Sequence features for peptidase A22.001: presenilin 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0689539 Acanthisitta chloris 481 1-481 D271, D399 GENBANK:XP_009077511
MER0200005 Ailuropoda melanoleuca 212 101-210 missing, missing GENBANK:XP_002920300
MER0270081 Alligator mississippiensis 468 1-468 D258, D386 GENBANK:XP_006272619
MER0319198 Anas platyrhynchos 473 1-473 D265, D391 GENBANK:XP_005021706
MER0688060 Apaloderma vittatum 481 1-481 D271, D399 GENBANK:XP_009873361
MER0687865 Aptenodytes forsteri 468 1-468 D258, D386 GENBANK:XP_009277534
MER0686855 Aquila chrysaetos 489 22-489 D279, D407 GENBANK:XP_011597511
MER0556293 Astatotilapia burtoni 490 92-490 D277, D408 GENBANK:XP_005946966
MER0365411 Astyanax mexicanus 461 1-461 D242, D379 GENBANK:XP_007257365
MER0396047 Balaenoptera acutorostrata 469 1-469 D259, D387 GENBANK:XP_007184475
MER0682265 Balearica regulorum 480 1-480 D270, D398 GENBANK:XP_010299311
MER0680578 Bison bison 478 1-478 D258, D396 GENBANK:XP_010854099
MER0586474 Boiga irregularis 467 72-466 D257, D385 UNIPROT:A0A0B8RPK7
MER0586474 Boiga irregularis 467 72-466 D257, D385 UNIPROT:A0A0B8RPK7
MER0090008 Bos grunniens 478 1-478 D258, D396 GENBANK:ELR57735
MER0012008 Bos taurus 478 1-478 D258, D396 UNIPROT:Q9XT97
MER0012008 Bos taurus 478 1-478 D258, D396 UNIPROT:Q9XT97
MER0012008 Bos taurus 478 1-478 D258, D396 UNIPROT:Q9XT97
MER0579578 Bubalus bubalis 478 1-478 D258, D396 GENBANK:XP_006055265
MER0678315 Buceros rhinoceros 481 1-481 D271, D399 GENBANK:XP_010132251
MER0198054 Callithrix jacchus 466 1-466 D257, D384 UNIPROT:U3E9M1
MER0198054 Callithrix jacchus 466 1-466 D257, D384 UNIPROT:U3E9M1
MER0581933 Calypte anna 481 1-481 D271, D399 GENBANK:XP_008501177
MER0021344 Camelus dromedarius 133 1-133 missing, missing UNIPROT:Q8HZ65
MER0021344 Camelus dromedarius 133 1-133 missing, missing UNIPROT:Q8HZ65
MER0520509 Camelus ferus 468 1-468 D258, D386 GENBANK:XP_006184569
MER0045746 Canis lupus familiaris 468 1-468 D258, D386 UNIPROT:F1PHD2
MER0045746 Canis lupus familiaris 468 1-468 D258, D386 UNIPROT:F1PHD2
MER0045746 Canis lupus familiaris 468 1-468 D258, D386 UNIPROT:F1PHD2
MER0530115 Capra hircus 468 1-468 D258, D386 GENBANK:XP_005686102
MER0676150 Cariama cristata 481 1-481 D271, D399 GENBANK:XP_009693852
MER0495941 Cathartes aura 388 6-387 D191, D306 UNIPROT:A0A091LDK0
MER0495941 Cathartes aura 388 6-387 D191, D306 UNIPROT:A0A091LDK0
MER0103186 Cavia porcellus 467 1-467 D257, D385 GENBANK:XP_003472446
MER0566670 Ceratotherium simum 468 1-468 D258, D386 GENBANK:XP_004426379
MER0587713 Cercopithecus sabaeus 467 1-467 D257, D385 GENBANK:XP_007985387
