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Literature for peptidase C14.010: caspase-9

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Borgeaud,A.C., Ganeva,I., Klein,C., Stooss,A., Ross-Kaschitza,D., Wu,L., Riley,J.S., Tait,S.W.G., Lemmin,T., Kaufmann,T. and Kukulski,W.
    Large transient assemblies of Apaf1 constitute the apoptosome in cells
    Nat Commun (2025) 16, 9429-9429. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Ma,X., Pan,Y., Lin,X. and Wang,Z.
    Polypeptide functionalized gold nanoprobes for SERS-fluorescence detection and imaging of caspase-9 during apoptosis
    Anal Chim Acta (2025) 1335, 343458-343458. PubMed  Europe PubMed DOI
  3. Matsui,K., Watanabe,M., Yamamoto,S., Kawagoe,S., Ikeda,T., Ohashi,H., Kuroda,T., Koda,N., Morimoto,K., Kinoshita,Y., Inage,Y., Saito,Y., Fukunaga,S., Fujimoto,T., Tajiri,S., Matsumoto,K., Kobayashi,E., Yokoo,T. and Yamanaka,S.
    Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling
    Nat Commun (2025) 16, 2572-2572. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2024
  4. Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
    The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
    Mol Cell (2024) 84, 170-179. PubMed  Europe PubMed DOI  V
  5. Ge,J., Wang,Y., Li,X., Lu,Q., Yu,H., Liu,H., Ma,K., Deng,X., Luo,Z.Q., Liu,X. and Qiu,J.
    Phosphorylation of caspases by a bacterial kinase inhibits host programmed cell death
    Nat Commun (2024) 15, 8464-8464. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Batoon,L., Koh,A.J., Kannan,R., McCauley,L.K. and Roca,H.
    Caspase-9 driven murine model of selective cell apoptosis and efferocytosis
    Cell Death Dis (2023) 14, 58-58. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
    A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
    Mol Neurobiol (2023) 60, 5805-5837. PubMed  Europe PubMed DOI  V
  8. Sever,A.I.M., Alderson,T.R., Rennella,E., Aramini,J.M., Liu,Z.H., Harkness,R.W. and Kay,L.E.
    Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR
    Proc Natl Acad Sci U S A (2023) 120, e2310944120-e2310944120. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2022
  9. Nakashima,I., Saito,S., Akahoshi,E., Yagyu,S., Sugano-Ishihara,M. and Nakazawa,Y.
    Non-viral inducible caspase 9 mRNA delivery using lipid nanoparticles against breast cancer: An in vitro study
    Biochem Biophys Res Commun (2022) 635, 144-153. PubMed  Europe PubMed DOI
    10. 2021
  10. Avrutsky,M.I. and Troy,C.M.
    Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease
    Front Pharmacol (2021) 12, 701301-701301. PubMed  Europe PubMed DOI  PMC  EPMC  V
  11. Du,Y., Taylor,C.G., Aukema,H.M. and Zahradka,P.
    Regulation of docosahexaenoic acid-induced apoptosis of confluent endothelial cells: Contributions of MAPKs and caspases
    Biochim Biophys Acta Mol Cell Biol Lipids (2021) 1866, 158902-158902. PubMed  Europe PubMed DOI
  12. Liao,G., Wang,R. and Tang,D.D.
    Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells
    Am J Respir Cell Mol Biol (2021) PubMed  Europe PubMed DOI
  13. Molnar,T., Pallagi,P., Tel,B., Kiraly,R., Csoma,E., Jenei,V., Varga,Z., Gogolak,P., Odile Hueber,A., Mate,Z., Erdelyi,F., Szabo,G., Pettko-Szandtner,A., Bacsi,A., Virag,L., Maleth,J. and Koncz,G.
