Literature for peptidase C14.007: caspase-4

(Topics flags: A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Elkayam,E., Gervais,F.G., Wu,H., Crackower,M.A. and Lieberman,J.
   New insights into the noncanonical inflammasome point to caspase-4 as a druggable target
   Nat Rev Immunol PubMed  Europe PubMed DOI
2. Shi,Y., He,T., Liu,H., Li,X., Li,Z., Wen,Q., Dai,Z., Sun,X., Tan,Q., Yang,W., Jiang,Y., Liu,Y., Yuan,H., Lei,F., Yi,Y. and Cai,J.
   Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury
   Int J Biol Sci21, 433-453. PubMed  Europe PubMed DOI  K
2024
3. Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
   The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
   Mol Cell84, 170-179. PubMed  Europe PubMed DOI  V
4. Amali,A.A., Ravikumar,S., Chew,W.L., Tan,Z., Sam,Q.H., Chen,K.W., Boucher,D., Maclaren,G. and Chai,L.Y.A.
   ECMO-Dependent Fulminant Melioidosis from Caspase 4 Mutation Reversed by Interferon Gamma Therapy
   Clin Infect Dis78, 94-97. PubMed  Europe PubMed DOI
5. Chiba,Y., Doi,T., Obayashi,K., Sumida,K., Nagasaka,S., Wang,K.Y., Yamasaki,K., Masago,K., Matsushita,H., Kuroda,H., Yatera,K. and Endo,M.
   Caspase-4 promotes metastasis and interferon-gamma-induced pyroptosis in lung adenocarcinoma
   Commun Biol7, 699-699. PubMed  Europe PubMed DOI
6. Daily,K.P., Badr,A., Eltobgy,M., Estfanous,S., Whitham,O., Tan,M.H., Carafice,C., Krause,K., McNamara,A., Hamilton,K., Houle,S., Gupta,S., Gupta,G.A., Madhu,S., Fitzgerald,J., Saadey,A.A., Laster,B., Yan,P., Webb,A., Zhang,X., Pietrzak,M., Kokiko-Cochran,O.N., Ghoneim,H.E. and Amer,A.O.
   DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-beta deposition in Alzheimer's disease
   Alzheimers Res Ther16, 29-29. PubMed  Europe PubMed DOI
7. Devant,P., Dong,Y., Mintseris,J., Ma,W., Gygi,S.P., Wu,H. and Kagan,J.C.
   Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4
   Nature625, E17-E17. PubMed  Europe PubMed DOI
8. Di,L., Li,M., Lei,X., Xie,W., Liu,G., Wang,Y., Zhang,W. and Zhu,W.G.
   Caspase-4 in glioma indicates deterioration and unfavorable prognosis by affecting tumor cell proliferation and immune cell recruitment
   Sci Rep14, 17443-17443. PubMed  Europe PubMed DOI
9. Li,S., Song,J., Liu,J., Zhou,S., Zhao,G., Li,T., Huang,L., Li,J. and Weng,C.
   African swine fever virus infection regulates pyroptosis by cleaving gasdermin A (GSDMA) via active caspase-3 and caspase-4
   J Biol Chem107307-107307. PubMed  Europe PubMed DOI
10. Sumida,K., Doi,T., Obayashi,K., Chiba,Y., Nagasaka,S., Ogino,N., Miyagawa,K., Baba,R., Morimoto,H., Hara,H., Terabayashi,T., Ishizaki,T., Harada,M. and Endo,M.
    Caspase-4 has a role in cell division in epithelial cells through actin depolymerization
    Biochem Biophys Res Commun695, 149394-149394. PubMed  Europe PubMed DOI
2023
11. Devant,P., Dong,Y., Mintseris,J., Ma,W., Gygi,S.P., Wu,H. and Kagan,J.C.
    Structural insights into cytokine cleavage by inflammatory caspase-4
    Nature624, 451-459. PubMed  Europe PubMed DOI
12. Dilucca,M. and Broz,P.
    Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria
    Methods Mol Biol2641, 49-65. PubMed  Europe PubMed DOI
13. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
    A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
    Mol Neurobiol60, 5805-5837. PubMed  Europe PubMed DOI  V
14. Shi,X., Sun,Q., Hou,Y., Zeng,H., Cao,Y., Dong,M., Ding,J. and Shao,F.
    Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
    Nature624, 442-450. PubMed  Europe PubMed DOI
15. Yi,Y.S.
    Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
2022
16. Bibo-Verdugo,B., Joglekar,I., Karadi Giridhar,M.N., Ramirez,M.L., Snipas,S.J., Clark,A.C., Poreba,M. and Salvesen,G.S.
    Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
    J Biol Chem298, 101931-101931. PubMed  Europe PubMed DOI
17. Chukai,Y., Ito,G., Konno,M., Sakata,Y. and Ozaki,T.
    Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress
    Biochem Biophys Res Commun608, 156-162. PubMed  Europe PubMed DOI  K
18. Eltobgy,M.M., Zani,A., Kenney,A.D., Estfanous,S., Kim,E., Badr,A., Carafice,C., Daily,K., Whitham,O., Pietrzak,M., Webb,A., Kawahara,J., Eddy,A.C., Denz,P., Lu,M., Kc,M., Peeples,M.E., Li,J., Zhu,J., Que,J., Robinson,R., Rosas Mejia,O., Rayner,R.E., Hall-Stoodley,L., Seveau,S., Gavrilin,M.A., Zhang,X., Thomas,J., Kohlmeier,J.E., Suthar,M.S., Oltz,E., Tedeschi,A., Robledo-Avila,F.H., Partida-Sanchez,S., Hemann,E.A., Abdelrazik,E., Forero,A., Nimjee,S.M., Boyaka,P.N., Cormet-Boyaka,E., Yount,J.S. and Amer,A.O.
    Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis
    Proc Natl Acad Sci U S A119, e2202012119-e2202012119. PubMed  Europe PubMed DOI
19. Ross,C., Chan,A.H., von Pein,J.B., Maddugoda,M.P., Boucher,D. and Schroder,K.
    Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes
    Annu Rev Immunol PubMed  Europe PubMed DOI  V
20. Smith,A.P. and Creagh,E.M.
    Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease
    Front Pharmacol13, 919567-919567. PubMed  Europe PubMed DOI  V
21. Wang,Z., Chan,W. and Yue,Y.
    A significant other: Non-canonical caspase-4/5/11 inflammasome in periodontitis
    Oral Dis PubMed  Europe PubMed DOI  V
2021
22. Bateman,G., Hill,B., Knight,R. and Boucher,D.
    Great balls of fire: activation and signalling of inflammatory caspases
    Biochem Soc Trans49, 1311-1324. PubMed  Europe PubMed DOI  V
23. Davies,C.W., Stowe,I., Phung,Q.T., Ho,H., Bakalarski,C.E., Gupta,A., Zhang,Y., Lill,J.R., Payandeh,J., Kayagaki,N. and Koerber,J.T.
    Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
24. Devant,P., Cao,A. and Kagan,J.C.
    Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1beta converting enzyme
    Sci Immunol6, PubMed  Europe PubMed DOI
25. Li,Z., Liu,W., Fu,J., Cheng,S., Xu,Y., Wang,Z., Liu,X., Shi,X., Liu,Y., Qi,X., Liu,X., Ding,J. and Shao,F.
    Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11
    Nature599, 290-295. PubMed  Europe PubMed DOI
2020
26. Ding,P.H., Yang,M.X., Wang,N.N., Jin,L.J., Dong,Y., Cai,X. and Chen,L.L.
    Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1beta Release Depend on Caspase-4
    Front Microbiol11, 1881-1881. PubMed  Europe PubMed DOI  K
27. Eren,E., Planes,R., Bagayoko,S., Bordignon,P.J., Chaoui,K., Hessel,A., Santoni,K., Pinilla,M., Lagrange,B., Burlet-Schiltz,O., Howard,J.C., Henry,T., Yamamoto,M. and Meunier,E.
    Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response
    EMBO Rep21, e50829-e50829. PubMed  Europe PubMed DOI
28. Fisch,D., Clough,B., Domart,M.C., Encheva,V., Bando,H., Snijders,A.P., Collinson,L.M., Yamamoto,M., Shenoy,A.R. and Frickel,E.M.
    Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death
    Cell Rep32, 108008-108008. PubMed  Europe PubMed DOI
29. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
    Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
    Genomics PubMed  Europe PubMed DOI
30. Jiao,Y., Wang,L., Lu,L., Liu,J., Li,X., Zhao,H., Hou,Z. and Zheng,B.
    The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
    Stem Cells Int2020, 8867115-8867115. PubMed  Europe PubMed DOI  K
31. Linares,G.R., Leng,Y., Maric,D. and Chuang,D.M.
    Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation
    Cell Biol Int PubMed  Europe PubMed DOI
32. Linder,A. and Hornung,V.
    Irgm2 and Gate-16 put a break on caspase-11 activation
    EMBO Rep21, e51787-e51787. PubMed  Europe PubMed DOI
33. Terlizzi,M., Molino,A., Colarusso,C., Somma,P., De Rosa,I., Troisi,J., Scala,G., Salvi,R., Pinto,A. and Sorrentino,R.
    Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients
    Oncotarget11, 3515-3525. PubMed  Europe PubMed DOI
34. Zaslona,Z., Flis,E., Nulty,C., Kearney,J., FitzGerald,R., Douglas,A.R., McNamara,D., Smith,S., O'Neill,L.A.J. and Creagh,E.M.
    Caspase-4: A Therapeutic Target for Peptic Ulcer Disease
    Immunohorizons4, 627-633. PubMed  Europe PubMed DOI
2019
35. Benaoudia,S., Martin,A., Puig Gamez,M., Gay,G., Lagrange,B., Cornut,M., Krasnykov,K., Claude,J.B., Bourgeois,C.F., Hughes,S., Gillet,B., Allatif,O., Corbin,A., Ricci,R. and Henry,T.
    A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells
    EMBO Repe48235-e48235. PubMed  Europe PubMed DOI
2018
36. Jun,H.K., Jung,Y.J., Ji,S., An,S.J. and Choi,B.K.
    Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts
    Cell Death Differ25, 380-391. PubMed  Europe PubMed DOI
37. Lagrange,B., Benaoudia,S., Wallet,P., Magnotti,F., Provost,A., Michal,F., Martin,A., Di Lorenzo,F., Py,B.F., Molinaro,A. and Henry,T.
    Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
    Nat Commun9, 242-242. PubMed  Europe PubMed DOI
2016
38. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A113, E2001-E2010. PubMed  Europe PubMed DOI  P
39. Kent,C.R., Bryja,M., Gustafson,H.A., Kawarski,M.Y., Lenti,G., Pierce,E.N., Knopp,R.C., Ceja,V., Pati,B., Walters,D.E. and Karver,C.E.
    Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases
    Bioorg Med Chem Lett26, 5476-5480. PubMed  Europe PubMed DOI  I
2015
40. Schmid-Burgk,J.L., Gaidt,M.M., Schmidt,T., Ebert,T.S., Bartok,E. and Hornung,V.
    Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells
    Eur J Immunol45, 2911-2917. PubMed  Europe PubMed DOI
41. Shi,J., Zhao,Y., Wang,K., Shi,X., Wang,Y., Huang,H., Zhuang,Y., Cai,T., Wang,F. and Shao,F.
    Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
    Nature526, 660-665. PubMed  Europe PubMed DOI
2014
42. 
    Neuromuscular disease: caspase-4 is a potential therapeutic target for Duchenne muscular dystrophy
    Nat Rev Neurol10, 366-366. DOI  T
43. Kajiwara,Y., Schiff,T., Voloudakis,G., Gama Sosa,M.A., Elder,G., Bozdagi,O. and Buxbaum,J.D.
    A critical role for human caspase-4 in endotoxin sensitivity
    J Immunol193, 335-343. PubMed  Europe PubMed DOI
44. Knodler,L.A., Crowley,S.M., Sham,H.P., Yang,H., Wrande,M., Ma,C., Ernst,R.K., Steele-Mortimer,O., Celli,J. and Vallance,B.A.
    Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens
    Cell Host Microbe16, 249-256. PubMed  Europe PubMed DOI
2012
45. Gao,J. and Wells,J.A.
    Caspase-4 and caspase-5
    [ISSN:978-0-12-407743-0]3, 2265-2269. DOI
46. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif84, 236-246. PubMed  Europe PubMed DOI  E
47. Sollberger,G., Strittmatter,G.E., Kistowska,M., French,L.E. and Beer,H.D.
    Caspase-4 is required for activation of inflammasomes
    J Immunol188, 1992-2000. PubMed  Europe PubMed DOI
2011
48. Yamamuro,A., Kishino,T., Ohshima,Y., Yoshioka,Y., Kimura,T., Kasai,A. and Maeda,S.
    Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells
    J Pharmacol Sci115, 239-243. PubMed  Europe PubMed DOI
2010
49. Agard,N.J., Maltby,D. and Wells,J.A.
    Inflammatory stimuli regulate caspase substrate profiles
    Mol Cell Proteomics9, 880-893. PubMed  Europe PubMed DOI  P
50. Matsuzaki,S., Hiratsuka,T., Kuwahara,R., Katayama,T. and Tohyama,M.
    Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress
    Neurochem Int56, 352-356. PubMed  Europe PubMed DOI
51. Yazdi,A.S., Guarda,G., D'Ombrain,M.C. and Drexler,S.K.
    Inflammatory caspases in innate immunity and inflammation
    J Innate Immun2, 228-237. PubMed  Europe PubMed DOI
2009
52. Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V.
    Evaluation of recombinant caspase specificity by competitive substrates
    Anal Biochem394, 68-74. PubMed  Europe PubMed DOI  A  P
53. Kajiwara,Y., Akram,A., Katsel,P., Haroutunian,V., Schmeidler,J., Beecham,G., Haines,J.L., Pericak-Vance,M.A. and Buxbaum,J.D.
    FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
    PLoS ONE4, e5071-e5071. PubMed  Europe PubMed DOI
2008
54. Soung,Y.H., Jeong,E.G., Ahn,C.H., Kim,S.S., Song,S.Y., Yoo,N.J. and Lee,S.H.
    Mutational analysis of caspase 1, 4, and 5 genes in common human cancers
    Hum Pathol39, 895-900. PubMed  Europe PubMed DOI  M
2007
55. Karki,P., Dahal,G.R. and Park,I.S.
    Both dimerization and interdomain processing are essential for caspase-4 activation
    Biochem Biophys Res Commun356, 1056-1061. PubMed  Europe PubMed DOI
56. Kersse,K., Vanden Berghe,T., Lamkanfi,M. and Vandenabeele,P.
    A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins
    Biochem Soc Trans35, 1508-1511. PubMed  Europe PubMed DOI
57. Martinon,F. and Tschopp,J.
    Inflammatory caspases and inflammasomes: master switches of inflammation
    Cell Death Differ14, 10-22. PubMed  Europe PubMed DOI
1999
58. Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A.
    Purification and catalytic properties of human caspase family members
    Cell Death Differ6, 362-369. PubMed  Europe PubMed DOI
59. Lee,D., Adams,J.L., Brandt,M., DeWolf,W.E., Jr., Keller,P.M. and Levy,M.A.
    A substrate combinatorial array for caspases
    Bioorg Med Chem Lett9, 1667-1672. PubMed  Europe PubMed DOI  P
1998
60. [YEAR:1-4-1998]Fassy,F., Krebs,O., Rey,H., Komara,B., Gillard,C., Capdevila,C., Yea,C., Faucheu,C., Blanchet,A.M., Miossec,C. and Diu-Hercend,A.
    Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme
    Eur J Biochem253, 76-83. PubMed  Europe PubMed DOI
1997
61. Kamada,S., Funahashi,Y. and Tsujimoto,Y.
    Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
    Cell Death Differ4, 473-478. PubMed  Europe PubMed DOI  I
62. [YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W.
    Substrate specificities of caspase family proteases
    J Biol Chem272, 9677-9682. PubMed  Europe PubMed DOI  P
1995
63. Kamens,J., Paskind,M., Hugunin,M., Talanian,R.V., Allen,H., Banach,D., Bump,N., Hackett,M., Johnston,C.G. and Li,P.
    Identification and characterization of ICH-2, a novel member of the interleukin-1beta-converting enzyme family of cysteine proteases
    J Biol Chem270, 15250-15256. PubMed  Europe PubMed DOI