MER0673154 Chaetura pelagica 481 1-481 D271, D399 GENBANK:XP_009998036
MER0671583 Charadrius vociferus 481 1-481 D271, D399 GENBANK:XP_009880621
MER0591763 Chelonia mydas 494 28-494 D284, D412 GENBANK:XP_007055805
MER0581423 Chinchilla lanigera 467 1-467 D257, D385 GENBANK:XP_005409484
MER0577337 Chrysemys picta 494 28-494 D284, D412 GENBANK:XP_005284646
MER0575827 Chrysochloris asiatica 469 1-469 D259, D387 GENBANK:XP_006865615
MER0558616 Colius striatus 371 6-370 D191, D289 UNIPROT:A0A091K1Y8
MER0558616 Colius striatus 371 6-370 D191, D289 UNIPROT:A0A091K1Y8
MER0671471 Colius striatus 479 1-479 D271, D397 GENBANK:XP_010198536
MER0670074 Colobus angolensis 467 1-467 D257, D385 GENBANK:XP_011805006
MER0090009 Columba livia 468 1-468 D258, D386 GENBANK:EMC83763
MER0574430 Condylura cristata 468 1-468 D258, D386 GENBANK:XP_004681775
MER0573102 Corvus brachyrhynchos 480 1-480 D271, D398 GENBANK:XP_008637714
MER0661176 Corvus cornix 480 1-480 D271, D398 GENBANK:XP_010388375
MER0198075 Cricetulus griseus 467 1-467 D257, D385 GENBANK:XP_003505169
MER0245610 Crotalus adamanteus 467 1-467 D257, D385 UNIPROT:J3S0J3
MER0245610 Crotalus adamanteus 467 1-467 D257, D385 UNIPROT:J3S0J3
MER0694498 Crotalus horridus 467 72-466 D257, D385, UNIPROT:T1D9N8
MER0694498 Crotalus horridus 467 72-466 D257, D385, UNIPROT:T1D9N8
MER0665164 Cuculus canorus 481 1-481 D271, D399 GENBANK:XP_009562104
MER0566843 Cynoglossus semilaevis 486 67-486 D278, D404 GENBANK:XP_008312331
MER0005236 Cyprinus carpio 384 1-384 D176, D302 UNIPROT:O73869
MER0005236 Cyprinus carpio 384 1-384 D176, D302 UNIPROT:O73869
MER0005237 Danio rerio 456 6-456 D246, D374 UNIPROT:Q9W6T7
MER0005237 Danio rerio 456 6-456 D246, D374 UNIPROT:Q9W6T7
MER0005237 Danio rerio 456 6-456 D246, D374 UNIPROT:Q9W6T7
MER0605833 Dasypus novemcinctus 469 1-469 D259, D387 GENBANK:XP_004466111
MER0245571 Desmodus rotundus 468 1-468 D258, D386 UNIPROT:K9IKI1
MER0245571 Desmodus rotundus 468 1-468 D258, D386 UNIPROT:K9IKI1
MER0599783 Echinops telfairi 470 1-470 D259, D388 GENBANK:XP_004698750
MER0664377 Egretta garzetta 471 1-471 D271, D399 GENBANK:XP_009643845
MER0564748 Elephantulus edwardii 469 1-469 D259, D387 GENBANK:XP_006884769
MER0563160 Eptesicus fuscus 468 1-468 D258, D386 GENBANK:XP_008137086
MER0098305 Equus caballus 470 1-470 D260, D388 GENBANK:XP_001489127
MER0627936 Equus caballus 380 1-379 D170, D298 UNIPROT:F6SAM1
MER0562724 Equus przewalskii 470 1-470 D260, D388 GENBANK:XP_008541966
MER0662235 Esox lucius 477 18-477 D255, D395 GENBANK:XP_010877695
MER0658619 Eurypyga helias 481 1-481 D271, D399 GENBANK:XP_010150209
