M.A., Rettko,N.J., Lim,S.A., Zha,S., Yamin,R., Kao,K., Rosenberg,O.S., Ravetch,J.V., Wiita,A.P., Leung,K.K., Zhou,X.X., Hobman,T.C., Kortemme,T. and Wells,J.A. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Golden,J.W., Cline,C.R., Zeng,X., Garrison,A.R., Carey,B.D., Mucker,E.M., White,L.E., Shamblin,J.D., Brocato,R.L., Liu,J., Babka,A.M., Rauch,H.B., Smith,J.M., Hollidge,B.S., Fitzpatrick,C., Badger,C.V. and Hooper,J.W. Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease JCI Insight (2020) PubMed Europe PubMed DOI
Gollapalli,P., B S,S., Rimac,H., Patil,P., Nalilu,S.K., Kandagalla,S. and Shetty,P. Pathway enrichment analysis of virus-host interactome and prioritization of novel compounds targeting the spike glycoprotein receptor binding domain-human angiotensin-converting enzyme 2 interface to combat SARS-CoV-2 J Biomol Struct Dyn (2020) , 1-14. PubMed Europe PubMed DOI PMC EPMC
Gomez,J., Albaiceta,G.M., Garcia-Clemente,M., Lopez-Larrea,C., Amado-Rodriguez,L., Lopez-Alonso,I., Hermida,T., Enriquez,A.I., Herrero,P., Melon,S., Alvarez-Arguelles,M.E., Boga,J.A., Rojo-Alba,S., Cuesta-Llavona,E., Alvarez,V., Lorca,R. and Coto,E. Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome Gene (2020) 762, 145102-145102. PubMed Europe PubMed DOI PMC EPMC
Gopinath,K., Jokinen,E.M., Kurkinen,S.T. and Pentikainen,O.T. Screening of Natural Products Targeting SARS-CoV-2-ACE2 Receptor Interface - A MixMD Based HTVS Pipeline Front Chem (2020) 8, 589769-589769. PubMed Europe PubMed DOI PMC EPMC
Gorshkov,K., Susumu,K., Chen,J., Xu,M., Pradhan,M., Zhu,W., Hu,X., Breger,J.C., Wolak,M. and Oh,E. Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Angiotensin Converting Enzyme 2 Binding and Endocytosis ACS Nano (2020) 14, 12234-12247. PubMed Europe PubMed DOI
Grajewski,R.S., Rokohl,A.C., Becker,M., Paulsen,F. and Heindl,L.M. Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases Ann Anat (2020) 234, 151661-151661. PubMed Europe PubMed DOI
Gregoriou,G.C., Patel,S.D., Winters,B.L. and Bagley,E.E. Neprilysin controls the synaptic activity of neuropeptides in the intercalated cells of the amygdala Mol Pharmacol (2020) PubMed Europe PubMed DOI I
Groban,L., Wang,H., Sun,X., Ahmad,S. and Ferrario,C.M. Is Sex a Determinant of COVID-19 Infection? Truth or Myth? Curr Hypertens Rep (2020) 22, 62-62. PubMed Europe PubMed DOI PMC EPMC V
Gross,L.Z.F., Sacerdoti,M., Piiper,A., Zeuzem,S., Leroux,A.E. and Biondi,R.M. ACE2, the Receptor that Enables Infection by SARS-CoV-2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators ChemMedChem (2020) PubMed Europe PubMed DOI PMC EPMC V
Grover,A. and Oberoi,M. A systematic review and meta-analysis to evaluate the clinical outcomes in COVID-19 patients on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers Eur Heart J Cardiovasc Pharmacother (2020) PubMed Europe PubMed DOI PMC EPMC
Gue,Y.X., Kanji,R., Markides,V. and Gorog,D.A. Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19 Am J Cardiol (2020) 130, 161-162. PubMed Europe PubMed DOI PMC EPMC
Gue,Y.X. and Gorog,D.A. Reduction in ACE2 may mediate the prothrombotic phenotype in COVID-19 Eur Heart J (2020) PubMed Europe PubMed DOI
Gue,Y.X., Kanji,R., Markides,V. and Gorog,D.A. Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19 Am J Cardiol (2020) 130, 161-162. PubMed Europe PubMed DOI PMC EPMC
Gul,R., Uh-Hyun,K. and Alfadda,A.A. Renin angiotensin system at the interface of COVID-19 infection Eur J Pharmacol (2020) , 173656-173656. PubMed Europe PubMed DOI PMC EPMC
Guler,N., Siddiqui,F. and Fareed,J. Is the Reason of Increased D-Dimer Levels in COVID-19 Because of ACE-2-Induced Apoptosis in Endothelium? Clin Appl Thromb Hemost (2020) 26, 1076029620935526-1076029620935526. PubMed Europe PubMed DOI PMC EPMC
Gumashta,J. and Gumashta,R. Role of the Backbenchers of the Renin-Angiotensin System ACE2 and AT2 Receptors in COVID-19: Lessons From SARS Cureus (2020) 12, e8411-e8411. PubMed Europe PubMed DOI PMC EPMC V
Guo,L., Bi,W., Wang,X., Xu,W., Yan,R., Zhang,Y., Zhao,K., Li,Y., Zhang,M., Cai,X., Jiang,S., Xie,Y., Zhou,Q., Lu,L. and Dang,B. Engineered trimeric ACE2 binds viral spike protein and locks it in "Three-up" conformation to potently inhibit SARS-CoV-2 infection Cell Res (2020) PubMed Europe PubMed DOI PMC EPMC
Guo,X., Chen,Z., Xia,Y., Lin,W. and Li,H. Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2) J Transl Med (2020) 18, 321-321. PubMed Europe PubMed DOI PMC EPMC
Gupta,R., Meena,K., Patnaik,I. and Kumar,A. ACE2 Expression in the Pancreas and Association With COVID-19 Infection Pancreas (2020) PubMed Europe PubMed DOI
Hadi-Alijanvand,H. and Rouhani,M. Studying the Effects of ACE2 Mutations on the Stability, Dynamics, and Dissociation Process of SARS-CoV-2 S1/hACE2 Complexes J Proteome Res (2020) PubMed Europe PubMed DOI
Haghighi,M.M., Kakhki,E.G., Sato,C., Ghani,M. and Rogaeva,E. The Intersection between COVID-19, the Gene Family of ACE2 and Alzheimer's Disease Neurosci Insights (2020) 15, 2633105520975743-2633105520975743. PubMed Europe PubMed DOI PMC EPMC
Hakmi,M., Bouricha,E.L.M., Akachar,J., Lmimouni,B., El Harti,J., Belyamani,L. and Ibrahimi,A. In silico exploration of small-molecule alpha-helix mimetics as inhibitors of SARS-COV-2 attachment to ACE2 J Biomol Struct Dyn (2020) , 1-12. PubMed Europe PubMed DOI
Hallaj,S., Ghorbani,A., Mousavi-Aghdas,S.A., Mirza-Aghazadeh-Attari,M., Sevbitov,A., Hashemi,V., Hallaj,T. and Jadidi-Niaragh,F. Angiotensin-Converting Enzyme as a new immunologic target for the new SARS-CoV-2 Immunol Cell Biol (2020) PubMed Europe PubMed DOI
Han,T., Kang,J., Li,G., Ge,J. and Gu,J. Analysis of 2019-nCoV receptor ACE2 expression in different tissues and its significance study Ann Transl Med (2020) 8, 1077-1077. PubMed Europe PubMed DOI PMC EPMC
Hanrahan,T.P., Lubel,J.S. and Garg,M. Letter to the Editor: Lessons from COVID-19, ACE2 and intestinal inflammation - could a virus trigger chronic intestinal inflammation? Clin Gastroenterol Hepatol (2020) PubMed Europe PubMed DOI PMC EPMC
Hanson,Q.M., Wilson,K.M., Shen,M., Itkin,Z., Eastman,R.T., Shinn,P. and Hall,M.D. Targeting ACE2-RBD Interaction as a Platform for COVID-19 Therapeutics: Development and Drug-Repurposing Screen of an AlphaLISA Proximity Assay ACS Pharmacol Transl Sci (2020) 3, 1352-1360. PubMed Europe PubMed DOI PMC EPMC
Hardenberg,J.B. and Luft,F.C. Covid-19, ACE2 and the kidney Acta Physiol (Oxf) (2020) 230, e13539-e13539. PubMed Europe PubMed DOI PMC EPMC
Hassan,S.S., Ghosh,S., Attrish,D., Choudhury,P.P., Aljabali,A.A.A., Uhal,B.D., Lundstrom,K., Rezaei,N., Uversky,V.N., Seyran,M., Pizzol,D., Adadi,P., Soares,A., El-Aziz,T.M.A., Kandimalla,R., Tambuwala,M.M., Azad,G.K., Sherchan,S.P., Baetas-da-Cruz,W., Takayama,K., Serrano-Aroca,A., Chauhan,G., Palu,G. and Brufsky,A.M. Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC
Hassert,M., Geerling,E., Stone,E.T., Steffen,T.L., Dickson,A., Feldman,M.S., Class,J., Richner,J.M., Brien,J.D. and Pinto,A.K. mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC M
Hassert,M., Geerling,E., Stone,E.T., Steffen,T.L., Feldman,M.S., Dickson,A.L., Class,J., Richner,J.M., Brien,J.D. and Pinto,A.K. mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2 PLoS Pathog (2020) 16, e1009163-e1009163. PubMed Europe PubMed DOI
Hati,S. and Bhattacharyya,S. Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin-Converting Enzyme 2 Receptor ACS Omega (2020) 5, 16292-16298. PubMed Europe PubMed DOI PMC EPMC
Hatmal,M.M., Alshaer,W., Al-Hatamleh,M.A.I., Hatmal,M., Smadi,O., Taha,M.O., Oweida,A.J., Boer,J.C., Mohamud,R. and Plebanski,M. Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2 Cells (2020) 9 PubMed Europe PubMed DOI PMC EPMC V
Hattori,T., Koide,A., Panchenko,T., Romero,L.A., Teng,K.W., Tada,T., Landau,N.R. and Koide,S. The ACE2-binding interface of SARS-CoV-2 Spike inherently deflects immune recognition bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Hattori,T., Koide,A., Noval,M.G., Panchenko,T., Romero,L.A., Teng,K.W., Tada,T., Landau,N.R., Stapleford,K.A. and Koide,S. The ACE2-binding Interface of SARS-CoV-2 Spike Inherently Deflects Immune Recognition J Mol Biol (2020) 433, 166748-166748. PubMed Europe PubMed DOI
He,Q., Mok,T.N., Yun,L., He,C., Li,J. and Pan,J. Single-cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: A potential pathway of COVID-19 infection Mol Genet Genomic Med (2020) , e1442-e1442. PubMed Europe PubMed DOI PMC EPMC
Heegaard,P.M.H., Sturek,M., Alloosh,M. and Belsham,G.J. Animal Models for COVID-19: More to the Picture Than ACE2, Rodents, Ferrets, and Non-human Primates. A Case for Porcine Respiratory Coronavirus and the Obese Ossabaw Pig Front Microbiol (2020) 11, 573756-573756. PubMed Europe PubMed DOI PMC EPMC
Hennighausen,L. and Lee,H.K. Activation of the SARS-CoV-2 Receptor Ace2 by Cytokines Through Pan JAK-STAT Enhancers SSRN (2020) , 3601827-3601827. PubMed Europe PubMed DOI PMC EPMC
Hikmet,F., Mear,L., Edvinsson,A., Micke,P., Uhlen,M. and Lindskog,C. The protein expression profile of ACE2 in human tissues Mol Syst Biol (2020) 16, e9610-e9610. PubMed Europe PubMed DOI PMC EPMC
Hoevenaar,M., Goossens,D. and Roorda,J. Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads J Renin Angiotensin Aldosterone Syst (2020) 21, 1470320320979097-1470320320979097. PubMed Europe PubMed DOI PMC EPMC V
Huang,H., Wang,J., Liu,Z. and Gao,F. The angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation Arch Biochem Biophys (2020) 693, 108562-108562. PubMed Europe PubMed DOI I
Huang,H.H., Wang,P.H., Yang,Y.P., Chou,S.J., Chu,P.W., Wu,G.J. and Chang,C.C. A review of severe acute respiratory syndrome coronavirus 2 infection in the reproductive system J Chin Med Assoc (2020) 83, 895-897. PubMed Europe PubMed DOI PMC EPMC
Huang,K.Y., Lin,M.S., Kuo,T.C., Chen,C.L., Lin,C.C., Chou,Y.C., Chao,T.L., Pang,Y.H., Kao,H.C., Huang,R.S., Lin,S., Chang,S.Y. and Yang,P.C. Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection EMBO Mol Med (2020) , e12828-e12828. PubMed Europe PubMed DOI
Huang,S.W., Miller,S.O., Yen,C.H. and Wang,S.F. Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation Genes (Basel) (2020) 12 PubMed Europe PubMed DOI PMC EPMC
Huang,X., Pearce,R. and Zhang,Y. De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2 Aging (Albany NY) (2020) 12, 11263-11276. PubMed Europe PubMed DOI PMC EPMC
Huang,X., Zhang,C., Pearce,R., Omenn,G.S. and Zhang,Y. Identifying the Zoonotic Origin of SARS-CoV-2 by Modeling the Binding Affinity between the Spike Receptor-Binding Domain and Host ACE2 J Proteome Res (2020) PubMed Europe PubMed DOI
Huh,T., Larouche-Lebel,E., Loughran,K.A. and Oyama,M.A. Effect of angiotensin receptor blockers and angiotensin-converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in cats with heart disease J Vet Intern Med (2020) PubMed Europe PubMed DOI
Huo,J., Le Bas,A., Ruza,R.R., Duyvesteyn,H.M.E., Mikolajek,H., Malinauskas,T., Tan,T.K., Rijal,P., Dumoux,M., Ward,P.N., Ren,J., Zhou,D., Harrison,P.J., Weckener,M., Clare,D.K., Vogirala,V.K., Radecke,J., Moynie,L., Zhao,Y., Gilbert-Jaramillo,J., Knight,M.L., Tree,J.A., Buttigieg,K.R., Coombes,N., Elmore,M.J., Carroll,M.W., Carrique,L., Shah,P.N.M., James,W., Townsend,A.R., Stuart,D.I., Owens,R.J. and Naismith,J.H. Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 Nat Struct Mol Biol (2020) PubMed Europe PubMed DOI
Hussien,M.A. and Abdelaziz,A.E.M. Molecular docking suggests repurposing of brincidofovir as a potential drug targeting SARS-CoV-2 ACE2 receptor and main protease Netw Model Anal Health Inform Bioinform (2020) 9, 56-56. PubMed Europe PubMed DOI PMC EPMC
Inal,J.M. Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy Clin Sci (Lond) (2020) 134, 1301-1304. PubMed Europe PubMed DOI PMC EPMC
Ionescu,M.I. An Overview of the Crystallized Structures of the SARS-CoV-2 Protein J (2020) PubMed Europe PubMed DOI PMC EPMC
Iwasaki,M., Saito,J., Zhao,H., Sakamoto,A., Hirota,K. and Ma,D. Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications Inflammation (2020) PubMed Europe PubMed DOI PMC EPMC V
Jacobs,M., Van Eeckhoutte,H.P., Wijnant,S.R.A., Janssens,W., Joos,G.F., Brusselle,G.G. and Bracke,K.R. Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjects Eur Respir J (2020) PubMed Europe PubMed DOI PMC EPMC
Ji,X., Tan,W., Zhang,C., Zhai,Y., Hsueh,Y., Zhang,Z., Zhang,C., Lu,Y., Duan,B., Tan,G., Na,R., Deng,G. and Niu,G. TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2 Drug Dev Res (2020) PubMed Europe PubMed DOI PMC EPMC
Jia,H., Neptune,E. and Cui,H. Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges Am J Respir Cell Mol Biol (2020) PubMed Europe PubMed DOI V
Jiang,X., Eales,J.M., Scannali,D., Nazgiewicz,A., Prestes,P., Maier,M., Denniff,M., Xu,X., Saluja,S., Cano-Gamez,E., Wystrychowski,W., Szulinska,M., Antczak,A., Byars,S., Skrypnik,D., Glyda,M., Krol,R., Zywiec,J., Zukowska-Szczechowska,E., Burrell,L.M., Woolf,A.S., Greenstein,A., Bogdanski,P., Keavney,B., Morris,A.P., Heagerty,A., Williams,B., Harrap,S.B., Trynka,G., Samani,N.J., Guzik,T.J., Charchar,F.J. and Tomaszewski,M. Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney Eur Heart J (2020) PubMed Europe PubMed DOI PMC EPMC
Jiang,Y.P., Zhao,X.X., Lv,H.Q. and Wen,C.P. Drug screening and development from the affinity of S protein of new coronavirus with ACE2 Eur J Clin Microbiol Infect Dis (2020) PubMed Europe PubMed DOI PMC EPMC
Jing,H., Ackerman,W.E., Zhao,G., El Helou,Y., Buhimschi,C.S. and Buhimschi,I.A. Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis - Potential roles of placental ACE2 and ENDOU Placenta (2020) 104, 16-19. PubMed Europe PubMed DOI PMC EPMC
Kalhor,H., Sadeghi,S., Abolhasani,H., Kalhor,R. and Rahimi,H. Repurposing of the approved small molecule drugs in order to inhibit SARS-CoV-2 S protein and human ACE2 interaction through virtual screening approaches J Biomol Struct Dyn (2020) , 1-16. PubMed Europe PubMed DOI PMC EPMC
Kalra,R.S., Tomar,D., Meena,A.S. and Kandimalla,R. SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings Pathogens (2020) 9 PubMed Europe PubMed DOI V
Kashour,T., Bin Abdulhak,A.A., Tlayjeh,H., Hassett,L.C., Noman,A., Mohsen,A., Al-Mallah,M.H. and Tleyjeh,I.M. Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Mortality Among COVID-19 Patients: A Systematic Review and Meta-Analysis Am J Ther (2020) PubMed Europe PubMed DOI
Kenarkoohi,A., Maleki,M., Safari,T., Kafashian,M., Saljoughi,F. and Sohrabipour,S. Angiotensin-converting Enzyme 2 roles in the Pathogenesis of COVID-19 Curr Hypertens Rev (2020) PubMed Europe PubMed DOI
Kerslake,R., Hall,M., Randeva,H.S., Spandidos,D.A., Chatha,K., Kyrou,I. and Karteris,E. Coexpression of peripheral olfactory receptors with SARSCoV2 infection mediators: Potential implications beyond loss of smell as a COVID19 symptom Int J Mol Med (2020) 46, 949-956. PubMed Europe PubMed DOI PMC EPMC
Khanna,K., Raymond,W., Charbit,A.R., Jin,J., Gitlin,I., Tang,M., Sperber,H.S., Franz,S., Pillai,S., Simmons,G. and Fahy,J.V. Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Khayat,A.S., de Assumpcao,P.P., Meireles Khayat,B.C., Thomaz Araujo,T.M., Batista-Gomes,J.A., Imbiriba,L.C., Ishak,G., de Assumpcao,P.B., Moreira,F.C., Burbano,R.R., Ribeiro-Dos-Santos,A., Ribeiro-Dos-Santos,A.K., Dos Santos,N.P.C. and Dos Santos,S.E.B. ACE2 polymorphisms as potential players in COVID-19 outcome PLoS ONE (2020) 15, e0243887-e0243887. PubMed Europe PubMed DOI PMC EPMC
Khelfaoui,H., Harkati,D. and Saleh,B.A. Molecular docking, molecular dynamics simulations and reactivity, studies on approved drugs library targeting ACE2 and SARS-CoV-2 binding with ACE2 J Biomol Struct Dyn (2020) , 1-17. PubMed Europe PubMed DOI
Kim,J., Mukherjee,A., Nelson,D., Jozic,A. and Sahay,G. Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Kim,K., Ko,Y., Ko,D.S. and Kim,Y.H. Prognostic Significance of COVID-19 Receptor ACE2 and Recommendation for Antihypertensive Drug in Renal Cell Carcinoma Biomed Res Int (2020) 2020, 2054376-2054376. PubMed Europe PubMed DOI PMC EPMC
Kintscher,U., Slagman,A., Domenig,O., Rohle,R., Konietschke,F., Poglitsch,M. and Mockel,M. Plasma Angiotensin Peptide Profiling and ACE2-Activity in COVID-19 Patients treated with Pharmacological Blockers of the Renin Angiotensin System Hypertension (2020) PubMed Europe PubMed DOI
Kipshidze,N., Dangas,G., White,C.J., Kipshidze,N., Siddiqui,F., Lattimer,C.R., Carter,C.A. and Fareed,J. Viral Coagulopathy in Patients With COVID-19: Treatment and Care Clin Appl Thromb Hemost (2020) 26, 1076029620936776-1076029620936776. PubMed Europe PubMed DOI
Kishk,S.M., Kishk,R.M., Yassen,A.S.A., Nafie,M.S., Nemr,N.A., ElMasry,G., Al-Rejaie,S. and Simons,C. Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC I
Klhufek,J. The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero? Acta Clin Belg (2020) , 1-8. PubMed Europe PubMed DOI
Kornilov,S.A., Lucas,I., Jade,K., Dai,C.L., Lovejoy,J.C. and Magis,A.T. Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19 Crit Care (2020) 24, 452-452. PubMed Europe PubMed DOI PMC EPMC
Kumar,A., Panwar,A., Batra,K., Dey,S. and Maan,S. In-silico analysis of angiotensin converting enzyme 2 (ACE2) of livestock, pet and poultry animals to determine its susceptibility to SARS-CoV- 2 infection Comb Chem High Throughput Screen (2020) PubMed Europe PubMed DOI
Kumar,A., Narayan,R.K., Kumari,C., Faiq,M.A., Kulandhasamy,M., Kant,K. and Pareek,V. SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients Med Hypotheses (2020) 145, 110320-110320. PubMed Europe PubMed DOI PMC EPMC
Kumar,A., Pandey,S.N., Pareek,V., Narayan,R.K., Faiq,M.A. and Kumari,C. Predicting susceptibility for SARS-CoV-2 infection in domestic and wildlife animals using ACE2 protein sequence homology Zoo Biol (2020) PubMed Europe PubMed DOI
