Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase C25.002: gingipain K

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Castillo,Y., Castellanos,J.E., Lafaurie,G.I. and Castillo,D.M.<br>Porphyromonas gingivalis outer membrane vesicles modulate cytokine and chemokine production by gingipain-dependent mechanisms in human macrophages<br>Arch Oral Biol (2022) 140, 105453-105453. PubMed  Europe PubMed DOI
    2. 2021
  2. Song,L.T., Tada,H., Nishioka,T., Nemoto,E., Imamura,T., Potempa,J., Li,C.Y., Matsushita,K. and Sugawara,S.<br>Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells<br>J Innate Immun (2021) , 1-14. PubMed  Europe PubMed DOI
    3. 2020
  3. Arastu-Kapur,S., Nguyen,M., Raha,D., Ermini,F., Haditsch,U., Araujo,J., De Lannoy,I.A.M., Ryder,M.I., Dominy,S.S., Lynch,C. and Holsinger,L.J.<br>Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388<br>Pharmacol Res Perspect (2020) 8, e00562-e00562. PubMed  Europe PubMed DOI  PMC  EPMC  I
  4. Mo,W., Luo,H., Wu,J., Xu,N., Zhang,F., Qiu,Q., Zhu,W. and Liang,M.<br>Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin beta3 in RAW264.7 cells<br>J Mol Histol (2020) 51, 147-159. PubMed  Europe PubMed DOI
  5. Seers,C.A., Mahmud,A.S.M., Huq,N.L., Cross,K.J. and Reynolds,E.C.<br>Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains<br>J Oral Microbiol (2020) 13, 1858001-1858001. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2019
  6. Guevara,T., Rodriguez-Banqueri,A., Lasica,A.M., Ksiazek,M., Potempa,B.A., Potempa,J. and Gomis-Ruth,F.X.<br>Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor<br>Sci Rep (2019) 9, 4935-4935. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  7. Lippold,S., Nicolardi,S., Wuhrer,M. and Falck,D.<br>Proteoform-resolved FcRIIIa binding assay for Fab glycosylated monoclonal antibodies achieved by affinity chromatography mass spectrometry of Fc moieties<br>Front Chem (2019) 7, 698-698. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2017
  8. Kariu,T., Nakao,R., Ikeda,T., Nakashima,K., Potempa,J. and Imamura,T.<br>Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids<br>J Periodontal Res (2017) 52, 89-96. PubMed  Europe PubMed DOI  I
  9. Pomowski,A., Uson,I., Nowakowska,Z., Veillard,F., Sztukowska,M.N., Guevara,T., Goulas,T., Mizgalska,D., Nowak,M., Potempa,B., Huntington,J.A., Potempa,J. and Gomis-Ruth,F.X.<br>Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome<br>J Biol Chem (2017) 292, 5724-5735. PubMed  Europe PubMed DOI
  10. Sjogren,J., Andersson,L., Mejare,M. and Olsson,F.<br>Generating and purifying Fab fragments from human and mouse IgG using the bacterial enzymes IdeS, SpeB and Kgp<br>Methods Mol Biol (2017) 1535, 319-329. PubMed  Europe PubMed DOI
    11. 2016
  11. Plaza,K., Kalinska,M., Bochenska,O., Meyer-Hoffert,U., Wu,Z., Fischer,J., Falkowski,K., Sasiadek,L., Bielecka,E., Potempa,B., Kozik,A., Potempa,J. and Kantyka,T.<br>Gingipains of Porphyromonas gingivalis affect the stability and function of serine protease inhibitor of Kazal-type 6 (SPINK6), a tissue inhibitor of human kallikreins<br>J Biol Chem (2016) 291, 18753-18764. PubMed  Europe PubMed DOI
    12. 2015
