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Literature for peptidase C25.002: gingipain K

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Castillo,Y., Castellanos,J.E., Lafaurie,G.I. and Castillo,D.M.
    Porphyromonas gingivalis outer membrane vesicles modulate cytokine and chemokine production by gingipain-dependent mechanisms in human macrophages
    Arch Oral Biol140, 105453-105453. PubMed  Europe PubMed DOI
    2. 2021
  2. Song,L.T., Tada,H., Nishioka,T., Nemoto,E., Imamura,T., Potempa,J., Li,C.Y., Matsushita,K. and Sugawara,S.
    Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells
    J Innate Immun1-14. PubMed  Europe PubMed DOI
    3. 2020
  3. Arastu-Kapur,S., Nguyen,M., Raha,D., Ermini,F., Haditsch,U., Araujo,J., De Lannoy,I.A.M., Ryder,M.I., Dominy,S.S., Lynch,C. and Holsinger,L.J.
    Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388
    Pharmacol Res Perspect8, e00562-e00562. PubMed  Europe PubMed DOI  I
  4. Mo,W., Luo,H., Wu,J., Xu,N., Zhang,F., Qiu,Q., Zhu,W. and Liang,M.
    Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin beta3 in RAW264.7 cells
    J Mol Histol51, 147-159. PubMed  Europe PubMed DOI
  5. Seers,C.A., Mahmud,A.S.M., Huq,N.L., Cross,K.J. and Reynolds,E.C.
    Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains
    J Oral Microbiol13, 1858001-1858001. PubMed  Europe PubMed DOI
    6. 2019
  6. Guevara,T., Rodriguez-Banqueri,A., Lasica,A.M., Ksiazek,M., Potempa,B.A., Potempa,J. and Gomis-Ruth,F.X.
    Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor
    Sci Rep9, 4935-4935. PubMed  Europe PubMed DOI  S  I
  7. Lippold,S., Nicolardi,S., Wuhrer,M. and Falck,D.
    Proteoform-resolved FcRIIIa binding assay for Fab glycosylated monoclonal antibodies achieved by affinity chromatography mass spectrometry of Fc moieties
    Front Chem7, 698-698. PubMed  Europe PubMed DOI
    8. 2017
  8. Kariu,T., Nakao,R., Ikeda,T., Nakashima,K., Potempa,J. and Imamura,T.
    Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids
    J Periodontal Res52, 89-96. PubMed  Europe PubMed DOI  I
  9. Pomowski,A., Uson,I., Nowakowska,Z., Veillard,F., Sztukowska,M.N., Guevara,T., Goulas,T., Mizgalska,D., Nowak,M., Potempa,B., Huntington,J.A., Potempa,J. and Gomis-Ruth,F.X.
    Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome
    J Biol Chem292, 5724-5735. PubMed  Europe PubMed DOI
  10. Sjogren,J., Andersson,L., Mejare,M. and Olsson,F.
    Generating and purifying Fab fragments from human and mouse IgG using the bacterial enzymes IdeS, SpeB and Kgp
    Methods Mol Biol1535, 319-329. PubMed  Europe PubMed DOI
    11. 2016
  11. Plaza,K., Kalinska,M., Bochenska,O., Meyer-Hoffert,U., Wu,Z., Fischer,J., Falkowski,K., Sasiadek,L., Bielecka,E., Potempa,B., Kozik,A., Potempa,J. and Kantyka,T.
    Gingipains of Porphyromonas gingivalis affect the stability and function of serine protease inhibitor of Kazal-type 6 (SPINK6), a tissue inhibitor of human kallikreins
    J Biol Chem291, 18753-18764. PubMed  Europe PubMed DOI
    12. 2015
  12. Dou,Y., Robles,A., Roy,F., Aruni,A.W., Sandberg,L., Nothnagel,E. and Fletcher,H.M.
    The roles of RgpB and Kgp in late onset gingipain activity in the vimA-defective mutant of Porphyromonas gingivalis W83
    Mol Oral Microbiol30, 347-360. PubMed  Europe PubMed DOI
  13. Gorman,M.A., Seers,C.A., Michell,B.J., Feil,S.C., Huq,N.L., Cross,K.J., Reynolds,E.C. and Parker,M.W.
    Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health
    Protein Sci24, 162-166. PubMed  Europe PubMed DOI  S
  14. Jung,Y.J., Jun,H.K. and Choi,B.K.
    Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation
    Cell Microbiol17, 1304-1319. PubMed  Europe PubMed DOI
  15. Palm,E., Khalaf,H. and Bengtsson,T.
    Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis
    Mol Oral Microbiol30, 74-85. PubMed  Europe PubMed DOI
  16. Tancharoen,S., Matsuyama,T., Kawahara,K., Tanaka,K., Lee,L.J., Machigashira,M., Noguchi,K., Ito,T., Imamura,T., Potempa,J., Kikuchi,K. and Maruyama,I.
    Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients
    PLoS ONE10, e0117775-e0117775. PubMed  Europe PubMed DOI
    17. 2014
  17. Akiyama,T., Miyamoto,Y., Yoshimura,K., Yamada,A., Takami,M., Suzawa,T., Hoshino,M., Imamura,T., Akiyama,C., Yasuhara,R., Mishima,K., Maruyama,T., Kohda,C., Tanaka,K., Potempa,J., Yasuda,H., Baba,K. and Kamijo,R.
    Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain
    J Biol Chem289, 15621-15630. PubMed  Europe PubMed DOI
  18. de Diego,I., Veillard,F., Sztukowska,M.N., Guevara,T., Potempa,B., Pomowski,A., Huntington,J.A., Potempa,J. and Gomis-Ruth,F.X.
    Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis
    J Biol Chem289, 32291-32302. PubMed  Europe PubMed DOI  S
  19. Haraguchi,A., Miura,M., Fujise,O., Hamachi,T. and Nishimura,F.
    Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm
    Mol Oral Microbiol29, 131-143. PubMed  Europe PubMed DOI  I
  20. Kataoka,S., Baba,A., Suda,Y., Takii,R., Hashimoto,M., Kawakubo,T., Asao,T., Kadowaki,T. and Yamamoto,K.
    A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy
    FASEB J28, 3564-3578. PubMed  Europe PubMed DOI  I
  21. Miyamoto,Y.
    Molecular mechanisms for bone resorption by gingipains: degradation of osteoprotegerin by lysine-specific gingipain is a key factor for enhanced osteoclastogenesis
    J Oral Biosci56, 120-124. DOI
    22. 2013
  22. Huq,N.L., Seers,C.A., Toh,E.C., Dashper,S.G., Slakeski,N., Zhang,L., Ward,B.R., Meuric,V., Chen,D., Cross,K.J. and Reynolds,E.C.
    Propeptide-mediated inhibition of cognate gingipain proteinases
    PLoS ONE8, e65447-e65447. PubMed  Europe PubMed DOI
  23. Veillard,F., Sztukowska,M., Mizgalska,D., Ksiazek,M., Houston,J., Potempa,B., Enghild,J.J., Thogersen,I.B., Gomis-Ruth,F.X., Nguyen,K.A. and Potempa,J.
    Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases
    Biochim Biophys Acta Gen Subj1830, 4218-4228. PubMed  Europe PubMed DOI
    24. 2012
  24. Pike,R.N. and Potempa,J.
    Gingipain K
    [ISSN:978-0-12-407743-0]3, 2337-2344. DOI
  25. Sztukowska,M., Veillard,F., Potempa,B., Bogyo,M., Enghild,J.J., Thogersen,I.B., Nguyen,K.A. and Potempa,J.
    Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes
    Biol Chem393, 971-977. PubMed  Europe PubMed DOI
  26. Veillard,F., Potempa,B., Poreba,M., Drag,M. and Potempa,J.
    Gingipain aminopeptidase activities in Porphyromonas gingivalis
    Biol Chem393, 1471-1476. PubMed  Europe PubMed DOI
    27. 2011
  27. Smalley,J.W., Byrne,D.P., Birss,A.J., Wojtowicz,H., Sroka,A., Potempa,J. and Olczak,T.
    HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis
    PLoS ONE6, e17182-e17182. PubMed  Europe PubMed DOI
  28. Toh,E.C., Dashper,S.G., Huq,N.L., Attard,T.J., O'Brien-Simpson,N.M., Chen,Y.Y., Cross,K.J., Stanton,D.P., Paolini,R.A. and Reynolds,E.C.