Kumar,A., Faiq,M.A., Pareek,V., Raza,K., Narayan,R.K., Prasoon,P., Kumar,P., Kulandhasamy,M., Kumari,C., Kant,K., Singh,H.N., Qadri,R., Pandey,S.N. and Kumar,S. Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients Med Hypotheses (2020) 144, 110271-110271. PubMed Europe PubMed DOI PMC EPMC
Kumar,P., Sah,A.K., Tripathi,G., Kashyap,A., Tripathi,A., Rao,R., Mishra,P.C., Mallick,K., Husain,A. and Kashyap,M.K. Role of ACE2 receptor and the landscape of treatment options from convalescent plasma therapy to the drug repurposing in COVID-19 Mol Cell Biochem (2020) PubMed Europe PubMed DOI PMC EPMC V I
Kurbel,S. The renin-angiotensin system in COVID-19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients? Bioessays (2020) , e2000112-e2000112. PubMed Europe PubMed DOI
Lai,Y.J., Chang,C.M., Lin,C.K., Yang,Y.P., Chien,C.S., Wang,P.H. and Chang,C.C. Severe acute respiratory syndrome coronavirus-2 and the deduction effect of angiotensin-converting enzyme 2 in pregnancy J Chin Med Assoc (2020) 83, 812-816. PubMed Europe PubMed DOI PMC EPMC
Lam,S.D., Bordin,N., Waman,V.P., Scholes,H.M., Ashford,P., Sen,N., van Dorp,L., Rauer,C., Dawson,N.L., Pang,C.S.M., Abbasian,M., Sillitoe,I., Edwards,S.J.L., Fraternali,F., Lees,J.G., Santini,J.M. and Orengo,C.A. SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals Sci Rep (2020) 10, 16471-16471. PubMed Europe PubMed DOI PMC EPMC
Laurini,E., Marson,D., Aulic,S., Fermeglia,M. and Pricl,S. Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Complex ACS Nano (2020) 14, 11821-11830. PubMed Europe PubMed DOI PMC EPMC
Lazartigues,E., Qadir,M.M.F. and Mauvais-Jarvis,F. Endocrine significance of SARS-CoV-2's reliance on ACE2 Endocrinology (2020) PubMed Europe PubMed DOI
Lee,A.C., Chakladar,J., Li,W.T., Chen,C., Chang,E.Y., Wang-Rodriguez,J. and Ongkeko,W.M. Tobacco, but Not Nicotine and Flavor-Less Electronic Cigarettes, Induces ACE2 and Immune Dysregulation Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI
Lee,H.K., Jung,O. and Hennighausen,L. Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors Res Sq (2020) PubMed Europe PubMed DOI PMC EPMC
Lee,I.H., Lee,J.W. and Kong,S.W. A survey of genetic variants in SARS-CoV-2 interacting domains of ACE2, TMPRSS2 and TLR3/7/8 across populations Infect Genet Evol (2020) 85, 104507-104507. PubMed Europe PubMed DOI PMC EPMC
Lee,I.T., Nakayama,T., Wu,C.T., Goltsev,Y., Jiang,S., Gall,P.A., Liao,C.K., Shih,L.C., Schurch,C.M., McIlwain,D.R., Chu,P., Borchard,N.A., Zarabanda,D., Dholakia,S.S., Yang,A., Kim,D., Chen,H., Kanie,T., Lin,C.D., Tsai,M.H., Phillips,K.M., Kim,R., Overdevest,J.B., Tyler,M.A., Yan,C.H., Lin,C.F., Lin,Y.T., Bau,D.T., Tsay,G.J., Patel,Z.M., Tsou,Y.A., Tzankov,A., Matter,M.S., Tai,C.J., Yeh,T.H., Hwang,P.H., Nolan,G.P., Nayak,J.V. and Jackson,P.K. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs Nat Commun (2020) 11, 5453-5453. PubMed Europe PubMed DOI PMC EPMC
Lee,J.J., Kopetz,S., Vilar,E., Shen,J.P., Chen,K. and Maitra,A. Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract Genes (Basel) (2020) 11 PubMed Europe PubMed DOI PMC EPMC
Lee,S.H., Jee,S.W., Hwang,D.Y. and Kang,J.K. Characterization of changes in global gene expression in the hearts and kidneys of transgenic mice overexpressing human angiotensin-converting enzyme 2 Lab Anim Res (2020) 36, 23-23. PubMed Europe PubMed DOI PMC EPMC I
Lehrer,S. and Rheinstein,P.H. Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2 In Vivo (2020) 34, 3023-3026. PubMed Europe PubMed DOI
Lei,Y., Zhang,J., Schiavon,C.R., He,M., Chen,L., Shen,H., Zhang,Y., Yin,Q., Cho,Y., Andrade,L., Shadel,G.S., Hepokoski,M., Lei,T., Wang,H., Zhang,J., Yuan,J.X., Malhotra,A., Manor,U., Wang,S., Yuan,Z.Y. and Shyy,J.Y. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Leow,M.K.S. Clarifying the controversial risk-benefit profile of soluble ACE2 in COVID-19 Crit Care (2020) 24, 396-396. PubMed Europe PubMed DOI PMC EPMC
Leung,C. and Wong,A.P. The role of angiotensin-converting enzyme 2 (ACE2) receptor in the intestine in COVID-19: more research needed Gastroenterol Hepatol Bed Bench (2020) 13, 280-281. PubMed Europe PubMed PMC EPMC
Li,F.F., Zhang,Q., Wang,G.Y. and Liu,S.L. Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses Aging (Albany NY) (2020) 12, 20938-20945. PubMed Europe PubMed DOI
Li,H., Xie,L., Chen,L., Zhang,L., Han,Y., Yan,Z. and Guo,X. Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer Aging (Albany NY) (2020) 12, 22370-22389. PubMed Europe PubMed DOI
Li,J., Ma,X., Guo,S., Hou,C., Shi,L., Zhang,H., Zheng,B., Liao,C., Yang,L., Ye,L. and He,X. A Hydrophobic-Interaction-Based Mechanism Triggers Docking between the SARS-CoV-2 Spike and Angiotensin-Converting Enzyme 2 Glob Chall (2020) , 2000067-2000067. PubMed Europe PubMed DOI PMC EPMC
Li,J., Stevens,B.R., Richards,E.M. and Raizada,M.K. SARS-CoV-2 Receptor ACE2 (Angiotensin-Converting Enzyme 2) Is Upregulated in Colonic Organoids From Hypertensive Rats Hypertension (2020) 76, e26-e26. PubMed Europe PubMed DOI PMC EPMC
Li,Y., Xu,Q., Ma,L., Wu,D., Gao,J., Chen,G. and Li,H. Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2 J Cell Mol Med (2020) PubMed Europe PubMed DOI PMC EPMC
Li,Y., Xu,Q., Ma,L., Wu,D., Gao,J., Chen,G. and Li,H. Systematic profiling of ACE2 expression in diverse physiological and pathological conditions for COVID-19/SARS-CoV-2 J Cell Mol Med (2020) PubMed Europe PubMed DOI PMC EPMC
Li,Y., Wang,H., Tang,X., Fang,S., Ma,D., Du,C., Wang,Y., Pan,H., Yao,W., Zhang,R., Zou,X., Zheng,J., Xu,L., Farzan,M. and Zhong,G. SARS-CoV-2 and three related coronaviruses utilize multiple ACE2 orthologs and are potently blocked by an improved ACE2-Ig J Virol (2020) PubMed Europe PubMed DOI
Li,Z., Li,X., Shen,J., Tan,H., Rong,T., Lin,Y., Feng,E., Chen,Z., Jiao,Y., Liu,G., Zhang,L., Vai Chan,M.T. and Kei Wu,W.K. Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury Brief Bioinform (2020) PubMed Europe PubMed DOI
Li,Z., Xu,X., Yang,M., Feng,J., Liu,C. and Yang,C. Role of angiotensin-converting enzyme 2 in neurodegenerative diseases during the COVID-19 pandemic Aging (Albany NY) (2020) 12 PubMed Europe PubMed DOI V
Liao,W. and Wu,J. The ACE2/Ang (1-7)/MasR axis as an emerging target for antihypertensive peptides Crit Rev Food Sci Nutr (2020) , 1-15. PubMed Europe PubMed DOI
Lim,H., Baek,A., Kim,J., Kim,M.S., Liu,J., Nam,K.Y., Yoon,J. and No,K.T. Hot spot profiles of SARS-CoV-2 and human ACE2 receptor protein protein interaction obtained by density functional tight binding fragment molecular orbital method Sci Rep (2020) 10, 16862-16862. PubMed Europe PubMed DOI PMC EPMC
Lim,K.H., Yang,S., Kim,S.H. and Joo,J.Y. Elevation of ACE2 as a SARS-CoV-2 entry receptor gene expression in Alzheimer's disease J Infect (2020) 81, e33-e33. PubMed Europe PubMed DOI
Lin,H.B. and Liu,P.P. COVID-19 and the Heart: ACE2 Level is Not Destiny, But the Company It Keeps May Hold the Fate JACC Basic Transl Sci (2020) PubMed Europe PubMed DOI PMC EPMC
Linsky,T.W., Vergara,R., Codina,N., Nelson,J.W., Walker,M.J., Su,W., Hsiang,T.Y., Esser-Nobis,K., Yu,K., Hou,Y.J., Priya,T., Mitsumoto,M., Pong,A., Lau,U.Y., Mason,M.L., Chen,J., Chen,A., Berrocal,T., Peng,H., Clairmont,N.S., Castellanos,J., Lin,Y.R., Josephson-Day,A., Baric,R., Walkey,C.D., Swanson,R., Gale,M., Blancas-Mejia,L.M., Yen,H.L. and Silva,D.A. De novo design of ACE2 protein decoys to neutralize SARS-CoV-2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Lippi,G., Lavie,C.J., Henry,B.M. and Sanchis-Gomar,F. Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)? Clin Chem Lab Med (2020) PubMed Europe PubMed DOI
Liu,H., Gai,S., Wang,X., Zeng,J., Sun,C., Zhao,Y. and Zheng,Z. Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart Cardiovasc Res (2020) 116, 1733-1741. PubMed Europe PubMed DOI
Liu,J., Chen,G.Q., Wei,L. and Jiao,F.Y. [A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019] Zhongguo Dang Dai Er Ke Za Zhi (2020) 22, 1344-1348. PubMed Europe PubMed PMC EPMC
Liu,X., Raghuvanshi,R., Ceylan,F.D. and Bolling,B.W. Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity J Agric Food Chem (2020) PubMed Europe PubMed DOI I
Liu,Y., Qu,H.Q., Qu,J., Tian,L. and Hakonarson,H. Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract Viruses (2020) 12 PubMed Europe PubMed DOI PMC EPMC
Lopes,L.R., de Mattos Cardillo,G. and Paiva,P.B. Molecular evolution and phylogenetic analysis of SARS-CoV-2 and hosts ACE2 protein suggest Malayan pangolin as intermediary host Braz J Microbiol (2020) PubMed Europe PubMed DOI PMC EPMC
Lores,E., Wysocki,J. and Batlle,D. ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery Clin Sci (Lond) (2020) 134, 2791-2805. PubMed Europe PubMed DOI V
Lou,L.L., Xie,L., Hu,Y., Chen,L.N., Liang,P., Shi,F., Liu,C.J. and Liu,H.M. [Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice] Zhongguo Dang Dai Er Ke Za Zhi (2020) 22, 1119-1124. PubMed Europe PubMed PMC EPMC
Low-Gan,J., Huang,R., Warner,G., Kelley,A., McGregor,D. and Smider,V. Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Lozano-Gonzalez,K., Padilla-Rodriguez,E., Texis,T., Gutierrez,M.N., Rodriguez-Dorantes,M., Cuevas-Cordoba,B., Ramirez-Garcia,E., Mino-Leon,D., Sanchez-Garcia,S. and Gonzalez-Covarrubias,V. Allele Frequency of ACE2 Intron Variants and Its Association with Blood Pressure DNA Cell Biol (2020) PubMed Europe PubMed DOI
Lu,D., Chatterjee,S., Xiao,K., Riedel,I., Wang,Y., Foo,R., Bar,C. and Thum,T. MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes J Mol Cell Cardiol (2020) 148, 46-49. PubMed Europe PubMed DOI PMC EPMC
Lu,J. and Sun,P.D. High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Lu,J. and Sun,P.D. High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity J Biol Chem (2020) PubMed Europe PubMed DOI
Lu,J., Hou,Y., Ge,S., Wang,X., Wang,J., Hu,T., Lv,Y., He,H. and Wang,C. Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro Life Sci (2020) 266, 118889-118889. PubMed Europe PubMed DOI
Lu,L., Liu,X., Jin,R., Guan,R., Lin,R. and Qu,Z. Potential Roles of the Renin-Angiotensin System in the Pathogenesis and Treatment of COVID-19 Biomed Res Int (2020) 2020, 7520746-7520746. PubMed Europe PubMed DOI PMC EPMC V
Lu,M., Qiu,L., Jia,G., Guo,R. and Leng,Q. Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2 Aging (Albany NY) (2020) 12, 19880-19897. PubMed Europe PubMed DOI
Luo,J., Lu,S., Yu,M., Zhu,L., Zhu,C., Li,C., Fang,J., Zhu,X. and Wang,X. The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2 Gene (2020) , 145325-145325. PubMed Europe PubMed DOI PMC EPMC
Lupi,L., Adamo,M., Inciardi,R.M. and Metra,M. ACE2 down-regulation may contribute to the increased thrombotic risk in COVID-19 Eur Heart J (2020) PubMed Europe PubMed DOI
Ma,A., Gao,L., Wafi,A.M., Yu,L., Rudebush,T., Zhou,W. and Zucker,I.H. Overexpression of Central ACE2 (Angiotensin-Converting Enzyme 2) Attenuates the Pressor Response to Chronic Central Infusion of Ang II (Angiotensin II): A Potential Role for Nrf2 (Nuclear Factor [Erythroid-Derived 2]-Like 2) Hypertension (2020) 76, 1514-1525. PubMed Europe PubMed DOI PMC EPMC K
Ma,X., Gao,F., Chen,Q., Xuan,X., Wang,Y., Deng,H., Yang,F. and Yuan,L. ACE2 modulates glucose homeostasis through GABA signaling during metabolic stress J Endocrinol (2020) 246, 223-236. PubMed Europe PubMed DOI
Mahdian,S., Ebrahim-Habibi,A. and Zarrabi,M. Drug repurposing using computational methods to identify therapeutic options for COVID-19 J Diabetes Metab Disord (2020) , 1-9. PubMed Europe PubMed DOI PMC EPMC I
Majeed,J., Ajmera,P. and Goyal,R.K. Delineating clinical characteristics and comorbidities among 206 COVID-19deceasedpatients in India: Emerging significance of renin angiotensin system derangement Diabetes Res Clin Pract (2020) , 108349-108349. PubMed Europe PubMed DOI PMC EPMC
Maksimowski,N., Williams,V.R. and Scholey,J.W. Kidney ACE2 expression: Implications for chronic kidney disease PLoS ONE (2020) 15, e0241534-e0241534. PubMed Europe PubMed DOI PMC EPMC
Maleki Dana,P., Sadoughi,F., Hallajzadeh,J., Asemi,Z., Mansournia,M.A., Yousefi,B. and Momen-Heravi,M. An Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes? Prehosp Disaster Med (2020) 35, 438-441. PubMed Europe PubMed DOI PMC EPMC
Manolis,A.S., Manolis,T.A., Manolis,A.A. and Melita,H. The Controversy of Renin-Angiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection J Cardiovasc Pharmacol (2020) PubMed Europe PubMed DOI
Maremanda,K.P., Sundar,I.K., Li,D. and Rahman,I. Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis Res Sq (2020) PubMed Europe PubMed DOI PMC EPMC
Martelli-Junior,H., Machado,R.A., Martelli,D.R.B., Andrade,M.C. and Coletta,R.D. Oral cancer and ACE2 receptor of SARS-CoV-2 Oral Oncol (2020) , 104920-104920. PubMed Europe PubMed DOI PMC EPMC
Masre,S.F., Jufri,N.F., Ibrahim,F.W. and Abdul Raub,S.H. Classical and alternative receptors for SARS-CoV-2 therapeutic strategy Rev Med Virol (2020) , e2207-e2207. PubMed Europe PubMed DOI V
Matarese,A., Gambardella,J., Sardu,C. and Santulli,G. miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19 Biomedicines (2020) 8 PubMed Europe PubMed DOI
McLachlan,C.S. The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms Clin Hypertens (2020) 26, 14-14. PubMed Europe PubMed DOI PMC EPMC
McNaughton,B. and Rosario,P.A. Computational Hot-Spot Analysis of the SARS-CoV-2 Receptor Binding Domain / ACE2 Complex Chembiochem (2020) PubMed Europe PubMed DOI
Medina-Enriquez,M.M., Lopez-Leon,S., Carlos-Escalante,J.A., Aponte-Torres,Z., Cuapio,A. and Wegman-Ostrosky,T. ACE2: the molecular doorway to SARS-CoV-2 Cell Biosci (2020) 10, 148-148. PubMed Europe PubMed DOI PMC EPMC V
Meini,S., Zanichelli,A., Sbrojavacca,R., Iuri,F., Roberts,A.T., Suffritti,C. and Tascini,C. Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key? Front Immunol (2020) 11, 2014-2014. PubMed Europe PubMed DOI PMC EPMC
Melin,A.D., Janiak,M.C., Marrone,F., III, Arora,P.S. and Higham,J.P. Comparative ACE2 variation and primate COVID-19 risk Commun Biol (2020) 3, 641-641. PubMed Europe PubMed DOI PMC EPMC
Mellott,D., Tseng,C.T., Drelich,A., Fajtova,P., Chenna,B.C., Kostomiris,D., Hsu,J.C., Zhu,J., Taylor,Z., Tat,V., Katzfuss,A., Li,L., Giardini,M.A., Skinner,D., Hirata,K., Beck,S., Carlin,A.F., Clark,A.E., Berreta,L., Maneval,D., Frueh,F., Hurst,B.L., Wang,H., Kocurek,K.I., Raushel,F.M., O'Donoghue,A., Siqueira-Neto,J.L., Meek,T.D. and McKerrow,J.H. A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC I
Melo Junior,A.F., Dalpiaz,P.L.M., Escouto,L.D.S., Sousa,G.J., Aires,R., Oliveira,N.D., Carmona,A.K., Gava,A.L. and Bissoli,N.S. Involvement of sex hormones, oxidative stress, ACE and ACE2 activity in the impairment of renal function and remodelling in SHR Life Sci (2020) 257, 118138-118138. PubMed Europe PubMed DOI
Mercurio,I., Tragni,V., Busto,F., De Grassi,A. and Pierri,C.L. Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Cell Mol Life Sci (2020) PubMed Europe PubMed DOI PMC EPMC
Michaud,V., Deodhar,M., Arwood,M., Al Rihani,S.B., Dow,P. and Turgeon,J. ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System J Clin Med (2020) 9 PubMed Europe PubMed DOI V
Ming,Y. and Qiang,L. Involvement of Spike Protein, Furin, and ACE2 in SARS-CoV-2-Related Cardiovascular Complications SN Compr Clin Med (2020) , 1-6. PubMed Europe PubMed DOI PMC EPMC
Mjaess,G., Karam,A., Aoun,F., Albisinni,S. and Roumeguere,T. COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor Prog Urol (2020) PubMed Europe PubMed DOI PMC EPMC
Mohammad,A., Marafie,S.K., Alshawaf,E., Abu-Farha,M., Abubaker,J. and Al-Mulla,F. Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2 Life Sci (2020) 259, 118219-118219. PubMed Europe PubMed DOI PMC EPMC
Moin,A.S.M., Sathyapalan,T., Atkin,S.L. and Butler,A.E. Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection? Metabol Open (2020) 7, 100052-100052. PubMed Europe PubMed DOI PMC EPMC
Mokuda,S., Tokunaga,T., Masumoto,J. and Sugiyama,E. Angiotensin-converting Enzyme 2, a SARS-CoV-2 receptor, Is Upregulated by Interleukin 6 through STAT3 Signaling in Synovial Tissues J Rheumatol (2020) PubMed Europe PubMed DOI
Momtazi-Borojeni,A.A., Banach,M., Reiner,Z., Pirro,M., Bianconi,V., Al-Rasadi,K. and Sahebkar,A. Interaction Between Coronavirus S-Protein and Human ACE2: Hints for Exploring Efficient Therapeutic Targets to Treat COVID-19 Angiology (2020) , 3319720952284-3319720952284. PubMed Europe PubMed DOI V
Monda,V.M., Porcellati,F., Strollo,F. and Gentile,S. ACE2 and SARS-CoV-2 Infection: Might GLP-1 Receptor Agonists Play a Role? Diabetes Ther (2020) 11, 1909-1914. PubMed Europe PubMed DOI PMC EPMC
Monteil,V., Dyczynski,M., Lauschke,V.M., Kwon,H., Wirnsberger,G., Youhanna,S., Zhang,H., Slutsky,S., Hurtado Del Pozo,C., Horn,M., Montserrat,N., Penninger,J.M. and Mirazimi,A. Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection EMBO Mol Med (2020) , e13426-e13426. PubMed Europe PubMed DOI
Mou,H., Quinlan,B.D., Peng,H., Guo,Y., Peng,S., Zhang,L., Davis-Gardner,M.E., Gardner,M.R., Crynen,G., Voo,Z.X., Bailey,C.C., Alpert,M.D., Rader,C., Choe,H. and Farzan,M. Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Mouffouk,C., Mouffouk,S., Mouffouk,S., Hambaba,L. and Haba,H. Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CL(pro) and PL(pro)), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2) Eur J Pharmacol (2020) 891, 173759-173759. PubMed Europe PubMed DOI PMC EPMC
Mu,C., Sheng,Y., Wang,Q., Amin,A., Li,X. and Xie,Y. Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology J Funct Foods (2020) , 104149-104149. PubMed Europe PubMed DOI PMC EPMC
Muchtaridi,M., Fauzi,M., Khairul Ikram,N.K., Mohd Gazzali,A. and Wahab,H.A. Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2 Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC
Mugnai,M.L., Templeton,C., Elber,R. and Thirumalai,D. Role of Long-range Allosteric Communication in Determining the Stability and Disassembly of SARS-COV-2 in Complex with ACE2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Muhanna,D., Arnipalli,S.R., Kumar,S.B. and Ziouzenkova,O. Osmotic Adaptation by Na(+)-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19 Biomedicines (2020) 8 PubMed Europe PubMed DOI V
Muller,W.E.G., Neufurth,M., Schepler,H., Wang,S., Tolba,E., Schroder,H.C. and Wang,X. The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor Biomater Sci (2020) 8, 6603-6610. PubMed Europe PubMed DOI
Nagy,B., Fejes,Z., Szentkereszty,Z., Suto,R., Varkonyi,I., Ajzner,E., Kappelmayer,J., Papp,Z., Toth,A. and Fagyas,M. A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient Int J Infect Dis (2020) PubMed Europe PubMed DOI PMC EPMC
Nascimento Conde,J., Schutt,W.R., Gorbunova,E.E. and Mackow,E.R. Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses MBio (2020) 11 PubMed Europe PubMed DOI PMC EPMC
Navarra,A., Albani,E., Castellano,S., Arruzzolo,L. and Levi-Setti,P.E. Coronavirus Disease-19 Infection: Implications on Male Fertility and Reproduction Front Physiol (2020) 11, 574761-574761. PubMed Europe PubMed DOI PMC EPMC V
Nawijn,M.C. and Timens,W. Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19? Mol Syst Biol (2020) 16, e9841-e9841. PubMed Europe PubMed DOI PMC EPMC
Nersisyan,S., Shkurnikov,M., Turchinovich,A., Knyazev,E. and Tonevitsky,A. Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2 PLoS ONE (2020) 15, e0235987-e0235987. PubMed Europe PubMed DOI PMC EPMC
Neufurth,M., Wang,X., Tolba,E., Lieberwirth,I., Wang,S., Schroder,H.C. and Muller,W.E.G. The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations Biochem Pharmacol (2020) 182, 114215-114215. PubMed Europe PubMed DOI PMC EPMC
Nguyen,H.L., Lan,P.D., Thai,N.Q., Nissley,D.A., O'Brien,E.P. and Li,M.S. Does SARS-CoV-2 Bind to Human ACE2 More Strongly Than Does SARS-CoV? J Phys Chem B (2020) 124, 7336-7347. PubMed Europe PubMed DOI PMC EPMC
Nguyen,H.T., Zhang,S., Wang,Q., Anang,S., Wang,J., Ding,H., Kappes,J.C. and Sodroski,J. Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects J Virol (2020) PubMed Europe PubMed DOI
Ni,J., Yang,F., Huang,X.R., Meng,J., Chen,J., Bader,M., Penninger,J.M., Fung,E., Yu,X.Q. and Lan,H.Y. Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy J Cell Mol Med (2020) PubMed Europe PubMed DOI
Ni,W., Yang,X., Yang,D., Bao,J., Li,R., Xiao,Y., Hou,C., Wang,H., Liu,J., Yang,D., Xu,Y., Cao,Z. and Gao,Z. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19 Crit Care (2020) 24, 422-422. PubMed Europe PubMed DOI PMC EPMC
Ni,X., Sun,C., Tian,Y., Huang,Y., Gong,T., Song,L., Yang,X., Li,K., Zheng,N., Wang,J., Wu,H., Zhang,R., Wang,Y., Wang,G. and Qin,J. Could urinary ACE2 protein level help identify individuals susceptible to SARS-CoV-2 infection and complication? Sci China Life Sci (2020) PubMed Europe PubMed DOI PMC EPMC
Nicolau,L.A.D., Noleto,I.R.S.G. and Medeiros,J.V.R. Could a specific ACE2 activator drug improve the clinical outcome of SARS-CoV-2? A potential pharmacological insight Expert Rev Clin Pharmacol (2020) , 1-5. PubMed Europe PubMed DOI
Niu,W., Wu,F., Cui,H., Cao,W., Chao,Y., Wu,Z., Fan,M. and Liang,C. Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19 Evid Based Complement Alternat Med (2020) 2020, 7493281-7493281. PubMed Europe PubMed DOI PMC EPMC I
Noy-Porat,T., Makdasi,E., Alcalay,R., Mechaly,A., Levy,Y., Bercovich-Kinori,A., Zauberman,A., Tamir,H., Yahalom-Ronen,Y., Israeli,M., Epstein,E., Achdout,H., Melamed,S., Chitlaru,T., Weiss,S., Peretz,E., Rosen,O., Paran,N., Yitzhaki,S., Shapira,S.C., Israely,T., Mazor,O. and Rosenfeld,R. A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes Nat Commun (2020) 11, 4303-4303. PubMed Europe PubMed DOI PMC EPMC
Nunes,J.P.L. Mortality and use of angiotensin-converting enzyme inhibitors in COVID 19 disease: a systematic review Porto Biomed J (2020) 5, e085-e085. PubMed Europe PubMed DOI PMC EPMC V
O'Sullivan,M.J., Mitchel,J.A., Mwase,C., McGill,M., Kanki,P. and Park,J.A. In well-differentiated primary human bronchial epithelial cells, TGF-beta1 and TGF-beta2 induce expression of furin Am J Physiol Lung Cell Mol Physiol (2020) PubMed Europe PubMed DOI
Oaklander,A.L. Discovery of ACE2 receptors for SARS-CoV-2 (COVID-19) on peripheral small-fiber sensory neurons of uncertain clinical significance Pain (2020) PubMed Europe PubMed DOI
Obukhov,A.G., Stevens,B.R., Prasad,R., Li Calzi,S., Boulton,M.E., Raizada,M.K., Oudit,G.Y. and Grant,M.B. SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes Diabetes (2020) PubMed Europe PubMed DOI
Ogawa,J., Zhu,W., Tonnu,N., Singer,O., Hunter,T., Ryan,A.L. and Pao,G.M. The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Ogunlade,B., Guidry,J.J., Mukerjee,S., Sriramula,S., Lazartigues,E. and Filipeanu,C.M. The Actin Bundling Protein Fascin-1 as an ACE2-Accessory Protein Cell Mol Neurobiol (2020) PubMed Europe PubMed DOI PMC EPMC
Oladunni,F.S., Park,J.G., Pino,P.A., Gonzalez,O., Akhter,A., Allue-Guardia,A., Olmo-Fontanez,A., Gautam,S., Garcia-Vilanova,A., Ye,C., Chiem,K., Headley,C., Dwivedi,V., Parodi,L.M., Alfson,K.J., Staples,H.M., Schami,A., Garcia,J.I., Whigham,A., Platt,R.N., Gazi,M., Martinez,J., Chuba,C., Earley,S., Rodriguez,O.H., Mdaki,S.D., Kavelish,K.N., Escalona,R., Hallam,C.R.A., Christie,C., Patterson,J.L., Anderson,T.J.C., Carrion,R., Jr., Dick,E.J., Jr., Hall-Ursone,S., Schlesinger,L.S., Alvarez,X., Kaushal,D., Giavedoni,L.D., Turner,J., Martinez-Sobrido,L. and Torrelles,J.B. Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice Nat Commun (2020) 11, 6122-6122. PubMed Europe PubMed DOI PMC EPMC
Onabajo,O.O., Banday,A.R., Yan,W., Obajemu,A., Stanifer,M.L., Santer,D.M., Florez-Vargas,O., Piontkivska,H., Vargas,J., Kee,C., Tyrrell,D.L.J., Mendoza,J.L., Boulant,S. and Prokunina-Olsson,L. Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2 bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Onweni,C.L., Zhang,Y.S., Caulfield,T., Hopkins,C.E., Fairweather,L. and Freeman,W.D. ACEI/ARB therapy in COVID-19: the double-edged sword of ACE2 and SARS-CoV-2 viral docking Crit Care (2020) 24, 475-475. PubMed Europe PubMed DOI PMC EPMC
Ortiz-Fernandez,L. and Sawalha,A.H. Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations Genes Immun (2020) PubMed Europe PubMed DOI
Oz,M., Lorke,D.E. and Kabbani,N. A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor Pharmacol Ther (2020) , 107750-107750. PubMed Europe PubMed DOI V
Pabalan,N., Tharabenjasin,P., Suntornsaratoon,P., Jarjanazi,H. and Muanprasat,C. Ethnic and age-specific acute lung injury/acute respiratory distress syndrome risk associated with angiotensin-converting enzyme insertion/deletion polymorphisms, implications for COVID-19: A meta-analysis Infect Genet Evol (2020) , 104682-104682. PubMed Europe PubMed DOI PMC EPMC
Pagliaro,P. and Penna,C. ACE/ACE2 Ratio: A Key Also in 2019 Coronavirus Disease (Covid-19)? Front Med (Lausanne) (2020) 7, 335-335. PubMed Europe PubMed DOI PMC EPMC
Pan,B., Fang,S., Zhang,J., Pan,Y., Liu,H., Wang,Y., Li,M. and Liu,L. Chinese herbal compounds against SARS-CoV-2: Puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor Comput Struct Biotechnol J (2020) 18, 3518-3527. PubMed Europe PubMed DOI PMC EPMC I
Pang,X.C., Zhang,H.X., Zhang,Z., Rinkiko,S., Cui,Y.M. and Zhu,Y.Z. The Two-Way Switch Role of ACE2 in the Treatment of Novel Coronavirus Pneumonia and Underlying Comorbidities Molecules (2020) 26 PubMed Europe PubMed DOI PMC EPMC V
Papageorgiou,A.C. and Mohsin,I. The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies Cells (2020) 9 PubMed Europe PubMed DOI V
Parekh,R.U. and Sriramula,S. Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons Int J Mol Sci (2020) 22 PubMed Europe PubMed DOI PMC EPMC
Pathak,G.A., Wendt,F.R., Goswami,A., De Angelis,F. and Polimanti,R. ACE2 Netlas: In-silico functional characterization and drug-gene interactions of ACE2 gene network to understand its potential involvement in COVID-19 susceptibility medRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Payandeh,Z., Rahbar,M.R., Jahangiri,A., Hashemi,Z.S., Zakeri,A., Jafarisani,M., Rasaee,M.J. and Khalili,S. Design of an engineered ACE2 as a novel therapeutics against COVID-19 J Theor Biol (2020) 505, 110425-110425. PubMed Europe PubMed DOI PMC EPMC
Penninger,J.M., Grant,M.B. and Sung,J.J.Y. The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection Gastroenterology (2020) PubMed Europe PubMed DOI
Pereira,V.M., Reis,F.M., Casalechi,M. and Reis,A.M. Angiotensin-(1-7), angiotensin-converting enzyme 2 and Mas receptor in rat polycystic ovaries Protein Pept Lett (2020) PubMed Europe PubMed DOI
Perez-Vizcaino,F. Lung ACE2 and ADAM17 in pulmonary arterial hypertension: Implications for COVID-19? J Heart Lung Transplant (2020) PubMed Europe PubMed DOI PMC EPMC
Pierce,J.B., Simion,V., Icli,B., Perez-Cremades,D., Cheng,H.S. and Feinberg,M.W. Computational Analysis of Targeting SARS-CoV-2, Viral Entry Proteins ACE2 and TMPRSS2, and Interferon Genes by Host MicroRNAs Genes (Basel) (2020) 11 PubMed Europe PubMed DOI PMC EPMC
Pique-Regi,R., Romero,R., Tarca,A.L., Luca,F., Xu,Y., Alazizi,A., Leng,Y., Hsu,C.D. and Gomez-Lopez,N. Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? elife (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Ponga,M. Quantifying the adhesive strength between the SARS-CoV-2 S-proteins and human receptor and its effect in therapeutics Sci Rep (2020) 10, 17538-17538. PubMed Europe PubMed DOI PMC EPMC
Poochi,S.P., Easwaran,M., Balasubramanian,B., Anbuselvam,M., Meyyazhagan,A., Park,S., Bhotla,H.K., Anbuselvam,J., Arumugam,V.A., Keshavarao,S., Kanniyappan,G.V., Pappusamy,M. and Kaul,T. Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS-CoV-2 main protease and ACE2 protein Food Front (2020) PubMed Europe PubMed DOI PMC EPMC
Prajapat,M., Shekhar,N., Sarma,P., Avti,P., Singh,S., Kaur,H., Bhattacharyya,A., Kumar,S., Sharma,S., Prakash,A. and Medhi,B. Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2 J Mol Graph Model (2020) 101, 107716-107716. PubMed Europe PubMed DOI PMC EPMC I
Prashantha,C.N., Gouthami,K., Lavanya,L., Bhavanam,S., Jakhar,A., Shakthiraju,R.G., Suraj,V., Sahana,K.V., Sujana,H.S., Guruprasad,N.M. and Ramachandra,R. Molecular screening of antimalarial, antiviral, anti-inflammatory and HIV protease inhibitors against spike glycoprotein of coronavirus J Mol Graph Model (2020) 102, 107769-107769. PubMed Europe PubMed DOI PMC EPMC I
Preziuso,S. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Exhibits High Predicted Binding Affinity to ACE2 from Lagomorphs (Rabbits and Pikas) Animals (Basel) (2020) 10 PubMed Europe PubMed DOI
Qian,K. and Hu,S. Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic MAbs (2020) 12, e1782600-e1782600. PubMed Europe PubMed DOI
Qiao,J., Li,W., Bao,J., Peng,Q., Wen,D., Wang,J. and Sun,B. The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues Biochem Biophys Res Commun (2020) PubMed Europe PubMed DOI PMC EPMC
Qiao,Y., Wang,X.M., Mannan,R., Pitchiaya,S., Zhang,Y., Wotring,J.W., Xiao,L., Robinson,D.R., Wu,Y.M., Tien,J.C., Cao,X., Simko,S.A., Apel,I.J., Bawa,P., Kregel,S., Narayanan,S.P., Raskind,G., Ellison,S.J., Parolia,A., Zelenka-Wang,S., McMurry,L., Su,F., Wang,R., Cheng,Y., Delekta,A.D., Mei,Z., Pretto,C.D., Wang,S., Mehra,R., Sexton,J.Z. and Chinnaiyan,A.M. Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2 Proc Natl Acad Sci U S A (2020) PubMed Europe PubMed DOI
Ragia,G. and Manolopoulos,V.G. Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies Eur J Clin Pharmacol (2020) PubMed Europe PubMed DOI PMC EPMC V I
Ragia,G. and Manolopoulos,V.G. Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2 mediated SARS-CoV-2 entry Pharmacogenomics (2020) PubMed Europe PubMed DOI PMC EPMC
Rangel,H.R., Ortega,J.T., Maksoud,S., Pujol,F.H. and Serrano,M.L. SARS-CoV-2 host tropism: An in silico analysis of the main cellular factors Virus Res (2020) 289, 198154-198154. PubMed Europe PubMed DOI PMC EPMC
Ratajczak,M.Z., Bujko,K., Ciechanowicz,A., Sielatycka,K., Cymer,M., Marlicz,W. and Kucia,M. SARS-CoV-2 Entry Receptor ACE2 Is Expressed on Very Small CD45(-) Precursors of Hematopoietic and Endothelial Cells and in Response to Virus Spike Protein Activates the Nlrp3 Inflammasome Stem Cell Rev Rep (2020) PubMed Europe PubMed DOI PMC EPMC
Rathod,S.B., Prajapati,P.B., Punjabi,L.B., Prajapati,K.N., Chauhan,N. and Mansuri,M.F. Peptide modelling and screening against human ACE2 and spike glycoprotein RBD of SARS-CoV-2 In Silico Pharmacol (2020) 8, 3-3. PubMed Europe PubMed DOI PMC EPMC
Ravaioli,S., Tebaldi,M., Fonzi,E., Angeli,D., Mazza,M., Nicolini,F., Lucchesi,A., Fanini,F., Pirini,F., Tumedei,M.M., Cerchione,C., Viale,P., Sambri,V., Martinelli,G. and Bravaccini,S. ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients Cell Transplant (2020) 29, 963689720968749-963689720968749. PubMed Europe PubMed DOI PMC EPMC
Rawat,P., Jemimah,S., Ponnuswamy,P.K. and Gromiha,M.M. Why are ACE2 binding coronavirus strains SARS-CoV/SARS-CoV-2 wild and NL63 mild? Proteins (2020) PubMed Europe PubMed DOI
Razeghian-Jahromi,I., Zibaeenezhad,M.J., Lu,Z., Zahra,E., Mahboobeh,R. and Lionetti,V. Angiotensin-converting enzyme 2: a double-edged sword in COVID-19 patients with an increased risk of heart failure Heart Fail Rev (2020) PubMed Europe PubMed DOI PMC EPMC
Reis,F.M. and Reis,A.M. Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions Clin Sci (Lond) (2020) 134, 2929-2941. PubMed Europe PubMed DOI
Ren,P., Gong,C. and Ma,S. Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients Open Med (Wars) (2020) 15, 613-622. PubMed Europe PubMed DOI PMC EPMC
Ren,X., Wang,S., Chen,X., Wei,X., Li,G., Ren,S., Zhang,T., Zhang,X., Lu,Z., You,Z., Wang,Z., Song,N. and Qin,C. Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19 Infect Drug Resist (2020) 13, 3977-3990. PubMed Europe PubMed DOI PMC EPMC
Rezaei,M., Ziai,S.A., Fakhri,S. and Pouriran,R. ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19 J Cell Physiol (2020) PubMed Europe PubMed DOI
Rhodes,J.M., Subramanian,S., Laird,E., Griffin,G. and Kenny,R.A. Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis J Intern Med (2020) PubMed Europe PubMed DOI PMC EPMC
Rizzo,A., Mollica,V. and Massari,F. Re: Hanbing Song, Bobak Seddighzadeh, Matthew R. Cooperberg, Franklin W. Huang. Expression of ACE2 and TMPRSS2, the SARS-CoV-2 Receptor and Co-Receptor, in Prostate Epithelial Cells. Eur Urol. In press DOI: 10.1016/j.eururo.2020.04.065 Eur Urol (2020) PubMed Europe PubMed DOI PMC EPMC
Roberts,J., Pritchard,A.L., Treweeke,A.T., Rossi,A.G., Brace,N., Cahill,P., MacRury,S.M., Wei,J. and Megson,I.L. Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System Front Cardiovasc Med (2020) 7, 629933-629933. PubMed Europe PubMed DOI PMC EPMC V
Robinson,F.A., Mihealsick,R.P., Wagener,B.M., Hanna,P., Poston,M.D., Efimov,I.F., Shivkumar,K. and Hoover,D.B. Role of angiotensin converting enzyme 2 and pericytes in cardiac complications of COVID-19 infection Am J Physiol Heart Circ Physiol (2020) PubMed Europe PubMed DOI V
Roehrich,H., Yuan,C. and Hou,J.H. Immunohistochemical Study of SARS-CoV-2 Viral Entry Factors in the Cornea and Ocular Surface Cornea (2020) PubMed Europe PubMed DOI
Roganovic,J. and Radenkovic,M. Letter to the Editor: Diabetes, obesity and hypertension may promote oral SARS-CoV-2 infection- salivary soluble ACE2 perspective Oral Dis (2020) PubMed Europe PubMed DOI
Roncati,L., Gallo,G., Manenti,A. and Palmieri,B. Renin-angiotensin system: the unexpected flaw inside the human immune system revealed by SARS-CoV-2 Med Hypotheses (2020) 140, 109686-109686. PubMed Europe PubMed DOI PMC EPMC
Roncati,L. and Lusenti,B. The <<moonlighting protein>> able to explain the Th1 immune lockdown in severe COVID-19 Med Hypotheses (2020) 143, 110087-110087. PubMed Europe PubMed DOI PMC EPMC
Rosario,P.A. and McNaughton,B.R. Computational Hot-Spot Analysis of the SARS-CoV-2 Receptor Binding Domain / ACE2 Complex bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Rui,L., Haonan,L. and Wanyi,C. Silico analysis of interaction between full-length SARS-CoV2 S protein with human Ace2 receptor: Modelling, docking, MD simulation Biophys Chem (2020) 267, 106472-106472. PubMed Europe PubMed DOI PMC EPMC
Ryan,P.M. and Caplice,N. COVID-19 and relative angiotensin-converting enzyme 2 deficiency: role in disease severity and therapeutic response Open Heart (2020) 7 PubMed Europe PubMed DOI PMC EPMC
Saadah,L.M., Deiab,G.I.A., Al-Balas,Q. and Basheti,I.A. Carnosine to Combat Novel Coronavirus (nCoV): Molecular Docking and Modeling to Cocrystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein Molecules (2020) 25 PubMed Europe PubMed DOI PMC EPMC I
Saba,L., Gerosa,C., Fanni,D., Marongiu,F., La Nasa,G., Caocci,G., Barcellona,D., Balestrieri,A., Coghe,F., Orru,G., Coni,P., Piras,M., Ledda,F., Suri,J.S., Ronchi,A., D'Andrea,F., Cau,R., Castagnola,M. and Faa,G. Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review Eur Rev Med Pharmacol Sci (2020) 24, 12609-12622. PubMed Europe PubMed DOI
Saffern,M. ACE2 is not induced by interferon Nat Rev Immunol (2020) PubMed Europe PubMed DOI PMC EPMC
Saggese,C.E., Del Bianco,C., Di Ruzza,M.R., Magarelli,M., Gandini,R. and Plocco,M. COVID-19 and Stroke: Casual or Causal Role? Cerebrovasc Dis (2020) 49, 341-344. PubMed Europe PubMed DOI
Saha,S., Chakrabarti,S., Singh,P.K., Poddar,J., Satapathi,S., Saini,S., Kakar,S.S. and Roy,P. Physiological Relevance of Angiotensin Converting Enzyme 2 As a Metabolic Linker and Therapeutic Implication of Mesenchymal Stem Cells in COVID-19 and Hypertension Stem Cell Rev Rep (2020) PubMed Europe PubMed DOI PMC EPMC V