  12. Dou,Y., Robles,A., Roy,F., Aruni,A.W., Sandberg,L., Nothnagel,E. and Fletcher,H.M.<br>The roles of RgpB and Kgp in late onset gingipain activity in the vimA-defective mutant of Porphyromonas gingivalis W83<br>Mol Oral Microbiol (2015) 30, 347-360. PubMed  Europe PubMed DOI
  13. Gorman,M.A., Seers,C.A., Michell,B.J., Feil,S.C., Huq,N.L., Cross,K.J., Reynolds,E.C. and Parker,M.W.<br>Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health<br>Protein Sci (2015) 24, 162-166. PubMed  Europe PubMed DOI  S
  14. Jung,Y.J., Jun,H.K. and Choi,B.K.<br>Contradictory roles of Porphyromonas gingivalis gingipains in caspase-1 activation<br>Cell Microbiol (2015) 17, 1304-1319. PubMed  Europe PubMed DOI
  15. Palm,E., Khalaf,H. and Bengtsson,T.<br>Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis<br>Mol Oral Microbiol (2015) 30, 74-85. PubMed  Europe PubMed DOI
  16. Tancharoen,S., Matsuyama,T., Kawahara,K., Tanaka,K., Lee,L.J., Machigashira,M., Noguchi,K., Ito,T., Imamura,T., Potempa,J., Kikuchi,K. and Maruyama,I.<br>Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients<br>PLoS ONE (2015) 10, e0117775-e0117775. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2014
  17. Akiyama,T., Miyamoto,Y., Yoshimura,K., Yamada,A., Takami,M., Suzawa,T., Hoshino,M., Imamura,T., Akiyama,C., Yasuhara,R., Mishima,K., Maruyama,T., Kohda,C., Tanaka,K., Potempa,J., Yasuda,H., Baba,K. and Kamijo,R.<br>Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain<br>J Biol Chem (2014) 289, 15621-15630. PubMed  Europe PubMed DOI
  18. de Diego,I., Veillard,F., Sztukowska,M.N., Guevara,T., Potempa,B., Pomowski,A., Huntington,J.A., Potempa,J. and Gomis-Ruth,F.X.<br>Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis<br>J Biol Chem (2014) 289, 32291-32302. PubMed  Europe PubMed DOI  S
  19. Haraguchi,A., Miura,M., Fujise,O., Hamachi,T. and Nishimura,F.<br>Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm<br>Mol Oral Microbiol (2014) 29, 131-143. PubMed  Europe PubMed DOI  I
  20. Kataoka,S., Baba,A., Suda,Y., Takii,R., Hashimoto,M., Kawakubo,T., Asao,T., Kadowaki,T. and Yamamoto,K.<br>A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy<br>FASEB J (2014) 28, 3564-3578. PubMed  Europe PubMed DOI  I
  21. Miyamoto,Y.<br>Molecular mechanisms for bone resorption by gingipains: degradation of osteoprotegerin by lysine-specific gingipain is a key factor for enhanced osteoclastogenesis<br>J Oral Biosci (2014) 56, 120-124. DOI
    22. 2013
  22. Huq,N.L., Seers,C.A., Toh,E.C., Dashper,S.G., Slakeski,N., Zhang,L., Ward,B.R., Meuric,V., Chen,D., Cross,K.J. and Reynolds,E.C.<br>Propeptide-mediated inhibition of cognate gingipain proteinases<br>PLoS ONE (2013) 8, e65447-e65447. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Veillard,F., Sztukowska,M., Mizgalska,D., Ksiazek,M., Houston,J., Potempa,B., Enghild,J.J., Thogersen,I.B., Gomis-Ruth,F.X., Nguyen,K.A. and Potempa,J.<br>Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases<br>Biochim Biophys Acta Gen Subj (2013) 1830, 4218-4228. PubMed  Europe PubMed DOI
    24. 2012
  24. Pike,R.N. and Potempa,J.<br>Gingipain K<br>[ISSN:978-0-12-407743-0] (2012) 3, 2337-2344. DOI
