Literature for peptidase C14.007: caspase-4

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Elkayam,E., Gervais,F.G., Wu,H., Crackower,M.A. and Lieberman,J. New insights into the noncanonical inflammasome point to caspase-4 as a druggable target Nat Rev Immunol (2025) PubMed Europe PubMed DOI
Nagasaka,S., Doi,T., Obayashi,K., Kohzaki,M., Sumida,K., Chiba,Y., Yamamoto,J. and Endo,M. Caspase-4 deficiency impairs nuclear actin-mediated DNA double-strand break repair and increases radiosensitivity in cancer cells Biochem Biophys Res Commun (2025) 787, 152764-152764. PubMed Europe PubMed DOI
Shi,Y., He,T., Liu,H., Li,X., Li,Z., Wen,Q., Dai,Z., Sun,X., Tan,Q., Yang,W., Jiang,Y., Liu,Y., Yuan,H., Lei,F., Yi,Y. and Cai,J. Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury Int J Biol Sci (2025) 21, 433-453. PubMed Europe PubMed DOI PMC EPMC K
Wang,X., Lu,Y., Yuan,C. and Yang,X. KLF7-IT1-ARPC2 axis in macrophages orchestrates caspase-4-driven hypercoagulation in sepsis Biochem Biophys Res Commun (2025) 793, 153015-153015. PubMed Europe PubMed DOI

2024

Ai,Y., Meng,Y., Yan,B., Zhou,Q. and Wang,X. The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death Mol Cell (2024) 84, 170-179. PubMed Europe PubMed DOI V
Amali,A.A., Ravikumar,S., Chew,W.L., Tan,Z., Sam,Q.H., Chen,K.W., Boucher,D., Maclaren,G. and Chai,L.Y.A. ECMO-Dependent Fulminant Melioidosis from Caspase 4 Mutation Reversed by Interferon Gamma Therapy Clin Infect Dis (2024) 78, 94-97. PubMed Europe PubMed DOI
Chiba,Y., Doi,T., Obayashi,K., Sumida,K., Nagasaka,S., Wang,K.Y., Yamasaki,K., Masago,K., Matsushita,H., Kuroda,H., Yatera,K. and Endo,M. Caspase-4 promotes metastasis and interferon-gamma-induced pyroptosis in lung adenocarcinoma Commun Biol (2024) 7, 699-699. PubMed Europe PubMed DOI PMC EPMC
Daily,K.P., Badr,A., Eltobgy,M., Estfanous,S., Whitham,O., Tan,M.H., Carafice,C., Krause,K., McNamara,A., Hamilton,K., Houle,S., Gupta,S., Gupta,G.A., Madhu,S., Fitzgerald,J., Saadey,A.A., Laster,B., Yan,P., Webb,A., Zhang,X., Pietrzak,M., Kokiko-Cochran,O.N., Ghoneim,H.E. and Amer,A.O. DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-beta deposition in Alzheimer's disease Alzheimers Res Ther (2024) 16, 29-29. PubMed Europe PubMed DOI PMC EPMC
Devant,P., Dong,Y., Mintseris,J., Ma,W., Gygi,S.P., Wu,H. and Kagan,J.C. Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4 Nature (2024) 625, E17-E17. PubMed Europe PubMed DOI
Di,L., Li,M., Lei,X., Xie,W., Liu,G., Wang,Y., Zhang,W. and Zhu,W.G. Caspase-4 in glioma indicates deterioration and unfavorable prognosis by affecting tumor cell proliferation and immune cell recruitment Sci Rep (2024) 14, 17443-17443. PubMed Europe PubMed DOI PMC EPMC
Li,S., Song,J., Liu,J., Zhou,S., Zhao,G., Li,T., Huang,L., Li,J. and Weng,C. African swine fever virus infection regulates pyroptosis by cleaving gasdermin A (GSDMA) via active caspase-3 and caspase-4 J Biol Chem (2024) , 107307-107307. PubMed Europe PubMed DOI
Sumida,K., Doi,T., Obayashi,K., Chiba,Y., Nagasaka,S., Ogino,N., Miyagawa,K., Baba,R., Morimoto,H., Hara,H., Terabayashi,T., Ishizaki,T., Harada,M. and Endo,M. Caspase-4 has a role in cell division in epithelial cells through actin depolymerization Biochem Biophys Res Commun (2024) 695, 149394-149394. PubMed Europe PubMed DOI