MER0560689 Falco cherrug 481 1-481 D271, D399 GENBANK:XP_005441178
MER0525267 Falco peregrinus 481 1-481 D271, D399 GENBANK:XP_005243807
MER0245549 Felis catus 467 1-467 D257, D385 UNIPROT:M3WQU7
MER0245549 Felis catus 467 1-467 D257, D385 UNIPROT:M3WQU7
MER0568714 Ficedula albicollis 467 1-467 D258, D385 UNIPROT:U3JSE4
MER0568714 Ficedula albicollis 467 1-467 D258, D385 UNIPROT:U3JSE4
MER0656781 Fukomys damarensis 467 1-467 D257, D385 GENBANK:XP_010643728
MER0654787 Fulmarus glacialis 481 1-481 D271, D399 GENBANK:XP_009576146
MER0558627 Galeopterus variegatus 465 1-465 D255, D383 GENBANK:XP_008582117
MER0021225 Gallus gallus 468 1-468 D258, D386 UNIPROT:Q4JIM4
MER0021225 Gallus gallus 468 1-468 D258, D386 UNIPROT:Q4JIM4
MER0021225 Gallus gallus 468 1-468 D258, D386 UNIPROT:Q4JIM4
MER0654220 Gavia stellata 481 1-481 D271, D399 GENBANK:XP_009811368
MER0559188 Geospiza fortis 480 1-480 D271, D398 GENBANK:XP_005417614
MER0245637 Gorilla gorilla 483 129-423 D362, missing GENBANK:XP_004055463
MER0653337 Haliaeetus albicilla 481 1-481 D271, D399 GENBANK:XP_009921077
MER0651588 Haliaeetus leucocephalus 481 1-481 D271, D399 GENBANK:XP_010564792
MER0198582 Heterocephalus glaber 334 74-329 missing, missing UNIPROT:G5BP42
MER0198582 Heterocephalus glaber 334 74-329 missing, missing UNIPROT:G5BP42
MER0200523 Heterocephalus glaber 94 5-94 missing, D12 UNIPROT:G5C1P7
MER0200523 Heterocephalus glaber 94 5-94 missing, D12 UNIPROT:G5C1P7
MER0005221 Homo sapiens 467 1-467 D257, D385 PIR:S58396
MER0005221 Homo sapiens 467 1-467 D257, D385 PIR:S58396
MER0201268 Hydra magnipapillata 204 94-182 missing, missing GENBANK:XP_002155463
MER0200816 Hymenochirus curtipes 127 75-127 missing, missing UNIPROT:G5E3X4
MER0200816 Hymenochirus curtipes 127 75-127 missing, missing UNIPROT:G5E3X4
MER0106282 Ictidomys tridecemlineatus 467 1-467 D257, D385 GENBANK:XP_005321261
MER0547908 Jaculus jaculus 448 1-448 D257, D384 GENBANK:XP_004649765
MER0650079 Larimichthys crocea 437 43-437 D225, D355 GENBANK:XP_010749491
MER0554117 Lepisosteus oculatus 403 1-403 D250, D321 GENBANK:XP_006632655
MER0691051 Lepisosteus oculatus 522 65-521 D250, D440 GENBANK:-
MER0481446 Leptosomus discolor 388 6-387 D191, D306 UNIPROT:A0A091PBT7
MER0481446 Leptosomus discolor 388 6-387 D191, D306 UNIPROT:A0A091PBT7
MER0549167 Lipotes vexillifer 468 1-468 D258, D386 GENBANK:XP_007459764
MER0021342 Macaca fascicularis 467 1-467 D257, D385 GENBANK:EHH63751
MER0021342 Macaca fascicularis 467 1-467 D257, D385 GENBANK:EHH63751
MER0021342 Macaca fascicularis 467 1-467 D257, D385 GENBANK:EHH63751
MER0021342 Macaca fascicularis 467 1-467 D257, D385 GENBANK:EHH63751