  25. Sztukowska,M., Veillard,F., Potempa,B., Bogyo,M., Enghild,J.J., Thogersen,I.B., Nguyen,K.A. and Potempa,J.<br>Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes<br>Biol Chem (2012) 393, 971-977. PubMed  Europe PubMed DOI
  26. Veillard,F., Potempa,B., Poreba,M., Drag,M. and Potempa,J.<br>Gingipain aminopeptidase activities in Porphyromonas gingivalis<br>Biol Chem (2012) 393, 1471-1476. PubMed  Europe PubMed DOI
    27. 2011
  27. Smalley,J.W., Byrne,D.P., Birss,A.J., Wojtowicz,H., Sroka,A., Potempa,J. and Olczak,T.<br>HmuY haemophore and gingipain proteases constitute a unique syntrophic system of haem acquisition by Porphyromonas gingivalis<br>PLoS ONE (2011) 6, e17182-e17182. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Toh,E.C., Dashper,S.G., Huq,N.L., Attard,T.J., O'Brien-Simpson,N.M., Chen,Y.Y., Cross,K.J., Stanton,D.P., Paolini,R.A. and Reynolds,E.C.<br>Porphyromonas gingivalis cysteine proteinase inhibition by kappa-casein peptides<br>Antimicrob Agents Chemother (2011) 55, 1155-1161. PubMed  Europe PubMed DOI
  29. Vincents,B., Guentsch,A., Kostolowska,D., von Pawel-Rammingen,U., Eick,S., Potempa,J. and Abrahamson,M.<br>Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis<br>FASEB J (2011) 25, 3741-3750. PubMed  Europe PubMed DOI
  30. Yongqing,T., Potempa,J., Pike,R.N. and Wijeyewickrema,L.C.<br>The lysine-specific gingipain of Porphyromonas gingivalis: importance to pathogenicity and potential strategies for inhibition<br>Adv Exp Med Biol (2011) 712, 15-29. PubMed  Europe PubMed DOI  I
    31. 2010
  31. Guo,Y., Nguyen,K.A. and Potempa,J.<br>Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins<br>Periodontol 2000 (2010) 54, 15-44. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Saiki,K. and Konishi,K.<br>Identification of a novel Porphyromonas gingivalis outer membrane protein, PG534, required for the production of active gingipains<br>FEMS Microbiol Lett (2010) 310, 168-174. PubMed  Europe PubMed DOI
    33. 2009
  33. Fitzpatrick,R.E., Wijeyewickrema,L.C. and Pike,R.N.<br>The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis<br>Future Microbiol (2009) 4, 471-487. PubMed  Europe PubMed DOI
  34. Inomata,M., Ishihara,Y., Matsuyama,T., Imamura,T., Maruyama,I., Noguchi,T. and Matsushita,K.<br>Degradation of vascular endothelial thrombomodulin by arginine-and lysine-specific cysteine proteases from Porphyromonas gingivalis<br>J Periodontol (2009) 80, 1511-1517. PubMed  Europe PubMed DOI
  35. Ishiguro,I., Saiki,K. and Konishi,K.<br>PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system<br>FEMS Microbiol Lett (2009) 292, 261-267. PubMed  Europe PubMed DOI
  36. Tam,V., O'Brien-Simpson,N.M., Chen,Y.Y., Sanderson,C.J., Kinnear,B. and Reynolds,E.C.<br>The RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis inactivate the Th2 cytokines interleukin-4 and interleukin-5<br>Infect Immun (2009) 77, 1451-1458. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Yasuhara,R., Miyamoto,Y., Takami,M., Imamura,T., Potempa,J., Yoshimura,K. and Kamijo,R.<br>Lysine-specific gingipain promotes lipopolysaccharide- and active-vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin<br>Biochem J (2009) 419, 159-166. PubMed  Europe PubMed DOI