    Caspase-9 acts as a regulator of necroptotic cell death
    FEBS J (2021) PubMed  Europe PubMed DOI
  14. Shao,B., Zheng,L., Shi,J. and Sun,N.
    Acetylation of ANXA1 reduces caspase-3 activation by enhancing the phosphorylation of caspase-9 under OGD/R conditions
    Cell Signal (2021) 88, 110157-110157. PubMed  Europe PubMed DOI
  15. Soni,I.V. and Hardy,J.A.
    Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence
    Biochemistry (2021) 60, 2824-2835. PubMed  Europe PubMed DOI
    16. 2020
  16. Akpinar,O., Ozsimsek,A., Guzel,M. and Naziroglu,M.
    Clostridium botulinum neurotoxin A induces apoptosis and mitochondrial oxidative stress via activation of TRPM2 channel signaling pathway in neuroblastoma and glioblastoma tumor cells
    J Recept Signal Transduct Res (2020) , 1-13. PubMed  Europe PubMed DOI
  17. Avrutsky,M.I., Ortiz,C.C., Johnson,K.V., Potenski,A.M., Chen,C.W., Lawson,J.M., White,A.J., Yuen,S.K., Morales,F.N., Canepa,E., Snipas,S., Salvesen,G.S., Jean,Y.Y. and Troy,C.M.
    Author Correction: Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion
    Nat Commun (2020) 11, 3502-3502. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Cui,X.Y., Park,S.H. and Park,W.H.
    Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspasedependent apoptosis
    Oncol Rep (2020) 44, 2715-2724. PubMed  Europe PubMed DOI  I
  19. Eslami,F., Mahdavi,M., Babaei,E., Hussen,B.M., Mostafavi,H., Shahbazi,A. and Hidayat,H.J.
    Down-regulation of Survivin and Bcl-2 concomitant with the activation of caspase-3 as a mechanism of apoptotic death in KG1a and K562 cells upon exposure to a derivative from ciprofloxacin family
    Toxicol Appl Pharmacol (2020) 409, 115331-115331. PubMed  Europe PubMed DOI
  20. Fathi,E. and Vietor,I.
    Mesenchymal stem cells promote caspase expression in Molt-4 leukemia cells via GSK-3alpha/beta and ERK1/2 signaling pathways as a therapeutic strategy
    Curr Gene Ther (2020) PubMed  Europe PubMed DOI
  21. Gu,T., Wang,X., Yang,H., She,X.N., Chen,K.H., Wu,T., Yang,Q., Yang,Q. and Wang,R.H.
    [Impacts of electroacupuncture on neurological function and protein expressions of apoptosis-related Cyt-C and Caspase-9 in rats with traumatic brain injury]
    Zhongguo Zhen Jiu (2020) 40, 749-755. PubMed  Europe PubMed DOI
  22. Israelov,H., Ravid,O., Atrakchi,D., Rand,D., Elhaik,S., Bresler,Y., Twitto-Greenberg,R., Omesi,L., Liraz-Zaltsman,S., Gosselet,F., Schnaider Beeri,M. and Cooper,I.
    Caspase-1 has a critical role in blood-brain barrier injury and its inhibition contributes to multifaceted repair
    J Neuroinflammation (2020) 17, 267-267. PubMed  Europe PubMed DOI  PMC  EPMC  I
  23. Jin,B., Liu,J., Gao,D., Xu,Y., He,L., Zang,Y., Li,N. and Lin,D.
    Detailed studies on the anticancer action of rosmarinic acid in human Hep-G2 liver carcinoma cells: evaluating its effects on cellular apoptosis, caspase activation and suppression of cell migration and invasion
    J BUON (2020) 25, 1383-1389. PubMed  Europe PubMed
  24. Jin,Q., Lin,C., Zhu,X., Cao,Y., Guo,C. and Wang,L.
    (125)I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts
    Radiat Oncol (2020) 15, 238-238. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Kirubhanand,C., Selvaraj,J., Rekha,U.V., Vishnupriya,V., Nalini,D., Mohan,S.K., Vijayalakshmi,P., Rajalakshmi,M. and Ponnulakshmi,R.
    Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9
    Bioinformation (2020) 16, 458-461. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Lopatniuk,P., Puchalska,Z., Mital,A., Mikosik,A., Frackowiak,J., Hellmann,A., Daca,A., Bryl,E., Fulop,T. and Witkowski,J.M.
