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Literature for peptidase C14.007: caspase-4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Elkayam,E., Gervais,F.G., Wu,H., Crackower,M.A. and Lieberman,J.
    New insights into the noncanonical inflammasome point to caspase-4 as a druggable target
    Nat Rev Immunol (2025) PubMed  Europe PubMed DOI
  2. Nagasaka,S., Doi,T., Obayashi,K., Kohzaki,M., Sumida,K., Chiba,Y., Yamamoto,J. and Endo,M.
    Caspase-4 deficiency impairs nuclear actin-mediated DNA double-strand break repair and increases radiosensitivity in cancer cells
    Biochem Biophys Res Commun (2025) 787, 152764-152764. PubMed  Europe PubMed DOI
  3. Shi,Y., He,T., Liu,H., Li,X., Li,Z., Wen,Q., Dai,Z., Sun,X., Tan,Q., Yang,W., Jiang,Y., Liu,Y., Yuan,H., Lei,F., Yi,Y. and Cai,J.
    Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury
    Int J Biol Sci (2025) 21, 433-453. PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Wang,X., Lu,Y., Yuan,C. and Yang,X.
    KLF7-IT1-ARPC2 axis in macrophages orchestrates caspase-4-driven hypercoagulation in sepsis
    Biochem Biophys Res Commun (2025) 793, 153015-153015. PubMed  Europe PubMed DOI
    5. 2024
  5. Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X.
    The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
    Mol Cell (2024) 84, 170-179. PubMed  Europe PubMed DOI  V
  6. Amali,A.A., Ravikumar,S., Chew,W.L., Tan,Z., Sam,Q.H., Chen,K.W., Boucher,D., Maclaren,G. and Chai,L.Y.A.
    ECMO-Dependent Fulminant Melioidosis from Caspase 4 Mutation Reversed by Interferon Gamma Therapy
    Clin Infect Dis (2024) 78, 94-97. PubMed  Europe PubMed DOI
  7. Chiba,Y., Doi,T., Obayashi,K., Sumida,K., Nagasaka,S., Wang,K.Y., Yamasaki,K., Masago,K., Matsushita,H., Kuroda,H., Yatera,K. and Endo,M.
    Caspase-4 promotes metastasis and interferon-gamma-induced pyroptosis in lung adenocarcinoma
    Commun Biol (2024) 7, 699-699. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Daily,K.P., Badr,A., Eltobgy,M., Estfanous,S., Whitham,O., Tan,M.H., Carafice,C., Krause,K., McNamara,A., Hamilton,K., Houle,S., Gupta,S., Gupta,G.A., Madhu,S., Fitzgerald,J., Saadey,A.A., Laster,B., Yan,P., Webb,A., Zhang,X., Pietrzak,M., Kokiko-Cochran,O.N., Ghoneim,H.E. and Amer,A.O.
    DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-beta deposition in Alzheimer's disease
    Alzheimers Res Ther (2024) 16, 29-29. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Devant,P., Dong,Y., Mintseris,J., Ma,W., Gygi,S.P., Wu,H. and Kagan,J.C.
    Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4
    Nature (2024) 625, E17-E17. PubMed  Europe PubMed DOI
  10. Di,L., Li,M., Lei,X., Xie,W., Liu,G., Wang,Y., Zhang,W. and Zhu,W.G.
    Caspase-4 in glioma indicates deterioration and unfavorable prognosis by affecting tumor cell proliferation and immune cell recruitment
    Sci Rep (2024) 14, 17443-17443. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Li,S., Song,J., Liu,J., Zhou,S., Zhao,G., Li,T., Huang,L., Li,J. and Weng,C.
    African swine fever virus infection regulates pyroptosis by cleaving gasdermin A (GSDMA) via active caspase-3 and caspase-4
    J Biol Chem (2024) , 107307-107307. PubMed  Europe PubMed DOI
  12. Sumida,K., Doi,T., Obayashi,K., Chiba,Y., Nagasaka,S., Ogino,N., Miyagawa,K., Baba,R., Morimoto,H., Hara,H., Terabayashi,T., Ishizaki,T., Harada,M. and Endo,M.
    Caspase-4 has a role in cell division in epithelial cells through actin depolymerization
    Biochem Biophys Res Commun (2024) 695, 149394-149394. PubMed  Europe PubMed DOI
    13. 2023
  13. Devant,P., Dong,Y., Mintseris,J., Ma,W., Gygi,S.P., Wu,H. and Kagan,J.C.
    Structural insights into cytokine cleavage by inflammatory caspase-4
    Nature (2023) 624, 451-459. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Dilucca,M. and Broz,P.
    Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria
    Methods Mol Biol (2023) 2641, 49-65. PubMed  Europe PubMed DOI
  15. Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K.
    A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
    Mol Neurobiol (2023) 60, 5805-5837. PubMed  Europe PubMed DOI  V
  16. Shi,X., Sun,Q., Hou,Y., Zeng,H., Cao,Y., Dong,M., Ding,J. and Shao,F.
    Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
    Nature (2023) 624, 442-450. PubMed  Europe PubMed DOI
  17. Yi,Y.S.
    Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
    18. 2022
  18. Bibo-Verdugo,B., Joglekar,I., Karadi Giridhar,M.N., Ramirez,M.L., Snipas,S.J., Clark,A.C., Poreba,M. and Salvesen,G.S.
    Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
    J Biol Chem (2022) 298, 101931-101931. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Chukai,Y., Ito,G., Konno,M., Sakata,Y. and Ozaki,T.
    Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress
    Biochem Biophys Res Commun (2022) 608, 156-162. PubMed  Europe PubMed DOI  K
  20. Eltobgy,M.M., Zani,A., Kenney,A.D., Estfanous,S., Kim,E., Badr,A., Carafice,C., Daily,K., Whitham,O., Pietrzak,M., Webb,A., Kawahara,J., Eddy,A.C., Denz,P., Lu,M., Kc,M., Peeples,M.E., Li,J., Zhu,J., Que,J., Robinson,R., Rosas Mejia,O., Rayner,R.E., Hall-Stoodley,L., Seveau,S., Gavrilin,M.A., Zhang,X., Thomas,J., Kohlmeier,J.E., Suthar,M.S., Oltz,E., Tedeschi,A., Robledo-Avila,F.H., Partida-Sanchez,S., Hemann,E.A., Abdelrazik,E., Forero,A., Nimjee,S.M., Boyaka,P.N., Cormet-Boyaka,E., Yount,J.S. and Amer,A.O.
    Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis
    Proc Natl Acad Sci U S A (2022) 119, e2202012119-e2202012119. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Ross,C., Chan,A.H., von Pein,J.B., Maddugoda,M.P., Boucher,D. and Schroder,K.
    Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes
    Annu Rev Immunol (2022) PubMed  Europe PubMed DOI  V
  22. Smith,A.P. and Creagh,E.M.
    Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease
    Front Pharmacol (2022) 13, 919567-919567. PubMed  Europe PubMed DOI  PMC  EPMC  V
  23. Wang,Z., Chan,W. and Yue,Y.
    A significant other: Non-canonical caspase-4/5/11 inflammasome in periodontitis
    Oral Dis (2022) PubMed  Europe PubMed DOI  V
    24. 2021
  24. Bateman,G., Hill,B., Knight,R. and Boucher,D.
    Great balls of fire: activation and signalling of inflammatory caspases
    Biochem Soc Trans (2021) 49, 1311-1324. PubMed  Europe PubMed DOI  V
  25. Davies,C.W., Stowe,I., Phung,Q.T., Ho,H., Bakalarski,C.E., Gupta,A., Zhang,Y., Lill,J.R., Payandeh,J., Kayagaki,N. and Koerber,J.T.
    Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function
    Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI  PMC  EPMC
  26. Devant,P., Cao,A. and Kagan,J.C.
    Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1beta converting enzyme
    Sci Immunol (2021) 6 PubMed  Europe PubMed DOI  PMC  EPMC
  27. Li,Z., Liu,W., Fu,J., Cheng,S., Xu,Y., Wang,Z., Liu,X., Shi,X., Liu,Y., Qi,X., Liu,X., Ding,J. and Shao,F.
    Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11
    Nature (2021) 599, 290-295. PubMed  Europe PubMed DOI
    28. 2020
  28. Ding,P.H., Yang,M.X., Wang,N.N., Jin,L.J., Dong,Y., Cai,X. and Chen,L.L.
    Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1beta Release Depend on Caspase-4
    Front Microbiol (2020) 11, 1881-1881. PubMed  Europe PubMed DOI  PMC  EPMC  K
  29. Eren,E., Planes,R., Bagayoko,S., Bordignon,P.J., Chaoui,K., Hessel,A., Santoni,K., Pinilla,M., Lagrange,B., Burlet-Schiltz,O., Howard,J.C., Henry,T., Yamamoto,M. and Meunier,E.
    Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response
    EMBO Rep (2020) 21, e50829-e50829. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Fisch,D., Clough,B., Domart,M.C., Encheva,V., Bando,H., Snijders,A.P., Collinson,L.M., Yamamoto,M., Shenoy,A.R. and Frickel,E.M.
    Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death
    Cell Rep (2020) 32, 108008-108008. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
    Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
    Genomics (2020) PubMed  Europe PubMed DOI
  32. Jiao,Y., Wang,L., Lu,L., Liu,J., Li,X., Zhao,H., Hou,Z. and Zheng,B.
    The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors
    Stem Cells Int (2020) 2020, 8867115-8867115. PubMed  Europe PubMed DOI  PMC  EPMC  K
  33. Linares,G.R., Leng,Y., Maric,D. and Chuang,D.M.
    Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation
    Cell Biol Int (2020) PubMed  Europe PubMed DOI
  34. Linder,A. and Hornung,V.
    Irgm2 and Gate-16 put a break on caspase-11 activation
    EMBO Rep (2020) 21, e51787-e51787. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Terlizzi,M., Molino,A., Colarusso,C., Somma,P., De Rosa,I., Troisi,J., Scala,G., Salvi,R., Pinto,A. and Sorrentino,R.
    Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients
    Oncotarget (2020) 11, 3515-3525. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Zaslona,Z., Flis,E., Nulty,C., Kearney,J., FitzGerald,R., Douglas,A.R., McNamara,D., Smith,S., O'Neill,L.A.J. and Creagh,E.M.
    Caspase-4: A Therapeutic Target for Peptic Ulcer Disease
    Immunohorizons (2020) 4, 627-633. PubMed  Europe PubMed DOI
    37. 2019
  37. Benaoudia,S., Martin,A., Puig Gamez,M., Gay,G., Lagrange,B., Cornut,M., Krasnykov,K., Claude,J.B., Bourgeois,C.F., Hughes,S., Gillet,B., Allatif,O., Corbin,A., Ricci,R. and Henry,T.
    A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells
    EMBO Rep (2019) , e48235-e48235. PubMed  Europe PubMed DOI
    38. 2018
  38. Jun,H.K., Jung,Y.J., Ji,S., An,S.J. and Choi,B.K.
    Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts
    Cell Death Differ (2018) 25, 380-391. PubMed  Europe PubMed DOI
  39. Lagrange,B., Benaoudia,S., Wallet,P., Magnotti,F., Provost,A., Michal,F., Martin,A., Di Lorenzo,F., Py,B.F., Molinaro,A. and Henry,T.
    Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
    Nat Commun (2018) 9, 242-242. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2016
  40. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed  Europe PubMed DOI  P
  41. Kent,C.R., Bryja,M., Gustafson,H.A., Kawarski,M.Y., Lenti,G., Pierce,E.N., Knopp,R.C., Ceja,V., Pati,B., Walters,D.E. and Karver,C.E.
    Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases
    Bioorg Med Chem Lett (2016) 26, 5476-5480. PubMed  Europe PubMed DOI  I
    42. 2015
  42. Schmid-Burgk,J.L., Gaidt,M.M., Schmidt,T., Ebert,T.S., Bartok,E. and Hornung,V.
    Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells
    Eur J Immunol (2015) 45, 2911-2917. PubMed  Europe PubMed DOI
  43. Shi,J., Zhao,Y., Wang,K., Shi,X., Wang,Y., Huang,H., Zhuang,Y., Cai,T., Wang,F. and Shao,F.
    Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
    Nature (2015) 526, 660-665. PubMed  Europe PubMed DOI
    44. 2014

  44. Neuromuscular disease: caspase-4 is a potential therapeutic target for Duchenne muscular dystrophy
    Nat Rev Neurol (2014) 10, 366-366. DOI  T
  45. Kajiwara,Y., Schiff,T., Voloudakis,G., Gama Sosa,M.A., Elder,G., Bozdagi,O. and Buxbaum,J.D.
    A critical role for human caspase-4 in endotoxin sensitivity
    J Immunol (2014) 193, 335-343. PubMed  Europe PubMed DOI
  46. Knodler,L.A., Crowley,S.M., Sham,H.P., Yang,H., Wrande,M., Ma,C., Ernst,R.K., Steele-Mortimer,O., Celli,J. and Vallance,B.A.
    Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens
    Cell Host Microbe (2014) 16, 249-256. PubMed  Europe PubMed DOI
    47. 2012
  47. Gao,J. and Wells,J.A.
    Caspase-4 and caspase-5
    [ISSN:978-0-12-407743-0] (2012) 3, 2265-2269. DOI
  48. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif (2012) 84, 236-246. PubMed  Europe PubMed DOI  E
  49. Sollberger,G., Strittmatter,G.E., Kistowska,M., French,L.E. and Beer,H.D.
    Caspase-4 is required for activation of inflammasomes
    J Immunol (2012) 188, 1992-2000. PubMed  Europe PubMed DOI
    50. 2011
  50. Yamamuro,A., Kishino,T., Ohshima,Y., Yoshioka,Y., Kimura,T., Kasai,A. and Maeda,S.
    Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells
    J Pharmacol Sci (2011) 115, 239-243. PubMed  Europe PubMed DOI
    51. 2010
  51. Agard,N.J., Maltby,D. and Wells,J.A.
    Inflammatory stimuli regulate caspase substrate profiles
    Mol Cell Proteomics (2010) 9, 880-893. PubMed  Europe PubMed DOI  P
  52. Matsuzaki,S., Hiratsuka,T., Kuwahara,R., Katayama,T. and Tohyama,M.
    Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress
    Neurochem Int (2010) 56, 352-356. PubMed  Europe PubMed DOI
  53. Yazdi,A.S., Guarda,G., D'Ombrain,M.C. and Drexler,S.K.
    Inflammatory caspases in innate immunity and inflammation
    J Innate Immun (2010) 2, 228-237. PubMed  Europe PubMed DOI
    54. 2009
  54. Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V.
    Evaluation of recombinant caspase specificity by competitive substrates
    Anal Biochem (2009) 394, 68-74. PubMed  Europe PubMed DOI  A  P
  55. Kajiwara,Y., Akram,A., Katsel,P., Haroutunian,V., Schmeidler,J., Beecham,G., Haines,J.L., Pericak-Vance,M.A. and Buxbaum,J.D.
    FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
    PLoS ONE (2009) 4, e5071-e5071. PubMed  Europe PubMed DOI  PMC  EPMC
    56. 2008
  56. Soung,Y.H., Jeong,E.G., Ahn,C.H., Kim,S.S., Song,S.Y., Yoo,N.J. and Lee,S.H.
    Mutational analysis of caspase 1, 4, and 5 genes in common human cancers
    Hum Pathol (2008) 39, 895-900. PubMed  Europe PubMed DOI  M
    57. 2007
  57. Karki,P., Dahal,G.R. and Park,I.S.
    Both dimerization and interdomain processing are essential for caspase-4 activation
    Biochem Biophys Res Commun (2007) 356, 1056-1061. PubMed  Europe PubMed DOI
  58. Kersse,K., Vanden Berghe,T., Lamkanfi,M. and Vandenabeele,P.
    A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins
    Biochem Soc Trans (2007) 35, 1508-1511. PubMed  Europe PubMed DOI
  59. Martinon,F. and Tschopp,J.
    Inflammatory caspases and inflammasomes: master switches of inflammation
    Cell Death Differ (2007) 14, 10-22. PubMed  Europe PubMed DOI
    60. 1999
  60. Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A.
    Purification and catalytic properties of human caspase family members
    Cell Death Differ (1999) 6, 362-369. PubMed  Europe PubMed DOI
  61. Lee,D., Adams,J.L., Brandt,M., DeWolf,W.E., Jr., Keller,P.M. and Levy,M.A.
    A substrate combinatorial array for caspases
    Bioorg Med Chem Lett (1999) 9, 1667-1672. PubMed  Europe PubMed DOI  P
    62. 1998
  62. [YEAR:1-4-1998]Fassy,F., Krebs,O., Rey,H., Komara,B., Gillard,C., Capdevila,C., Yea,C., Faucheu,C., Blanchet,A.M., Miossec,C. and Diu-Hercend,A.
    Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme
    Eur J Biochem (1-4-1998) 253, 76-83. PubMed  Europe PubMed DOI
    63. 1997
  63. Kamada,S., Funahashi,Y. and Tsujimoto,Y.
    Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases
    Cell Death Differ (1997) 4, 473-478. PubMed  Europe PubMed DOI  I
  64. [YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W.
    Substrate specificities of caspase family proteases
    J Biol Chem (11-4-1997) 272, 9677-9682. PubMed  Europe PubMed DOI  P
    65. 1995
  65. Kamens,J., Paskind,M., Hugunin,M., Talanian,R.V., Allen,H., Banach,D., Bump,N., Hackett,M., Johnston,C.G. and Li,P.
    Identification and characterization of ICH-2, a novel member of the interleukin-1beta-converting enzyme family of cysteine proteases
    J Biol Chem (1995) 270, 15250-15256. PubMed  Europe PubMed DOI

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