2023

Devant,P., Dong,Y., Mintseris,J., Ma,W., Gygi,S.P., Wu,H. and Kagan,J.C. Structural insights into cytokine cleavage by inflammatory caspase-4 Nature (2023) 624, 451-459. PubMed Europe PubMed DOI PMC EPMC
Dilucca,M. and Broz,P. Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria Methods Mol Biol (2023) 2641, 49-65. PubMed Europe PubMed DOI
Sahoo,G., Samal,D., Khandayataray,P. and Murthy,M.K. A Review on Caspases: Key Regulators of Biological Activities and Apoptosis Mol Neurobiol (2023) 60, 5805-5837. PubMed Europe PubMed DOI V
Shi,X., Sun,Q., Hou,Y., Zeng,H., Cao,Y., Dong,M., Ding,J. and Shao,F. Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome Nature (2023) 624, 442-450. PubMed Europe PubMed DOI
Yi,Y.S. Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V

2022

Bibo-Verdugo,B., Joglekar,I., Karadi Giridhar,M.N., Ramirez,M.L., Snipas,S.J., Clark,A.C., Poreba,M. and Salvesen,G.S. Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold J Biol Chem (2022) 298, 101931-101931. PubMed Europe PubMed DOI PMC EPMC
Chukai,Y., Ito,G., Konno,M., Sakata,Y. and Ozaki,T. Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress Biochem Biophys Res Commun (2022) 608, 156-162. PubMed Europe PubMed DOI K
Eltobgy,M.M., Zani,A., Kenney,A.D., Estfanous,S., Kim,E., Badr,A., Carafice,C., Daily,K., Whitham,O., Pietrzak,M., Webb,A., Kawahara,J., Eddy,A.C., Denz,P., Lu,M., Kc,M., Peeples,M.E., Li,J., Zhu,J., Que,J., Robinson,R., Rosas Mejia,O., Rayner,R.E., Hall-Stoodley,L., Seveau,S., Gavrilin,M.A., Zhang,X., Thomas,J., Kohlmeier,J.E., Suthar,M.S., Oltz,E., Tedeschi,A., Robledo-Avila,F.H., Partida-Sanchez,S., Hemann,E.A., Abdelrazik,E., Forero,A., Nimjee,S.M., Boyaka,P.N., Cormet-Boyaka,E., Yount,J.S. and Amer,A.O. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis Proc Natl Acad Sci U S A (2022) 119, e2202012119-e2202012119. PubMed Europe PubMed DOI PMC EPMC
Ross,C., Chan,A.H., von Pein,J.B., Maddugoda,M.P., Boucher,D. and Schroder,K. Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes Annu Rev Immunol (2022) PubMed Europe PubMed DOI V
Smith,A.P. and Creagh,E.M. Caspase-4 and -5 Biology in the Pathogenesis of Inflammatory Bowel Disease Front Pharmacol (2022) 13, 919567-919567. PubMed Europe PubMed DOI PMC EPMC V
Wang,Z., Chan,W. and Yue,Y. A significant other: Non-canonical caspase-4/5/11 inflammasome in periodontitis Oral Dis (2022) PubMed Europe PubMed DOI V

2021

Bateman,G., Hill,B., Knight,R. and Boucher,D. Great balls of fire: activation and signalling of inflammatory caspases Biochem Soc Trans (2021) 49, 1311-1324. PubMed Europe PubMed DOI V
Davies,C.W., Stowe,I., Phung,Q.T., Ho,H., Bakalarski,C.E., Gupta,A., Zhang,Y., Lill,J.R., Payandeh,J., Kayagaki,N. and Koerber,J.T. Discovery of a caspase cleavage motif antibody reveals insights into noncanonical inflammasome function Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC
Devant,P., Cao,A. and Kagan,J.C. Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1beta converting enzyme Sci Immunol (2021) 6 PubMed Europe PubMed DOI PMC EPMC
Li,Z., Liu,W., Fu,J., Cheng,S., Xu,Y., Wang,Z., Liu,X., Shi,X., Liu,Y., Qi,X., Liu,X., Ding,J. and Shao,F. Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11 Nature (2021) 599, 290-295. PubMed Europe PubMed DOI