    Porphyromonas gingivalis cysteine proteinase inhibition by kappa-casein peptides
    Antimicrob Agents Chemother55, 1155-1161. PubMed  Europe PubMed DOI
  29. Vincents,B., Guentsch,A., Kostolowska,D., von Pawel-Rammingen,U., Eick,S., Potempa,J. and Abrahamson,M.
    Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis
    FASEB J25, 3741-3750. PubMed  Europe PubMed DOI
  30. Yongqing,T., Potempa,J., Pike,R.N. and Wijeyewickrema,L.C.
    The lysine-specific gingipain of Porphyromonas gingivalis: importance to pathogenicity and potential strategies for inhibition
    Adv Exp Med Biol712, 15-29. PubMed  Europe PubMed DOI  I
    31. 2010
  31. Guo,Y., Nguyen,K.A. and Potempa,J.
    Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins
    Periodontol 200054, 15-44. PubMed  Europe PubMed DOI
  32. Saiki,K. and Konishi,K.
    Identification of a novel Porphyromonas gingivalis outer membrane protein, PG534, required for the production of active gingipains
    FEMS Microbiol Lett310, 168-174. PubMed  Europe PubMed DOI
    33. 2009
  33. Fitzpatrick,R.E., Wijeyewickrema,L.C. and Pike,R.N.
    The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis
    Future Microbiol4, 471-487. PubMed  Europe PubMed DOI
  34. Inomata,M., Ishihara,Y., Matsuyama,T., Imamura,T., Maruyama,I., Noguchi,T. and Matsushita,K.
    Degradation of vascular endothelial thrombomodulin by arginine-and lysine-specific cysteine proteases from Porphyromonas gingivalis
    J Periodontol80, 1511-1517. PubMed  Europe PubMed DOI
  35. Ishiguro,I., Saiki,K. and Konishi,K.
    PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system
    FEMS Microbiol Lett292, 261-267. PubMed  Europe PubMed DOI
  36. Tam,V., O'Brien-Simpson,N.M., Chen,Y.Y., Sanderson,C.J., Kinnear,B. and Reynolds,E.C.
    The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis inactivate the Th2 cytokines interleukin-4 and interleukin-5
    Infect Immun77, 1451-1458. PubMed  Europe PubMed DOI
  37. Yasuhara,R., Miyamoto,Y., Takami,M., Imamura,T., Potempa,J., Yoshimura,K. and Kamijo,R.
    Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin
    Biochem J419, 159-166. PubMed  Europe PubMed DOI
    38. 2008
  38. Bania,J., Kubiak,A., Wojtachnio,K. and Polanowski,A.
    Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis
    J Periodontal Res43, 232-236. PubMed  Europe PubMed DOI
  39. Dias,I.H., Marshall,L., Lambert,P.A., Chapple,I.L., Matthews,J.B. and Griffiths,H.R.
    Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant
    Infect Immun76, 317-323. PubMed  Europe PubMed DOI
  40. Ishida,Y., Hu,J., Sakai,E., Kadowaki,T., Yamamoto,K., Tsukuba,T., Kato,Y., Nakayama,K. and Okamoto,K.
    Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system
    Arch Oral Biol53, 538-544. PubMed  Europe PubMed DOI
  41. Sheets,S.M., Robles-Price,A.G., McKenzie,R.M., Casiano,C.A. and Fletcher,H.M.
    Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis
    Front Biosci13, 3215-3238. PubMed  Europe PubMed DOI  V
  42. Smalley,J.W., Birss,A.J., Szmigielski,B. and Potempa,J.
    Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis
    Biol Chem389, 1235-1238. PubMed  Europe PubMed DOI
    43. 2007
  43. Kadowaki,T., Takii,R., Yamatake,K., Kawakubo,T., Tsukuba,T. and Yamamoto,K.
    A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells
    Front Biosci12, 4800-4809. PubMed  Europe PubMed DOI
  44. Popadiak,K., Potempa,J., Riesbeck,K. and Blom,A.M.
    Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system
    J Immunol178, 7242-7250. PubMed  Europe PubMed
  45. Saiki,K. and Konishi,K.
    Identification of a Porphyromonas gingivalis novel protein sov required for the secretion of gingipains
    Microbiol Immunol51, 483-491. PubMed  Europe PubMed
  46. Smalley,J.W., Birss,A.J., Szmigielski,B. and Potempa,J.
    Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin
    Arch Biochem Biophys465, 44-49. PubMed  Europe PubMed DOI  I
    47. 2006
  47. [YEAR:9-3-2006]Bialas,A., Grembecka,J., Krowarsch,D., Otlewski,J., Potempa,J. and Mucha,A.
    Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity
    J Med Chem49, 1744-1753. PubMed  Europe PubMed DOI  I
  48. Cronan,C.A., Potempa,J., Travis,J. and Mayo,J.A.
    Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II)
    Oral Microbiol Immunol21, 212-217. PubMed  Europe PubMed DOI  I
  49. Matsushita,K., Imamura,T., Tancharoen,S., Tatsuyama,S., Tomikawa,M., Travis,J., Potempa,J., Torii,M. and Maruyama,I.
    Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a
    J Periodontal Res41, 171-176. PubMed  Europe PubMed DOI  I
  50. Slaney,J.M., Gallagher,A., Aduse-Opoku,J., Pell,K. and Curtis,M.A.
    Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement
    Infect Immun74, 5352-5361. PubMed  Europe PubMed DOI  K
    51. 2005
  51. Sato,K., Sakai,E., Veith,P.D., Shoji,M., Kikuchi,Y., Yukitake,H., Ohara,N., Naito,M., Okamoto,K., Reynolds,E.C. and Nakayama,K.
    Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis
    J Biol Chem280, 8668-8677. PubMed  Europe PubMed DOI
    52. 2004
  52. Imamura,T., Potempa,J. and Travis,J.
    Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases
    Biol Chem385, 989-996. PubMed  Europe PubMed DOI  V
  53. [YEAR:10-9-2004]Kadowaki,T., Baba,A., Abe,N., Takii,R., Hashimoto,M., Tsukuba,T., Okazaki,S., Suda,Y., Asao,T. and Yamamoto,K.
    Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors
    Mol Pharmacol66, 1599-1606. PubMed  Europe PubMed DOI  I
  54. Liu,X., Sroka,A., Potempa,J. and Genco,C.A.
    Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR
    Biol Chem385, 1049-1057. PubMed  Europe PubMed DOI
  55. Nadkarni,M.A., Nguyen,K.A., Chapple,C.C., Decarlo,A.A., Jacques,N.A. and Hunter,N.
    Distribution of Porphyromonas gingivalis biotypes defined by alleles of the kgp (Lys-gingipain) gene
    J Clin Microbiol42, 3873-3876. PubMed  Europe PubMed DOI
  56. Okamoto,M., Sugimoto,A., Leung,K.P., Nakayama,K., Kamaguchi,A. and Maeda,N.
    Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis
    Oral Microbiol Immunol19, 118-120. PubMed  Europe PubMed DOI  I
  57. Pike,R., Potempa,J. and Travis,J.
    Gingipain K
    [ISSN:0-12-079610-4]2, 1328-1333.  V
  58. Simpsonv,W., Olczak,T. and Genco,C.A.
    Lysine-specific gingipain K and heme/hemoglobin receptor HmuR are involved in heme utilization in Porphyromonas gingivalis
    Acta Biochim Pol51, 253-262. PubMed  Europe PubMed DOI
  59. [YEAR:23-1-2004]Smalley,J.W., Thomas,M.F., Birss,A.J., Withnall,R. and Silver,J.
    A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    Biochem J379, 833-840. PubMed  Europe PubMed DOI
  60. Sztukowska,M., Sroka,A., Bugno,M., Banbula,A., Takahashi,Y., Pike,R.N., Genco,C.A., Travis,J. and Potempa,J.
    The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities
    Mol Microbiol54, 1393-1408. PubMed  Europe PubMed DOI
  61. Vanterpool,E., Roy,F. and Fletcher,H.M.
    The vimE gene downstream of vimA is independently expressed and is involved in modulating proteolytic activity in Porphyromonas gingivalis W83
    Infect Immun72, 5555-5564. PubMed  Europe PubMed DOI
    62. 2003
  62. Beikler,T., Peters,U., Ehmke,B. and Flemmig,T.F.
    Sequence analysis of kgp in Porphyromonas gingivalis isolates from periodontitis patients
    Oral Microbiol Immunol18, 393-397. PubMed  Europe PubMed DOI
  63. Grenier,D., Roy,S., Chandad,F., Plamondon,P., Yoshioka,M., Nakayama,K. and Mayrand,D.
    Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis
    Infect Immun71, 4742-4748. PubMed  Europe PubMed DOI
  64. Imamura,T., Travis,J. and Potempa,J.
    The biphasic virulence activities of gingipains: activation and inactivation of host proteins
