$VAR1 = undef;

Summary for peptidase C14.007: caspase-4

Names
MEROPS Name	caspase-4
Other names	Ich-2, ICErel-II, TX

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.007
Holotype	caspase-4 (Homo sapiens), Uniprot accession P49662 (peptidase unit: 93-377), MERNUM MER0001938
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.57
Enzymology	BRENDA database
Proteolytic events	CutDB database (3 cleavages)
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Caspase_4
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/et/-/Dsga/-/-/- (based on 11 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	0	0	0	3	1	1	1
Pro	1	0	2	0	0	2	2	0
Ala	0	0	1	0	2	0	1	2
Val	0	1	0	0	0	1	3	1
Leu	1	1	0	0	0	1	1	0
Ile	1	0	0	0	0	0	0	0
Met	1	0	0	0	0	0	0	0
Phe	2	0	0	0	0	1	0	1
Tyr	1	0	1	0	1	1	0	0
Trp	1	0	0	0	0	0	0	0
Ser	1	0	1	0	4	1	0	1
Thr	0	2	3	0	0	1	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	1	0	0	0	0	0	1
Asp	1	0	0	11	0	0	0	1
Glu	0	6	0	0	0	0	0	0
Lys	0	0	1	0	0	1	1	1
Arg	0	0	0	0	0	0	0	1
His	0	0	2	0	0	0	0	0

Specificity from combinatorial peptides

Organism	comment	P4	P3	P2	P1	P1'	P2'	P3'	P4'	optimal substrate	fluorophore or acceptor-donor pair	Reference
Homo sapiens	recombinant	W/L	E	H/I	D	-	-	-	-	WEHD	AMC	Thornberry et al., 1997
Homo sapiens	recombinant	W	E	nd	D	-	-	-	-	WE(nd)D	AMC	Lee et al., 1999

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
CASP4	11q22.2-q22.3		ENSG00000137756	837	CASP4	602664