    38. 2008
  38. Bania,J., Kubiak,A., Wojtachnio,K. and Polanowski,A.<br>Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis<br>J Periodontal Res (2008) 43, 232-236. PubMed  Europe PubMed DOI
  39. Dias,I.H., Marshall,L., Lambert,P.A., Chapple,I.L., Matthews,J.B. and Griffiths,H.R.<br>Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant<br>Infect Immun (2008) 76, 317-323. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Ishida,Y., Hu,J., Sakai,E., Kadowaki,T., Yamamoto,K., Tsukuba,T., Kato,Y., Nakayama,K. and Okamoto,K.<br>Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system<br>Arch Oral Biol (2008) 53, 538-544. PubMed  Europe PubMed DOI
  41. Sheets,S.M., Robles-Price,A.G., McKenzie,R.M., Casiano,C.A. and Fletcher,H.M.<br>Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis<br>Front Biosci (2008) 13, 3215-3238. PubMed  Europe PubMed DOI  V
  42. Smalley,J.W., Birss,A.J., Szmigielski,B. and Potempa,J.<br>Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis<br>Biol Chem (2008) 389, 1235-1238. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2007
  43. Kadowaki,T., Takii,R., Yamatake,K., Kawakubo,T., Tsukuba,T. and Yamamoto,K.<br>A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells<br>Front Biosci (2007) 12, 4800-4809. PubMed  Europe PubMed DOI
  44. Popadiak,K., Potempa,J., Riesbeck,K. and Blom,A.M.<br>Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system<br>J Immunol (2007) 178, 7242-7250. PubMed  Europe PubMed
  45. Saiki,K. and Konishi,K.<br>Identification of a Porphyromonas gingivalis novel protein sov required for the secretion of gingipains<br>Microbiol Immunol (2007) 51, 483-491. PubMed  Europe PubMed
  46. Smalley,J.W., Birss,A.J., Szmigielski,B. and Potempa,J.<br>Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin<br>Arch Biochem Biophys (2007) 465, 44-49. PubMed  Europe PubMed DOI  I
    47. 2006
  47. [YEAR:9-3-2006]Bialas,A., Grembecka,J., Krowarsch,D., Otlewski,J., Potempa,J. and Mucha,A.<br>Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity<br>J Med Chem (9-3-2006) 49, 1744-1753. PubMed  Europe PubMed DOI  I
  48. Cronan,C.A., Potempa,J., Travis,J. and Mayo,J.A.<br>Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine: synergistic effect of Zn(II)<br>Oral Microbiol Immunol (2006) 21, 212-217. PubMed  Europe PubMed DOI  I
  49. Matsushita,K., Imamura,T., Tancharoen,S., Tatsuyama,S., Tomikawa,M., Travis,J., Potempa,J., Torii,M. and Maruyama,I.<br>Selective inhibition of Porphyromonas gingivalis growth by a factor Xa inhibitor, DX-9065a<br>J Periodontal Res (2006) 41, 171-176. PubMed  Europe PubMed DOI  I
  50. Slaney,J.M., Gallagher,A., Aduse-Opoku,J., Pell,K. and Curtis,M.A.<br>Mechanisms of resistance of Porphyromonas gingivalis to killing by serum complement<br>Infect Immun (2006) 74, 5352-5361. PubMed  Europe PubMed DOI  K
    51. 2005
  51. Sato,K., Sakai,E., Veith,P.D., Shoji,M., Kikuchi,Y., Yukitake,H., Ohara,N., Naito,M., Okamoto,K., Reynolds,E.C. and Nakayama,K.<br>Identification of a new membrane-associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis<br>J Biol Chem (2005) 280, 8668-8677. PubMed  Europe PubMed DOI
    52. 2004
