$VAR1 = undef;

Summary for peptidase C14.010: caspase-9

Names
MEROPS Name	caspase-9
Other names	CASP9 g.p. (Homo sapiens), ICE-LAP6, Mch6

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.010
Holotype	caspase-9 (Homo sapiens), Uniprot accession P55211 (peptidase unit: 117-416), MERNUM MER0002707
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00104
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.62
Enzymology	BRENDA database
Proteolytic events	CutDB database (9 cleavages)
Activity status	human: active (Garcia-Calvo et al., 1999) mouse: active (Fujita et al., 2001)
Physiology	One of the "initator" caspases in mammalian cell apoptosis, activating caspase-3.
Knockout	The majority of caspase-9 knockout mice die perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development (Kuida et al., 1998).
Pharmaceutical relevance	Inoue et al. (2003) suggest that caspase-9 plays a crucial role in the disease progression of amyotrophic lateral sclerosis, and constitutes a promising therapeutic target.
Pathways	KEGG	Alzheimer's disease
	KEGG	Amyotrophic lateral sclerosis (ALS)
	KEGG	Apoptosis
	KEGG	Colorectal cancer
	KEGG	Hepatitis B
	KEGG	Huntington's disease
	KEGG	Influenza A
	KEGG	Legionellosis
	KEGG	p53 signaling pathway
	KEGG	Parkinson's disease
	KEGG	Pathways in cancer
	KEGG	Small cell lung cancer
	KEGG	Toxoplasmosis
	KEGG	Tuberculosis
	KEGG	Viral myocarditis
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Caspase-9
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/ed/-/D-/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	3	1	3	1
Pro	2	0	2	0	0	1	2	1
Ala	0	0	0	0	2	1	1	0
Val	2	0	2	0	2	1	1	0
Leu	1	1	1	0	0	1	1	0
Ile	2	1	0	0	0	1	1	1
Met	1	0	0	0	1	0	1	1
Phe	0	0	1	0	0	0	0	1
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	1	1	1	0	2	1	1	4
Thr	1	1	1	0	1	2	0	1
Cys	0	0	0	0	1	0	0	0
Asn	0	0	1	0	0	0	0	0
Gln	0	0	0	0	0	1	0	0
Asp	3	3	1	12	1	0	0	2
Glu	1	6	2	2	0	1	0	0
Lys	0	0	0	0	0	1	1	0
Arg	0	0	1	0	0	1	1	1
His	0	1	1	0	0	0	0	0