Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P16070

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-742	P		NT	<%Agarwal et al., 2012[]%>
162	membrane-type matrix metallopeptidase-1	21-742	P			Kajita et al., 2001
186	membrane-type matrix metallopeptidase-1	21-742	P			Kajita et al., 2001
192	membrane-type matrix metallopeptidase-1	21-742	P			Kajita et al., 2001
659	presenilin 1	21-742	P	release from a membrane surface		Lammich et al., 2002