  52. Imamura,T., Potempa,J. and Travis,J.<br>Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases<br>Biol Chem (2004) 385, 989-996. PubMed  Europe PubMed DOI  V
  53. [YEAR:10-9-2004]Kadowaki,T., Baba,A., Abe,N., Takii,R., Hashimoto,M., Tsukuba,T., Okazaki,S., Suda,Y., Asao,T. and Yamamoto,K.<br>Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors<br>Mol Pharmacol (10-9-2004) 66, 1599-1606. PubMed  Europe PubMed DOI  I
  54. Liu,X., Sroka,A., Potempa,J. and Genco,C.A.<br>Coordinate expression of the Porphyromonas gingivalis lysine-specific gingipain proteinase, Kgp, arginine-specific gingipain proteinase, RgpA, and the heme/hemoglobin receptor, HmuR<br>Biol Chem (2004) 385, 1049-1057. PubMed  Europe PubMed DOI
  55. Nadkarni,M.A., Nguyen,K.A., Chapple,C.C., Decarlo,A.A., Jacques,N.A. and Hunter,N.<br>Distribution of Porphyromonas gingivalis biotypes defined by alleles of the kgp (Lys-gingipain) gene<br>J Clin Microbiol (2004) 42, 3873-3876. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Okamoto,M., Sugimoto,A., Leung,K.P., Nakayama,K., Kamaguchi,A. and Maeda,N.<br>Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis<br>Oral Microbiol Immunol (2004) 19, 118-120. PubMed  Europe PubMed DOI  I
  57. Pike,R., Potempa,J. and Travis,J.<br>Gingipain K<br>[ISSN:0-12-079610-4] (2004) 2, 1328-1333.  V
  58. Simpsonv,W., Olczak,T. and Genco,C.A.<br>Lysine-specific gingipain K and heme/hemoglobin receptor HmuR are involved in heme utilization in Porphyromonas gingivalis<br>Acta Biochim Pol (2004) 51, 253-262. PubMed  Europe PubMed DOI
  59. [YEAR:23-1-2004]Smalley,J.W., Thomas,M.F., Birss,A.J., Withnall,R. and Silver,J.<br>A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin<br>Biochem J (23-1-2004) 379, 833-840. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Sztukowska,M., Sroka,A., Bugno,M., Banbula,A., Takahashi,Y., Pike,R.N., Genco,C.A., Travis,J. and Potempa,J.<br>The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities<br>Mol Microbiol (2004) 54, 1393-1408. PubMed  Europe PubMed DOI
  61. Vanterpool,E., Roy,F. and Fletcher,H.M.<br>The vimE gene downstream of vimA is independently expressed and is involved in modulating proteolytic activity in Porphyromonas gingivalis W83<br>Infect Immun (2004) 72, 5555-5564. PubMed  Europe PubMed DOI  PMC  EPMC
    62. 2003
  62. Beikler,T., Peters,U., Ehmke,B. and Flemmig,T.F.<br>Sequence analysis of kgp in Porphyromonas gingivalis isolates from periodontitis patients<br>Oral Microbiol Immunol (2003) 18, 393-397. PubMed  Europe PubMed DOI
  63. Grenier,D., Roy,S., Chandad,F., Plamondon,P., Yoshioka,M., Nakayama,K. and Mayrand,D.<br>Effect of inactivation of the Arg- and/or Lys-gingipain gene on selected virulence and physiological properties of Porphyromonas gingivalis<br>Infect Immun (2003) 71, 4742-4748. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Imamura,T., Travis,J. and Potempa,J.<br>The biphasic virulence activities of gingipains: activation and inactivation of host proteins<br>Curr Protein Pept Sci (2003) 4, 443-450. PubMed  Europe PubMed DOI