Saheb Sharif-Askari,N., Saheb Sharif-Askari,F., Alabed,M., Temsah,M.H., Al Heialy,S., Hamid,Q. and Halwani,R. Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD Mol Ther Methods Clin Dev (2020) 18, 1-6. PubMed Europe PubMed DOI PMC EPMC
Sainz-Cort,A. and Heeroma,J.H. The interaction between the endocannabinoid system and the renin angiotensin system and its potential implication for COVID-19 infection J Cannabis Res (2020) 2, 23-23. PubMed Europe PubMed DOI PMC EPMC
Sakaguchi,W., Kubota,N., Shimizu,T., Saruta,J., Fuchida,S., Kawata,A., Yamamoto,Y., Sugimoto,M., Yakeishi,M. and Tsukinoki,K. Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI
Sakamoto,A., Kawakami,R., Kawai,K., Gianatti,A., Pellegrini,D., Kutys,R., Guo,L., Mori,M., Cornelissen,A., Sato,Y., Bellasi,A., Faggi,L., Hong,C., Romero,M., Guagliumi,G., Virmani,R. and Finn,A.V. ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Serine Protease 2) Expression and Localization of SARS-CoV-2 Infection in the Human Heart Arterioscler Thromb Vasc Biol (2020) , ATVBAHA120315229-ATVBAHA120315229. PubMed Europe PubMed DOI
Salah,H.M., Calcaterra,G. and Mehta,J.L. Renin-Angiotensin System Blockade and Mortality in Patients With Hypertension and COVID-19 Infection J Cardiovasc Pharmacol Ther (2020) , 1074248420947628-1074248420947628. PubMed Europe PubMed DOI PMC EPMC
Salah,H.M., Arthur,J.M. and Mehta,J.L. Implications of renal ACE2 expression in the age of COVID-19 Eur Heart J (2020) PubMed Europe PubMed DOI
Sama,I.E., Voors,A.A. and van Veldhuisen,D.J. New data on soluble ACE2 in patients with atrial fibrillation reveal potential value for treatment of patients with COVID-19 and cardiovascular disease Eur Heart J (2020) PubMed Europe PubMed DOI
Samad,A., Jafar,T. and Rafi,J.H. Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analysis Genomics (2020) PubMed Europe PubMed DOI
Sanchez-Aguilar,M., Ibarra-Lara,L., Del Valle-Mondragon,L., Soria-Castro,E., Torres-Narvaez,J.C., Carreon-Torres,E., Sanchez-Mendoza,A. and Rubio-Ruiz,M.E. Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model PPAR Res (2020) 2020, 8894525-8894525. PubMed Europe PubMed DOI PMC EPMC
Sang,E.R., Tian,Y., Gong,Y., Miller,L.C. and Sang,Y. Integrate structural analysis, isoform diversity, and interferon-inductive propensity of ACE2 to predict SARS-CoV2 susceptibility in vertebrates Heliyon (2020) 6, e04818-e04818. PubMed Europe PubMed DOI PMC EPMC
Saponaro,F., Rutigliano,G., Sestito,S., Bandini,L., Storti,B., Bizzarri,R. and Zucchi,R. ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives Front Mol Biosci (2020) 7, 588618-588618. PubMed Europe PubMed DOI PMC EPMC V
Sarzani,R., Giulietti,F., Di Pentima,C., Giordano,P. and Spannella,F. Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury Am J Physiol Lung Cell Mol Physiol (2020) 319, L325-L325. PubMed Europe PubMed DOI V
Scialo,F., Daniele,A., Amato,F., Pastore,L., Matera,M.G., Cazzola,M., Castaldo,G. and Bianco,A. ACE2: The Major Cell Entry Receptor for SARS-CoV-2 Lung (2020) 198, 867-877. PubMed Europe PubMed DOI PMC EPMC
Sedokani,A. and Feizollahzadeh,S. Plasmapheresis, Anti-ACE2 and Anti-FcgammaRII Monoclonal Antibodies: A Possible Treatment for Severe Cases of COVID-19 Drug Des Devel Ther (2020) 14, 2607-2611. PubMed Europe PubMed DOI PMC EPMC
Senapati,S., Kumar,S., Singh,A.K., Banerjee,P. and Bhagavatula,S. Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human J Genet (2020) 99 PubMed Europe PubMed PMC EPMC
Senkal,N., Meral,R., Medetalibeyoglu,A., Konyaoglu,H., Kose,M. and Tukek,T. Association between chronic ACE inhibitor exposure and decreased odds of severe disease in patients with COVID-19 Anatol J Cardiol (2020) 24, 21-29. PubMed Europe PubMed DOI
Seo,S.H. and Jang,Y. Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 Infection Vaccines (Basel) (2020) 8 PubMed Europe PubMed DOI
Seth,S., Batra,J. and Srinivasan,S. COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response Front Mol Biosci (2020) 7, 215-215. PubMed Europe PubMed DOI PMC EPMC V
Shahid,M. and Shahzad-Ul-Hussan,S. Structural insights of key enzymes into therapeutic intervention against SARS-CoV-2 J Struct Biol (2020) 213, 107690-107690. PubMed Europe PubMed DOI PMC EPMC V
Sharifkashani,S., Bafrani,M.A., Khaboushan,A.S., Pirzadeh,M., Kheirandish,A., Yavarpour Bali,H., Hessami,A., Saghazadeh,A. and Rezaei,N. Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting Eur J Pharmacol (2020) 884, 173455-173455. PubMed Europe PubMed DOI V
Sharma,P. and Shanavas,A. Natural derivatives with dual binding potential against SARS-CoV-2 main protease and human ACE2 possess low oral bioavailability: a brief computational analysis J Biomol Struct Dyn (2020) , 1-12. PubMed Europe PubMed DOI
Sharma,R.K., Oliveira,A.C., Yang,T., Karas,M.M., Li,J., Lobaton,G.O., Aquino,V.P., Robles-Vera,I., de Kloet,A.D., Krause,E.G., Bryant,A.J., Verma,A., Li,Q., Richards,E.M. and Raizada,M.K. Correction to: Gut Pathology and Its Rescue by ACE2 (Angiotensin Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension Hypertension (2020) 76, e40-e40. PubMed Europe PubMed DOI
Sheikhi,A. and Hojjat-Farsangi,M. An immunotherapeutic method for COVID-19 patients: a soluble ACE2-Anti-CD16 VHH to block SARS-CoV-2 Spike protein Hum Vaccin Immunother (2020) , 1-6. PubMed Europe PubMed DOI
Shen,H., Zhang,J., Wang,C., Jain,P.P., Xiong,M., Shi,X., Lei,Y., Chen,S., Yin,Q., Thistlethwaite,P.A., Wang,J., Gong,K., Yuan,Z.Y., Yuan,J.X. and Shyy,J.Y. MDM2-Mediated Ubiquitination of ACE2 Contributes to the Development of Pulmonary Arterial Hypertension Circulation (2020) 142, 1190-1204. PubMed Europe PubMed DOI
Shen,M., Zhang,B., Wang,M., Meng,L. and Lv,B. Mica Can Alleviate TNBS-Induced Colitis in Mice by Reducing Angiotensin II and IL-17A and Increasing Angiotensin-Converting Enzyme 2, Angiotensin 1-7, and IL-10 Mediators Inflamm (2020) 2020, 3070345-3070345. PubMed Europe PubMed DOI PMC EPMC
Shen,M., Liu,C., Xu,R., Ruan,Z., Zhao,S., Zhang,H., Wang,W., Huang,X., Yang,L., Tang,Y., Yang,T. and Jia,X. Predicting the Animal Susceptibility and Therapeutic Drugs to SARS-CoV-2 Based on Spike Glycoprotein Combined With ACE2 Front Genet (2020) 11, 575012-575012. PubMed Europe PubMed DOI PMC EPMC I
Shen,Q., Xiao,X., Aierken,A., Yue,W., Wu,X., Liao,M. and Hua,J. The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection J Cell Mol Med (2020) 24, 9472-9477. PubMed Europe PubMed DOI PMC EPMC
Shi,C., Lu,K., Xia,H., Zhang,P. and Zhang,B. Alteration and association between serum ACE2/ angiotensin(1-7)/Mas axis and oxidative stress in chronic kidney disease: A pilot study Medicine (Baltimore) (2020) 99, e21492-e21492. PubMed Europe PubMed DOI PMC EPMC
Shiers,S., Ray,P.R., Wangzhou,A., Sankaranarayanan,I., Tatsui,C.E., Rhines,L.D., Li,Y., Uhelski,M.L., Dougherty,P.M. and Price,T.J. ACE2 and SCARF expression in human DRG nociceptors: implications for SARS-CoV-2 virus neurological effects Pain (2020) 161, 2494-2501. PubMed Europe PubMed DOI
Shikov,A.E., Barbitoff,Y.A., Glotov,A.S., Danilova,M.M., Tonyan,Z.N., Nasykhova,Y.A., Mikhailova,A.A., Bespalova,O.N., Kalinin,R.S., Mirzorustamova,A.M., Kogan,I.Y., Baranov,V.S., Chernov,A.N., Pavlovich,D.M., Azarenko,S.V., Fedyakov,M.A., Tsay,V.V., Eismont,Y.A., Romanova,O.V., Hobotnikov,D.N., Vologzhanin,D.A., Mosenko,S.V., Ponomareva,T.A., Talts,Y.A., Anisenkova,A.U., Lisovets,D.G., Sarana,A.M., Urazov,S.P., Scherbak,S.G. and Glotov,O.S. Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome Front Genet (2020) 11, 551220-551220. PubMed Europe PubMed DOI PMC EPMC
Shrimp,J.H., Kales,S.C., Sanderson,P.E., Simeonov,A., Shen,M. and Hall,M.D. An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19 ACS Pharmacol Transl Sci (2020) 3, 997-1007. PubMed Europe PubMed DOI PMC EPMC I
Siljee,S., Pilkington,T., Brasch,H.D., Bockett,N., Patel,J., Paterson,E., Davis,P.F. and Tan,S.T. Cancer Stem Cells in Head and Neck Metastatic Malignant Melanoma Express Components of the Renin-Angiotensin System Life (Basel) (2020) 10 PubMed Europe PubMed DOI
Silva-Aguiar,R.P., Peruchetti,D.B., Rocco,P.R.M., Schmaier,A.H., Silva,P.M.R., Martins,M.A., Carvalho,V.F., Pinheiro,A.A.S. and Caruso-Neves,C. Role of the renin angiotensin system in the development of severe COVID-19 in hypertensive patients Am J Physiol Lung Cell Mol Physiol (2020) 319, L596-L602. PubMed Europe PubMed DOI
Silva de Almeida,T.C., Lanza,K., da Silva Filha,R., Campos,C., Fonseca,E.G., Chagas,M.W., Rocha,N.P., de Sa,M.A., Vieira,M.A.R., Caliari,M.V., Kangussu,L.M., Ferreira,A.J. and Simoes e Silva ACE2 activator diminazene aceturate exerts renoprotective effects in gentamicin-induced acute renal injury in rats Clin Sci (Lond) (2020) 134, 3093-3106. PubMed Europe PubMed DOI I
Singh,H., Choudhari,R., Nema,V. and Khan,A.A. ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease Microb Pathog (2020) 150, 104621-104621. PubMed Europe PubMed DOI PMC EPMC
Sinha,S., Cheng,K., Schaffer,A.A., Aldape,K., Schiff,E. and Ruppin,E. In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression Mol Syst Biol (2020) 16, e9628-e9628. PubMed Europe PubMed DOI PMC EPMC
Sinha,S., Sehgal,A. and Sehgal,R. Association of ACE2 receptor and ACEIs/ARBs with disease severity in COVID-19 Drug Discov Ther (2020) 14, 161-170. PubMed Europe PubMed DOI V
Siri-Angkul,N., Chattipakorn,S.C. and Chattipakorn,N. Angiotensin converting enzyme 2 at the interface between renin-angiotensin system inhibition and coronavirus disease 2019 J Physiol (2020) 598, 4181-4195. PubMed Europe PubMed DOI
Sokolowska,M. Outsmarting SARS-CoV-2 by empowering a decoy ACE2 Signal Transduct Target Ther (2020) 5, 260-260. PubMed Europe PubMed DOI PMC EPMC
Soldo,J., Heni,M., Konigsrainer,A., Haring,H.U., Birkenfeld,A.L. and Peter,A. Increased Hepatic ACE2 Expression in NAFL and Diabetes-A Risk for COVID-19 Patients? Diabetes Care (2020) 43, e134-e136. PubMed Europe PubMed DOI
Sollena,P., Cappilli,S., Piccerillo,A., Chiricozzi,A. and Peris,K. COVID-19 hygiene measures: hand eczema and insights into ACE2 and integrins as key molecules for SARS-CoV-2 cutaneous transmission Int J Dermatol (2020) 59, 1409-1410. PubMed Europe PubMed DOI PMC EPMC
Somekh,I., Yakub Hanna,H., Heller,E., Bibi,H. and Somekh,E. AGE-DEPENDENT SENSORY IMPAIRMENT IN COVID-19 INFECTION AND ITS CORRELATION WITH ACE2 EXPRESSION Pediatr Infect Dis J (2020) 39, e270-e272. PubMed Europe PubMed DOI
Son,M., Seo,J. and Yang,S. Association Between Renin-Angiotensin-Aldosterone System Inhibitors and COVID-19 Infection in South Korea Hypertension (2020) 76, 742-749. PubMed Europe PubMed DOI
Song,J., Han,J., Liu,F., Chen,X., Qian,S., Wang,Y., Jia,Z., Duan,X., Zhang,X. and Zhu,J. Systematic Analysis of Coronavirus Disease 2019 (COVID-19) Receptor ACE2 in Malignant Tumors: Pan-Cancer Analysis Front Mol Biosci (2020) 7, 569414-569414. PubMed Europe PubMed DOI PMC EPMC
Song,J., Zhu,J., Chen,W., Zhu,G., Wang,W., Chen,C., Jia,Z., Zha,Y., Xu,P., Wang,Z., Sun,F. and Zhang,X. Expression profiles revealed potential kidney injury caused by SARS-CoV-2: a systematic analysis of ACE2 and clinical lessons learned from this discovery Aging (Albany NY) (2020) 12 PubMed Europe PubMed DOI
Song,J.J., Yang,M., Liu,Y., Song,J.W., Wang,J., Chi,H.J., Liu,X.Y., Zuo,K., Yang,X.C. and Zhong,J.C. MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 signaling Eur J Pharmacol (2020) 883, 173374-173374. PubMed Europe PubMed DOI PMC EPMC
South,A.M., Diz,D.I. and Chappell,M.C. COVID-19, ACE2 and the cardiovascular consequences Am J Physiol Heart Circ Physiol (2020) 318, H1084-H1084. PubMed Europe PubMed DOI
Souza,P.F.N., Lopes,F.E.S., Amaral,J.L., Freitas,C.D.T. and Oliveira,J.T.A. A molecular docking study revealed that synthetic peptides induced conformational changes in the structure of SARS-CoV-2 spike glycoprotein, disrupting the interaction with human ACE2 receptor Int J Biol Macromol (2020) 164, 66-76. PubMed Europe PubMed DOI PMC EPMC
Srivastava,A., Bandopadhyay,A., Das,D., Pandey,R.K., Singh,V., Khanam,N., Srivastava,N., Singh,P.P., Dubey,P.K., Pathak,A., Gupta,P., Rai,N., Sultana,G.N.N. and Chaubey,G. Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India Front Genet (2020) 11, 564741-564741. PubMed Europe PubMed DOI PMC EPMC
Stanton,B.A., Hampton,T.H. and Ashare,A. SARS-CoV-2 (COVID-19) and Cystic Fibrosis Am J Physiol Lung Cell Mol Physiol (2020) 319, L408-L415. PubMed Europe PubMed DOI
Starr,T.N., Greaney,A.J., Hilton,S.K., Ellis,D., Crawford,K.H.D., Dingens,A.S., Navarro,M.J., Bowen,J.E., Tortorici,M.A., Walls,A.C., King,N.P., Veesler,D. and Bloom,J.D. Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding Cell (2020) 182, 1295-1310. PubMed Europe PubMed DOI PMC EPMC
Stein,R.A. and Young,L.M. From ACE2 to COVID-19: A multiorgan endothelial disease Int J Infect Dis (2020) 100, 425-430. PubMed Europe PubMed DOI
Stout,A.E., Andre,N.M., Jaimes,J.A., Millet,J.K. and Whittaker,G.R. Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit? Vet Microbiol (2020) 247, 108777-108777. PubMed Europe PubMed DOI PMC EPMC V
Strafella,C., Caputo,V., Termine,A., Barati,S., Gambardella,S., Borgiani,P., Caltagirone,C., Novelli,G., Giardina,E. and Cascella,R. Analysis of ACE2 Genetic Variability among Populations Highlights a Possible Link with COVID-19-Related Neurological Complications Genes (Basel) (2020) 11 PubMed Europe PubMed DOI
Straughn,A.R. and Kakar,S.S. Withaferin A: a potential therapeutic agent against COVID-19 infection J Ovarian Res (2020) 13, 79-79. PubMed Europe PubMed DOI PMC EPMC
Sungnak,W., Huang,N., Becavin,C. and Berg,M. SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways ArXiv (2020) PubMed Europe PubMed PMC EPMC
Tabary,M., Khanmohammadi,S., Araghi,F., Dadkhahfar,S. and Tavangar,S.M. Pathologic features of COVID-19: A concise review Pathol Res Pract (2020) 216, 153097-153097. PubMed Europe PubMed DOI PMC EPMC
Tada,T., Fan,C., Chen,J.S., Kaur,R., Stapleford,K.A., Gristick,H., Dcosta,B.M., Wilen,C.B., Nimigean,C.M. and Landau,N.R. An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2 Cell Rep (2020) 33, 108528-108528. PubMed Europe PubMed DOI PMC EPMC
Taglauer,E., Benarroch,Y., Rop,K., Barnett,E., Sabharwal,V., Yarrington,C. and Wachman,E.M. Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads Placenta (2020) 100, 69-74. PubMed Europe PubMed DOI PMC EPMC
Tamanna,S., Clifton,V.L., Rae,K., van Helden,D.F., Lumbers,E.R. and Pringle,K.G. Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age Front Physiol (2020) 11, 590787-590787. PubMed Europe PubMed DOI PMC EPMC
Tan,A.L., Farrow,M., Biglands,J., Fernandes,R.J., Abraldes,J.A., de Souza Castro,F.A., de Souza,H.L., Arriel,R.A., Meireles,A., Marocolo,M., Gonzalez-Rayas,J.M., Rayas-Gomez,A.L., Mobayed-Vega,F.N., Gonzalez-Yanez,J.M., Hirai,D.M., Belbis,M.D., Holmes,M.J., Calvo,N., Ferguson,S.K., Fernandes,T., Oliveira,E.M., Pun,M. and Bhandari,S.S. Commentaries on Viewpoint: The interaction between SARS-CoV-2 and ACE2 may have consequences for skeletal muscle viral susceptibility and myopathies J Appl Physiol (1985) (2020) 129, 868-871. PubMed Europe PubMed DOI
Tan,C.S., Yeoh,S.F. and Long,C.M. COVID-19: Critical Role of Angiotensin 1-7 in ACE2 Modulation Ann Acad Med Singap (2020) 49, 398-400. PubMed Europe PubMed
Tan,C.W., Chia,W.N., Qin,X., Liu,P., Chen,M.I., Tiu,C., Hu,Z., Chen,V.C., Young,B.E., Sia,W.R., Tan,Y.J., Foo,R., Yi,Y., Lye,D.C., Anderson,D.E. and Wang,L.F. A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction Nat Biotechnol (2020) 38, 1073-1078. PubMed Europe PubMed DOI
Tan,H.W., Xu,Y.M. and Lau,A.T.Y. Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection Rev Med Virol (2020) , e2122-e2122. PubMed Europe PubMed DOI PMC EPMC V
Taneera,J., El-Huneidi,W., Hamad,M., Mohammed,A.K., Elaraby,E. and Hachim,M.Y. Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors Biology (Basel) (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Tao,H., Bai,J., Zhang,W., Zheng,K., Guan,P., Ge,G., Li,M. and Geng,D. Bone biology and COVID-19 infection: Is ACE2 a potential influence factor? Med Hypotheses (2020) 144, 110178-110178. PubMed Europe PubMed DOI PMC EPMC
Tao,Q., Du,J., Li,X., Zeng,J., Tan,B., Xu,J., Lin,W. and Chen,X.L. Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19 Drug Dev Ind Pharm (2020) 46, 1345-1353. PubMed Europe PubMed DOI I
Tavares,C.A.M., Avelino-Silva,T.J., Benard,G., Cardozo,F.A.M., Fernandes,J.R., Girardi,A.C.C. and Jacob Filho,W. ACE2 Expression and Risk Factors for COVID-19 Severity in Patients with Advanced Age Arq Bras Cardiol (2020) 115, 701-707. PubMed Europe PubMed DOI
Ten Hove,A.S., Brinkman,D.J., Li Yim,A.Y.F., Verseijden,C., Hakvoort,T.B.M., Admiraal,I., Welting,O., van Hamersveld,P.H.P., Sinniger,V., Bonaz,B., Luyer,M.D. and de Jonge,W.J. The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia Bioelectron Med (2020) 6, 20-20. PubMed Europe PubMed DOI PMC EPMC
Teng,S. and Tang,Q. ACE2 enhance viral infection or viral infection aggravate the underlying diseases Comput Struct Biotechnol J (2020) 18, 2100-2106. PubMed Europe PubMed DOI PMC EPMC
Terali,K., Baddal,B. and Gulcan,H.O. Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment J Mol Graph Model (2020) 100, 107697-107697. PubMed Europe PubMed DOI PMC EPMC
Thunders,M. and Delahunt,B. Gene of the month: TMPRSS2 (transmembrane serine protease 2) J Clin Pathol (2020) 73, 773-776. PubMed Europe PubMed DOI PMC EPMC
Tiwari,V. Denovo designing, retrosynthetic analysis, and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2 Biol Open (2020) 9, bio054056-bio054056. PubMed Europe PubMed DOI I