2020

Ding,P.H., Yang,M.X., Wang,N.N., Jin,L.J., Dong,Y., Cai,X. and Chen,L.L. Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1beta Release Depend on Caspase-4 Front Microbiol (2020) 11, 1881-1881. PubMed Europe PubMed DOI PMC EPMC K
Eren,E., Planes,R., Bagayoko,S., Bordignon,P.J., Chaoui,K., Hessel,A., Santoni,K., Pinilla,M., Lagrange,B., Burlet-Schiltz,O., Howard,J.C., Henry,T., Yamamoto,M. and Meunier,E. Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response EMBO Rep (2020) 21, e50829-e50829. PubMed Europe PubMed DOI PMC EPMC
Fisch,D., Clough,B., Domart,M.C., Encheva,V., Bando,H., Snijders,A.P., Collinson,L.M., Yamamoto,M., Shenoy,A.R. and Frickel,E.M. Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death Cell Rep (2020) 32, 108008-108008. PubMed Europe PubMed DOI PMC EPMC
Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M. Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets Genomics (2020) PubMed Europe PubMed DOI
Jiao,Y., Wang,L., Lu,L., Liu,J., Li,X., Zhao,H., Hou,Z. and Zheng,B. The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors Stem Cells Int (2020) 2020, 8867115-8867115. PubMed Europe PubMed DOI PMC EPMC K
Linares,G.R., Leng,Y., Maric,D. and Chuang,D.M. Overexpression of fibroblast growth factor-21 (FGF-21) protects mesenchymal stem cells against caspase-dependent apoptosis induced by oxidative stress and inflammation Cell Biol Int (2020) PubMed Europe PubMed DOI
Linder,A. and Hornung,V. Irgm2 and Gate-16 put a break on caspase-11 activation EMBO Rep (2020) 21, e51787-e51787. PubMed Europe PubMed DOI PMC EPMC
Terlizzi,M., Molino,A., Colarusso,C., Somma,P., De Rosa,I., Troisi,J., Scala,G., Salvi,R., Pinto,A. and Sorrentino,R. Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients Oncotarget (2020) 11, 3515-3525. PubMed Europe PubMed DOI PMC EPMC
Zaslona,Z., Flis,E., Nulty,C., Kearney,J., FitzGerald,R., Douglas,A.R., McNamara,D., Smith,S., O'Neill,L.A.J. and Creagh,E.M. Caspase-4: A Therapeutic Target for Peptic Ulcer Disease Immunohorizons (2020) 4, 627-633. PubMed Europe PubMed DOI

2019

Benaoudia,S., Martin,A., Puig Gamez,M., Gay,G., Lagrange,B., Cornut,M., Krasnykov,K., Claude,J.B., Bourgeois,C.F., Hughes,S., Gillet,B., Allatif,O., Corbin,A., Ricci,R. and Henry,T. A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells EMBO Rep (2019) , e48235-e48235. PubMed Europe PubMed DOI

2018

Jun,H.K., Jung,Y.J., Ji,S., An,S.J. and Choi,B.K. Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts Cell Death Differ (2018) 25, 380-391. PubMed Europe PubMed DOI
Lagrange,B., Benaoudia,S., Wallet,P., Magnotti,F., Provost,A., Michal,F., Martin,A., Di Lorenzo,F., Py,B.F., Molinaro,A. and Henry,T. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11 Nat Commun (2018) 9, 242-242. PubMed Europe PubMed DOI PMC EPMC

2016

Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed Europe PubMed DOI P
Kent,C.R., Bryja,M., Gustafson,H.A., Kawarski,M.Y., Lenti,G., Pierce,E.N., Knopp,R.C., Ceja,V., Pati,B., Walters,D.E. and Karver,C.E. Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases Bioorg Med Chem Lett (2016) 26, 5476-5480. PubMed Europe PubMed DOI I

2015

Schmid-Burgk,J.L., Gaidt,M.M., Schmidt,T., Ebert,T.S., Bartok,E. and Hornung,V. Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells Eur J Immunol (2015) 45, 2911-2917. PubMed Europe PubMed DOI
Shi,J., Zhao,Y., Wang,K., Shi,X., Wang,Y., Huang,H., Zhuang,Y., Cai,T., Wang,F. and Shao,F. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death Nature (2015) 526, 660-665. PubMed Europe PubMed DOI

2014

Neuromuscular disease: caspase-4 is a potential therapeutic target for Duchenne muscular dystrophy Nat Rev Neurol (2014) 10, 366-366. DOI T
Kajiwara,Y., Schiff,T., Voloudakis,G., Gama Sosa,M.A., Elder,G., Bozdagi,O. and Buxbaum,J.D. A critical role for human caspase-4 in endotoxin sensitivity J Immunol (2014) 193, 335-343. PubMed Europe PubMed DOI
Knodler,L.A., Crowley,S.M., Sham,H.P., Yang,H., Wrande,M., Ma,C., Ernst,R.K., Steele-Mortimer,O., Celli,J. and Vallance,B.A. Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens Cell Host Microbe (2014) 16, 249-256. PubMed Europe PubMed DOI