  65. Kamaguchi,A., Ohyama,T., Sakai,E., Nakamura,R., Watanabe,T., Baba,H. and Nakayama,K.<br>Adhesins encoded by the gingipain genes of Porphyromonas gingivalis are responsible for co-aggregation with Prevotella intermedia<br>Microbiology (Reading) (2003) 149, 1257-1264. PubMed  Europe PubMed DOI
  66. Potempa,J., Sroka,A., Imamura,T. and Travis,J.<br>Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes<br>Curr Protein Pept Sci (2003) 4, 397-407. PubMed  Europe PubMed DOI
    67. 2002
  67. Baba,A., Kadowaki,T., Asao,T. and Yamamoto,K.<br>Roles for Arg- and Lys-gingipains in the disruption of cytokine responses and loss of viability of human endothelial cells by Porphyromonas gingivalis infection<br>Biol Chem (2002) 383, 1223-1230. PubMed  Europe PubMed DOI
  68. Curtis,M.A., Aduse Opoku,J., Rangarajan,M., Gallagher,A., Sterne,J.A., Reid,C.R., Evans,H.E. and Samuelsson,B.<br>Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor<br>Infect Immun (2002) 70, 6968-6975. PubMed  Europe PubMed DOI  PMC  EPMC  I
  69. Katz,J., Yang,Q.B., Zhang,P., Potempa,J., Travis,J., Michalek,S.M. and Balkovetz,D.F.<br>Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains<br>Infect Immun (2002) 70, 2512-2518. PubMed  Europe PubMed DOI  PMC  EPMC
  70. Nassar,H., Chou,H.H., Khlgatian,M., Gibson,F.C., III, Van Dyke,T.E. and Genco,C.A.<br>Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells<br>Infect Immun (2002) 70, 268-276. PubMed  Europe PubMed DOI  PMC  EPMC  I
  71. Oleksy,A., Banbula,A., Bugno,M., Travis,J. and Potempa,J.<br>Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation<br>Microb Pathog (2002) 32, 173-181. PubMed  Europe PubMed DOI
    72. 2001
  72. Brochu,V., Grenier,D., Nakayama,K. and Mayrand,D.<br>Acquisition of iron from human transferrin by Porphyromonas gingivalis: a role for Arg- and Lys-gingipain activities<br>Oral Microbiol Immunol (2001) 16, 79-87. PubMed  Europe PubMed DOI
  73. Chen,T., Nakayama,K., Belliveau,L. and Duncan,M.J.<br>Porphyromonas gingivalis gingipains and adhesion to epithelial cells<br>Infect Immun (2001) 69, 3048-3056. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Grenier,D., Imbeault,S., Plamondon,P., Grenier,G., Nakayama,K. and Mayrand,D.<br>Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin<br>Infect Immun (2001) 69, 5166-5172. PubMed  Europe PubMed DOI  PMC  EPMC
  75. Imamura,T., Matsushita,K., Travis,J. and Potempa,J.<br>Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues<br>Antimicrobial Agents Chemother (2001) 45, 2871-2876. PubMed  Europe PubMed DOI  PMC  EPMC  I
  76. [YEAR:15-6-2001]Lourbakos,A., Yuan,Y.P., Jenkins,A.L., Travis,J., Andrade-Gordon,P., Santulli,R., Potempa,J. and Pike,R.N.<br>Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity<br>Blood (15-6-2001) 97, 3790-3797. PubMed  Europe PubMed DOI
  77. Nakagawa,T., Sims,T., Fan,Q., Potempa,J., Travis,J., Houston,L. and Page,R.C.<br>Functional characteristics of antibodies induced by Arg-gingipain (HRgpA) and Lys-gingipain (Kgp) from Porphyromonas gingivalis<br>Oral Microbiol Immunol (2001) 16, 202-211. PubMed  Europe PubMed DOI
  78. O'Brien-Simpson,N.M., Paolini,R.A., Hoffmann,B., Slakeski,N., Dashper,S.G. and Reynolds,E.C.<br>Role of RgpA, RgpB, and Kgp proteinases in virulence of Porphyromonas gingivalis W50 in a murine lesion model<br>Infect Immun (2001) 69, 7527-7534. PubMed  Europe PubMed DOI  PMC  EPMC