Tomchaney,M., Contoli,M., Mayo,J., Baraldo,S., Shuaizhi,L., Cabel,C.R., Bull,D.A., Lick,S., Malo,J., Knoper,S., Kim,S.S., Tram,J., Rojas-Quintero,J., Kraft,M., Ledford,J., Tesfaigzi,Y., Martinez,F.D., Thorne,C.A., Kheradmand,F., Campos,S.K., Papi,A. and Polverino,F. Paradoxical effects of cigarette smoke and COPD on SARS-CoV2 infection and disease bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Uversky,V.N., Elrashdy,F., Aljadawi,A. and Redwan,E.M. Household pets and SARS-CoV2 transmissibility in the light of the ACE2 intrinsic disorder status J Biomol Struct Dyn (2020) , 1-4. PubMed Europe PubMed DOI
Valencia,I., Peiro,C., Lorenzo,O., Sanchez-Ferrer,C.F., Eckel,J. and Romacho,T. DPP4 and ACE2 in Diabetes and COVID-19: Therapeutic Targets for Cardiovascular Complications? Front Pharmacol (2020) 11, 1161-1161. PubMed Europe PubMed DOI PMC EPMC
Vardhan,S. and Sahoo,S.K. In silico ADMET and molecular docking study on searching potential inhibitors from limonoids and triterpenoids for COVID-19 Comput Biol Med (2020) 124, 103936-103936. PubMed Europe PubMed DOI PMC EPMC
Vargas-Alarcon,G., Posadas-Sanchez,R. and Ramirez-Bello,J. Variability in genes related to SARS-CoV-2 entry into host cells (ACE2, TMPRSS2, TMPRSS11A, ELANE, and CTSL) and its potential use in association studies Life Sci (2020) 260, 118313-118313. PubMed Europe PubMed DOI PMC EPMC
Vargas-Ferrer,J. and Zamora-Mostacero,V. Re-detectable positive RT-PCR test results in recovered COVID-19 patients: The potential role of ACE2 Disaster Med Public Health Prep (2020) , 1-4. PubMed Europe PubMed DOI
Varma,P., Lybrand,Z.R., Antopia,M.C. and Hsieh,J. Novel Targets of SARS-CoV-2 Spike Protein in Human Fetal Brain Development Suggest Early Pregnancy Vulnerability Front Neurosci (2020) 14, 614680-614680. PubMed Europe PubMed DOI PMC EPMC
Vazquez-Cornejo,E. Considerations on the use of antihypertensive blockers of the renin-angiotensin system in adults and children in the face of the COVID-19 pandemic Bol Med Hosp Infant Mex (2020) 77, 274-281. PubMed Europe PubMed DOI
Verano-Braga,T., Martins,A.L.V., Motta-Santos,D., Campagnole-Santos,M.J. and Santos,R.A.S. ACE2 in the renin-angiotensin system Clin Sci (Lond) (2020) 134, 3063-3078. PubMed Europe PubMed DOI V
Verkhivker,G. Coevolution, Dynamics and Allostery Conspire in Shaping Cooperative Binding and Signal Transmission of the SARS-CoV-2 Spike Protein with Human Angiotensin-Converting Enzyme 2 Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC
Verma,N.K., Fazil,M.H.U.T., Duggan,S.P. and Kelleher,D. Combination Therapy Using Inhalable GapmeR and Recombinant ACE2 for COVID-19 Front Mol Biosci (2020) 7, 197-197. PubMed Europe PubMed DOI PMC EPMC K
Viana,S.D., Nunes,S. and Reis,F. ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis Ageing Res Rev (2020) 62, 101123-101123. PubMed Europe PubMed DOI PMC EPMC V
Vikse,J., Lippi,G. and Henry,B.M. Do sex-specific immunobiological factors and differences in angiotensin converting enzyme 2 (ACE2) expression explain increased severity and mortality of COVID-19 in males? Diagnosis (Berl) (2020) 7, 385-386. PubMed Europe PubMed DOI
Voinsky,I. and Gurwitz,D. Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers Drug Dev Res (2020) 81, 1073-1080. PubMed Europe PubMed DOI PMC EPMC
Walker,S.N., Chokkalingam,N., Reuschel,E.L., Purwar,M., Xu,Z., Gary,E.N., Kim,K.Y., Helble,M., Schultheis,K., Walters,J., Ramos,S., Muthumani,K., Smith,T.R.F., Broderick,K.E., Tebas,P., Patel,A., Weiner,D.B. and Kulp,D.W. SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients J Clin Microbiol (2020) 58, e01533-20-e01533-20. PubMed Europe PubMed DOI
Wang,B., Kovalchuk,A., Li,D., Rodriguez-Juarez,R., Ilnytskyy,Y., Kovalchuk,I. and Kovalchuk,O. In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues Aging (Albany NY) (2020) 12, 22425-22444. PubMed Europe PubMed DOI
Wang,J., Xu,X., Zhou,X., Chen,P., Liang,H., Li,X., Zhong,W. and Hao,P. Molecular simulation of SARS-CoV-2 spike protein binding to pangolin ACE2 or human ACE2 natural variants reveals altered susceptibility to infection J Gen Virol (2020) 101, 921-924. PubMed Europe PubMed DOI
Wang,J., Li,J., Cheng,C. and Liu,S. Angiotensin-converting enzyme 2 augments the effects of endothelial progenitor cells-exosomes on vascular smooth muscle cell phenotype transition Cell Tissue Res (2020) 382, 509-518. PubMed Europe PubMed DOI
Wang,K., Gheblawi,M. and Oudit,G.Y. Angiotensin converting enzyme 2: a double-edged sword Circulation (2020) 142, 426-428. PubMed Europe PubMed DOI V
Wang,Q., Sundar,I.K., Li,D., Lucas,J.H., Muthumalage,T., McDonough,S.R. and Rahman,I. E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR alpha7 receptor: role of nAChR alpha7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation Respir Res (2020) 21, 154-154. PubMed Europe PubMed DOI PMC EPMC
Wang,W., Lv,S., Gan,W., Zeng,Z. and Yang,M. A bioinformatics analysis on the potential role of ACE2 in cardiac impairment of patients with coronavirus disease 2019 Ann Transl Med (2020) 8, 1403-1403. PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Wang,Y., Luo,W., Huang,L., Xiao,J., Li,F., Qin,S., Song,X., Wu,Y., Zeng,Q., Jin,F. and Wang,Y. A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells Int J Med Sci (2020) 17, 1522-1531. PubMed Europe PubMed DOI PMC EPMC
Warner,F.J., Rajapaksha,H., Shackel,N. and Herath,C.B. ACE2: from protection of liver disease to propagation of COVID-19 Clin Sci (Lond) (2020) 134, 3137-3158. PubMed Europe PubMed DOI V
Weatherbee,B.A.T., Glover,D.M. and Zernicka-Goetz,M. Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester Open Biol (2020) 10, 200162-200162. PubMed Europe PubMed DOI
Wei,S., Duan,S., Liu,X., Wang,H., Ding,S., Chen,Y., Xie,J., Tian,J., Yu,N., Ge,P., Zhang,X., Chen,X., Li,Y. and Meng,Q. Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2 Int Immunopharmacol (2020) , 107172-107172. PubMed Europe PubMed DOI PMC EPMC
Weir,R.A.P. Letter by Weir Regarding Article, "Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2" Circ Res (2020) 127, e44-e44. PubMed Europe PubMed DOI
Wells,H.L., Letko,M., Lasso,G., Ssebide,B., Nziza,J., Byarugaba,D.K., Navarrete-Macias,I., Liang,E., Cranfield,M., Han,B.A., Tingley,M.W., Diuk-Wasser,M., Goldstein,T., Johnson,C.K., Mazet,J., Chandran,K., Munster,V.J., Gilardi,K. and Anthony,S.J. The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Wicik,Z., Eyileten,C., Jakubik,D., Simoes,S.N., Martins,D.C., Jr., Pavao,R., Siller-Matula,J.M. and Postula,M. ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors J Clin Med (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Wijnant,S.R., Jacobs,M., Van Eeckhoutte,H.P., Lapauw,B., Joos,G.F., Bracke,K.R. and Brusselle,G.G. Expression of ACE2, the SARS-CoV-2 Receptor, in Lung Tissue of Patients With Type 2 Diabetes Diabetes (2020) 69, 2691-2699. PubMed Europe PubMed DOI
Williamson,G. and Kerimi,A. Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction Biochem Pharmacol (2020) 178, 114123-114123. PubMed Europe PubMed DOI PMC EPMC I
Winkler,E.S., Bailey,A.L., Kafai,N.M., Nair,S., McCune,B.T., Yu,J., Fox,J.M., Chen,R.E., Earnest,J.T., Keeler,S.P., Ritter,J.H., Kang,L.I., Dort,S., Robichaud,A., Head,R., Holtzman,M.J. and Diamond,M.S. Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function Nat Immunol (2020) 21, 1470-1470. PubMed Europe PubMed DOI PMC EPMC
Winkler,E.S., Bailey,A.L., Kafai,N.M., Nair,S., McCune,B.T., Yu,J., Fox,J.M., Chen,R.E., Earnest,J.T., Keeler,S.P., Ritter,J.H., Kang,L.I., Dort,S., Robichaud,A., Head,R., Holtzman,M.J. and Diamond,M.S. SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function Nat Immunol (2020) 21, 1327-1335. PubMed Europe PubMed DOI
Winkler,E.S., Bailey,A.L., Kafai,N.M., Nair,S., McCune,B.T., Yu,J., Fox,J.M., Chen,R.E., Earnest,J.T., Keeler,S.P., Ritter,J.H., Kang,L.I., Dort,S., Robichaud,A., Head,R., Holtzman,M.J. and Diamond,M.S. SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Wrobel,A.G., Benton,D.J., Xu,P., Roustan,C., Martin,S.R., Rosenthal,P.B., Skehel,J.J. and Gamblin,S.J. SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects Nat Struct Mol Biol (2020) 27, 763-767. PubMed Europe PubMed DOI
Wruck,W. and Adjaye,J. SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress Sci Rep (2020) 10, 21415-21415. PubMed Europe PubMed DOI PMC EPMC
Wu,C., Ye,D., Mullick,A.E., Li,Z., Danser,A.H.J., Daugherty,A. and Lu,H.S. Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19 Hypertension (2020) 76, e29-e30. PubMed Europe PubMed DOI PMC EPMC
Wu,C.Y., Lin,Y.S., Yang,Y.H., Shu,L.H., Cheng,Y.C. and Liu,H.T. GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies Biomed Pharmacother (2020) 132, 110816-110816. PubMed Europe PubMed DOI PMC EPMC
Wu,C.Y., Lin,Y.S., Yang,Y.H., Shu,L.H., Cheng,Y.C. and Liu,H.T. Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2 Front Pharmacol (2020) 11, 584158-584158. PubMed Europe PubMed DOI PMC EPMC
Wu,J. A Novel Angiotensin Converting Enzyme 2 (ACE2) Activating Peptide: A Reflection of 10 Years of Research on a Small Peptide Ile-Arg-Trp (IRW) J Agric Food Chem (2020) 68, 14402-14408. PubMed Europe PubMed DOI
Wu,L., Chen,Q., Liu,K., Wang,J., Han,P., Zhang,Y., Hu,Y., Meng,Y., Pan,X., Qiao,C., Tian,S., Du,P., Song,H., Shi,W., Qi,J., Wang,H.W., Yan,J., Gao,G.F. and Wang,Q. Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2 Cell Discov (2020) 6, 68-68. PubMed Europe PubMed DOI PMC EPMC
Wysocki,J., Lores,E., Ye,M., Soler,M.J. and Batlle,D. Kidney and Lung ACE2 Expression after an ACE Inhibitor or an Ang II Receptor Blocker: Implications for COVID-19 J Am Soc Nephrol (2020) 31, 1941-1943. PubMed Europe PubMed DOI
Xiang,Z., Liu,J., Shi,D., Chen,W., Li,J., Yan,R., Bi,Y., Hu,W., Zhu,Z., Yu,Y. and Yang,Z. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels Int J Biol Sci (2020) 16, 2382-2391. PubMed Europe PubMed DOI PMC EPMC
Xie,Y., Karki,C.B., Du,D., Li,H., Wang,J., Sobitan,A., Teng,S., Tang,Q. and Li,L. Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2 Front Mol Biosci (2020) 7, 591873-591873. PubMed Europe PubMed DOI PMC EPMC
Xing,Y., Hua,Y.R., Shang,J., Ge,W.H. and Liao,J. Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019 Chin J Nat Med (2020) 18, 941-951. PubMed Europe PubMed DOI PMC EPMC I
Xiong,H.L., Wu,Y.T., Cao,J.L., Yang,R., Liu,Y.X., Ma,J., Qiao,X.Y., Yao,X.Y., Zhang,B.H., Zhang,Y.L., Hou,W.H., Shi,Y., Xu,J.J., Zhang,L., Wang,S.J., Fu,B.R., Yang,T., Ge,S.X., Zhang,J., Yuan,Q., Huang,B.Y., Li,Z.Y., Zhang,T.Y. and Xia,N.S. Robust neutralization assay based on SARS-CoV-2 S-protein-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressing BHK21 cells Emerg Microbes Infect (2020) 9, 2105-2113. PubMed Europe PubMed DOI PMC EPMC
Xu,F., Gao,J., Munkhsaikhan,U., Li,N., Gu,Q., Pierre,J.F., Starlard-Davenport,A., Towbin,J.A., Cui,Y., Purevjav,E. and Lu,L. The Genetic Dissection of Ace2 Expression Variation in the Heart of Murine Genetic Reference Population Front Cardiovasc Med (2020) 7, 582949-582949. PubMed Europe PubMed DOI PMC EPMC
Xu,Y., Liu,S., Zhang,Y. and Zhi,Y. Does hereditary angioedema make COVID-19 worse? World Allergy Organ J (2020) 13, 100454-100454. PubMed Europe PubMed DOI PMC EPMC V
Xu,Y., Liu,S., Zhang,Y. and Zhi,Y. Does hereditary angioedema make COVID-19 worse? World Allergy Organ J (2020) 13, 100454-100454. PubMed Europe PubMed DOI PMC EPMC V
Yamamoto,K., Takeshita,H. and Rakugi,H. ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19 Clin Sci (Lond) (2020) 134, 3047-3062. PubMed Europe PubMed DOI PMC EPMC
Yan,R., Zhang,Y., Li,Y., Xia,L., Guo,Y. and Zhou,Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 Science (2020) 367, 1444-1448. PubMed Europe PubMed DOI S
Yao,J., Gong,X., Shi,X., Fan,S., Chen,J. and Chen,Q. The efficacy of angiotensin converting enzyme inhibitors versus angiotensin II receptor blockers on insulin resistance in hypertensive patients: A protocol for a systematic review and meta-analysis Medicine (Baltimore) (2020) 99, e20674-e20674. PubMed Europe PubMed DOI PMC EPMC
Yao,Y., Wang,H. and Liu,Z. Expression of ACE2 in airways: Implication for COVID-19 risk and disease management in patients with chronic inflammatory respiratory diseases Clin Exp Allergy (2020) 50, 1313-1324. PubMed Europe PubMed DOI V
Yu,W., Ou,X., Liu,X., Zhang,S., Gao,X., Cheng,H., Zhu,B. and Yan,J. ACE2 contributes to the maintenance of mouse epithelial barrier function Biochem Biophys Res Commun (2020) 533, 1276-1282. PubMed Europe PubMed DOI PMC EPMC
Zamai,L. The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients Cells (2020) 9 PubMed Europe PubMed DOI
Zamorano Cuervo,N. and Grandvaux,N. ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities elife (2020) 9 PubMed Europe PubMed DOI PMC EPMC
Zhang,H., Quek,K., Chen,R., Chen,J. and Chen,B. Expression of the SAR2-Cov-2 receptor ACE2 reveals the susceptibility of COVID-19 in non-small cell lung cancer J Cancer (2020) 11, 5289-5292. PubMed Europe PubMed DOI PMC EPMC
Zhang,H., Quek,K., Chen,R., Chen,J. and Chen,B. Expression of the SAR2-Cov-2 receptor ACE2 reveals the susceptibility of COVID-19 in non-small cell lung cancer J Cancer (2020) 11, 5289-5292. PubMed Europe PubMed DOI PMC EPMC
Zhang,S., Liu,Y., Wang,X., Yang,L., Li,H., Wang,Y., Liu,M., Zhao,X., Xie,Y., Yang,Y., Zhang,S., Fan,Z., Dong,J., Yuan,Z., Ding,Z., Zhang,Y. and Hu,L. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19 J Hematol Oncol (2020) 13, 120-120. PubMed Europe PubMed DOI PMC EPMC
Zhang,T., Zhong,S. and Cao,W. COVID-19 and Comorbid Hypertension: Is ACE2 the Culprit? Prehosp Disaster Med (2020) , 1-2. PubMed Europe PubMed DOI PMC EPMC
Zhang,X.Y., Huang,H.J., Zhuang,D.L., Nasser,M.I., Yang,M.H., Zhu,P. and Zhao,M.Y. Biological, clinical and epidemiological features of COVID-19, SARS and MERS and AutoDock simulation of ACE2 Infect Dis Poverty (2020) 9, 99-99. PubMed Europe PubMed DOI PMC EPMC V
Zhang,Z., Li,L., Li,M. and Wang,X. The SARS-CoV-2 host cell receptor ACE2 correlates positively with immunotherapy response and is a potential protective factor for cancer progression Comput Struct Biotechnol J (2020) 18, 2438-2444. PubMed Europe PubMed DOI PMC EPMC
Zhao,P., Praissman,J.L., Grant,O.C., Cai,Y., Xiao,T., Rosenbalm,K.E., Aoki,K., Kellman,B.P., Bridger,R., Barouch,D.H., Brindley,M.A., Lewis,N.E., Tiemeyer,M., Chen,B., Woods,R.J. and Wells,L. Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Zhao,X., Chen,D., Szabla,R., Zheng,M., Li,G., Du,P., Zheng,S., Li,X., Song,C., Li,R., Guo,J.T., Junop,M., Zeng,H. and Lin,H. Broad and differential animal ACE2 receptor usage by SARS-CoV-2 J Virol (2020) 94, e00940-20-e00940-20. PubMed Europe PubMed DOI
Zhao,Y., Zhao,Z., Wang,Y., Zhou,Y., Ma,Y. and Zuo,W. Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2 Am J Respir Crit Care Med (2020) 202, 756-759. PubMed Europe PubMed DOI
Zheng,L., Zhang,L., Huang,J., Nandakumar,K.S., Liu,S. and Cheng,K. Potential treatment methods targeting 2019-nCoV infection Eur J Med Chem (2020) 205, 112687-112687. PubMed Europe PubMed DOI PMC EPMC V I
Zheng,M., Zhao,X., Zheng,S., Chen,D., Du,P., Li,X., Jiang,D., Guo,J.T., Zeng,H. and Lin,H. Bat SARS-Like WIV1 coronavirus uses the ACE2 of multiple animal species as receptor and evades IFITM3 restriction via TMPRSS2 activation of membrane fusion Emerg Microbes Infect (2020) 9, 1567-1579. PubMed Europe PubMed DOI
Zhong,M., Lin,B., Pathak,J.L., Gao,H., Young,A.J., Wang,X., Liu,C., Wu,K., Liu,M., Chen,J.M., Huang,J., Lee,L.H., Qi,C.L., Ge,L. and Wang,L. ACE2 and Furin Expressions in Oral Epithelial Cells Possibly Facilitate COVID-19 Infection via Respiratory and Fecal-Oral Routes Front Med (Lausanne) (2020) 7, 580796-580796. PubMed Europe PubMed DOI PMC EPMC
Zhou,L., Xu,Z., Castiglione,G.M., Soiberman,U.S., Eberhart,C.G. and Duh,E.J. ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection Ocul Surf (2020) 18, 537-544. PubMed Europe PubMed DOI PMC EPMC
Zhou,L., Huntington,K., Zhang,S., Carlsen,L., So,E.Y., Parker,C., Sahin,I., Safran,H., Kamle,S., Lee,C.M., Lee,C.G., Elias,J.A., Campbell,K.S., Naik,M.T., Atwood,W.J., Youssef,E., Pachter,J.A., Navaraj,A., Seyhan,A.A., Liang,O. and El-Deiry,W.S. Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells bioRxiv (2020) PubMed Europe PubMed DOI PMC EPMC
Zhou,L., Niu,Z., Jiang,X., Zhang,Z., Zheng,Y., Wang,Z., Zhu,Y., Gao,L., Huang,H., Wang,X. and Sun,Q. SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin Proteases iScience (2020) 23, 101744-101744. PubMed Europe PubMed DOI PMC EPMC
Zhou,L., Huntington,K., Zhang,S., Carlsen,L., So,E.Y., Parker,C., Sahin,I., Safran,H., Kamle,S., Lee,C.M., Geun Lee,C., Elias,A., Campbell,S., Naik,T., Atwood,J., Youssef,E., Pachter,A., Navaraj,A., Seyhan,A., Liang,O. and El-Deiry,W.S. MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Oncotarget (2020) 11, 4201-4223. PubMed Europe PubMed DOI PMC EPMC
Zhou,T., Tsybovsky,Y., Gorman,J., Rapp,M., Cerutti,G., Chuang,G.Y., Katsamba,P.S., Sampson,J.M., Schon,A., Bimela,J., Boyington,J.C., Nazzari,A., Olia,A.S., Shi,W., Sastry,M., Stephens,T., Stuckey,J., Teng,I.T., Wang,P., Wang,S., Zhang,B., Friesner,R.A., Ho,D.D., Mascola,J.R., Shapiro,L. and Kwong,P.D. Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains Cell Host Microbe (2020) 28, 867-879. PubMed Europe PubMed DOI PMC EPMC
Zipeto,D., Palmeira,J.D.F., Arganaraz,G.A. and Arganaraz,E.R. ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 Front Immunol (2020) 11, 576745-576745. PubMed Europe PubMed DOI PMC EPMC V
Zoufaly,A., Poglitsch,M., Aberle,J.H., Hoepler,W., Seitz,T., Traugott,M., Grieb,A., Pawelka,E., Laferl,H., Wenisch,C., Neuhold,S., Haider,D., Stiasny,K., Bergthaler,A., Puchhammer-Stoeckl,E., Mirazimi,A., Montserrat,N., Zhang,H., Slutsky,A.S. and Penninger,J.M. Human recombinant soluble ACE2 in severe COVID-19 Lancet Respir Med (2020) 8, 1154-1158. PubMed Europe PubMed DOI PMC EPMC

