Structure for peptidase C14.010: caspase-9

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1NW9_B Homo sapiens 2.40 Å complex with BIR-4 protein
Only the peptidase is shown. Catalytic residues are shown in ball-and-stick representation: His237 in purple and Cys287 in yellow.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
cleaved form lacking caspase recruitment domain 2.80 Å 1JXQ 1JXQ 1JXQ 1JXQ 1JXQ 1JXQ Renatus et al., 2001
complex with BIR-4 protein 2.40 Å 1NW9 1NW9 1NW9 1NW9 1NW9 1NW9 Shiozaki et al., 2003
dimeric form 2.80 Å 2AR9 2AR9 2AR9 2AR9 2AR9 2AR9 Chao et al., 2005
ciap1-bir3 in complex with n-terminal peptide from caspase- 9 (atpfqe) 1.50 Å 3D9T 3D9T 3D9T 3D9T 3D9T 3D9T Kulathila et al., 2009
complex with NleF 3.49 Å 3V3K 3V3K 3V3K 3V3K 3V3K 3V3K Blasche et al., 2013
propeptide only; complex with apoptotic protease activating factor 1 2.50 Å 3YGS 3YGS 3YGS 3YGS 3YGS 3YGS Qin et al., 1999