    Excessive amount and activity of mu-calpain affects apoptotic machinery in chronic B-cell leukemia cells and influences the course of the disease
    Acta Biochim Pol (2020) 67, 247-257. PubMed  Europe PubMed DOI
  27. Nishimura,T., Xu,H., Iwasaki,M., Karigane,D., Saavedra,B., Takahashi,Y., Suchy,F.P., Monobe,S., Martin,R.M., Ohtaka,M., Nakanishi,M., Burrows,S.R., Cleary,M.L., Majeti,R., Shibuya,A. and Nakauchi,H.
    Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells
    Gene Ther (2020) PubMed  Europe PubMed DOI
  28. Noori,A.R., Tashakor,A., Nikkhah,M., Eriksson,L.A., Hosseinkhani,S. and Fearnhead,H.O.
    Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9
    Biochimie (2020) 180, 23-29. PubMed  Europe PubMed DOI
  29. Ofuegbe,S.O., Oyagbemi,A.A., Omobowale,T.O., Adedapo,A.D., Ayodele,A.E., Yakubu,M.A., Oguntibeju,O.O. and Adedapo,A.A.
    Methanol leaf extract of Momordica charantia protects alloxan-induced hepatopathy through modulation of caspase-9 and interleukin-1beta signaling pathways in rats
    Vet World (2020) 13, 1528-1535. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Rashidbaghan,A., Mostafaie,A., Yazdani,Y. and Mansouri,K.
    Urtica dioica agglutinin (a plant lectin) has a caspase-dependent apoptosis induction effect on the acute lymphoblastic leukemia cell line
    Cell Mol Biol (Noisy-le-grand) (2020) 66, 121-126. PubMed  Europe PubMed
  31. Yu,Q.S., Xin,H.R., Qiu,R.L., Deng,Z.L., Deng,F. and Yan,Z.J.
    Niclosamide: drug repurposing for human chondrosarcoma treatment via the caspase-dependent mitochondrial apoptotic pathway
    Am J Transl Res (2020) 12, 3688-3701. PubMed  Europe PubMed  PMC  EPMC
  32. Zang,Y., Yi,Q., Pan,J., Ding,M., Zuo,X. and Hu,X.
    LINC01980 stimulates the progression of hepatocellular carcinoma via downregulating caspase 9
    J BUON (2020) 25, 1395-1403. PubMed  Europe PubMed
  33. Zhang,J.W., Long,T.Y., Pan,W., Zhong,Q.Q., Qian,Z.X. and Jing,R.
    MiR-808 inhibits cardiomyocyte apoptosis and expressions of caspase-3 and caspase-9 in rats with myocardial infarction by regulating TGF-beta1 signaling pathway
    Eur Rev Med Pharmacol Sci (2020) 24, 6955-6960. PubMed  Europe PubMed DOI  I
    34. 2019
  34. Liu,L., Zhang,H., Wang,Z. and Song,D.
    Peptide-functionalized upconversion nanoparticles-based FRET sensing platform for caspase-9 activity detection in vitro and in vivo
    Biosens Bioelectron (2019) 141, 111403-111403. PubMed  Europe PubMed DOI  A
  35. Tsujimura,M., Kusamori,K. and Nishikawa,M.
    Rapid Regulation of Human Mesenchymal Stem Cell Proliferation Using Inducible Caspase-9 Suicide Gene for Safe Cell-Based Therapy
    Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI
    36. 2018
  36. Byun,M.R. and Choi,J.W.
    Phosphorylation of caspase-9 at Thr125 directs paclitaxel resistance in ovarian cancer
    Oncotarget (2018) 9, 1041-1047. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Mokhtar-Ahmadabadi,R., Madadi,Z., Akbari-Birgani,S., Grillon,C., Hasani,L., Hosseinkhani,S. and Zareian,S.