2019

Kangussu,L.M., de Almeida,T.C.S., Prestes,T.R.R., de Andrade De Maria,M.L., da Silva Filha,R., Vieira,M.A.R., Silva,A.C.S.E. and Ferreira,A.J. Beneficial effects of the angiotensin-converting enzyme 2 activator DIZE in renovascular hypertension Protein Pept Lett (2019) 26, 523-531. PubMed Europe PubMed DOI I
Liu,C., Chen,C.Y., Shang,Q.H. and Liu,J. [Establishment of Ace2 knockout mouse model with CRISPR/Cas9 gene targeting technology] Sheng Li Xue Bao (2019) 71, 588-596. PubMed Europe PubMed K

2018

Bruce,E.B., Sakarya,Y., Kirichenko,N., Toklu,H.Z., Sumners,C., Morgan,D., Tumer,N., Scarpace,P.J. and Carter,C.S. ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats Exp Gerontol (2018) 111, 133-140. PubMed Europe PubMed DOI I
Liao,W., Bhullar,K.S., Chakrabarti,S., Davidge,S.T. and Wu,J. Egg white-derived tripeptide IRW (Ile-Arg-Trp) is an activator of angiotensin converting enzyme 2 J Agric Food Chem (2018) 66, 11330-11336. PubMed Europe PubMed DOI
Liu,P., Wysocki,J., Souma,T., Ye,M., Ramirez,V., Zhou,B., Wilsbacher,L.D., Quaggin,S.E., Batlle,D. and Jin,J. Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation Kidney Int (2018) 94, 114-125. PubMed Europe PubMed DOI U
Williams,V.R. and Scholey,J.W. Angiotensin-converting enzyme 2 and renal disease Curr Opin Nephrol Hypertens (2018) 27, 35-41. PubMed Europe PubMed DOI
Zhang,J., Dong,J., Martin,M., He,M., Gongol,B., Marin,T.L., Chen,L., Shi,X., Yin,Y., Shang,F., Wu,Y., Huang,H.Y., Zhang,J., Zhang,Y., Kang,J., Moya,E.A., Huang,H.D., Powell,F.L., Chen,Z., Thistlethwaite,P.A., Yuan,Z.Y. and Shyy,J.Y. AMP-activated protein kinase phosphorylation of angiotensin-converting enzyme 2 in endothelium mitigates pulmonary hypertension Am J Respir Crit Care Med (2018) 198, 509-520. PubMed Europe PubMed DOI

2017

Bae,E.H., Fang,F., Williams,V.R., Konvalinka,A., Zhou,X., Patel,V.B., Song,X., John,R., Oudit,G.Y., Pei,Y. and Scholey,J.W. Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome Kidney Int (2017) 91, 1347-1361. PubMed Europe PubMed DOI U
Sriramula,S., Pedersen,K.B., Xia,H. and Lazartigues,E. Determining the enzymatic activity of angiotensin-converting enzyme 2 (ACE2) in brain tissue and cerebrospinal fluid using a quenched fluorescent substrate Methods Mol Biol (2017) 1527, 117-126. PubMed Europe PubMed DOI A
Wang,Y., Cassis,L.A. and Thatcher,S.E. Use of a fluorescent substrate to measure ACE2 activity in the mouse abdominal aorta Methods Mol Biol (2017) 1614, 61-67. PubMed Europe PubMed DOI A
Yang,P., Kuc,R.E., Brame,A.L., Dyson,A., Singer,M., Glen,R.C., Cheriyan,J., Wilkinson,I.B., Davenport,A.P. and Maguire,J.J. [Pyr1]Apelin-13(1-12) is a biologically active ACE2 metabolite of the endogenous cardiovascular peptide [Pyr1]apelin-13 Front Neurosci (2017) 11, 92-92. PubMed Europe PubMed DOI PMC EPMC

2016

Chen,Y.Y., Liu,D., Zhang,P., Zhong,J.C., Zhang,C.J., Wu,S.L., Zhang,Y.Q., Liu,G.Z., He,M., Jin,L.J. and Yu,H.M. Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors J Hum Hypertens (2016) 30, 766-771. PubMed Europe PubMed DOI M I
Joshi,S., Balasubramanian,N., Vasam,G. and Jarajapu,Y.P. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells Eur J Pharmacol (2016) 774, 25-33. PubMed Europe PubMed DOI I
Motta-Santos,D., dos Santos,R.A., Oliveira,M., Qadri,F., Poglitsch,M., Mosienko,V., Kappes Becker,L., Campagnole-Santos,M.J., M Penninger,J., Alenina,N. and Bader,M. Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise Hypertens Res (2016) 39, 506-512. PubMed Europe PubMed DOI K
Qiu,Y., Tao,L., Zheng,S., Lin,R., Fu,X., Chen,Z., Lei,C., Wang,J., Li,H., Li,Q. and Lei,B. AAV8-mediated angiotensin-converting enzyme 2 gene delivery prevents experimental autoimmune uveitis by regulating MAPK, NF-kappaB and STAT3 pathways Sci Rep (2016) 6, 31912-31912. PubMed Europe PubMed DOI PMC EPMC U
Rabelo,L.A., Todiras,M., Nunes-Souza,V., Qadri,F., Szijarto,I.A., Gollasch,M., Penninger,J.M., Bader,M., Santos,R.A. and Alenina,N. Genetic deletion of ACE2 induces vascular dysfunction in C57BL/6 mice: role of nitric oxide imbalance and oxidative stress PLoS ONE (2016) 11, e0150255-e0150255. PubMed Europe PubMed DOI PMC EPMC K
Tao,L., Qiu,Y., Fu,X., Lin,R., Lei,C., Wang,J. and Lei,B. Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-kappaB pathways in human retinal pigment epithelium J Neuroinflammation (2016) 13, 35-35. PubMed Europe PubMed DOI PMC EPMC I
Velkoska,E., Patel,S.K. and Burrell,L.M. Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation Curr Opin Nephrol Hypertens (2016) 25, 384-395. PubMed Europe PubMed DOI
Wang,L., de Kloet,A.D., Pati,D., Hiller,H., Smith,J.A., Pioquinto,D.J., Ludin,J.A., Oh,S.P., Katovich,M.J., Frazier,C.J., Raizada,M.K. and Krause,E.G. Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors Neuropharmacology (2016) 105, 114-123. PubMed Europe PubMed DOI
Wang,W., McKinnie,S.M., Farhan,M., Paul,M., McDonald,T., McLean,B., Llorens-Cortes,C., Hazra,S., Murray,A.G., Vederas,J.C. and Oudit,G.Y. Angiotensin-converting enzyme 2 metabolizes and partially inactivates pyr-apelin-13 and apelin-17: physiological effects in the cardiovascular system Hypertension (2016) 68, 365-377. PubMed Europe PubMed DOI I

2015

Bernardi,S., Tikellis,C., Candido,R., Tsorotes,D., Pickering,R.J., Bossi,F., Carretta,R., Fabris,B., Cooper,M.E. and Thomas,M.C. ACE2 deficiency shifts energy metabolism towards glucose utilization Metabolism (2015) 64, 406-415. PubMed Europe PubMed DOI K
Clayton,D., Hanchapola,I., Thomas,W.G., Widdop,R.E., Smith,A.I., Perlmutter,P. and Aguilar,M.I. Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2 Front Pharmacol (2015) 6, 5-5. PubMed Europe PubMed DOI PMC EPMC
Liu,C., Xiao,L., Li,F., Zhang,H., Li,Q., Liu,H., Fu,S., Li,C., Zhang,X., Wang,J., Staunstrup,N.H., Li,Y. and Yang,H. Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation Transgenic Res (2015) 24, 433-446. PubMed Europe PubMed DOI K
Mak,K.Y., Chin,R., Cunningham,S.C., Habib,M.R., Torresi,J., Sharland,A.F., Alexander,I.E., Angus,P.W. and Herath,C.B. ACE2 therapy using adeno-associated viral vector inhibits liver fibrosis in mice Mol Ther (2015) 23, 1434-1443. PubMed Europe PubMed DOI U
Takahashi,S., Yoshiya,T., Yoshizawa-Kumagaye,K. and Sugiyama,T. Nicotianamine is a novel angiotensin-converting enzyme 2 inhibitor in soybean Biomed Res (2015) 36, 219-224. PubMed Europe PubMed DOI A I

2014

Jiang,F., Yang,J., Zhang,Y., Dong,M., Wang,S., Zhang,Q., Liu,F.F., Zhang,K. and Zhang,C. Angiotensin-converting enzyme 2 and angiotensin 1-7: novel therapeutic targets Nat Rev Cardiol (2014) 11, 413-426. PubMed Europe PubMed DOI V
Lambert,D.W., Lambert,L.A., Clarke,N.E., Hooper,N.M., Porter,K.E. and Turner,A.J. Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421 Clin Sci (Lond) (2014) 127, 243-249. PubMed Europe PubMed DOI
Liu,S., Liu,J., Miura,Y., Tanabe,C., Maeda,T., Terayama,Y., Turner,A.J., Zou,K. and Komano,H. Conversion of Abeta43 to Abeta40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme J Neurosci Res (2014) 92, 1178-1186. PubMed Europe PubMed DOI I
Niu,J. and Shi,F. The recombinant expression of truncated human ACE2 in E. coli Chin J Pharm Biotechnol (2014) 21, 398-401. E
Xue,T., Wei,N., Xin,Z. and Qingyu,X. Angiotensin-converting enzyme-2 overexpression attenuates inflammation in rat model of chronic obstructive pulmonary disease Inhal Toxicol (2014) 26, 14-22. PubMed Europe PubMed DOI
Yang,P., Gu,H., Zhao,Z., Wang,W., Cao,B., Lai,C., Yang,X., Zhang,L., Duan,Y., Zhang,S., Chen,W., Zhen,W., Cai,M., Penninger,J.M., Jiang,C. and Wang,X. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury Sci Rep (2014) 4, 7027-7027. PubMed Europe PubMed DOI PMC EPMC

2013

Chen,J., Xiao,X., Chen,S., Zhang,C., Chen,J., Yi,D., Shenoy,V., Raizada,M.K., Zhao,B. and Chen,Y. Angiotensin-converting enzyme 2 priming enhances the function of endothelial progenitor cells and their therapeutic efficacy Hypertension (2013) 61, 681-689. PubMed Europe PubMed DOI U
Chhabra,K.H., Xia,H., Pedersen,K.B., Speth,R.C. and Lazartigues,E. Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice Am J Physiol Endocrinol Metab (2013) 304, E874-E884. PubMed Europe PubMed DOI U
Fraga-Silva,R.A., Costa-Fraga,F.P., Murca,T.M., Moraes,P.L., Martins Lima,A., Lautner,R.Q., Castro,C.H., Soares,C.M., Borges,C.L., Nadu,A.P., Oliveira,M.L., Shenoy,V., Katovich,M.J., Santos,R.A., Raizada,M.K. and Ferreira,A.J. Angiotensin-converting enzyme 2 activation improves endothelial function Hypertension (2013) 61, 1233-1238. PubMed Europe PubMed DOI
Kuba,K., Imai,Y. and Penninger,J.M. Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases Circ J (2013) 77, 301-308. PubMed Europe PubMed DOI
Marian,A.J. The discovery of the ACE2 gene Circ Res (2013) 112, 1307-1309. PubMed Europe PubMed DOI
Takeda,M., Yamamoto,K., Takemura,Y., Takeshita,H., Hongyo,K., Kawai,T., Hanasaki-Yamamoto,H., Oguro,R., Takami,Y., Tatara,Y., Takeya,Y., Sugimoto,K., Kamide,K., Ohishi,M. and Rakugi,H. Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice Diabetes (2013) 62, 223-233. PubMed Europe PubMed DOI