    Curr Protein Pept Sci4, 443-450. PubMed  Europe PubMed DOI
  65. Kamaguchi,A., Ohyama,T., Sakai,E., Nakamura,R., Watanabe,T., Baba,H. and Nakayama,K.
    Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermedia
    Microbiology (Reading)149, 1257-1264. PubMed  Europe PubMed DOI
  66. Potempa,J., Sroka,A., Imamura,T. and Travis,J.
    Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes
    Curr Protein Pept Sci4, 397-407. PubMed  Europe PubMed DOI
    67. 2002
  67. Baba,A., Kadowaki,T., Asao,T. and Yamamoto,K.
    Roles for Arg- and Lys-gingipains in the disruption of cytokine responses and loss of viability of human endothelial cells by Porphyromonas gingivalis infection
    Biol Chem383, 1223-1230. PubMed  Europe PubMed DOI
  68. Curtis,M.A., Aduse Opoku,J., Rangarajan,M., Gallagher,A., Sterne,J.A., Reid,C.R., Evans,H.E. and Samuelsson,B.
    Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor
    Infect Immun70, 6968-6975. PubMed  Europe PubMed DOI  I
  69. Katz,J., Yang,Q.B., Zhang,P., Potempa,J., Travis,J., Michalek,S.M. and Balkovetz,D.F.
    Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains
    Infect Immun70, 2512-2518. PubMed  Europe PubMed DOI
  70. Nassar,H., Chou,H.H., Khlgatian,M., Gibson,F.C., III, Van Dyke,T.E. and Genco,C.A.
    Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells
    Infect Immun70, 268-276. PubMed  Europe PubMed DOI  I
  71. Oleksy,A., Banbula,A., Bugno,M., Travis,J. and Potempa,J.
    Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation
    Microb Pathog32, 173-181. PubMed  Europe PubMed DOI
    72. 2001
  72. Brochu,V., Grenier,D., Nakayama,K. and Mayrand,D.
    Acquisition of iron from human transferrin by Porphyromonas gingivalis: a role for Arg- and Lys-gingipain activities
    Oral Microbiol Immunol16, 79-87. PubMed  Europe PubMed DOI
  73. Chen,T., Nakayama,K., Belliveau,L. and Duncan,M.J.
    Porphyromonas gingivalis gingipains and adhesion to epithelial cells
    Infect Immun69, 3048-3056. PubMed  Europe PubMed DOI
  74. Grenier,D., Imbeault,S., Plamondon,P., Grenier,G., Nakayama,K. and Mayrand,D.
    Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin
    Infect Immun69, 5166-5172. PubMed  Europe PubMed DOI
  75. Imamura,T., Matsushita,K., Travis,J. and Potempa,J.
    Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues
    Antimicrobial Agents Chemother45, 2871-2876. PubMed  Europe PubMed DOI  I
  76. [YEAR:15-6-2001]Lourbakos,A., Yuan,Y.P., Jenkins,A.L., Travis,J., Andrade-Gordon,P., Santulli,R., Potempa,J. and Pike,R.N.
    Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity
    Blood97, 3790-3797. PubMed  Europe PubMed DOI
  77. Nakagawa,T., Sims,T., Fan,Q., Potempa,J., Travis,J., Houston,L. and Page,R.C.
    Functional characteristics of antibodies induced by Arg-gingipain (HRgpA) and Lys-gingipain (Kgp) from Porphyromonas gingivalis
    Oral Microbiol Immunol16, 202-211. PubMed  Europe PubMed DOI
  78. O'Brien-Simpson,N.M., Paolini,R.A., Hoffmann,B., Slakeski,N., Dashper,S.G. and Reynolds,E.C.
    Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model
    Infect Immun69, 7527-7534. PubMed  Europe PubMed DOI
  79. Sroka,A., Sztukowska,M., Potempa,J., Travis,J. and Genco,C.A.
    Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis
    J Bacteriol183, 5609-5616. PubMed  Europe PubMed DOI
    80. 2000
  80. Abe,N., Baba,A., Kadowaki,T., Okamoto,K., Okazaki,S., Asao,T. and Yamamoto,K.
    Design and synthesis of sensitive fluorogenic substrates specific for Lys-gingipain
    J Biochem128, 877-881. PubMed  Europe PubMed
  81. Aduse-Opoku,J., Davies,N.N., Gallagher,A., Hashim,A., Evans,H.E., Rangarajan,M., Slaney,J.M. and Curtis,M.A.
    Generation of Lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities
    Microbiology (Reading, Engl )146, 1933-1940. PubMed  Europe PubMed
    82. 1999
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