    Developing a circularly permuted variant of Renilla luciferase as a bioluminescent sensor for measuring caspase-9 activity in the cell-free and cell-based systems
    Biochem Biophys Res Commun (2018) 506, 1032-1039. PubMed  Europe PubMed DOI  A
  38. Serrano,B.P. and Hardy,J.A.
    Phosphorylation by protein kinase A disassembles the caspase-9 core
    Cell Death Differ (2018) 25, 1025-1039. PubMed  Europe PubMed DOI
    39. 2017
  39. Li,P., Zhou,L., Zhao,T., Liu,X., Zhang,P., Liu,Y., Zheng,X. and Li,Q.
    Caspase-9: structure, mechanisms and clinical application
    Oncotarget (2017) 8, 23996-24008. PubMed  Europe PubMed DOI
  40. Serrano,B.P., Szydlo,H.S., Alfandari,D. and Hardy,J.A.
    Active-site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9
    J Biol Chem (2017) 292, 21352-21365. PubMed  Europe PubMed DOI
    41. 2016
  41. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed  Europe PubMed DOI  P
    42. 2015
  42. Clemente,N., Boggio,E., Gigliotti,C.L., Orilieri,E., Cappellano,G., Toth,E., Valletti,P.A., Santoro,C., Quinti,I., Pignata,C., Notarangelo,L.D., Dianzani,C., Dianzani,I., Ramenghi,U., Dianzani,U. and Chiocchetti,A.
    A mutation in caspase-9 decreases the expression of BAFFR and ICOS in patients with immunodeficiency and lymphoproliferation
    Genes Immun (2015) 16, 151-161. PubMed  Europe PubMed DOI  M
  43. Kim,B., Srivastava,S.K. and Kim,S.H.
    Caspase-9 as a therapeutic target for treating cancer
    Expert Opin Ther Targets (2015) 19, 113-127. PubMed  Europe PubMed DOI
  44. Suzuki,M., Sakata,I., Sakai,T., Tomioka,H., Nishigaki,K., Tramier,M. and Coppey-Moisan,M.
    A high-throughput direct fluorescence resonance energy transfer-based assay for analyzing apoptotic proteases using flow cytometry and fluorescence lifetime measurements
    Anal Biochem (2015) 491, 10-17. PubMed  Europe PubMed DOI  L
    45. 2014
  45. Bourguet,C.B., Boulay,P.L., Claing,A. and Lubell,W.D.
    Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells
    Bioorg Med Chem Lett (2014) 24, 3361-3365. PubMed  Europe PubMed DOI
  46. Vickers,C.J., Gonzalez-Paez,G.E., Litwin,K.M., Umotoy,J.C., Coutsias,E.A. and Wolan,D.W.
    Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids
    ACS Chem Biol (2014) 9, 2194-2198. PubMed  Europe PubMed DOI  I
  47. Wurstle,M.L. and Rehm,M.
    A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation
    J Biol Chem (2014) 289, 26277-26289. PubMed  Europe PubMed DOI
    48. 2013
  48. Blasche,S., Mortl,M., Steuber,H., Siszler,G., Nisa,S., Schwarz,F., Lavrik,I., Gronewold,T.M., Maskos,K., Donnenberg,M.S., Ullmann,D., Uetz,P. and Kogl,M.
    The E. coli effector protein NleF is a caspase inhibitor
    PLoS ONE (2013) 8, e58937-e58937. PubMed  Europe PubMed DOI  PMC  EPMC  S
  49. Brentnall,M., Rodriguez-Menocal,L., De Guevara,R.L., Cepero,E. and Boise,L.H.
    Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis
    BMC Cell Biol (2013) 14, 32-32. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Gao,D., Xu,Z., Zhang,X., Wang,H., Wang,Y. and Min,W.
    Molecular cloning, immunohistochemical localization, characterization and expression analysis of caspase-9 from the purse red common carp (Cyprinus carpio) exposed to cadmium
    Aquat Toxicol (2013) 142-143, 53-62. PubMed  Europe PubMed DOI
  51. Hu,Q., Wu,D., Chen,W., Yan,Z. and Shi,Y.
    Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9
    J Biol Chem (2013) 288, 15142-15147. PubMed  Europe PubMed DOI
    52. 2012
  52. Huber,K.L. and Hardy,J.A.
    Mechanism of zinc-mediated inhibition of caspase-9
    Protein Sci (2012) 21, 1056-1065. PubMed  Europe PubMed DOI  I
  53. Huber,K.L., Ghosh,S. and Hardy,J.A.
    Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface
    Biopolymers (2012) 98, 451-465. PubMed  Europe PubMed DOI  I
  54. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif (2012) 84, 236-246. PubMed  Europe PubMed DOI  E
  55. van Raam,B.J. and Salvesen,G.S.