  79. Sroka,A., Sztukowska,M., Potempa,J., Travis,J. and Genco,C.A.<br>Degradation of host heme proteins by lysine- and arginine-specific cysteine proteinases (gingipains) of Porphyromonas gingivalis<br>J Bacteriol (2001) 183, 5609-5616. PubMed  Europe PubMed DOI  PMC  EPMC
    80. 2000
  80. Abe,N., Baba,A., Kadowaki,T., Okamoto,K., Okazaki,S., Asao,T. and Yamamoto,K.<br>Design and synthesis of sensitive fluorogenic substrates specific for Lys-gingipain<br>J Biochem (2000) 128, 877-881. PubMed  Europe PubMed
  81. Aduse-Opoku,J., Davies,N.N., Gallagher,A., Hashim,A., Evans,H.E., Rangarajan,M., Slaney,J.M. and Curtis,M.A.<br>Generation of Lys-gingipain protease activity in Porphyromonas gingivalis W50 is independent of Arg-gingipain protease activities<br>Microbiology (Reading, Engl.) (2000) 146, 1933-1940. PubMed  Europe PubMed
    82. 1999
  82. [YEAR:11-8-1999]Banbula,A., Bugno,M., Kuster,A., Heinrich,P.C., Travis,J. and Potempa,J.<br>Rapid and efficient inactivation of IL-6 [by] gingipains, lysine- and arginine-specific proteinases from Porphyromonas gingivalis<br>Biochem Biophys Res Commun (11-8-1999) 261, 598-602. PubMed  Europe PubMed DOI
  83. Barkocy-Gallagher,G.A., Foley,J.W. and Lantz,M.S.<br>Activities of the Porphyromonas gingivalis PrtP proteinase determined by construction of prtP-deficient mutants and expression of the gene in Bacteroides species<br>J Bacteriol (1999) 181, 246-255. PubMed  Europe PubMed  PMC  EPMC
  84. Chen,W. and Kuramitsu,H.K.<br>Molecular mechanism for the spontaneous generation of pigmentless Porphyromonas gingivalis mutants<br>Infect Immun (1999) 67, 4926-4930. PubMed  Europe PubMed  PMC  EPMC
  85. Lewis,J.P., Dawson,J.A., Hannis,J.C., Muddiman,D. and Macrina,F.L.<br>Hemoglobinase activity of the lysine gingipain protease (Kgp) of Porphyromonas gingivalis W83<br>J Bacteriol (1999) 181, 4905-4913. PubMed  Europe PubMed  PMC  EPMC
  86. Simpson,W., Wang,C.Y., Mikolajczyk-Pawlinska,J., Potempa,J., Travis,J., Bond,V.C. and Genco,C.A.<br>Transposition of the endogenous insertion sequence element IS1126 modulates gingipain expression in Porphyromonas gingivalis<br>Infect Immun (1999) 67, 5012-5020. PubMed  Europe PubMed  PMC  EPMC
  87. Yun,P.L., Decarlo,A.A. and Hunter,N.<br>Modulation of major histocompatibility complex protein expression by human gamma interferon mediated by cysteine proteinase-adhesin polyproteins of Porphyromonas gingivalis<br>Infect Immun (1999) 67, 2986-2995. PubMed  Europe PubMed  PMC  EPMC
    88. 1998
  88. Abe,N., Kadowaki,T., Okamoto,K., Nakayama,K., Ohishi,M. and Yamamoto,K.<br>Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease<br>J Biochem (1998) 123, 305-312. PubMed  Europe PubMed
  89. [YEAR:15-6-1998]Fujimura,S., Hirai,K., Shibata,Y., Nakayama,K. and Nakamura,T.<br>Comparative properties of envelope-associated arginine-gingipains and lysine-gingipain of Porphyromonas gingivalis<br>FEMS Microbiol Lett (15-6-1998) 163, 173-179. PubMed  Europe PubMed DOI
  90. Han,N., Lepine,G., Whitlock,J., Wojciechowski,L. and Progulske-Fox,A.<br>The Porphyromonas gingivalis prtP/kgp homologue exists as two open reading frames in strain 381<br>Oral Dis (1998) 4, 170-179. PubMed  Europe PubMed