2012

Gao,J. and Wells,J.A. Caspase-4 and caspase-5 [ISSN:978-0-12-407743-0] (2012) 3, 2265-2269. DOI
Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G. Human caspases in vitro: expression, purification and kinetic characterization Protein Expr Purif (2012) 84, 236-246. PubMed Europe PubMed DOI E
Sollberger,G., Strittmatter,G.E., Kistowska,M., French,L.E. and Beer,H.D. Caspase-4 is required for activation of inflammasomes J Immunol (2012) 188, 1992-2000. PubMed Europe PubMed DOI

2011

Yamamuro,A., Kishino,T., Ohshima,Y., Yoshioka,Y., Kimura,T., Kasai,A. and Maeda,S. Caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells J Pharmacol Sci (2011) 115, 239-243. PubMed Europe PubMed DOI

2010

Agard,N.J., Maltby,D. and Wells,J.A. Inflammatory stimuli regulate caspase substrate profiles Mol Cell Proteomics (2010) 9, 880-893. PubMed Europe PubMed DOI P
Matsuzaki,S., Hiratsuka,T., Kuwahara,R., Katayama,T. and Tohyama,M. Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress Neurochem Int (2010) 56, 352-356. PubMed Europe PubMed DOI
Yazdi,A.S., Guarda,G., D'Ombrain,M.C. and Drexler,S.K. Inflammatory caspases in innate immunity and inflammation J Innate Immun (2010) 2, 228-237. PubMed Europe PubMed DOI

2009

Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V. Evaluation of recombinant caspase specificity by competitive substrates Anal Biochem (2009) 394, 68-74. PubMed Europe PubMed DOI A P
Kajiwara,Y., Akram,A., Katsel,P., Haroutunian,V., Schmeidler,J., Beecham,G., Haines,J.L., Pericak-Vance,M.A. and Buxbaum,J.D. FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4 PLoS ONE (2009) 4, e5071-e5071. PubMed Europe PubMed DOI PMC EPMC

2008

Soung,Y.H., Jeong,E.G., Ahn,C.H., Kim,S.S., Song,S.Y., Yoo,N.J. and Lee,S.H. Mutational analysis of caspase 1, 4, and 5 genes in common human cancers Hum Pathol (2008) 39, 895-900. PubMed Europe PubMed DOI M

2007

Karki,P., Dahal,G.R. and Park,I.S. Both dimerization and interdomain processing are essential for caspase-4 activation Biochem Biophys Res Commun (2007) 356, 1056-1061. PubMed Europe PubMed DOI
Kersse,K., Vanden Berghe,T., Lamkanfi,M. and Vandenabeele,P. A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins Biochem Soc Trans (2007) 35, 1508-1511. PubMed Europe PubMed DOI
Martinon,F. and Tschopp,J. Inflammatory caspases and inflammasomes: master switches of inflammation Cell Death Differ (2007) 14, 10-22. PubMed Europe PubMed DOI

1999

Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A. Purification and catalytic properties of human caspase family members Cell Death Differ (1999) 6, 362-369. PubMed Europe PubMed DOI
Lee,D., Adams,J.L., Brandt,M., DeWolf,W.E., Jr., Keller,P.M. and Levy,M.A. A substrate combinatorial array for caspases Bioorg Med Chem Lett (1999) 9, 1667-1672. PubMed Europe PubMed DOI P

1998

[YEAR:1-4-1998]Fassy,F., Krebs,O., Rey,H., Komara,B., Gillard,C., Capdevila,C., Yea,C., Faucheu,C., Blanchet,A.M., Miossec,C. and Diu-Hercend,A. Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme Eur J Biochem (1-4-1998) 253, 76-83. PubMed Europe PubMed DOI

1997

Kamada,S., Funahashi,Y. and Tsujimoto,Y. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases Cell Death Differ (1997) 4, 473-478. PubMed Europe PubMed DOI I
[YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W. Substrate specificities of caspase family proteases J Biol Chem (11-4-1997) 272, 9677-9682. PubMed Europe PubMed DOI P

1995

Kamens,J., Paskind,M., Hugunin,M., Talanian,R.V., Allen,H., Banach,D., Bump,N., Hackett,M., Johnston,C.G. and Li,P. Identification and characterization of ICH-2, a novel member of the interleukin-1beta-converting enzyme family of cysteine proteases J Biol Chem (1995) 270, 15250-15256. PubMed Europe PubMed DOI