    Caspase-9
    [ISSN:978-0-12-407743-0] (2012) 3, 2252-2255. DOI
  56. Xu,W., Jiang,S., Xu,Y., Chen,B., Li,Y., Zong,F., Zhao,W. and Wu,J.
    A meta-analysis of caspase 9 polymorphisms in promoter and exon sequence on cancer susceptibility
    PLoS ONE (2012) 7, e37443-e37443. PubMed  Europe PubMed DOI  PMC  EPMC  M
    57. 2011
  57. Akpan,N., Serrano-Saiz,E., Zacharia,B.E., Otten,M.L., Ducruet,A.F., Snipas,S.J., Liu,W., Velloza,J., Cohen,G., Sosunov,S.A., Frey,W.H., Salvesen,G.S., Connolly,E.S., Jr. and Troy,C.M.
    Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke
    J Neurosci (2011) 31, 8894-8904. PubMed  Europe PubMed DOI  U
  58. Liamarkopoulos,E., Gazouli,M., Aravantinos,G., Tzanakis,N., Theodoropoulos,G., Rizos,S. and Nikiteas,N.
    Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer
    Gastric Cancer (2011) 14, 317-321. PubMed  Europe PubMed DOI  M
  59. Luan,Y., Yang,Q., Xie,Y., Duan,S., Cai,S. and Forrest,M.L.
    A sensitive near-infrared fluorescent probe for caspase-mediated apoptosis: synthesis and application in cell imaging
    Drug Discov Ther (2011) 5, 220-226. PubMed  Europe PubMed DOI  PMC  EPMC  L
  60. Shultz,J.C. and Chalfant,C.E.
    Caspase 9b: a new target for therapy in non-small-cell lung cancer
    Expert Rev Anticancer Ther (2011) 11, 499-502. PubMed  Europe PubMed DOI  T
  61. Shultz,J.C., Goehe,R.W., Murudkar,C.S., Wijesinghe,D.S., Mayton,E.K., Massiello,A., Hawkins,A.J., Mukerjee,P., Pinkerman,R.L., Park,M.A. and Chalfant,C.E.
    SRSF1 regulates the alternative splicing of caspase 9 via a novel intronic splicing enhancer affecting the chemotherapeutic sensitivity of non-small cell lung cancer cells
    Mol Cancer Res (2011) 9, 889-900. PubMed  Europe PubMed DOI  R
    62. 2010
  62. Bratton,S.B. and Salvesen,G.S.
    Regulation of the Apaf-1-caspase-9 apoptosome
    J Cell Sci (2010) 123, 3209-3214. PubMed  Europe PubMed DOI  PMC  EPMC  V
  63. Mu,Y., Xiao,X., Zhang,J., Ao,J. and Chen,X.
    Molecular cloning and functional characterization of caspase 9 in large yellow croaker (Pseudosciaena crocea)
    Dev Comp Immunol (2010) 34, 300-307. PubMed  Europe PubMed DOI
  64. Ramos,C.A., Asgari,Z., Liu,E., Yvon,E., Heslop,H.E., Rooney,C.M., Brenner,M.K. and Dotti,G.
    An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies
    Stem Cells (2010) 28, 1107-1115. PubMed  Europe PubMed DOI
  65. Zhai,D., Yu,E., Jin,C., Welsh,K., Shiau,C.W., Chen,L., Salvesen,G.S., Liddington,R. and Reed,J.C.
    Vaccinia virus protein F1L is a caspase-9 inhibitor
    J Biol Chem (2010) 285, 5569-5580. PubMed  Europe PubMed DOI
    66. 2009
  66. Adrain,C. and Martin,S.J.
    Apoptosis: calling time on apoptosome activity
    Sci Signal (2009) 2, e62-e62. PubMed  Europe PubMed DOI
  67. Allan,L.A. and Clarke,P.R.
    Apoptosis and autophagy: regulation of caspase-9 by phosphorylation
    FEBS J (2009) 276, 6063-6073. PubMed  Europe PubMed DOI
  68. Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V.