2012

Batlle,D., Wysocki,J., Soler,M.J. and Ranganath,K. Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy Kidney Int (2012) 81, 520-528. PubMed Europe PubMed DOI
Clarke,N.E., Hooper,N.M. and Turner,A.J. Angiotensin-converting enzyme 2 [ISSN:978-0-12-407744-7] (2012) 3, 499-504. DOI
Jin,H.Y., Song,B., Oudit,G.Y., Davidge,S.T., Yu,H.M., Jiang,Y.Y., Gao,P.J., Zhu,D.L., Ning,G., Kassiri,Z., Penninger,J.M. and Zhong,J.C. ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production PLoS ONE (2012) 7, e38502-e38502. PubMed Europe PubMed DOI PMC EPMC
Kleinsasser,A., Pircher,I., Treml,B., Schwienbacher,M., Schuster,M., Janzek,E., Loibner,H., Penninger,J.M. and Loeckinger,A. Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia Wilderness Environ Med (2012) 23, 24-30. PubMed Europe PubMed DOI U
Murca,T.M., Moraes,P.L., Capuruco,C.A., Santos,S.H., Melo,M.B., Santos,R.A., Shenoy,V., Katovich,M.J., Raizada,M.K. and Ferreira,A.J. Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction Regul Pept (2012) 177, 107-115. PubMed Europe PubMed DOI
Poglitsch,M., Domenig,O., Schwager,C., Stranner,S., Peball,B., Janzek,E., Wagner,B., Jungwirth,H., Loibner,H. and Schuster,M. Recombinant expression and characterization of human and murine ACE2: species-specific activation of the alternative renin-angiotensin-system Int J Hypertens (2012) 2012, 428950-428950. PubMed Europe PubMed DOI PMC EPMC E
Tikellis,C. and Thomas,M.C. Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease Int J Pept (2012) 2012, 256294-256294. PubMed Europe PubMed DOI PMC EPMC K U
Wang,W., Bodiga,S., Das,S.K., Lo,J., Patel,V. and Oudit,G.Y. Role of ACE2 in diastolic and systolic heart failure Heart Fail Rev (2012) 17, 683-691. PubMed Europe PubMed DOI
Ye,M., Wysocki,J., Gonzalez-Pacheco,F.R., Salem,M., Evora,K., Garcia-Halpin,L., Poglitsch,M., Schuster,M. and Batlle,D. Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2 Hypertension (2012) 60, 730-740. PubMed Europe PubMed DOI I

2011

Aragao,D.S., Cunha,T.S., Arita,D.Y., Andrade,M.C., Fernandes,A.B., Watanabe,I.K., Mortara,R.A. and Casarini,D.E. Purification and characterization of angiotensin converting enzyme 2 (ACE2) from murine model of mesangial cell in culture Int J Biol Macromol (2011) 49, 79-84. PubMed Europe PubMed DOI
Bharadwaj,M.S., Strawn,W.B., Groban,L., Yamaleyeva,L.M., Chappell,M.C., Horta,C., Atkins,K., Firmes,L., Gurley,S.B. and Brosnihan,K.B. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction Hypertension (2011) 58, 852-858. PubMed Europe PubMed DOI K
Clayton,D., Hanchapola,I., Hausler,N., Unabia,S., Lew,R.A., Widdop,R.E., Smith,A.I., Perlmutter,P. and Aguilar,M.I. beta-Amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2) J Mol Recognit (2011) 24, 235-244. PubMed Europe PubMed DOI
Jin,X.Q., Lu,Z.Q. and Lin,X. Effect of ACE2 gene transfection on the proliferation of vascular smooth muscle cells in rats Zhonghua Yi Xue Za Zhi (2011) 91, 125-128. DOI
Lai,Z.W., Hanchapola,I., Steer,D.L. and Smith,A.I. Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints Biochemistry (2011) 50, 5182-5194. PubMed Europe PubMed DOI
Miller,L.K., Hou,X., Rodriguiz,R.M., Gagnidze,K., Sweedler,J.V., Wetsel,W.C. and Devi,L.A. Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord J Neurochem (2011) 119, 1074-1085. PubMed Europe PubMed DOI K
Oudit,G.Y. and Penninger,J.M. Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy Curr Heart Fail Rep (2011) 8, 176-183. PubMed Europe PubMed DOI U
Pedersen,K.B., Sriramula,S., Chhabra,K.H., Xia,H. and Lazartigues,E. Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays Am J Physiol Regul Integr Comp Physiol (2011) 301, R1293-R1299. PubMed Europe PubMed DOI I
Sriramula,S., Cardinale,J.P., Lazartigues,E. and Francis,J. ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension Cardiovasc Res (2011) 92, 401-408. PubMed Europe PubMed DOI U
Vangjeli,C., Dicker,P., Tregouet,D.A., Shields,D.C., Evans,A. and Stanton,A.V. A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project J Renin Angiotensin Aldosterone Syst (2011) 12, 504-509. PubMed Europe PubMed DOI M
Wosten-van Asperen,R.M., Lutter,R., Specht,P.A., Moll,G.N., van Woensel,J.B., Van der Loos,C.M., van Goor,H., Kamilic,J., Florquin,S. and Bos,A.P. Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist J Pathol (2011) 225, 618-627. PubMed Europe PubMed DOI U
Xiao,L., Gao,L., Lazartigues,E. and Zucker,I.H. Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure Hypertension (2011) 58, 1057-1065. PubMed Europe PubMed DOI U

2010

Batlle,D., Wysocki,J. and Khan,M.S. Vascular angiotensin-converting enzyme 2: lord of the ring? Circ Res (2010) 107, 822-824. PubMed Europe PubMed DOI PMC EPMC
Feng,Y., Xia,H., Cai,Y., Halabi,C.M., Becker,L.K., Santos,R.A., Speth,R.C., Sigmund,C.D. and Lazartigues,E. Brain-selective overexpression of human angiotensin-converting enzyme type 2 attenuates neurogenic hypertension Circ Res (2010) 106, 373-382. PubMed Europe PubMed DOI
Feng,Y., Xia,H., Santos,R.A., Speth,R. and Lazartigues,E. Angiotensin-converting enzyme 2: a new target for neurogenic hypertension Exp Physiol (2010) 95, 601-606. PubMed Europe PubMed DOI
Fraga-Silva,R.A., Sorg,B.S., Wankhede,M., Dedeugd,C., Jun,J.Y., Baker,M.B., Li,Y., Castellano,R.K., Katovich,M.J., Raizada,M.K. and Ferreira,A.J. ACE2 activation promotes antithrombotic activity Mol Med (2010) 16, 210-215. PubMed Europe PubMed DOI PMC EPMC I
Kuba,K., Imai,Y., Ohto-Nakanishi,T. and Penninger,J.M. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters Pharmacol Ther (2010) 128, 119-128. PubMed Europe PubMed DOI V
Lambert,D.W., Clarke,N.E. and Turner,A.J. Not just angiotensinases: new roles for the angiotensin-converting enzymes Cell Mol Life Sci (2010) 67, 89-98. PubMed Europe PubMed DOI V
Shiota,A., Yamamoto,K., Ohishi,M., Tatara,Y., Ohnishi,M., Maekawa,Y., Iwamoto,Y., Takeda,M. and Rakugi,H. Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice Hypertens Res (2010) 33, 298-307. PubMed Europe PubMed DOI K
Thomas,M.C., Pickering,R.J., Tsorotes,D., Koitka,A., Sheehy,K., Bernardi,S., Toffoli,B., Nguyen-Huu,T.P., Head,G.A., Fu,Y., Chin-Dusting,J., Cooper,M.E. and Tikellis,C. Genetic Ace2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse Circ Res (2010) 107, 888-897. PubMed Europe PubMed DOI K I
Trask,A.J., Groban,L., Westwood,B.M., Varagic,J., Ganten,D., Gallagher,P.E., Chappell,M.C. and Ferrario,C.M. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats Am J Hypertens (2010) 23, 687-693. PubMed Europe PubMed DOI I
Treml,B., Neu,N., Kleinsasser,A., Gritsch,C., Finsterwalder,T., Geiger,R., Schuster,M., Janzek,E., Loibner,H., Penninger,J. and Loeckinger,A. Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets Crit Care Med (2010) 38, 596-601. PubMed Europe PubMed DOI U
Wysocki,J., Ye,M., Rodriguez,E., Gonzalez-Pacheco,F.R., Barrios,C., Evora,K., Schuster,M., Loibner,H., Brosnihan,K.B., Ferrario,C.M., Penninger,J.M. and Batlle,D. Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension Hypertension (2010) 55, 90-98. PubMed Europe PubMed DOI PMC EPMC U
Xia,H. and Lazartigues,E. Angiotensin-converting enzyme 2: central regulator for cardiovascular function Curr Hypertens Rep (2010) 12, 170-175. PubMed Europe PubMed DOI
Zhao,Y.X., Yin,H.Q., Yu,Q.T., Qiao,Y., Dai,H.Y., Zhang,M.X., Zhang,L., Liu,Y.F., Wang,L.C., Liu,d.S., Deng,B.P., Zhang,Y.H., Pan,C.M., Song,H.D., Qu,X., Jiang,H., Liu,C.X., Lu,X.T., Liu,B., Gao,F. and Dong,B. ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction Hum Gene Ther (2010) 21, 1545-1554. PubMed Europe PubMed DOI

2009

Bindom,S.M. and Lazartigues,E. The sweeter side of ACE2: physiological evidence for a role in diabetes Mol Cell Endocrinol (2009) 302, 193-202. PubMed Europe PubMed DOI PMC EPMC
Clayton,D., Hanchapola,I., Perlmutter,P., Smith,A.I. and Aguilar,M.I. The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and beta-amino acid substrate analogs Adv Exp Med Biol (2009) 611, 559-560. PubMed Europe PubMed DOI P
De Mello,W.C. Opposite effects of angiotensin II and angiotensin (1-7) on impulse propagation, excitability and cardiac arrhythmias. Is the overexpression of ACE2 arrhythmogenic? Regul Pept (2009) 153, 7-10. PubMed Europe PubMed DOI
Lai,Z.W., Lew,R.A., Yarski,M.A., Mu,F.T., Andrews,R.K. and Smith,A.I. The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2 Endocrinology (2009) 150, 2376-2381. PubMed Europe PubMed DOI
Oudit,G.Y., Imai,Y., Kuba,K., Scholey,J.W. and Penninger,J.M. The role of ACE2 in pulmonary diseases - relevance for the nephrologist Nephrol Dial Transplant (2009) 24, 1362-1365. PubMed Europe PubMed DOI
Riviere,G. [Angiotensin-converting enzyme: a protein conserved during evolution] J Soc Biol (2009) 203, 281-293. PubMed Europe PubMed DOI V
Wu,K., Li,W., Peng,G. and Li,F. Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor Proc Natl Acad Sci U S A (2009) 106, 19970-19974. PubMed Europe PubMed DOI PMC EPMC S
Xu,L., Zhang,Y., Liu,Y., Chen,Z., Deng,H., Ma,Z., Wang,H., Hu,Z. and Deng,F. Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus J Gen Virol (2009) 90, 2695-2703. PubMed Europe PubMed DOI

2008

Batlle,D., Soler,M.J. and Wysocki,J. New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy Curr Opin Nephrol Hypertens (2008) 17, 250-257. PubMed Europe PubMed DOI T
Deaton,D.N., Gao,E.N., Graham,K.P., Gross,J.W., Miller,A.B. and Strelow,J.M. Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite Bioorg Med Chem Lett (2008) 18, 732-737. PubMed Europe PubMed DOI I
Deaton,D.N., Graham,K.P., Gross,J.W. and Miller,A.B. Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite Bioorg Med Chem Lett (2008) 18, 1681-1687. PubMed Europe PubMed DOI I
Elased,K.M., Cunha,T.S., Marcondes,F.K. and Morris,M. Brain angiotensin-converting enzymes: role of angiotensin-converting enzyme 2 in processing angiotensin II in mice Exp Physiol (2008) 93, 665-675. PubMed Europe PubMed DOI
Feng,Y., Yue,X., Xia,H., Bindom,S.M., Hickman,P.J., Filipeanu,C.M., Wu,G. and Lazartigues,E. Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation Circ Res (2008) 102, 729-736. PubMed Europe PubMed DOI PMC EPMC
Ferreira,A.J. and Raizada,M.K. Are we poised to target ACE2 for the next generation of antihypertensives? J Mol Med (Berl) (2008) 86, 685-690. PubMed Europe PubMed DOI V T
Ferreira,A.J., Hernandez Prada,J.A., Ostrov,D.A. and Raizada,M.K. Cardiovascular protection by angiotensin-converting enzyme 2: a new paradigm Future Cardiol (2008) 4, 175-182. PubMed Europe PubMed DOI
Garabelli,P.J., Modrall,J.G., Penninger,J.M., Ferrario,C.M. and Chappell,M.C. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart Exp Physiol (2008) 93, 613-621. PubMed Europe PubMed DOI PMC EPMC I
Guo,H., Guo,A., Wang,C., Yan,B., Lu,H. and Chen,H. Expression of feline angiotensin converting enzyme 2 and its interaction with SARS-CoV S1 protein Res Vet Sci (2008) 84, 494-496. PubMed Europe PubMed DOI E
Guo,Y.J., Li,W.H., Wu,R., Xie,Q. and Cui,L.Q. ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages Arch Med Res (2008) 39, 149-154. PubMed Europe PubMed DOI
Gurley,S.B. and Coffman,T.M. Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages Exp Physiol (2008) 93, 538-542. PubMed Europe PubMed DOI
Hernandez Prada,J.A., Ferreira,A.J., Katovich,M.J., Shenoy,V., Qi,Y., Santos,R.A., Castellano,R.K., Lampkins,A.J., Gubala,V., Ostrov,D.A. and Raizada,M.K. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents Hypertension (2008) 51, 1312-1317. PubMed Europe PubMed DOI
Imai,Y., Kuba,K. and Penninger,J.M. [Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)] Masui (2008) 57, 302-310. PubMed Europe PubMed
Koitka,A., Cooper,M.E., Thomas,M.C. and Tikellis,C. Angiotensin converting enzyme 2 in the kidney Clin Exp Pharmacol Physiol (2008) 35, 420-425. PubMed Europe PubMed DOI
Lambert,D.W., Hooper,N.M. and Turner,A.J. Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system Biochem Pharmacol (2008) 75, 781-786. PubMed Europe PubMed DOI V
Lew,R.A., Warner,F.J., Hanchapola,I., Yarski,M.A., Manohar,J., Burrell,L.M. and Smith,A.I. Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor Exp Physiol (2008) 93, 685-693. PubMed Europe PubMed DOI
Lubel,J.S., Herath,C.B., Velkoska,E., Casley,D.J., Burrell,L.M. and Angus,P.W. Angiotensin converting enzyme 2 (ACE2) activity in fetal calf serum: implications for cell culture research Cytotechnology (2008) 58, 119-126. PubMed Europe PubMed DOI PMC EPMC
Mores,A., Matziari,M., Beau,F., Cuniasse,P., Yiotakis,A. and Dive,V. Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2 J Med Chem (2008) 51, 2216-2226. PubMed Europe PubMed DOI I
Nakamura,K., Koibuchi,N., Nishimatsu,H., Higashikuni,Y., Hirata,Y., Kugiyama,K., Nagai,R. and Sata,M. Candesartan ameliorates cardiac dysfunction observed in Angiotensin-converting enzyme 2-deficient mice Hypertens Res (2008) 31, 1953-1961. PubMed Europe PubMed DOI K
Niu,M.J., Yang,J.K., Lin,S.S., Ji,X.J. and Guo,L.M. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice Endocrine (2008) 34, 56-61. PubMed Europe PubMed DOI K
Rushworth,C.A., Guy,J.L. and Turner,A.J. Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis FEBS J (2008) 275, 6033-6042. PubMed Europe PubMed DOI I
Soler,M.J., Wysocki,J. and Batlle,D. Angiotensin-converting enzyme 2 and the kidney Exp Physiol (2008) 93, 549-556. PubMed Europe PubMed DOI
Tikellis,C., Bialkowski,K., Pete,J., Sheehy,K., Su,Q., Johnston,C., Cooper,M.E. and Thomas,M.C. ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes Diabetes (2008) 57, 1018-1025. PubMed Europe PubMed DOI I
Zucker,I.H. Angiotensin-converting enzyme 2: a new player in central sympathetic regulation? Circ Res (2008) 102, 628-629. PubMed Europe PubMed DOI

2007

Burns,K.D. The emerging role of angiotensin-converting enzyme-2 in the kidney Curr Opin Nephrol Hypertens (2007) 16, 116-121. PubMed Europe PubMed DOI
Doobay,M.F., Talman,L.S., Obr,T.D., Tian,X., Davisson,R.L. and Lazartigues,E. Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system Am J Physiol Regul Integr Comp Physiol (2007) 292, R373-R381. PubMed Europe PubMed DOI PMC EPMC
Fan,X., Wang,Y., Sun,K., Zhang,W., Yang,X., Wang,S., Zhen,Y., Wang,J., Li,W., Han,Y., Liu,T., Wang,X., Chen,J., Wu,H. and Hui,R. Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of captopril in women Clin Pharmacol Ther (2007) 82, 187-196. PubMed Europe PubMed DOI M
Grobe,J.L., Der Sarkissian,S., Stewart,J.M., Meszaros,J.G., Raizada,M.K. and Katovich,M.J. ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts Clin Sci (Lond) (2007) 113, 357-364. PubMed Europe PubMed DOI U
Hamming,I., Cooper,M.E., Haagmans,B.L., Hooper,N.M., Korstanje,R., Osterhaus,A.D., Timens,W., Turner,A.J., Navis,G. and van Goor,H. The emerging role of ACE2 in physiology and disease J Pathol (2007) 212, 1-11. PubMed Europe PubMed DOI V
Keidar,S., Kaplan,M. and Gamliel-Lazarovich,A. ACE2 of the heart: from angiotensin I to angiotensin (1-7) Cardiovasc Res (2007) 73, 463-469. PubMed Europe PubMed DOI
Li,W., Sui,J., Huang,I.C., Kuhn,J.H., Radoshitzky,S.R., Marasco,W.A., Choe,H. and Farzan,M. The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2 Virology (2007) 367, 367-374. PubMed Europe PubMed DOI PMC EPMC
Oudit,G.Y., Kassiri,Z., Patel,M.P., Chappell,M., Butany,J., Backx,P.H., Tsushima,R.G., Scholey,J.W., Khokha,R. and Penninger,J.M. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice Cardiovasc Res (2007) 75, 29-39. PubMed Europe PubMed DOI K
Raizada,M.K. and Ferreira,A.J. ACE2: a new target for cardiovascular disease therapeutics J Cardiovasc Pharmacol (2007) 50, 112-119. PubMed Europe PubMed DOI V
Shaltout,H.A., Westwood,B.M., Averill,D.B., Ferrario,C.M., Figueroa,J.P., Diz,D.I., Rose,J.C. and Chappell,M.C. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II Am J Physiol Renal Physiol (2007) 292, F82-F91. PubMed Europe PubMed DOI
Soler,M.J., Wysocki,J., Ye,M., Lloveras,J., Kanwar,Y. and Batlle,D. ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice Kidney Int (2007) 72, 614-623. PubMed Europe PubMed DOI I
Trask,A.J., Averill,D.B., Ganten,D., Chappell,M.C. and Ferrario,C.M. Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats Am J Physiol Heart Circ Physiol (2007) 292, H3019-H3024. PubMed Europe PubMed DOI I
Wiener,R.S., Cao,Y.X., Hinds,A., Ramirez,M.I. and Williams,M.C. Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung J Cell Biochem (2007) 101, 1278-1291. PubMed Europe PubMed DOI
Wong,D.W., Oudit,G.Y., Reich,H., Kassiri,Z., Zhou,J., Liu,Q.C., Backx,P.H., Penninger,J.M., Herzenberg,A.M. and Scholey,J.W. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury Am J Pathol (2007) 171, 438-451. PubMed Europe PubMed DOI PMC EPMC K
Yang,X.H., Deng,W., Tong,Z., Liu,Y.X., Zhang,L.F., Zhu,H., Gao,H., Huang,L., Liu,Y.L., Ma,C.M., Xu,Y.F., Ding,M.X., Deng,H.K. and Qin,C. Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection Comp Med (2007) 57, 450-459. PubMed Europe PubMed
Zhang,Y. and Wada,J. Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives Biochem Biophys Res Commun (2007) 363, 1-5. PubMed Europe PubMed DOI