  91. [YEAR:10-8-1998]Kuboniwa,M., Amano,A. and Shizukuishi,S.<br>Hemoglobin-binding protein purified from Porphyromonas gingivalis is identical to lysine-specific cysteine proteinase (Lys-Gingipain)<br>Biochem Biophys Res Commun (10-8-1998) 249, 38-43. PubMed  Europe PubMed DOI
  92. Lewis,J.P. and Macrina,F.L.<br>IS195, an insertion sequence-like element associated with protease genes in Porphyromonas gingivalis<br>Infect Immun (1998) 66, 3035-3042. PubMed  Europe PubMed  PMC  EPMC
  93. Nakayama,K., Ratnayake,D.B., Tsukuba,T., Kadowaki,T., Yamamoto,K. and Fujimura,S.<br>Haemoglobin receptor protein is intragenically encoded by the cysteine proteinase-encoding genes and the haemagglutinin-encoding gene of Porphyromonas gingivalis<br>Mol Microbiol (1998) 27, 51-61. PubMed  Europe PubMed DOI
  94. [YEAR:18-9-1998]O'Brien-Simpson,N.M., Dashper,S.G. and Reynolds,E.C.<br>Histatin 5 is a substrate and not an inhibitor of the Arg- and Lys-specific proteinases of Porphyromonas gingivalis<br>Biochem Biophys Res Commun (18-9-1998) 250, 474-478. PubMed  Europe PubMed DOI
    95. 1997
  95. Pavloff,N., Pemberton,P.A., Potempa,J., Chen,W.C., Pike,R.N., Prochazka,V., Kiefer,M.C., Travis,J. and Barr,P.J.<br>Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases<br>J Biol Chem (1997) 272, 1595-1600. PubMed  Europe PubMed DOI
  96. Potempa,J., Pike,R. and Travis,J.<br>Titration and mapping of the active site of cysteine proteinases from Porphyromonas gingivalis (Gingipains) using peptidyl chloromethanes<br>Biol Chem (1997) 378, 223-230. PubMed  Europe PubMed  I
    97. 1996
  97. Barkocy-Gallagher,G.A., Han,N., Patti,J.M., Whitlock,J., Progulske-Fox,A. and Lantz,M.S.<br>Analysis of the prtP gene encoding porphypain, a cysteine proteinase of Porphyromonas gingivalis<br>J Bacteriol (1996) 178, 2734-2741. PubMed  Europe PubMed  PMC  EPMC
  98. Jagels,M.A., Travis,J., Potempa,J., Pike,R. and Hugli,T.E.<br>Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis<br>Infect Immun (1996) 64, 1984-1991. PubMed  Europe PubMed  PMC  EPMC
  99. Okamoto,K., Kadowaki,T., Nakayama,K. and Yamamoto,K.<br>Cloning and sequencing of the gene encoding a novel lysine-specific cysteine proteinase (Lys-gingipain) in Porphyromonas gingivalis: Structural relationship with the arginine- specific cysteine proteinase (Arg-gingipain)<br>J Biochem (1996) 120, 398-406. PubMed  Europe PubMed
    100. 1995
  100. Potempa,J., Pavloff,N. and Travis,J.<br>Porphyromonas gingivalis: a proteinase/gene accounting audit<br>Trends Microbiol (1995) 3, 430-434. PubMed  Europe PubMed DOI
    101. 1994
  101. Pike,R., McGraw,W., Potempa,J. and Travis,J.<br>Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins<br>J Biol Chem (1994) 269, 406-411. PubMed  Europe PubMed
    102. 1991
  102. Chen,Z.X., Potempa,J., Polanowski,A., Renvert,S., Wikstrom,M. and Travis,J.<br>Stimulation of proteinase and amidase activities in Porphyromonas (Bacteroides) gingivalis by amino acids and dipeptides<br>Infect Immun (1991) 59, 2846-2850. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use