MER0083808 Macaca mulatta 466 1-466 D256, D384 UNIPROT:G7MYL4
MER0083808 Macaca mulatta 466 1-466 D256, D384 UNIPROT:G7MYL4
MER0694471 Macaca mulatta 409 72-408 D257, D327 UNIPROT:F6SRH1
MER0647128 Manacus vitellinus 469 48-469 D258, D386 GENBANK:XP_008925039
MER0645470 Mandrillus leucophaeus 467 1-467 D257, D385 GENBANK:XP_011838490
MER0541731 Maylandia zebra 491 93-491 D278, D409 GENBANK:XP_004540048
MER0198091 Meleagris gallopavo 468 1-468 D258, D386 GENBANK:XP_003206537
MER0540992 Melopsittacus undulatus 467 1-467 D257, D385 GENBANK:XP_005149693
MER0644365 Merops nubicus 465 1-465 D255, D383 GENBANK:XP_008936107
MER0643655 Mesitornis unicolor 481 1-481 D271, D399 GENBANK:XP_010188256
MER0544069 Mesocricetus auratus 467 1-467 D257, D385 GENBANK:XP_005072757
MER0005235 Microcebus murinus 467 1-467 D257, D385 PIR:JC5080
MER0005235 Microcebus murinus 467 1-467 D257, D385 PIR:JC5080
MER0538957 Microtus ochrogaster 467 1-467 D257, D385 GENBANK:XP_005343368
MER0694372 Micrurus fulvius 468 73-467 D258, D386 UNIPROT:U3FBQ5
MER0694372 Micrurus fulvius 468 73-467 D258, D386 UNIPROT:U3FBQ5
MER0005222 Mus musculus 467 1-467 D257, D385 GENBANK:EDL02743
MER0005222 Mus musculus 467 1-467 D257, D385 GENBANK:EDL02743
MER0005222 Mus musculus 467 1-467 D257, D385 GENBANK:EDL02743
MER0198086 Mustela putorius 427 1-418 D263, D391 UNIPROT:G9KIX0
MER0198086 Mustela putorius 427 1-418 D263, D391 UNIPROT:G9KIX0
MER0564591 Myotis brandtii 468 1-468 D258, D386 GENBANK:XP_005865871
MER0188263 Myotis lucifugus 475 53-475 D265, D393 GENBANK:XP_006097662
MER0641331 Nannospalax galili 464 1-464 D254, D382 GENBANK:XP_008848011
MER0534640 Neolamprologus brichardi 491 91-491 D276, D409 GENBANK:XP_006798674
MER0264060 Neovison vison 254 1-254 D103, D231 UNIPROT:U6DN17
MER0264060 Neovison vison 254 1-254 D103, D231 UNIPROT:U6DN17
MER0638650 Nestor notabilis 480 1-480 D270, D398 GENBANK:XP_010009327
MER0634839 Nipponia nippon 481 1-481 D271, D399 GENBANK:XP_009472014
MER0533202 Octodon degus 468 1-468 D257, D386 GENBANK:XP_004624901
MER0530993 Odobenus rosmarus 468 1-468 D258, D386 GENBANK:XP_004399461
MER0633759 Opisthocomus hoazin 481 1-481 D271, D399 GENBANK:XP_009931413
MER0694347 Opisthocomus hoazin 371 6-370 D191, D289 UNIPROT:A0A091W1P6
MER0694347 Opisthocomus hoazin 371 6-370 D191, D289 UNIPROT:A0A091W1P6
MER0528941 Orcinus orca 468 1-468 D258, D386 GENBANK:XP_004262253
MER0198180 Oreochromis niloticus 484 88-484 D273, D402 GENBANK:XP_003443002
MER0527988 Orycteropus afer 469 1-469 D259, D387 GENBANK:XP_007939585
MER0021287 Oryctolagus cuniculus 464 1-464 D253, D382 GENBANK:XP_002719715
