Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01584

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	HIV-1 retropepsin	1-269	N			Tomasselli et al., 1991
23	HIV-2 retropepsin	1-269	N			Tomasselli et al., 1991
27	caspase-1	1-269	P			Thornberry et al., 1997
27	caspase-4	1-269	P			Kamens et al., 1995
76	trypsin 1	1-269	N			Hazuda et al., 1990
98	HIV-1 retropepsin	1-269	N			Tomasselli et al., 1991
103	elastase-1	1-269	P			Hazuda et al., 1990
110	meprin beta subunit	1-269	P		NT	Herzog et al., 2005
113	elastase-2	1-269	P			Hazuda et al., 1990
113	cathepsin G	1-269	P			Hazuda et al., 1990
113	chymase (Homo sapiens-type)	1-269	P			Raymond et al., 2003
115	streptopain	1-269	N		NT	Kapur et al., 1993
115	meprin alpha subunit	1-269	P		NT	Herzog et al., 2009
116	caspase-1	1-269	P			Thornberry et al., 1992
116	caspase-4	1-269	P			Kamens et al., 1995
118	dipeptidyl-peptidase 4 (bacteria-type 2)	117-132	N		MS	Banbula et al., 2000
120	granzyme A	1-269	P
141	matrix metallopeptidase-2	117-269	P		NT	Ito et al., 1996