2006

[YEAR:5-4-2006]Chou,C.F., Loh,C.B., Foo,Y.K., Shen,S., Fielding,B.C., Tan,T.H., Khan,S., Wang,Y., Lim,S.G., Hong,W., Tan,Y.J. and Fu,J. ACE2 orthologues in non-mammalian vertebrates (Danio, Gallus, Fugu, Tetraodon and Xenopus) Gene (5-4-2006) 377, 46-55. PubMed Europe PubMed DOI
[YEAR:3-3-2006]Danilczyk,U. and Penninger,J.M. Angiotensin-converting enzyme II in the heart and the kidney Circ Res (3-3-2006) 98, 463-471. PubMed Europe PubMed DOI K
[YEAR:8-7-2006]Der Sarkissian,S., Huentelman,M.J., Stewart,J., Katovich,M.J. and Raizada,M.K. ACE2: a novel therapeutic target for cardiovascular diseases Prog Biophys Mol Biol (8-7-2006) 91, 163-198. PubMed Europe PubMed DOI
[YEAR:20-6-2006]Diez-Freire,C., Vazquez,J., Correa de Adjounian,M.F., Ferrari,M.F., Yuan,L., Silver,X., Torres,R. and Raizada,M.K. ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR Physiol Genomics (20-6-2006) 27, 12-19. PubMed Europe PubMed DOI
Elased,K.M., Cunha,T.S., Gurley,S.B., Coffman,T.M. and Morris,M. New mass spectrometric assay for angiotensin-converting enzyme 2 activity Hypertension (2006) 47, 1010-1017. PubMed Europe PubMed DOI A I
[YEAR:1-8-2006]Gurley,S.B., Allred,A., Le,T.H., Griffiths,R., Mao,L., Philip,N., Haystead,T.A., Donoghue,M., Breitbart,R.E., Acton,S.L., Rockman,H.A. and Coffman,T.M. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice J Clin Invest (1-8-2006) 116, 2218-2225. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:4-10-2006]Ingelfinger,J.R. ACE2: a new target for prevention of diabetic nephropathy? J Am Soc Nephrol (4-10-2006) 17, 2957-2959. PubMed Europe PubMed DOI T
Kuba,K., Imai,Y., Rao,S., Jiang,C. and Penninger,J.M. Lessons from SARS: control of acute lung failure by the SARS receptor ACE2 J Mol Med (Berl) (2006) 84, 814-820. PubMed Europe PubMed DOI
[YEAR:11-11-2006]Lieb,W., Graf,J., Gotz,A., Konig,I.R., Mayer,B., Fischer,M., Stritzke,J., Hengstenberg,C., Holmer,S.R., Doring,A., Lowel,H., Schunkert,H. and Erdmann,J. Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men. Results of the MONICA Augsburg echocardiographic substudy J Mol Med (Berl) (11-11-2006) 84, 88-96. PubMed Europe PubMed DOI M
Rella,M., Rushworth,C.A., Guy,J.L., Turner,A.J., Langer,T. and Jackson,R.M. Structure-based pharmacophore design and virtual screening for novel Angiotensin converting enzyme 2 inhibitors J Chem Inf Model (2006) 46, 708-716. PubMed Europe PubMed DOI I
[YEAR:25-9-2006]Rice,G.I., Jones,A.L., Grant,P.J., Carter,A.M., Turner,A.J. and Hooper,N.M. Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study Hypertension (25-9-2006) 48, 914-920. PubMed Europe PubMed DOI
[YEAR:17-5-2006]Tikellis,C., Cooper,M.E., Bialkowski,K., Johnston,C.I., Burns,W.C., Lew,R.A., Smith,A.I. and Thomas,M.C. Developmental expression of ACE2 in the SHR kidney: a role in hypertension? Kidney Int (17-5-2006) 70, 34-41. PubMed Europe PubMed DOI
Yamamoto,K., Ohishi,M., Katsuya,T., Ito,N., Ikushima,M., Kaibe,M., Tatara,Y., Shiota,A., Sugano,S., Takeda,S., Rakugi,H. and Ogihara,T. Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II Hypertension (2006) 47, 718-726. PubMed Europe PubMed DOI K

2005

Burrell,L.M., Risvanis,J., Kubota,E., Dean,R.G., MacDonald,P.S., Lu,S., Tikellis,C., Grant,S.L., Lew,R.A., Smith,A.I., Cooper,M.E. and Johnston,C.I. Myocardial infarction increases ACE2 expression in rat and humans Eur Heart J (2005) 26, 369-375. PubMed Europe PubMed DOI
[YEAR:15-4-2005]Ferrario,C.M. Myocardial infarction increases ACE2 expression in rat and humans Eur Heart J (15-4-2005) 26, 1141-1143. PubMed Europe PubMed DOI
[YEAR:24-5-2005]Ferrario,C.M., Jessup,J., Chappell,M.C., Averill,D.B., Brosnihan,K.B., Tallant,E.A., Diz,D.I. and Gallagher,P.E. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2 Circulation (24-5-2005) 111, 2605-2610. PubMed Europe PubMed DOI
[YEAR:7-10-2005]Frojdo,S., Sjolind,L., Parkkonen,M., Makinen,V.P., Kilpikari,R., Pettersson-Fernholm,K., Forsblom,C., Fagerudd,J., Tikellis,C., Cooper,M.E., Wessman,M. and Groop,P.H. Polymorphisms in the gene encoding angiotensin I converting enzyme 2 and diabetic nephropathy Diabetologia (7-10-2005) 48, 2278-2281. PubMed Europe PubMed DOI
Gembardt,F., Sterner-Kock,A., Imboden,H., Spalteholz,M., Reibitz,F., Schultheiss,H.P., Siems,W.E. and Walther,T. Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents Peptides (2005) 26, 1270-1277. PubMed Europe PubMed DOI
Guy,J.L., Jackson,R.M., Jensen,H.A., Hooper,N.M. and Turner,A.J. Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis FEBS J (2005) 272, 3512-3520. PubMed Europe PubMed DOI
[YEAR:1-8-2005]Guy,J.L., Lambert,D.W., Warner,F.J., Hooper,N.M. and Turner,A.J. Membrane-associated zinc peptidase families: comparing ACE and ACE2 Biochim Biophys Acta (1-8-2005) 1751, 2-8. PubMed Europe PubMed DOI
[YEAR:7-7-2005]Imai,Y., Kuba,K., Rao,S., Huan,Y., Guo,F., Guan,B., Yang,P., Sarao,R., Wada,T., Leong-Poi,H., Crackower,M.A., Fukamizu,A., Hui,C.C., Hein,L., Uhlig,S., Slutsky,A.S., Jiang,C. and Penninger,J.M. Angiotensin-converting enzyme 2 protects from severe acute lung failure Nature (7-7-2005) 436, 112-116. PubMed Europe PubMed DOI
[YEAR:1-7-2005]Itoyama,S., Keicho,N., Hijikata,M., Quy,T., Phi,N.C., Long,H.T., Ha,L.D., Ban,V.V., Matsushita,I., Yanai,H., Kirikae,F., Kirikae,T., Kuratsuji,T. and Sasazuki,T. Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population Am J Med Genet A (1-7-2005) 136, 52-57. PubMed Europe PubMed DOI
[YEAR:7-1-2005]Katovich,M.J., Grobe,J.L., Huentelman,M. and Raizada,M.K. Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension Exp Physiol (7-1-2005) 90, 299-305. PubMed Europe PubMed DOI
Kruit,A., Ruven,H.J., Grutters,J.C. and van den Bosch,J.M. Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients Sarcoidosis Vasc Diffuse Lung Dis (2005) 22, 195-203. PubMed Europe PubMed M
[YEAR:10-7-2005]Kuba,K., Imai,Y., Rao,S., Gao,H., Guo,F., Guan,B., Huan,Y., Yang,P., Zhang,Y., Deng,W., Bao,L., Zhang,B., Liu,G., Wang,Z., Chappell,M., Liu,Y., Zheng,D., Leibbrandt,A., Wada,T., Slutsky,A.S., Liu,D., Qin,C., Jiang,C. and Penninger,J.M. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Nat Med (10-7-2005) 11, 875-879. PubMed Europe PubMed DOI
[YEAR:27-6-2005]Lambert,D.W., Yarski,M., Warner,F.J., Thornhill,P., Parkin,E.T., Smith,A.I., Hooper,N.M. and Turner,A.J. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2) J Biol Chem (27-6-2005) 280, 30113-30119. PubMed Europe PubMed DOI
Leckie,B.J. Targeting the renin-angiotensin system: what's new? Curr Med Chem Cardiovasc Hematol Agents (2005) 3, 23-32. PubMed Europe PubMed DOI V
[YEAR:16-9-2005]Li,F., Li,W., Farzan,M. and Harrison,S.C. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Science (16-9-2005) 309, 1864-1868. PubMed Europe PubMed DOI S
[YEAR:5-10-2005]Li,N., Zimpelmann,J., Cheng,K., Wilkins,J.A. and Burns,K.D. The role of angiotensin converting enzyme 2 in the generation of angiotensin 1-7 by rat proximal tubules Am J Physiol Renal Physiol (5-10-2005) 288, F353-F362. PubMed Europe PubMed DOI I
[YEAR:20-4-2005]Li,W., Zhang,C., Sui,J., Kuhn,J.H., Moore,M.J., Luo,S., Wong,S.K., Huang,I.C., Xu,K., Vasilieva,N., Murakami,A., He,Y., Marasco,W.A., Guan,Y., Choe,H. and Farzan,M. Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 EMBO J (20-4-2005) 24, 1634-1643. PubMed Europe PubMed DOI PMC EPMC
Mossel,E.C., Huang,C., Narayanan,K., Makino,S., Tesh,R.B. and Peters,C.J. Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication J Virol (2005) 79, 3846-3850. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-9-2005]Paizis,G., Tikellis,C., Cooper,M.E., Schembri,J.M., Lew,R.A., Smith,A.I., Shaw,T., Warner,F.J., Zuilli,A., Burrell,L.M. and Angus,P.W. Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2 Gut (15-9-2005) 54, 1790-1796. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-9-2005]Warner,F.J., Lew,R.A., Smith,A.I., Lambert,D.W., Hooper,N.M. and Turner,A.J. Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells J Biol Chem (15-9-2005) 280, 39353-39362. PubMed Europe PubMed DOI
Zhang,Y., Zheng,N., Hao,P., Cao,Y. and Zhong,Y. A molecular docking model of SARS-CoV S1 protein in complex with its receptor, human ACE2 Comput Biol Chem (2005) 29, 254-257. PubMed Europe PubMed DOI

2004

Benjafield,A.V., Wang,W.Y. and Morris,B.J. No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension Am J Hypertens (2004) 17, 624-628. PubMed Europe PubMed DOI M
Burrell,L.M., Johnston,C.I., Tikellis,C. and Cooper,M.E. ACE2, a new regulator of the renin-angiotensin system Trends Endocrinol Metab (2004) 15, 166-169. PubMed Europe PubMed DOI
Campbell,D.J., Zeitz,C.J., Esler,M.D. and Horowitz,J.D. Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation J Hypertens (2004) 22, 1971-1976. PubMed Europe PubMed DOI
Chiu,R.W., Tang,N.L., Hui,D.S., Chung,G.T., Chim,S.S., Chan,K.C., Sung,Y.M., Chan,L.Y., Tong,Y.K., Lee,W.S., Chan,P.K. and Lo,Y.M. ACE2 gene polymorphisms do not affect outcome of severe acute respiratory syndrome Clin Chem (2004) 50, 1683-1686. PubMed Europe PubMed DOI M
Danilczyk,U., Eriksson,U., Oudit,G.Y. and Penninger,J.M. Physiological roles of angiotensin-converting enzyme 2 Cell Mol Life Sci (2004) 61, 2714-2719. PubMed Europe PubMed DOI
[YEAR:1-7-2004]Douglas,G.C., O'Bryan,M.K., Hedger,M.P., Lee,D.K., Yarski,M.A., Smith,A.I. and Lew,R.A. The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis Endocrinology (1-7-2004) 145, 4703-4711. PubMed Europe PubMed DOI
Hamming,I., Timens,W., Bulthuis,M.L., Lely,A.T., Navis,G.J. and van Goor,H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis J Pathol (2004) 203, 631-637. PubMed Europe PubMed DOI
[YEAR:9-7-2004]Hofmann,H., Geier,M., Marzi,A., Krumbiegel,M., Peipp,M., Fey,G.H., Gramberg,T. and Pohlmann,S. Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor Biochem Biophys Res Commun (9-7-2004) 319, 1216-1221. PubMed Europe PubMed DOI
[YEAR:15-10-2004]Huentelman,M.J., Zubcevic,J., Katovich,M.J. and Raizada,M.K. Cloning and characterization of a secreted form of angiotensin-converting enzyme 2 Regul Pept (15-10-2004) 122, 61-67. PubMed Europe PubMed DOI
Huentelman,M.J., Zubcevic,J., Hernandez Prada,J.A., Xiao,X., Dimitrov,D.S., Raizada,M.K. and Ostrov,D.A. Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor Hypertension (2004) 44, 903-906. PubMed Europe PubMed DOI I
Kuhn,J.H., Li,W., Choe,H. and Farzan,M. Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus Cell Mol Life Sci (2004) 61, 2738-2743. PubMed Europe PubMed DOI
Lely,A.T., Hamming,I., van Goor,H. and Navis,G.J. Renal ACE2 expression in human kidney disease J Pathol (2004) 204, 587-593. PubMed Europe PubMed DOI
Li,W., Greenough,T.C., Moore,M.J., Vasilieva,N., Somasundaran,M., Sullivan,J.L., Farzan,M. and Choe,H. Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2 J Virol (2004) 78, 11429-11433. PubMed Europe PubMed DOI PMC EPMC
[YEAR:4-8-2004]Lin,Q., Keller,R.S., Weaver,B. and Zisman,L.S. Interaction of ACE2 and integrin beta1 in failing human heart Biochim Biophys Acta (4-8-2004) 1689, 175-178. PubMed Europe PubMed DOI
Moore,M.J., Dorfman,T., Li,W., Wong,S.K., Li,Y., Kuhn,J.H., Coderre,J., Vasilieva,N., Han,Z., Greenough,T.C., Farzan,M. and Choe,H. Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2 J Virol (2004) 78, 10628-10635. PubMed Europe PubMed DOI PMC EPMC
[YEAR:29-7-2004]Rice,G.I., Thomas,D.A., Grant,P.J., Turner,A.J. and Hooper,N.M. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Biochem J (29-7-2004) 383, 45-51. PubMed Europe PubMed DOI PMC EPMC
Towler,P., Staker,B., Prasad,S.G., Menon,S., Tang,J., Parsons,T., Ryan,D., Fisher,M., Williams,D., Dales,N.A., Patane,M.A. and Pantoliano,M.W. ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis J Biol Chem (2004) 279, 17996-18007. PubMed Europe PubMed DOI S I
Turner,A.J. and Hooper,N.M. Angiotensin-converting enzyme 2 [ISSN:0-12-079610-4] (2004) 2, 349-352. V
Turner,A.J., Hiscox,J.A. and Hooper,N.M. ACE2: from vasopeptidase to SARS virus receptor Trends Pharmacol Sci (2004) 25, 291-294. PubMed Europe PubMed DOI
Warner,F.J., Smith,A.I., Hooper,N.M. and Turner,A.J. Angiotensin-converting enzyme-2: a molecular and cellular perspective Cell Mol Life Sci (2004) 61, 2704-2713. PubMed Europe PubMed DOI V

2003

Danilczyk,U., Eriksson,U., Crackower,M.A. and Penninger,J.M. A story of two ACEs J Mol Med (2003) 81, 227-234. PubMed Europe PubMed DOI
[YEAR:18-11-2003]Guy,J.L., Jackson,R.M., Acharya,K.R., Sturrock,E.D., Hooper,N.M. and Turner,A.J. Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence Biochemistry (18-11-2003) 42, 13185-13192. PubMed Europe PubMed DOI
[YEAR:2-5-2003]Huang,L., Sexton,D.J., Skogerson,K., Devlin,M., Smith,R., Sanyal,I., Parry,T., Kent,R., Enright,J., Wu,Q.L., Conley,G., DeOliveira,D., Morganelli,L., Ducar,M., Wescott,C.R. and Ladner,R.C. Novel peptide inhibitors of angiotensin-converting enzyme 2 J Biol Chem (2-5-2003) 278, 15532-15540. PubMed Europe PubMed DOI I
Tikellis,C., Johnston,C.I., Forbes,J.M., Burns,W.C., Burrell,L.M., Risvanis,J. and Cooper,M.E. Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy Hypertension (2003) 41, 392-397. PubMed Europe PubMed DOI I
[YEAR:15-1-2003]Yan,Z.H., Ren,K.J., Wang,Y., Chen,S., Brock,T.A. and Rege,A.A. Development of intramolecularly quenched fluorescent peptides as substrates of angiotensin-converting enzyme 2 Anal Biochem (15-1-2003) 312, 141-147. PubMed Europe PubMed DOI

2002

[YEAR:20-6-2002]Crackower,M.A., Sarao,R., Oudit,G.Y., Yagil,C., Kozieradzki,I., Scanga,S.E., Oliveira-dos-Santos,A.J., da Costa,J., Zhang,L., Pei,Y., Scholey,J., Ferrario,C.M., Manoukian,A.S., Chappell,M.C., Backx,P.H., Yagil,Y. and Penninger,J.M. Angiotensin-converting enzyme 2 is an essential regulator of heart function Nature (20-6-2002) 417, 822-828. PubMed Europe PubMed DOI
[YEAR:9-10-2002]Dales,N.A., Gould,A.E., Brown,J.A., Calderwood,E.F., Guan,B., Minor,C.A., Gavin,J.M., Hales,P., Kaushik,V.K., Stewart,M., Tummino,P.J., Vickers,C.S., Ocain,T.D. and Patane,M.A. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors J Am Chem Soc (9-10-2002) 124, 11852-11853. PubMed Europe PubMed DOI I
[YEAR:29-10-2002]Eriksson,U., Danilczyk,U. and Penninger,J.M. Just the beginning: novel functions for angiotensin-converting enzymes Curr Biol (29-10-2002) 12, R745-R752. PubMed Europe PubMed DOI
[YEAR:4-12-2002]Harmer,D., Gilbert,M., Borman,R. and Clark,K.L. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme FEBS Lett (4-12-2002) 532, 107-110. PubMed Europe PubMed DOI
Turner,A.J., Tipnis,S.R., Guy,J.L., Rice,G. and Hooper,N.M. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors Can J Physiol Pharmacol (2002) 80, 346-353. PubMed Europe PubMed DOI
Turner,A.J. and Hooper,N.M. The angiotensin-converting enzyme gene family: genomics and pharmacology Trends Pharmacol Sci (2002) 23, 177-183. PubMed Europe PubMed DOI
[YEAR:26-4-2002]Vickers,C., Hales,P., Kaushik,V., Dick,L., Gavin,J., Tang,J., Godbout,K., Parsons,T., Baronas,E., Hsieh,F., Acton,S., Patane,M., Nichols,A. and Tummino,P. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase J Biol Chem (26-4-2002) 277, 14838-14843. PubMed Europe PubMed DOI

2000

Buchatskii,A.G., Kazachenko,K.Y. and Alexandrov,A.A. Hypothetical 92.3-kD human protein homologous to angiotensin-converting enzyme: a new member of the zinc metalloprotease family? Biochemistry (Mosc) (2000) 65, 1019-1022. PubMed Europe PubMed
[YEAR:1-9-2000]Donoghue,M., Hsieh,F., Baronas,E., Godbout,K., Gosselin,M., Stagliano,N., Donovan,M., Woolf,B., Robison,K., Jeyaseelan,R., Breitbart,R.E. and Acton,S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Circ Res (1-9-2000) 87, E1-E9. PubMed Europe PubMed I
[YEAR:27-10-2000]Tipnis,S.R., Hooper,N.M., Hyde,R., Karran,E., Christie,G. and Turner,A.J. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase J Biol Chem (27-10-2000) 275, 33238-33243. PubMed Europe PubMed DOI E I