MER0246411 Oryzias latipes 215 5-215 missing, missing GENBANK:XP_004086023
MER0321065 Otolemur garnettii 156 1-156 missing, missing GENBANK:XP_003801112
MER0321068 Otolemur garnettii 90 1-90 missing, D8 GENBANK:XP_003803662
MER0245602 Ovis aries 464 1-464 D254, D382 GENBANK:XP_004010819
MER0324769 Pan paniscus 467 1-467 D257, D385 GENBANK:XP_003824183
MER0053370 Pan troglodytes 463 1-467 V257, Y385 UNIPROT:K7CVQ1
MER0053370 Pan troglodytes 463 1-467 V257, Y385 UNIPROT:K7CVQ1
MER0518477 Panthera tigris 467 1-467 D257, D385 GENBANK:XP_007095160
MER0516215 Pantholops hodgsonii 468 1-468 D258, D386 GENBANK:XP_005980540
MER0245611 Papio anubis 318 1-318 D257, missing GENBANK:XP_003902061
MER0633084 Pelecanus crispus 481 1-481 D271, D399 GENBANK:XP_009482163
MER0524830 Pelodiscus sinensis 467 1-467 D257, D385 GENBANK:XP_006128653
MER0393895 Phaethon lepturus 371 6-370 D191, D289 UNIPROT:A0A091TKZ4
MER0393895 Phaethon lepturus 371 6-370 D191, D289 UNIPROT:A0A091TKZ4
MER0631933 Phaethon lepturus 480 1-480 D270, D398 GENBANK:XP_010286488
MER0631330 Phalacrocorax carbo 481 1-481 D271, D399 GENBANK:XP_009507370
MER0520324 Physeter catodon 468 1-468 D258, D386 GENBANK:XP_007107265
MER0629700 Picoides pubescens 480 1-480 D270, D398 GENBANK:XP_009898897
MER0200034 Pipa carvalhoi 142 1-142 missing, missing UNIPROT:G5E462
MER0200034 Pipa carvalhoi 142 1-142 missing, missing UNIPROT:G5E462
MER0420636 Podiceps cristatus 388 6-387 D191, D306 UNIPROT:A0A094L7T8
MER0420636 Podiceps cristatus 388 6-387 D191, D306 UNIPROT:A0A094L7T8
MER0521344 Poecilia formosa 476 53-476 D263, D394 UNIPROT:A0A096LTC9
MER0521344 Poecilia formosa 476 53-476 D263, D394 UNIPROT:A0A096LTC9
MER0184691 Pongo abelii 467 1-467 D257, D385 UNIPROT:Q5R780
MER0184691 Pongo abelii 467 1-467 D257, D385 UNIPROT:Q5R780
MER0109614 Pongo pygmaeus 467 1-467 D257, D385 GENBANK:CAH92380
MER0109614 Pongo pygmaeus 467 1-467 D257, D385 GENBANK:CAH92380
MER0109614 Pongo pygmaeus 467 1-467 D257, D385 GENBANK:CAH92380
MER0109614 Pongo pygmaeus 467 1-467 D257, D385 GENBANK:CAH92380
MER0246428 Pteropus alecto 116 1-114 missing, missing UNIPROT:L5JS78
MER0246428 Pteropus alecto 116 1-114 missing, missing UNIPROT:L5JS78
MER0600297 Pteropus vampyrus 468 1-468 D258, D386 GENBANK:XP_011369212
MER0694438 Pygoscelis adeliae 388 6-387 D191, D306 UNIPROT:A0A093NFU2
MER0694438 Pygoscelis adeliae 388 6-387 D191, D306 UNIPROT:A0A093NFU2
MER0442056 Python bivittatus 467 1-467 D257, D385 GENBANK:XP_007428163
MER0005231 Rattus norvegicus 468 1-468 D257, D386 UNIPROT:P97887
MER0005231 Rattus norvegicus 468 1-468 D257, D386 UNIPROT:P97887