    Evaluation of recombinant caspase specificity by competitive substrates
    Anal Biochem (2009) 394, 68-74. PubMed  Europe PubMed DOI  A  P
  69. Lan,Q., Morton,L.M., Armstrong,B., Hartge,P., Menashe,I., Zheng,T., Purdue,M.P., Cerhan,J.R., Zhang,Y., Grulich,A., Cozen,W., Yeager,M., Holford,T.R., Vajdic,C.M., Davis,S., Leaderer,B., Kricker,A., Schenk,M., Zahm,S.H., Chatterjee,N., Chanock,S.J., Rothman,N. and Wang,S.S.
    Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies
    Blood (2009) 114, 264-267. PubMed  Europe PubMed DOI  PMC  EPMC  M
  70. Zuo,Y., Xiang,B., Yang,J., Sun,X., Wang,Y., Cang,H. and Yi,J.
    Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1
    Cell Res (2009) 19, 449-457. PubMed  Europe PubMed DOI
    71. 2008
  71. Guerrero,A.D., Chen,M. and Wang,J.
    Delineation of the caspase-9 signaling cascade
    Apoptosis (2008) 13, 177-186. PubMed  Europe PubMed DOI
  72. McStay,G.P., Salvesen,G.S. and Green,D.R.
    Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways
    Cell Death Differ (2008) 15, 322-331. PubMed  Europe PubMed DOI  P
  73. Pereira,N.A. and Song,Z.
    Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
    Biochem Biophys Res Commun (2008) 377, 873-877. PubMed  Europe PubMed DOI  P  I
  74. Song,W., Dong,Z., Jin,T., Mantellini,M.G., Nunez,G. and Nor,J.E.
    Cancer gene therapy with iCaspase-9 transcriptionally targeted to tumor endothelial cells
    Cancer Gene Ther (2008) 15, 667-675. PubMed  Europe PubMed DOI  PMC  EPMC  U
    75. 2007
  75. Denault,J.B., Eckelman,B.P., Shin,H., Pop,C. and Salvesen,G.S.
    Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9
    Biochem J (2007) 405, 11-19. PubMed  Europe PubMed DOI
  76. Liu,Y., Sercombe,R., Xie,D., Liu,K. and Chen,L.
    Inhibition of caspase-9 activation and apoptosis is involved in ischemic preconditioning-induced neuroprotection in rat brain
    Neurol Res (2007) 29, 855-861. PubMed  Europe PubMed DOI
  77. Milisav,I. and Suput,D.
    Procaspase-9 is attached to the mitochondrial outer membrane in the early stages of apoptosis
    Cell Mol Biol Lett (2007) 12, 509-522. PubMed  Europe PubMed DOI
  78. Reis,M.I., do Vale,A., Pinto,C., Nascimento,D.S., Costa-Ramos,C., Silva,D.S., Silva,M.T. and Dos Santos,N.M.
    First molecular cloning and characterisation of caspase-9 gene in fish and its involvement in a gram negative septicaemia
    Mol Immunol (2007) 44, 1754-1764. PubMed  Europe PubMed DOI
  79. Saikumar,P., Mikhailova,M. and Pandeswara,S.L.
    Regulation of caspase-9 activity by differential binding to the apoptosome complex
    Front Biosci (2007) 12, 3343-3354. PubMed  Europe PubMed DOI  PMC  EPMC
  80. Tey,S.K., Dotti,G., Rooney,C.M., Heslop,H.E. and Brenner,M.K.
    Inducible caspase 9 suicide gene to improve the safety of allodepleted T cells after haploidentical stem cell transplantation
    Biol Blood Marrow Transplant (2007) 13, 913-924. PubMed  Europe PubMed DOI  PMC  EPMC
  81. Twiddy,D. and Cain,K.
    Caspase-9 cleavage, do you need it?
    Biochem J (2007) 405, e1-e2. PubMed  Europe PubMed DOI  PMC  EPMC
  82. Wong,C.K., Chen,Z., So,K.L., Li,D. and Li,P.
    Polycomb group protein RING1B is a direct substrate of caspases-3 and -9
    Biochim Biophys Acta (2007) 1773, 844-852. PubMed  Europe PubMed DOI  P
    83. 2006
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