MER0005231 Rattus norvegicus 468 1-468 D257, D386 UNIPROT:P97887
MER0556637 Rhinopithecus roxellana 465 1-465 D255, D383 GENBANK:XP_010354148
MER0245502 Saimiri boliviensis 467 1-467 D257, D385 GENBANK:XP_003924553
MER0321055 Sarcophilus harrisii 470 1-470 D259, D388 UNIPROT:G3WGI8
MER0321055 Sarcophilus harrisii 470 1-470 D259, D388 UNIPROT:G3WGI8
MER0549081 Serinus canaria 480 1-480 D271, D398 GENBANK:XP_009100275
MER0597144 Sorex araneus 469 1-469 D259, D387 GENBANK:XP_004612354
MER0472444 Stegastes partitus 491 96-491 D278, D409 GENBANK:XP_008286705
MER0425247 Stenella coeruleoalba 43 1-43 missing, missing UNIPROT:Q56JK0
MER0425247 Stenella coeruleoalba 43 1-43 missing, missing UNIPROT:Q56JK0
MER0511994 Struthio camelus 468 1-468 D258, D386 GENBANK:XP_009668705
MER0091782 Sus scrofa 467 1-467 D258, D385 UNIPROT:Q0MS44
MER0091782 Sus scrofa 467 1-467 D258, D385 UNIPROT:Q0MS44
MER0163729 Taeniopygia guttata 467 1-467 D258, D385 GENBANK:XP_002200426
MER0245631 Takifugu rubripes 470 76-470 D258, D388 GENBANK:XP_003978532
MER0596148 Tarsius syrichta 467 1-467 D257, D385 GENBANK:XP_008067778
MER0694354 Tauraco erythrolophus 306 2-305 D98, D224 UNIPROT:A0A093EP38
MER0694354 Tauraco erythrolophus 306 2-305 D98, D224 UNIPROT:A0A093EP38
MER0109436 Tetraodon nigroviridis 481 2-481 D269, D399 UNIPROT:Q4TA47
MER0109436 Tetraodon nigroviridis 481 2-481 D269, D399 UNIPROT:Q4TA47
MER0176117 Tetraodon nigroviridis 446 20-373 P259, P340 UNIPROT:Q4TAL2
MER0176117 Tetraodon nigroviridis 446 20-373 P259, P340 UNIPROT:Q4TAL2
MER0694427 Tetraodon nigroviridis 463 67-462 D251, D381 GENBANK:-
MER0475331 Tinamus guttatus 468 48-468 D258, D386 GENBANK:XP_010210205
MER0425425 Toxoplasma gondii 390 294-376 missing, D310 GENBANK:EEE30821
MER0485577 Trichechus manatus 469 1-469 D259, D387 GENBANK:XP_004371070
MER0090016 Tupaia chinensis 1090 703-1090 Y941, D1008 UNIPROT:L8Y0M4
MER0090016 Tupaia chinensis 1090 703-1090 Y941, D1008 UNIPROT:L8Y0M4
MER0598962 Tupaia chinensis 467 1-467 D257, D385 GENBANK:XP_006170574
MER0452373 Tyto alba 481 1-481 D271, D399 GENBANK:XP_009969591
MER0297185 Ursus maritimus 474 1-474 D258, D386 GENBANK:XP_008698254
MER0616322 Vicugna pacos 468 1-468 D258, D386 GENBANK:XP_006206959
MER0246896 Wuchereria bancrofti 91 2-81 missing, D8 UNIPROT:J9AAT2
MER0246896 Wuchereria bancrofti 91 2-81 missing, D8 UNIPROT:J9AAT2
MER0005232 Xenopus laevis 433 1-433 D223, D351 PIR:JC5390
MER0005232 Xenopus laevis 433 1-433 D223, D351 PIR:JC5390
MER0450381 Xiphophorus maculatus 478 52-478 D262, D396 GENBANK:XP_005810726
MER0446467 Zonotrichia albicollis 467 1-467 D258, D385 GENBANK:XP_005480027